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DOE OSTI · 1531980

Method for atomic layer deposition

Jiang, Ying-Bing·Cecchi, Joseph L.·Fu, Yaqin·Brinker, C. Jeffrey
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Abstract

An atomic layer deposition method is disclosed for preparing polypeptides. The method comprises providing a solid-phase support comprising a reactive amine monolayer in an atomic layer deposition (ALD) chamber. The solid-phase support is contacted with a first protected amino acid substituted with a protecting group by atomic layer deposition, wherein the protecting group is bonded to a non-side chain amino group of the protected amino acid. A carboxylic acid group of the first protected amino acid is reacted with the reactive amine monolayer, thereby coupling the first protected amino acid to the solid-phase support to produce a coupled-product.

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59 BASIC BIOLOGICAL SCIENCES75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY

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BibTeXRIS

Jiang, Ying-Bing, Cecchi, Joseph L., Fu, Yaqin, Brinker, C. Jeffrey. 2017-03-28. Method for atomic layer deposition. https://www.osti.gov/biblio/1531980

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