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At least 19 records

Irreversibility of advanced osteoporosis: Limited role for pharmacologic intervention

Osteoporosis is of medical interest only because it increases bone fragility and risk of fracture, and except for relief of symptoms, preventing fracture is the only purpose of intervention. To prevent the first fracture, adequate bone density must be accumulated and conserved, but to prevent subsequent fracture, bone density must be augmented so that the supportive function of the skeleton can be restored. Almost 50 years after the recognition of post menopausal osteoporosis as a clinical entity, not one of the many treatments that have been used has been demonstrated to be efficacious in reducing subsequent fracture risk. My purpose is not to recite this chronicle of disappointment, but to account for it in terms of bone biology, to consider some possible exceptions, and to reiterate the importance of preventing damage to the skeleton rather than belatedly attempting its repair.

Parfitt, A. M.↗

Test-Free Fracture Toughness

Computational simulation results can give the prediction of damage growth and progression and fracture toughness of composite structures. The experimental data from literature provide environmental effects on the fracture behavior of metallic or fiber composite structures. However, the traditional experimental methods to analyze the influence of the imposed conditions are expensive and time consuming. This research used the CODSTRAN code to model the temperature effects, scaling effects and the loading effects of fiberbraided composite specimens with and without fiber-optic sensors on the damage initiation and energy release rates. The load-displacement relationship and fracture toughness assessment approach is compared with the test results from literature and it is verified that the computational simulation, with the use of established material modeling and finite element modules, adequately tracks the changes of fracture toughness and subsequent fracture propagation for any fiberbraided composite structure due to the change of fiber orientations, presence of large diameter optical fibers, and any loading conditions.

Minnetyan, Levon↗

Test-Free Fracture Toughness

Computational simulation results can give the prediction of damage growth and progression and fracture toughness of composite structures. The experimental data from literature provide environmental effects on the fracture behavior of metallic or fiber composite structures. However, the traditional experimental methods to analyze the influence of the imposed conditions are expensive and time consuming. This research used the CODSTRAN code to model the temperature effects, scaling effects and the loading effects of fiber/braided composite specimens with and without fiber-optic sensors on the damage initiation and energy release rates. The load-displacement relationship and fracture toughness assessment approach is compared with the test results from literature and it is verified that the computational simulation, with the use of established material modeling and finite element modules, adequately tracks the changes of fracture toughness and subsequent fracture propagation for any fiber/braided composite structure due to the change of fiber orientations, presence of large diameter optical fibers, and any loading conditions.

Minnetyan, Levon↗

Risk of Bone Fracture due to Spaceflight-induced Changes to Bone

The Human Research Program (HRP) is taking a biomechanical approach to assessing subsequent fracture risk in active astronauts as a consequence of spaceflight exposure. Triennial testing of active and retired astronauts continues as Space Medicine monitors for a premature diagnosis of primary osteoporosis, which is associated with age-related bone loss and skeletal fragility. This updated 2023 Fracture Evidence Report has expanded the description of skeletal changes to capture the full effects of spaceflight on bone: • Recent analysis of fractures from health records of the full astronaut cohort, suggests an increased incidence rate of hip and spine fractures in astronauts following longer spaceflight duration flights compared to incident rates found in shorter duration flights. • Routine preflight-to-postflight surveillance by DXA (dual-energy x-ray absorptiometry) does not provide the full detection of loss and recovery in the long-duration (LD) astronaut nor the full recovery of hip trabecular bone. • The inclusion of hip quantitative computed tomography (QCT) in flight studies delineates effects of spaceflight, of countermeasures, and of post-flight recovery on cortical and trabecular bone parameters—some of which are verified predictors of hip fracture in the aged. • QCT detects and compares the distinct countermeasure effects of the pharmaceutical alendronate and of resistive exercise (on the Advanced Resistive Exercise Device, ARED) in specific cortical and trabecular bone sub-regions during spaceflight. • A published comparison of QCT-determined loss rates of hip trabecular bone in LD astronauts compared to terrestrial cohorts suggest that accelerated loss rates in trabecular volumetric BMD (vBMD) during spaceflight might be analogous to skeletal effects of accelerated loss rates in females due to menopause, potentially leading to disruptions in trabecular microarchitecture. • A dataset of finite element (FE) estimates of hip bone strength in aging terrestrial cohorts (spanning astronaut age-range) provides comparative context for changes in the FE of hip bone strength in LD astronauts, including comparison (force unit of newton) to percentiles (50th, 75th, and 100th) of sex-matched aged humans with hip fractures. • Risk of fracture, due to the mechanical overloading of bones, is being updated with IMPACT, the next-generation tool suite for probabilistic risk assessment (PRA) for exploration missions being created by the Exploration and Medical Capability Element (ExMC) at NASA. IMPACT is currently in development and will not be included in this 2024 update. The risk for fracture necessitates understanding the relationship between applied loads to bone and the biomechanical competence of bone. The Risk for Early Onset Osteoporosis focuses on the weakened condition of bone (including development of new technologies, measurements of novel skeletal attributes, translation of multiple measures to an index of bone fragility, and interpretations of data used to reflect a weakened bone), while the Risk for Fracture assesses factors that influence the probability an astronaut would encounter applied loads exceeding the biomechanical competence of bones, resulting in fracture. This Evidence Report combines the research gaps and tasks associated with both risks.

Fracture↗

Altered post-fracture systemic bone loss in a mouse model of osteocyte dysfunction

Femur fracture leads to loss of bone at uninjured skeletal sites, which may increase risk of subsequent fracture. Osteocytes, the most abundant bone cells, can directly resorb bone matrix and regulate osteoclast and osteoblast activity, but their role in systemic bone loss after fracture remains poorly understood. In this study we used a transgenic (TG+) mouse model that overexpresses human B-cell lymphoma 2 (BCL-2) in osteoblasts and osteocytes. This causes enhanced osteoblast proliferation, followed by disruption in lacunar-canalicular connectivity and massive osteocyte death by 10 wk of age. We hypothesized that reduced viable osteocyte density would decrease the magnitude of systemic bone loss after femur fracture, reduce perilacunar remodeling, and alter callus formation. Bone remodeling was assessed using serum biomarkers of bone formation and resorption at 5 d post-fracture. We used micro-computed tomography, high resolution x-ray microscopy, mechanical testing, and Raman spectroscopy to quantify the magnitude of systemic bone loss, as well as changes in osteocyte lacunar volume, bone strength, and bone composition 2 wk post-fracture. Fracture was associated with a reduction in circulating markers of bone resorption in non-transgenic (TG-) animals. TG+ mice exhibited high bone mass in the limbs, greater cortical elastic modulus and reduced post-yield displacement. After fracture, TG+ mice lost less trabecular bone than TG- mice, but conversely TG+ mice exhibited trends toward a lower yield point and reduced femoral cortical thickness after fracture, though these were not statistically significant. Lacunar density was greater in TG+ mice, but fracture did not alter lacunar volume in TG+ or TG- mice. These findings suggest that osteocytes potentially play a significant role in the post-traumatic systemic response to fracture, though the effects differ between trabecular and cortical bone.

60 APPLIED LIFE SCIENCES↗

An Experimental Study of Incremental Surface Loading of an Elastic Plate: Application to Volcano Tectonics

Models of surface fractures due to volcanic loading an elastic plate are commonly used to constrain thickness of planetary lithospheres, but discrepancies exist in predictions of the style of initial failure and in the nature of subsequent fracture evolution. In this study, we perform an experiment to determine the mode of initial failure due to the incremental addition of a conical load to the surface of an elastic plate and compare the location of initial failure with that predicted by elastic theory. In all experiments, the mode of initial failure was tension cracking at the surface of the plate, with cracks oriented circumferential to the load. The cracks nucleated at a distance from load center that corresponds the maximum radial stress predicted by analytical solutions, so a tensile failure criterion is appropriate for predictions of initial failure. With continued loading of the plate, migration of tensional cracks was observed. In the same azimuthal direction as the initial crack, subsequent cracks formed at a smaller radial distance than the initial crack. When forming in a different azimuthal direction, the subsequent cracks formed at a distance greater than the radial distance of the initial crack. The observed fracture pattern may explain the distribution of extensional structures in annular bands around many large scale, circular volcanic features.

Williams, K. K.↗

Effects of proof loads and combined mode loadings on fracture and flaw growth characteristics of aerospace alloys

This experimental program was undertaken to determine the effects of (1) combined tensile and bending loadings, (2) combined tensile and shear loadings, and (3) proof overloads on fracture and flaw growth characteristics of aerospace alloys. Tests were performed on four alloys: 2219-T87 aluminum, 5Al-2.5Sn (ELl) titanium, 6Al-4V beta STA titanium and high strength 4340 steel. Tests were conducted in room air, gaseous nitrogen at -200F (144K), liquid nitrogen and liquid hydrogen. Flat center cracked and surface flawed specimens, cracked tube specimens, circumferentially notched round bar and surface flawed cylindrical specimens were tested. The three-dimensional photoelastic technique of stress freezing and slicing was used to determine stress intensity factors for surface flawed cylindrical specimens subjected to tension or torsion. Results showed that proof load/temperature histories used in the tests have a small beneficial effect or no effect on subsequent fracture strength and flaw growth rates.

Shah, R. C.↗

Size-dependent stochastic tensile properties in additively manufactured 316L stainless steel

Recent work in metal additive manufacturing (AM) suggests that mechanical properties may vary with feature size; however, these studies do not provide a statistically robust description of this phenomenon, nor do they provide a clear causal mechanism. Because of the huge design freedom afforded by 3D printing, AM parts typically contain a range of feature sizes, with particular interest in smaller features, so the size effect must be well understood in order to make informed design decisions. This work investigates the effect of feature size on the stochastic mechanical performance of laser powder bed fusion tensile specimens. A high-throughput tensile testing method was used to characterize the effect of specimen size on strength, elastic modulus and elongation in a statistically meaningful way. The effective yield strength, ultimate tensile strength and modulus decreased strongly with decreasing specimen size: all three properties were reduced by nearly a factor of two as feature dimensions were scaled down from 6.25 mm to 0.4 mm. Hardness and microstructural observations indicate that this size dependence was not due to an intrinsic change in material properties, but instead the effects of surface roughness on the geometry of the specimens. Finite element analysis using explicit representations of surface topography shows the critical role surface features play in creating stress concentrations that trigger deformation and subsequent fracture. The experimental and finite element results provide the tools needed to make corrections in the design process to more accurately predict the performance of AM components.

316L stainless steel↗

Historical photometric evidence for volatile migration on Triton

Analysis of CCD images of Triton obtained with the 1.5-m telescope on Palomar Mountain shows that in the time period surrounding the Voyager 2 encounter with the satellite (1985-1990), no changes in the satellite's visual albedo or color occurred. The published observations of Triton in the 0.35- to 0.60-micrometer spectral region obtained between 1950 and 1990 were reanalyzed to detect historical variability in both its albedo and visual color. Analysis of the photometry indicates that there is little, if any, change in Triton's visual geometric albedo. This result is consistent with the albedo pattern observed by Voyager and the change in sub-Earth latitude. Two distinct types of color changes are evident: a significant secular increase in the blue region of the visual spectrum since at least the 1950s, and the reported dramatic reddening of Triton's spectrum in the late 1970s. The latter change can be explained only by a short-lived geological phenomenon. Triton's changing pole orientation with respect to a terrestrial observer cannot explain the secular color changes. These changes imply volatile transport on a global scale on Triton's surface during the past 4 decades. We present two models which show that either removal of a red volatile from Triton's polar cap or deposition of a blue volatile in the equatorial regions can explain the secular color changes. A third possibility is that the changes are the result of the alpha-beta phase transition of nitrogen and subsequent fracturing of the polar cap region (N. S. Duxbury and R. H. Brown (1993).

Buratti, Bonnie J.↗

Probability of Detection (POD) Demonstration Transferability

NASA Special Level POD demonstration tests are typically performed on flat plates of a single material containing fatigue cracks with aspect rations between 0.3 and 0.5. Subsequent fracture mechanics analyses consider aspect ratios that range from 0.1 to 0.5. There is debate within the NDE community about the detectability of shallow cracks associated with NASA Special Level penetrant inspections that are routinely performed by propellant tank manufactures. The objective of the task is to investigate effect of crack aspect ratio on POD crack sizes for the penetrant inspection technique.

Parker, Bradford H.↗

Small Particle Impact Damage on Different Glass Substrates

Impact experiments using sand particles were performed on four distinct glass substrates. The sand particles were characterized using the X-Ray micro-CT technique; 3-D reconstruction of the particles was followed by further size and shape analyses. High-speed video footage from impact tests was used to calculate the incoming and rebound velocities of the individual sand impact events, as well as particle volume. Further, video analysis was used in conjunction with optical and scanning electron microscopy to relate the incoming velocity and shape of the particles to subsequent fractures, including both radial and lateral cracks. Analysis was performed using peridynamic simulations.

Waxman, R.↗

Turn Your Half-Cut Cells for a Stronger Module

Here, we employ an existing model of crystalline silicon photovoltaic module cell fracture to explore the effect of cell size and orientation on their probability of fracture under module uniform loading. In addition, we also apply continuum damage mechanics to modify this model to consider the effect of cell fracture on the probability of subsequent cell fracture. We elucidate that cell fracture increases the probability of subsequent cell fracture and that rectangular modules containing half-cells aligned with the module's long orientation are much more robust against cell fracture than full-cell and half-cell short orientation modules.

14 SOLAR ENERGY↗

Graphite fiber surface treatment to improve impact strength and fracture resistance in subsequent composites

Graphite (or carbon) fiber composite impact strength improvement was attempted by modifying the fiber surface. Elastomeric particles were made into lattices and deposited ionically on surface treated graphite fiber in an attempt to prepare a surface containing discrete rubber particles. With hard, nonelastomeric polystyrene discrete particle coverage was achieved. All the elastomeric containing lattices resulted in elastomer flow and filament agglomeration during drying.

Paul, J. T., Jr.↗

Experimental Validation of a Module Cell Cracking Model

The What's Cracking app can predict how changes in crystalline silicon photovoltaic (PV) module materials, design, and mounting affect its susceptibility for cell fracture under uniform loading. This work has experimentally validated the app. A set of commercial crystalline silicon PV modules was obtained for this study. The modules were uniformly loaded at three different mounting points, and their subsequent cell fractures were recorded. A large sample size allowed for the development of an experimental statistical model for cell fracture. Here, the comparison of the experiment to predictions from the app is in excellent agreement. Both experimental and modeling results also elucidate how moving the module mounting points toward the center of the module increases the probability of cell fracture.

14 SOLAR ENERGY↗

Predicting ductility of Mg/SiCp nanocomposite under multiaxial loading conditions based on unit cell modeling

This article presents an investigation on the ductility of Mg/SiCp under nine different multiaxial loading conditions based on a unit cell (or called representative volumetric element, RVE) finite element model. The constitutive relationship of magnesium matrix is characterized by a model combined Lode angle dependent plasticity model with the CPB06 plasticity model, which is able to describe the tension-compression asymmetry in magnesium matrix. The debonding of the matrix-particle interface and matrix fracture are considered by the modified Mohr-Coulomb (MMC) fracture model. Simulation results show that the interface debonding and subsequent matrix fracture are responsible for the ductility and fracture of nanocomposite. The computational results with parametric studies are compared and well correlated with experimental data, and it finally gives a stress-based full fracture locus of Mg/SiCp nanocomposite.

42 ENGINEERING↗

Sequentially coupled flow and geomechanical simulation with a discrete fracture model for analyzing fracturing fluid recovery and distribution in fractured ultra-low permeability gas reservoirs

More accurate characterization and prediction of the in-situ distribution of fracturing fluid in fractured reservoirs are needed for enhancing well productivity. In this study, an implicit-sequentially coupled flow/geomechanics simulator incorporating an efficient discrete fracture model is developed to model fluid distribution and recovery performance of ultra-low permeability gas reservoirs. The finite-volume and finite-element methods are used for space discretization of the flow and geomechanics equations, respectively, while the backward Euler method is employed for time discretization. The flow and geomechanics equations are solved sequentially based on fixed-stress splitting. An efficient discrete-fracture model is used to explicitly model the fractured system. Flexible unstructured gridding is employed to model arbitrarily-oriented fractures. The interrelations among pore volume, permeability and geomechanical conditions are considered dynamically using two-way coupled flow and geomechanics computations. The geometry of fracture (networks) due to hydraulic fracturing has significant impacts on the fracturing fluid recovery efficiency and ensuing fluid distribution. Under the same injection volume, the fracturing fluid recovery is higher when the fracture geometry is planar. Fluid recovery is relatively lower whenever natural fractures are activated during fracturing treatments; flowback time is also shortened when complex fracture network with enlarged fracture interface is present. Fracturing fluid in hydraulic fractures may leak off into the natural fractures and subsequently imbibes into the surrounding matrix due to capillarity effects. The fracturing fluid recovery and in-situ fluid distribution are sensitive to the shut-in duration and fracture closure behavior. This study analyzes the coupled flow-geomechanical responses of fractured gas reservoirs during the post-fracturing periods. Understanding the fate of the fracturing fluid can provide insights on, to some extent, the stimulated fracture volume, size of the water invasion zone, and efficiency of the fracturing design. The simulation predictions can also provide more accurate initial reservoir conditions (e.g. distributions of different phases and pressure) for long-term well performance estimation.

42 ENGINEERING↗

Method of rubblization for in-situ oil shale processing

A method that produces a uniformly rubblized oil shale bed of desirable porosity for underground, in-situ heat extraction of oil. Rubblization is the generation of rubble of various sized fragments. The method uses explosive loadings lying at different levels in adjacent holes and detonation of the explosives at different levels in sequence to achieve the fracturing and the subsequent expansion of the fractured oil shale into excavated rooms both above and below the hole pattern.

Yang, Lien C.↗

Effect of Shear Displacement and Stress Changes on Fracture Hydraulic Aperture and Flow Anisotropy

Fluid flow in fractures has the potential to drastically change the economic, environmental, and safety risks associated with a subsurface operation. This work focuses on the analysis of experimental shear fracturing and subsequent shear displacement of a shale specimen that contains multiple pre-existing natural fractures. A triaxial direct shear apparatus with concurrent µCT imaging allowed continuous monitoring of sample permeability and changes in fracture geometry during fracture creation, displacement, and changes in stress. Steady-state, low Reynolds number fluid flow simulations were used to determine the changes of each individual fracture’s hydraulic aperture due to displacement and effective stress. The development of anisotropy in the hydraulic aperture of a generated shear fracture was determined for shear displacements of 0.38, 0.74, and 2.04 mm. At high confining stress (30 MPa), shear displacement significantly reduced the hydraulic aperture of the shear fracture to below flow detectable limits and X-ray imaging resolution (23 × 23 × 23 µm 3 ). The shear generated fracture was found to be more sensitive to changes in effective stress compared to the pre-existing natural fractures. Existing models derived from fluid flow equations accounting for stochastic fracture roughness were able to partially fit the simulated flow properties of the pre-existing fractures, but no model was found to fit the flow properties of the newly formed shear fracture. These results are the first report of simultaneous changes in the geometry and flow properties of surrounding, parallel natural fractures as a shear fracture is generated with varying stress and shear displacement conditions.

58 GEOSCIENCES↗