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At least 1,549 records · Page 86

SU-F-P-20: Predicting Waiting Times in Radiation Oncology Using Machine Learning

Purpose: Waiting times remain one of the most vexing patient satisfaction challenges facing healthcare. Waiting time uncertainty can cause patients, who are already sick or in pain, to worry about when they will receive the care they need. These waiting periods are often difficult for staff to predict and only rough estimates are typically provided based on personal experience. This level of uncertainty leaves most patients unable to plan their calendar, making the waiting experience uncomfortable, even painful. In the present era of electronic health records (EHRs), waiting times need not be so uncertain. Extensive EHRs provide unprecedented amounts of data that can statistically cluster towards representative values when appropriate patient cohorts are selected. Predictive modelling, such as machine learning, is a powerful approach that benefits from large, potentially complex, datasets. The essence of machine learning is to predict future outcomes by learning from previous experience. The application of a machine learning algorithm to waiting time data has the potential to produce personalized waiting time predictions such that the uncertainty may be removed from the patient’s waiting experience. Methods: In radiation oncology, patients typically experience several types of waiting (eg waiting at home for treatment planning, waiting in the waiting room for oncologist appointments and daily waiting in the waiting room for radiotherapy treatments). A daily treatment wait time model is discussed in this report. To develop a prediction model using our large dataset (with more than 100k sample points) a variety of machine learning algorithms from the Python package sklearn were tested. Results: We found that the Random Forest Regressor model provides the best predictions for daily radiotherapy treatment waiting times. Using this model, we achieved a median residual (actual value minus predicted value) of 0.25 minutes and a standard deviation residual of 6.5 minutes. This means that the majority of our estimates are within 6.5 minutes of the actual wait time. Conclusion: The goal of this project was to define an appropriate machine learning algorithm to estimate waiting times based on the collective knowledge and experience learned from previous patients. Our results offer an opportunity to improve the information that is provided to patients and family members regarding the amount of time they can expect to wait for radiotherapy treatment at our centre. AJ acknowledges support by the CREATE Medical Physics Research Training Network grant of the Natural Sciences and Engineering Research Council (Grant number: 432290) and from the 2014 Q+ Initiative of the McGill University Health Centre.

60 APPLIED LIFE SCIENCES↗

Application of Linear Additive Conditions for Near-Infrared Diffuse Reflectance Absorption Spectroscopy

Determining the homogeneity of material mixing in real time during product processing is critical for quality control. According to the Kubelka–Munk (K-M) function of diffuse reflectance absorption spectrum, absorbance (A) is approximately linear with the content of the components when the sample scattering coefficient (S) is in a certain range. The S is determined by the particle size of powder samples. Therefore, this study determined particle size ranges that satisfy linear additivity in near-infrared diffuse reflectance spectroscopy (NIRDRS). Thus, the proposed NIRDRS analysis technique can be used to determine the homogeneity of material mixes or analyze the percentages of the components in the mixture. In this study, vitamin B3 and vitamin C were used for preparing mixed samples with varying percentages. The experimental results revealed that linear additivity is satisfied when the powder particle size is in the range of less than 280, 280–450, and 450–900 μm. When the confidence level is 0.01, the actual mixed spectra are not significantly different from the “simulated mixed spectra” constructed by linear addition, with their relative deviations less than 1.08%. The absolute errors of the actual and analytic percentages were within 2.98% for each component in the mixtures. The above conclusions also hold for sorghum, which has a complex material composition. Statistical models cannot analyze the percentages of components in the mixture. In contrast, linear addition and direct calibration approach avoids the use of a large number of samples for statistical modeling and analyze the percentages of mixed samples. Meanwhile, it can be used to discriminate and analyze the material mixing uniformity by building a mechanistic model.

Feng, Zhiyue↗

Climate variability and atmospheric teleconnection from satellite observed cloud fluctuations

To investigate the low-frequency variability of the large-scale circulation over the tropics and its relationship with different regions of the globe, statistics of cloud fluctuations, as inferred from outgoing longwave radiation (OLR) are used. The data consists of seven years of global OLR in a 2.5 x 2.5-deg grid derived from NOAA polar orbiting satellite observations. The time series of area-averaged monthly deviation from the seven-year mean of OLR over an equatorial Central Pacific region is presented. It is shown that positive and negative deviations reflect local drier and wetter than normal conditions, respectively. Consideration is given to teleconnection based on the Central Pacific variations and to southern oscillation contributions.

Lau, K. M.↗

Correlation of processing and sintering variables with the strength and radiography of silicon nitride

A sintered Si3N4-SiO2-Y2O3 composition, NASA 6Y, was developed that reached four-point flexural average strength/standard deviation values of 857/36, 544/33, and 462/59 MPa at room temperature, 1200 and 1370 C respectively. These strengths represented improvements of 56, 38, and 21 percent over baseline properties at the three test temperatures. At room temperature the standard deviation was reduced by over a factor of three. These accomplishments were realized by the iterative utilization of conventional x-radiography to characterize structural (density) uniformity as affected by systematic changes in powder processing and sintering parameters. Accompanying the improvement in mechanical properties was a change in the type of flaw causing failure from a pore to a large columnar beta- Si3N4 grain typically 40 to 80 microns long, 10 to 30 microns wide, and with an aspect ratio of 5:1.

Sanders, W. A.↗

Correlation of processing and sintering variables with the strength and radiography of silicon nitride

A sintered Si3N4-SiO2-Y2O3 composition, NASA 6Y, was developed that reached four-point flexural average strength/standard deviation values of 857/36, 544/33, and 462/59 MPa at room temperature, 1200 and 1370 C, respectively. These strengths represented improvements of 56, 38, and 21 percent over baseline properties at the three test temperatures. At room temperature the standard deviation was reduced by over a factor of three. These accomplishments were realized by the iterative utilization of conventional X-radiography to characterize structural (density) uniformity as affected by systematic changes in powder processing and sintering parameters. Accompanying the improvement in mechanical properties was a change in the type of flaw causing failure from a pore to a large columnar beta-Si3N4 grain typically 40-80 micron long, 10-30 micron wide, and with an aspect ratio of 5:1.

Sanders, W. A.↗

Analysis of Separation Corridors for Visiting Vehicles from the International Space Station

The International Space Station (ISS) is a very dynamic vehicle with many operational constraints that affect its performance, operations, and vehicle lifetime. Most constraints are designed to alleviate various safety concerns that are a result of dynamic activities between the ISS and various Visiting Vehicles (VVs). One such constraint that has been in place for Russian Vehicle (RV) operations is the limitation placed on Solar Array (SA) positioning in order to prevent collisions during separation and subsequent relative motion of VVs. An unintended consequence of the SA constraint has been the impacts to the operational flexibility of the ISS resulting from the reduced power generation capability as well as from a reduction in the operational lifetime of various SA components. The purpose of this paper is to discuss the technique and the analysis that were applied in order to relax the SA constraints for RV undockings, thereby improving both the ISS operational flexibility and extending its lifetime for many years to come. This analysis focused on the effects of the dynamic motion that occur both prior to and following RV separations. The analysis involved a parametric approach in the conservative application of various initial conditions and assumptions. These included the use of the worst case minimum and maximum vehicle configurations, worst case initial attitudes and attitude rates, and the worst case docking port separation dynamics. Separations were calculated for multiple ISS docking ports, at varied deviations from the nominal undocking attitudes and included the use of two separate attitude control schemes: continuous free-drift and a post separation attitude hold. The analysis required numerical propagation of both the separation motion and the vehicle attitudes using 3-degree-of-freedom (DOF) relative motion equations coupled with rigid body rotational dynamics to generate a large set of separation trajectories.

Zaczek, Mariusz P.↗

Speeding up equation of motion coupled cluster theory with the chain of spheres approximation

In the present paper, the chain of spheres exchange (COSX) approximation is applied to the highest scaling terms in the equation of motion (EOM) coupled cluster equations with single and double excitations, in particular, the terms involving integrals with four virtual labels. It is found that even the acceleration of this single term yields significant computational gains without compromising the desired accuracy of the method. For an excitation energy calculation on a cluster of five water molecules using 585 basis functions, the four virtual term is 9.4 times faster using COSX with a loose grid than using the canonical implementation, which yields a 2.6 fold acceleration for the whole of the EOM calculation. For electron attachment calculations, the four virtual term is 15 times and the total EOM calculation is 10 times faster than the canonical calculation for the same system. The accuracy of the new method was tested using Thiel’s test set for excited states using the same settings and the maximum absolute deviation over the whole test set was found to be 12.945 cm{sup −1} (59 μHartree) for excitation energies and 6.799 cm{sup −1} (31 μHartree) for electron attachments. Using MP2 amplitudes for the ground state in combination with the parallel evaluation of the full EOM equations in the manner discussed in this paper enabled us to perform calculations for large systems. Electron affinity values for the two lowest states of a Zn protoporphyrine model compound (224 correlated electrons and 1120 basis functions) were obtained in 3 days 19 h using 4 cores of a Xeon E5-2670 processor allocating 10 GB memory per core. Calculating the lowest two excitation energies for trans-retinal (114 correlated electrons and 539 basis functions) took 1 day 21 h using eight cores of the same processor and identical memory allocation per core.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Impurity induced confinement effects in size-separated Mn-doped CsPbCl 3 nanocrystals

Beyond quantum confinement, impurity doping of semiconductor nanocrystals (NCs) offers a degree of control over their optical and electronic properties, which are of interest for potential applications. Manganese (Mn)-doped CsPbCl 3 NCs, for example, show synergistic effects in the visible, with large enhancements in both blue (exciton) and red (dopant) emission over a narrow range of dopant concentration. Although Mn concentration is the primary parameter, NC size offers an additional degree of control over the number of dopants per NC. Size-resolved CsPbCl 3 NCs prepared in the limit of strong Mn doping highlight the emergence of defective NCs with deviations from anticipated confinement trends. In conclusion, the transition correlates with a redshift and increase in the amplitude of dopant emission, and we discuss these observations in the context of atomistic simulations of Ruddlesden-Popper defects in CsPbCl 3 .

36 MATERIALS SCIENCE↗

WE-DE-207B-10: Library-Based X-Ray Scatter Correction for Dedicated Cone-Beam Breast CT: Clinical Validation

Purpose: Scatter contamination is detrimental to image quality in dedicated cone-beam breast CT (CBBCT), resulting in cupping artifacts and loss of contrast in reconstructed images. Such effects impede visualization of breast lesions and the quantitative accuracy. Previously, we proposed a library-based software approach to suppress scatter on CBBCT images. In this work, we quantify the efficacy and stability of this approach using datasets from 15 human subjects. Methods: A pre-computed scatter library is generated using Monte Carlo simulations for semi-ellipsoid breast models and homogeneous fibroglandular/adipose tissue mixture encompassing the range reported in literature. Projection datasets from 15 human subjects that cover 95 percentile of breast dimensions and fibroglandular volume fraction were included in the analysis. Our investigations indicate that it is sufficient to consider the breast dimensions alone and variation in fibroglandular fraction does not significantly affect the scatter-to-primary ratio. The breast diameter is measured from a first-pass reconstruction; the appropriate scatter distribution is selected from the library; and, deformed by considering the discrepancy in total projection intensity between the clinical dataset and the simulated semi-ellipsoidal breast. The deformed scatter-distribution is subtracted from the measured projections for scatter correction. Spatial non-uniformity (SNU) and contrast-to-noise ratio (CNR) were used as quantitative metrics to evaluate the results. Results: On the 15 patient cases, our method reduced the overall image spatial non-uniformity (SNU) from 7.14%±2.94% (mean ± standard deviation) to 2.47%±0.68% in coronal view and from 10.14%±4.1% to 3.02% ±1.26% in sagittal view. The average contrast to noise ratio (CNR) improved by a factor of 1.49±0.40 in coronal view and by 2.12±1.54 in sagittal view. Conclusion: We demonstrate the robustness and effectiveness of a library-based scatter correction method using patient datasets with large variability in breast dimensions and composition. The high computational efficiency and simplicity in implementation make this attractive for clinical implementation. Supported partly by NIH R21EB019597, R21CA134128 and R01CA195512.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

60 APPLIED LIFE SCIENCES↗

Analysis of Nonlinear Dynamics by Square Matrix Method

The nonlinear dynamics of a system with periodic structure can be analyzed using a square matrix. In this paper, we show that because the special property of the square matrix constructed for nonlinear dynamics, we can reduce the dimension of the matrix from the original large number for high order calculation to low dimension in the first step of the analysis. Then a stable Jordan decomposition is obtained with much lower dimension. The transformation to Jordan form provides an excellent action-angle approximation to the solution of the nonlinear dynamics, in good agreement with trajectories and tune obtained from tracking. And more importantly, the deviation from constancy of the new action-angle variable provides a measure of the stability of the phase space trajectories and their tunes. Thus the square matrix provides a novel method to optimize the nonlinear dynamic system. The method is illustrated by many examples of comparison between theory and numerical simulation. Finally, in particular, we show that the square matrix method can be used for optimization to reduce the nonlinearity of a system.

43 PARTICLE ACCELERATORS↗

Collaborative Research: Multi-scale Dynamics of Kinetic Turbulence in Weakly Collisional, High-Beta Plasmas

The transport of energy and momentum and the heating of plasma particles by waves and turbulence are key ingredients in many problems at the frontiers of heliospheric and astrophysics research. This includes the heating and acceleration of the solar wind; the observational appearance of black-hole accretion flows on event-horizon scales; and the properties of the hot, diffuse plasmas that fill dark-matter halos. This work addressed the physics of plasma waves and turbulence in weakly collisional, weakly magnetized (high-beta) plasmas. In this regime, deviations from local thermodynamic equilibrium (i.e., pressure anisotropies) and the instabilities they excite can dramatically change the properties of waves and turbulence from those predicted by fluid (i.e., magnetohydrodynamic) and linear kinetic theories. Through a combination of analytic theory and first-principles kinetic simulations, we have shown that: (1) ion-acoustic waves of sufficient amplitude drive pressure anisotropies large enough to trigger kinetic Larmor-scale instabilities, which in turn interrupt the otherwise strong collisionless damping such waves suffer; (2) pressure anisotropies generated by fluctuating magnetic fields in strong Alfvénic turbulence produce a viscous scale comparable to the driving scale and a cascade with significant non-local interactions; (3) strong Alfvénic turbulence in an expanding high-beta plasma self-organizes to maintain critical balance, even as kinetic Larmor-scale instabilities regulate the plasma viscosity and reduce the elasticity of magnetic-field lines; (4) imbalanced Alfvénic turbulence leads to a "helicity barrier" that ultimately triggers the cyclotron heating of ions, in a manner consistent with spacecraft measurements taken in the solar wind; and (5) relativistic synchrotron-radiating plasmas develop kinetically unstable pressure anisotropy, which changes the nature of their cooling in a way that can couple the thermodynamics of ions and electrons.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

In-orbit performance of the OAO inertial reference unit

The Inertial Reference Unit (IRU) used in NASA's Orbiting Astronomical Observatory uses three single degree of freedom, floated, rate-integrating gyros operated in binary, pulse-restrained torque loops to provide an inertial attitude reference for the spacecraft's attitude control system. The drift rates observed on these inertial grade gyros during the 1 1/2 year of in-orbit operation have remained within a band of 16 arcsec per hour peak-to-peak. When the effects of known disturbances are considered, the standard deviation of drift rate appears to approach one arcsec per hour. Included in this paper are a brief description of the OAO and IRU, a summary of the data reduction programs used to calibrate the IRU in orbit, and some thoughts on how gyros with good long-term drift stability could be applied to future spacecraft such as the Large Space Telescope and Earth Observatory Satellite.

Harris, R. A.↗

Improved processing of Si3N4

A sintered Si3N4-SiO2-Y2O3 composition, NASA 6Y, was developed that reached four-point flexural average strength/standard deviation values of 857/36, 544/33, and 462/59 MPa at room temperature, 1200, and 1370 C, respectively. These strengths represented improvements of 56, 38, and 21 percent over baseline properties at the three test temperatures. At room temperature the standard deviation was reduced by more than a factor of three. These accomplishments were realized by the iterative utilization of conventional X-radiography to characterize structural (density) uniformity as affected by systematic changes in powder processing and sintering parameters. Accompanying the improvement in mechanical properties was a change in the type of flaw causing failure from a pore to a large columnar beta-Si3N4 grain typically 40 to 80 microns, 10 to 30 microns wide, and with an aspect ratio of 5:1.

Sanders, William A.↗

ANOPP Landing Gear Noise Prediction Comparisons to Model-scale Data

The NASA Aircraft NOise Prediction Program (ANOPP) includes two methods for computing the noise from landing gear: the "Fink" method and the "Guo" method. Both methods have been predominately validated and used to predict full-scale landing gear noise. The two methods are compared, and their ability to predict the noise for model-scale landing gear is investigated. Predictions are made using both the Fink and Guo methods and compared to measured acoustic data obtained for a high-fidelity, 6.3%-scale, Boeing 777 main landing gear. A process is developed by which full-scale predictions can be scaled to compare with model-scale data. The measurements were obtained in the NASA Langley Quiet Flow Facility for a range of Mach numbers at a large number of observer polar (flyover) and azimuthal (sideline) observer angles. Spectra and contours of the measured sound pressure levels as a function of polar and azimuthal angle characterize the directivity of landing gear noise. Comparisons of predicted noise spectra and contours from each ANOPP method are made. Both methods predict comparable amplitudes and trends for the flyover locations, but deviate at the sideline locations. Neither method fully captures the measured noise directivity. The availability of these measured data provides the opportunity to further understand and advance noise prediction capabilities, particularly for noise directivity.

Burley, Casey L.↗

Evaluation of the dosimetric properties of a synthetic single crystal diamond detector in high energy clinical proton beams

Purpose: To investigate the dosimetric properties of a synthetic single crystal diamond Schottky diode for accurate relative dose measurements in large and small field high-energy clinical proton beams.Methods: The dosimetric properties of a synthetic single crystal diamond detector were assessed by comparison with a reference Markus parallel plate ionization chamber, an Exradin A16 microionization chamber, and Exradin T1a ion chamber. The diamond detector was operated at zero bias voltage at all times. Comparative dose distribution measurements were performed by means of Fractional depth dose curves and lateral beam profiles in clinical proton beams of energies 155 and 250 MeV for a 14 cm square cerrobend aperture and 126 MeV for 3, 2, and 1 cm diameter circular brass collimators. ICRU Report No. 78 recommended beam parameters were used to compare fractional depth dose curves and beam profiles obtained using the diamond detector and the reference ionization chamber. Warm-up/stability of the detector response and linearity with dose were evaluated in a 250 MeV proton beam and dose rate dependence was evaluated in a 126 MeV proton beam. Stem effect and the azimuthal angle dependence of the diode response were also evaluated.Results: A maximum deviation in diamond detector signal from the average reading of less than 0.5% was found during the warm-up irradiation procedure. The detector response showed a good linear behavior as a function of dose with observed deviations below 0.5% over a dose range from 50 to 500 cGy. The detector response was dose rate independent, with deviations below 0.5% in the investigated dose rates ranging from 85 to 300 cGy/min. Stem effect and azimuthal angle dependence of the diode signal were within 0.5%. Fractional depth dose curves and lateral beam profiles obtained with the diamond detector were in good agreement with those measured using reference dosimeters.Conclusions: The observed dosimetric properties of the synthetic single crystal diamond detector indicate that its behavior is proton energy independent and dose rate independent in the investigated energy and dose rate range and it is suitable for accurate relative dosimetric measurements in large as well as in small field high energy clinical proton beams.

61 RADIATION PROTECTION AND DOSIMETRY↗

Sea Surface Salinity Distribution in the Southern Ocean as Observed from Space

Large-scale spatial and temporal variabilities of sea surface salinity (SSS) in the Southern Ocean from 2011 to 2017 were studied using products derived from microwave sensors on board Aquarius, Soil Moisture and Ocean Salinity (SMOS), and Soil Moisture Active and Passive (SMAP) satellites. Four products, three from Aquarius and one from SMOS, were evaluated and shown to be generally consistent within 0.3 to 0.6 psu and agree favorably with in situ measurements. However, although the Aquarius products show consistent seasonality of SSS with high values of 34.45 psu in October and low values of 33.40 psu in May, theSMOS and SMAP products lack such seasonal variations. This may be caused by larger uncertainties in the SMOS and SMAP data due in part to the lack of concurrent scatterometer measurements that is used to correct for roughness effects. The four products provide similar spatial distributions of SSS with root mean square difference from 0.25 to 0.58 psu. Differences among Aquarius products are mainly due to varying salinity retrieval algorithms, smoothing, and masking of sea ice, while the SMOS product showed the highest SSS deviation that is likely due to the bias adjustment done on the data set. Our analyses show that SSS in the Southern Ocean region has significant meridional variations with the lowest SSS near the ice edge and highest at lower latitudes. The SSS is also lowest in summer indicating the predominant influence of sea ice and glacial melt, but it stays low near ice edges even during the growth season. Salinity together with temperature is the key parameters that control the state and circulation of the World's oceans. The large‐scale distribution of the sea surface salinity of the Southern Ocean is quantified for the first time using Aquarius, Soil Moisture and Ocean Salinity, and Soil Moisture Active and Passive satellite microwave data. Seasonal and interannual changes in the distribution as affected by the sea ice cover, surface temperature, and precipitation are evaluated. Comparative studies were done, using four different products that are publicly available, in conjunction with in situ observations to gain insights into the true nature of the distribution and how consistently the sea surface salinity is depicted by the different products. There are general consistencies in the products, and discrepancies are attributed to different algorithms, smoothing techniques, and sea ice masking. Aquarius data are shown to have higher accuracy than Soil Moisture and Ocean Salinity and Soil Moisture Active and Passive products in part because of having concurrent scatterometer that provides accurate correction to roughness effects.

Garcia-Eidell, Cynthia↗

Observation of VVZ production at $\sqrt{s}$ = 13 TeV with the ATLAS detector

A search for the production of three massive vector bosons, VVZ(V = W, Z) , in proton-proton collisions at $\sqrt{s}$ = 13 TeV is performed using data with an integrated luminosity of 140 fb -1 recorded by the ATLAS detector at the Large Hadron Collider. Events produced in the leptonic final states WWZ → ℓvℓvℓℓ (ℓ = e,μ), WZZ → ℓvℓℓℓℓ, ZZZ → ℓℓℓℓℓ, and the semileptonic final states WWZ → qq ℓvℓℓ and WZZ → ℓv qq ℓℓ, are analysed. The measured cross section for the pp → VVZ process is 660$^{+93}_{-90}$(stat.)$^{+80}_{-81}$(syst.) fb, and the observed (expected) significance is 6.4 (4.7) standard deviations, representing the observation of VVZ production. In addition, the measured cross section for the pp → WWZ process is 442 ± 94(stat.)$^{+60}_{-52}$(syst.) fb, and the observed (expected) significance is 4.4 (3.6) standard deviations, representing evidence of WWZ production. The measured cross sections are consistent with the Standard Model predictions. Constraints on physics beyond the Standard Model are also derived in the effective field theory framework by setting limits on Wilson coefficients for dimension-8 operators describing anomalous quartic gauge boson couplings.

Aad, G. (ORCID:0000000266654934)↗

Data Set Analysis to Reduce Uncertainty in Formula Assignments of Ultrahigh Resolution Mass Spectra

Environmental samples contain a vast array of organic compounds with diverse elemental compositions and heteroatom content. Molecular formula assignments of ultrahigh resolution mass spectra (HRMS) hold promise for elucidating the molecular composition of these compounds. However, the need to account for an assortment of heteroatoms increases the uncertainty associated with individual assignments – and ultimately the ecological, biological, and biogeochemical insights gleaned from the assignments. To address this challenge, we introduce a formula assignment strategy that leverages HRMS data sets to improve assignment confidence, filter false assignments, and mitigate bias in assignment routines. The strategy, implemented using CoreMS, first identifies the highest confidence assignment for a recurring ion in a data set by assessing the mass accuracy and isotopologue similarity of all assignments to the ion across the data set. The second component of the strategy examines the consistency of mass errors for an assigned ion throughout a data set and flags formulas with statistically unlikely deviations in mass error. Here, we illustrate the application and utility of the strategy by comparing its results against documented misassignment patterns within a set of oceanographic samples that were measured with 21 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Because the efficacy of our strategy improves with data set size, it is particularly useful for enhancing assignment confidence in large HRMS data sets common in studies of environmental systems.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗