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At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
DOE OSTI1994

Nuclear Safety [Vol. 35, No. 2, July-December 1994]

Nuclear Safety is a journal that covers significant issues in the field of nuclear safety. Its primary scope is safety in the design, construction, operation, and decommissioning of nuclear power reactors worldwide and the research and analysis activities that promote this goal, but it also encompasses the safety aspects of the entire nuclear fuel cycle, including fuel fabrication, spent-fuel processing and handling, and nuclear waste disposal, the handling of fissionable materials and radioisotopes, and the environmental effects of all these activities. Table of Contents for this issue follows. GENERAL SAFETY CONSIDERATIONS: 179 Consideration of Postaccident Consequences in the Determination of Safety Objectives for Future Nuclear Power Plants in France, D. Queniart, A. Sugier, and J. Lochard; ACCIDENT ANALYSIS: 187 Nuclear Safety Research: The Phebus FP Severe Accident Experimental Program, P. von der Hardt, A. V. Jones, C. Lecomte, and A. Tattegrain; 205 Containment Performance Analysis of the Advanced Neutron Source Reactor at the Oak Ridge National Laboratory, S. H. Kim, R. P. Taleyarkhan, and V. Georgevich; 213 Assessment of Fission Product Deposits in the Reactor Coolant System: The DEVAP Program, G. Le Marois and M. Megnin; 222 Erratum to “A Review of the Available Information on the Triggering Stage of a Steam Explosion," Vol. 35, No. 1, CONTROL AND INSTRUMENTATION: 223 Effects of Normal Aging on Calibration and Response Time of Nuclear Plant Resistance Temperature Detectors and Pressure Sensors, H. M. Hashemian; DESIGN FEATURES: 235 Defense in Depth Against the Hydrogen Risk—A European Research Program, F. Fineschi; ENVIRONMENTAL EFFECTS: 246 Technical Note: A Preliminary Analysis of the Risks to Hong Kong Resulting from Potential Accidents of Daya Bay Nuclear Power Plant, Z. Shi and X. Wei; OPERATING EXPERIENCES: 253 Reactor Shutdown Experience, Compiled by J. W. Cletcher; SPECIAL SECTION ON TMI-2 VESSEL INVESTIGATION PROJECT: 256 Three Mile Island—New Findings 15 Years After the Accident A. M. Rubin and E. Beckjord; 269 Relocation of Molten Material to the TMI-2 Lower Head, J. R. Wolf, D. W. Akers, and L. A. Neimark; 280 Insight Into the TMI-2 Core Material Relocation Through Examination of Instrument Tube Nozzles, L. A. Neimark; 288 Physical and Radiochemical Examinations of Debris from the TMI-2 Lower Head, D. W. Akers and B. K. Schuetz; 301 Results of Metallographic Examinations and Mechanical Tests of Pressure Vessel Samples from the TMI-2 Lower Head, D. R. Diercks and G. E. Korth; 313 Margin-to-Failure Calculations for the TMI-2 Vessel, J. Rempe, L. Stickler, S. Chavez, G. Thinnes, R. Witt, and M. Corradini; U.S. NUCLEAR REGULATORY COMMISSION INFORMATION AND ANALYSES: 328 1993 Accident Sequence Precursor (ASP) Program Results, L. N. Vanden Heuvel, J. W. Cletcher, D. A. Copinger, J. W. Minarick, B. W. Dolan, and P. D. O’Reilley; RECENT DEVELOPMENTS: 339 Reports, Standards, and Safety Guides, D. S. Queener; 345 Proposed Rule Changes as of June 30, 1994; ANNOUNCEMENTS: 234 Thirty-First Annual Meeting of the National Council on Radiation Protection and Measurements; 356 1995 International Incineration Conference; 358 Fifth International Controls and Instrumentation Conference; 359 ANS International Topical Meeting on Safety of Operating Reactors; 359 Fifth International Conference on Nuclear Criticality Safety; 360 International Conference on Probabilistic Safety Assessment Methodology and Applications; 351 The Authors; 357 Reviewers of Nuclear Safety, Vol. 35.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2022

Analysis of DWPF Sludge Batch 6 (Macrobatch 7): Pour Stream Glass Samples

The Defense Waste Processing Facility (DWPF) began processing Sludge Batch 6 (SB6), also referred to as Macrobatch 7 (MB7), in June 2010. SB6 is a blend of the heel of Tank 40 from Sludge Batch 5 (SB5), H-Canyon Np transfers and SB6 that was transferred to Tank 40 from Tank 51.1 SB6 was processed using Frit 418. Sludge is received into the DWPF Chemical Processing Cell (CPC) and is processed through the Sludge Receipt and Adjustment Tank (SRAT) and Slurry Mix Evaporator Tank (SME). The treated sludge slurry is then transferred to the Melter Feed Tank (MFT) and fed to the melter. During processing of each sludge batch, the DWPF is required to take at least one glass sample to meet the objectives of the Glass Product Control Program (GPCP) and to complete the necessary Production Records so that the final glass product may be disposed of at a Federal Repository. The DWPF requested various analyses of radioactive glass samples obtained from the melter pour stream during processing of SB6 as well as reduction/oxidation (REDOX) analysis of MFT samples to determine the impact of Argon bubbling. Sample analysis followed the Task Technical and Quality Assurance Plan (TTQAP) and an Analytical Study Plan (ASP). Four Pour Stream (PS) glass samples and two MFT slurry samples were delivered to the Savannah River National Laboratory (SRNL) from the DWPF. Table 1-1 lists the sample information for each pour stream glass sample. SB6 PS3 (S03472) was selected as the official pour stream sample for SB6 and full analysis was requested. This report details the visual observations of the as-received SB6 PS No.3 glass sample as well as results for the chemical composition, Product Consistency Test (PCT), radionuclide content, noble metals, and glass density. REDOX results will be provided for all four pour stream samples and vitrified samples of MFT-558 and MFT-568A. Where appropriate, data from other pour stream samples will be provided.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2023

Pseudomonas aeruginosa Dps (PA0962) Functions in H 2 O 2 Mediated Oxidative Stress Defense and Exhibits In Vitro DNA Cleaving Activity

We report the structural, biochemical, and functional characterization of the product of gene PA0962 from Pseudomonas aeruginosa PAO1. The protein, termed Pa Dps, adopts the Dps subunit fold and oligomerizes into a nearly spherical 12-mer quaternary structure at pH 6.0 or in the presence of divalent cations at neutral pH and above. The 12-Mer Pa Dps contains two di-iron centers at the interface of each subunit dimer, coordinated by conserved His, Glu, and Asp residues. In vitro, the di-iron centers catalyze the oxidation of Fe 2+ utilizing H 2 O 2 (not O 2 ) as an oxidant, suggesting Pa Dps functions to aid P. aeruginosa to survive H 2 O 2 -mediated oxidative stress. In agreement, a P. aeruginosa Δdps mutant is significantly more susceptible to H 2 O 2 than the parent strain. The Pa Dps structure harbors a novel network of Tyr residues at the interface of each subunit dimer between the two di-iron centers, which captures radicals generated during Fe 2+ oxidation at the ferroxidase centers and forms di-tyrosine linkages, thus effectively trapping the radicals within the Dps shell. Surprisingly, incubating Pa Dps and DNA revealed unprecedented DNA cleaving activity that is independent of H 2 O 2 or O 2 but requires divalent cations and 12-mer Pa Dps.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2024

Mechanical Properties of a Solvated Biomolecule: RGD (1FUV) Peptide

The mechanical properties of proteins/peptides play an essential role in their functionalities and implications, as well as their structure and dynamic properties. Understanding mechanical properties is pivotal to our knowledge of protein folding and the molecular basis of diverse cellular processes. Herein, we present a computational approach using ab initio quantum mechanical calculations to determine the mechanical properties—such as bulk modulus, shear modulus, Young’s modulus, and Poisson’s ratio—of a solvated Arg-Gly-Asp (RGD) peptide model. Since this peptide serves as the RGD-directed integrin recognition site and may participate in cellular adhesion, it is considered a promising small peptide for medicinal applications. This successful approach paves the way for investigating larger and more complex biomolecules.

Biochemistry & Molecular Biology↗
DOE OSTI2023

Mechanistic Insights into Peptide Binding and Deactivation of an Adhesion G Protein-Coupled Receptor

Adhesion G protein-coupled receptors (ADGRGs) play critical roles in the reproductive, neurological, cardiovascular, and endocrine systems. In particular, ADGRG2 plays a significant role in Ewing sarcoma cell proliferation, parathyroid cell function, and male fertility. In 2022, a cryo-EM structure was reported for the active ADGRG2 bound by an optimized peptide agonist IP15 and the Gs protein. The IP15 peptide agonist was also modified to antagonists 4PH-E and 4PH-D with mutations of the 4PH residue to Glu and Asp, respectively. However, experimental structures of inactive antagonist-bound ADGRs remain to be resolved, and the activation mechanism of ADGRs such as ADGRG2 is poorly understood. Here, we applied Gaussian accelerated molecular dynamics (GaMD) simulations to probe conformational dynamics of the agonist- and antagonist-bound ADGRG2. By performing GaMD simulations, we were able to identify important low-energy conformations of ADGRG2 in the active, intermediate, and inactive states, as well as explore the binding conformations of each peptide. Moreover, our simulations revealed critical peptide-receptor residue interactions during the deactivation of ADGRG2. In conclusion, through GaMD simulations, we uncovered mechanistic insights into peptide (agonist and antagonist) binding and deactivation of the ADGRG2. These findings will potentially facilitate rational design of new peptide modulators of ADGRG2 and other ADGRs.

59 BASIC BIOLOGICAL SCIENCES↗
NASA NTRS1972

Variable dimension automatic synthesis programs (VASP)

Variable dimension FORTRAN 4 version of the Automatic Synthesis Program (ASP) compensates for limitations within the program itself. Improvements are versatile programming language, convenient input/output format, new subprograms, variable dimensioning, and efficient storage.

White, J. S.↗
NASA NTRS1973

Recently published protein sequences. III

A listing of polypeptide sequences announced in published papers in 1972 and 1973 is given. The listing contains twenty one new sequencies which were selected by using the distinction of Asn, Asp, Gln, and Glu from Asx and Glx, and the absence of unsequenced peptides as criteria.

Jukes, T. H.↗
NASA NTRS1974

Chemical evolution. XXI - The amino acids released on hydrolysis of HCN oligomers

Major amino acids released by hydrolysis of acidic and basic HCN oligomers are identified by chromatography as Gly, Asp, and diaminosuccinic acid. Smaller amounts of Ala, Ile and alpha-aminoisobutyric acid are also detected. The amino acids released did not change appreciably when the hydrolysis medium was changed from neutral to acidic or basic. The presence of both meso and d, l-diaminosuccinic acids was established by paper chromatography and on an amino acid analyzer.

Ferris, J. P.↗
NASA NTRS1976

Linear and nonlinear analysis of orbital telescope/space shuttle dynamics and control

Work completed on the design and study of an annular suspension and pointing (ASP) system for the space shuttle was presented. This system makes use of a magnetically suspended vernier pointing assembly. The following objectives were pursued in this study: (1) development of a detailed mathematical model of the Space Shuttle/ASP system, (2) design of control laws in order to obtain the desired pointing performance, and (3) prediction of the statistical pointing accuracies in the presence of stochastic disturbances such as crew-motion, and sensor and actuator noise. The first two of these objectives are documented in this report.

Roberts, A. S., Jr.↗
NASA NTRS1976

Spacelab science missions of the 1980's

The objectives and instrumentation of Spacelab missions planned for the 1980s are discussed. Initial flights will be multidisciplinary, serving to verify the performance of Spacelab subsystems and to demonstrate the capability of Spacelab to carry out broad-ranging research in a variety of fields. Further missions will use highly specialized payloads. Among these are the Atmospheres, Magnetospheres and Plasmas (AMPS) Payload, the Astronomy Spacelab Payload (ASP), including solar physics, stellar astronomy and high energy astrophysics variants, and the Spacelab Infrared Telescope Facility. The growing inventory of instruments developed for these missions will then be available for use in different combinations to meet the needs of individual mission objectives proposed by the international scientific community.

Chappell, C. R.↗
NASA NTRS1976

Early Spacelab physics and astronomy missions

Some of the scientific problems which will be investigated during the early Spacelab physics and astronomy missions are reviewed. The Solar Terrestrial Programs will include the Solar Physics Spacelab Payloads (SPSP) and the Atmospheres, Magnetospheres and Plasmas in Space (AMPS) missions. These missions will study the sun as a star and the influence of solar phenomena on the earth, including sun-solar wind interface, the nature of the solar flares, etc. The Astrophysics Spacelab Payloads (ASP) programs are divided into the Ultraviolet-Optical Astronomy and the High Energy Astrophysics areas. The themes of astrophysics Spacelab investigations will cover the nature of the universe, the fate of matter and the life cycles of stars. The paper discusses various scientific experiments and instruments to be used in the early Spacelab missions.

Chapman, R. D.↗
NASA NTRS1978

Analysis of a magnetically suspended, high-performance instrument pointing system

This paper describes a highly accurate auxiliary instrument pointing system which can provide fine pointing for a variety of solar-, stellar-, and Earth-viewing scientific instruments during extended space shuttle orbital missions. This system, called the Annular Suspension and Pointing System (ASPS), consists of pointing assemblies for coarse and vernier pointing. The 'coarse' assembly is attached to the spacecraft (e.g., the space shuttle) and consists of an elevation gimbal and a lateral gimbal to provide coarse pointing. The vernier pointing assembly consists of the payload instrument mounted on a plate around which is attached a continuous annular rim. The vernier assembly is suspended in the lateral gimbal using magnetic actuators which provide rim suspension forces and fine pointing torques. A detailed linearized mathematical model is developed for the ASPS/space shuttle system, and control laws and payload attitude state estimators are designed. Statistical pointing performance is predicted in the presence of stochastic disturbances such as crew motion, sensor noise, and actuator noise.

Joshi, S. M.↗
NASA NTRS1979

Interpretive computer simulator for the NASA Standard Spacecraft Computer-2 (NSSC-2)

An Interpretive Computer Simulator (ICS) for the NASA Standard Spacecraft Computer-II (NSSC-II) was developed as a code verification and testing tool for the Annular Suspension and Pointing System (ASPS) project. The simulator is written in the higher level language PASCAL and implented on the CDC CYBER series computer system. It is supported by a metal assembler, a linkage loader for the NSSC-II, and a utility library to meet the application requirements. The architectural design of the NSSC-II is that of an IBM System/360 (S/360) and supports all but four instructions of the S/360 standard instruction set. The structural design of the ICS is described with emphasis on the design differences between it and the NSSC-II hardware. The program flow is diagrammed, with the function of each procedure being defined; the instruction implementation is discussed in broad terms; and the instruction timings used in the ICS are listed. An example of the steps required to process an assembly level language program on the ICS is included. The example illustrates the control cards necessary to assemble, load, and execute assembly language code; the sample program to to be executed; the executable load module produced by the loader; and the resulting output produced by the ICS.

Smith, R. S.↗
NASA NTRS1979

DRIRU II - The NASA standard high performance Inertial Reference Unit

This paper discusses the design configuration, performance and environmental capability of NASA's Dry Rotor Inertial Reference Unit (DRIRU II) for use in spacecraft precision attitude stabilization systems. The system is a self-contained, strapdown, dual rate sensing unit for spacecraft requiring high accuracy, reliability and low power consumption. Modular construction of the basic unit, arrangement of gyros, electronic modules and power supplies, signal flow, and mounting are described. DRIRU II is designed to meet specified performance requirements for a minimum of two years of operating time in orbit and a reliability prediction analysis is presented. The characteristics of test equipment are given together with the results of the environmental, radiation, and magnetic field sensitivity tests. DRIRU II may be modified for unique requirements and the rate range and resolution options are tabulated. The flexibility of the unit afforded by the use of dry tuned gimbal gyros and its modular construction results in a system capable of satisfying the demanding requirements of a broad spectrum of future applications. The units are planned for the Solar Max, Landsat-D and ASPS missions in the 1980's.

Irvine, R. B.↗
NASA NTRS1981

Pinhole/coronograph pointing control system integration and noise reduction analysis

The Pinhole Occulter Facility (P/OF) is a Space Shuttle based experiment for the production of solar coronographics and hard X-ray images. The system is basically pinhole camera utilizing a deployable 50-m flexible boom for separating the pinholes and coronograph shields from the recording devices located in the Shuttle bay. At the distal end of the boom from the Shuttle is a 25 kg mask containing pinholes and coronograph shields. At the proximal end the detectors are located and mounted, along with the deployable boom, to the ASPS gimbal pointing system (AGS). The mask must be pointed at the Sun with a high degree of pointing stability and accuracy to align the axes of the detectors with the pinholes and shields. Failure to do so will result in a blurring of the images on the detectors and a loss of resolution. Being a Shuttle based experiment, the system will be subjected to the disturbances of the Shuttle. The worst of these is thruster firing for orbit correction; the Shuttle uses a bang-bang thruster control system to maintain orbit to within preset limits. Other disturbances include man motion, motion induced by other systems, and gravity gradient torques.

Greene, M.↗
NASA NTRS1984

High accuracy pointing for earth observation experiments

An evaluation of mission requirements for postulated earth observation orbital payload experiments has indicated that high accuracy pointing and stabilization must be provided for adequate performance. A computer simulation has been conducted to determine the capabilities of an auxiliary pointing system which employs a combination of conventional gimbals and magnetic bearing actuators. This Annular Suspension and Pointing System (ASPS) is found to be a viable means of providing the high slew rates associated with landmark tracking from low orbit, while simultaneously achieving the high degree pointing and stabilization dictated by science payload requirements.

Keckler, C. R.↗
NASA NTRS1985

Experiments with solid particle seeding

Kaoline, a hydrated aluminum silicate clay, is investigated as a seeding material for laser velocimetry. It is inexpensive but is polydispersed with some of the fineparticles being too large to follow wind tunnel flow and is in the form of nonspherical platelets having an aspect ratio of approximately 4/1. Gravity sedimentation experiments as a means of narrowing the fineparticle sizes distribution are being conducted. The fineparticle size distribution of Engelhard ASP 200 kaolin suspended in ethanol (0.00792 grams kaolin/ml ethanol) as received, after 24 hours gravity sedimentation and after 48 hours sedimentation, respectively is shown. A shearing atomizer is used to inject the fineparticles. Gravity sedimentation is carried out in an 800 ml pyrex beaker. Following gravity sedimentation, the top 3.5 inches are siphoned from the liquid, which has a column height of 4.5 inches. In a like manner, longer settling times will serve to further narrow the fineparticle distribution range. As successive sedimentations are effected, the number of fineparticles per unit volume of ethanol decreased markedly.

Nichols, C. E., Jr.↗