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A multi-spacecraft study of the coronal and interplanetary transport of solar cosmic rays. I, II

The analysis and interpretation of the multiple-spacecraft observations of a collection of flare events in six energy bands between 3 and 60 MeV/nucleon are presented. The longitudinal and radial dependence of the times of maximum flux, the relative maximum fluxes, and the decay constants, are determined; and the propagation model is compared with a simplified single-spacecraft model. The analytical model developed accounts for the effects of diffusion, convection, adiabatic deceleration, and corotation. The intensity time profiles are calculated for hypothetical spacecraft spaced at 60-deg longitude intervals between -120 and 120 deg. It is concluded that the large value of k(IP) (greater than or equal to 6 x 10 to the 21st sq cm/s) indicates the nonnegligibility of focused diffusion in the interplanetary modeling of these events.

Mcguire, R. E.↗

NASA Planning for Orion Multi-Purpose Crew Vehicle Ground Operations

The NASA Orion Ground Processing Team was originally formed by the Kennedy Space Center (KSC) Constellation (Cx) Project Office's Orion Division to define, refine and mature pre-launch and post-landing ground operations for the Orion human spacecraft. The multidisciplined KSC Orion team consisted of KSC civil servant, SAIC, Productivity Apex, Inc. and Boeing-CAPPS engineers, project managers and safety engineers, as well as engineers from Constellation's Orion Project and Lockheed Martin Orion Prime contractor. The team evaluated the Orion design configurations as the spacecraft concept matured between Systems Design Review (SDR), Systems Requirement Review (SRR) and Preliminary Design Review (PDR). The team functionally decomposed prelaunch and post-landing steps at three levels' of detail, or tiers, beginning with functional flow block diagrams (FFBDs). The third tier FFBDs were used to build logic networks and nominal timelines. Orion ground support equipment (GSE) was identified and mapped to each step. This information was subsequently used in developing lower level operations steps in a Ground Operations Planning Document PDR product. Subject matter experts for each spacecraft and GSE subsystem were used to define 5th - 95th percentile processing times for each FFBD step, using the Delphi Method. Discrete event simulations used this information and the logic network to provide processing timeline confidence intervals for launch rate assessments. The team also used the capabilities of the KSC Visualization Lab, the FFBDs and knowledge of the spacecraft, GSE and facilities to build visualizations of Orion pre-launch and postlanding processing at KSC. Visualizations were a powerful tool for communicating planned operations within the KSC community (i.e., Ground Systems design team), and externally to the Orion Project, Lockheed Martin spacecraft designers and other Constellation Program stakeholders during the SRR to PDR timeframe. Other operations planning tools included Kaizen/Lean events, mockups and human factors analysis. The majority of products developed by this team are applicable as KSC prepares 21st Century Ground Systems for the Orion Multi-Purpose Crew Vehicle and Space Launch System.

Letchworth, Gary↗

Contraceptive Sabotage and Contraceptive Use at the Time of Pregnancy: An Analysis of People with a Recent Live Birth in the United States

Contraceptive sabotage and other forms of intimate partner violence (IPV) can interfere with contraceptive use. We used 2012 to 2015 Pregnancy Risk Assessment Monitoring System data from 8,981 people residing in five states who reported that when they became pregnant, they were not trying to get pregnant. We assessed the relationships between ever experiencing contraceptive sabotage and physical IPV 12 months before pregnancy (both by the current partner) and contraceptive use at the time of pregnancy using multivariable logistic regression. We also assessed the joint associations between physical IPV 12 months before pregnancy and ever experienced contraceptive sabotage with contraceptive use at the time of pregnancy. Few people ever experienced contraceptive sabotage (1.8%; 95% confidence interval [CI]: 1.4, 2.3) or physical IPV 12 months before pregnancy (2.8%; 95% CI: 2.3, 3.3). In models adjusted for age, race/ethnicity, marital status, education, and state of residence, ever experiencing contraceptive sabotage was associated with contraceptive use at the time of pregnancy (adjusted odds ratio [aOR]: 1.73; 95% CI: 1.06, 2.82), but not with physical IPV 12 months before pregnancy (aOR: 0.69; 95% CI: 0.46, 1.02). When examining the joint association, compared to not ever experiencing contraceptive sabotage or physical IPV 12 months before pregnancy, ever experiencing contraceptive sabotage was significantly related to contraceptive use at the time of pregnancy (aOR: 1.72; 95% CI: 1.00, 2.95). However, it was not associated with experiencing physical IPV 12 months before pregnancy (aOR: 0.68; 95% CI: 0.45, 1.04) or with experiencing both contraceptive sabotage and physical IPV 12 months before pregnancy (aOR: 1.21; 95% CI: 0.42, 3.50), compared to not ever experiencing contraceptive sabotage or physical IPV 12 months before pregnancy. Our study highlights that current partner contraceptive sabotage may motivate those not trying to get pregnant to use contraception; however, all people in our sample still experienced a pregnancy.

Huber-Krum, Sarah↗

Statistical Analysis of Complexity Generators for Cost Estimation

Predicting the cost of cutting edge new technologies involved with spacecraft hardware can be quite complicated. A new feature of the NASA Air Force Cost Model (NAFCOM), called the Complexity Generator, is being developed to model the complexity factors that drive the cost of space hardware. This parametric approach is also designed to account for the differences in cost, based on factors that are unique to each system and subsystem. The cost driver categories included in this model are weight, inheritance from previous missions, technical complexity, and management factors. This paper explains the Complexity Generator framework, the statistical methods used to select the best model within this framework, and the procedures used to find the region of predictability and the prediction intervals for the cost of a mission.

Rowell, Ginger Holmes↗

MM and subMM molecular line observations of the southwest lobe of L1551: Evidence of a shell structure

Observations have been made of the southwest outflow lobe of L1551 in several millimeter and submillimeter molecular lines. Maps have been made in the J=3-2 and J=2-1 transitions of CO over areas of 7.5 by 2.5 arc minutes and 5 by 5 arc minutes respectively at UKIRT. More detailed maps have also been made in the J=2-1 CO transition over an area of about 6 by 3.5 arc minutes at the NRAO 12m telescope. Additional observations of the J=4-3 transitions of HCN, HCO(+) abd H(13)CO(+) were made at selected positions. The HC(+) J=4-3 transition was detected at several positions along the outflow axis and at the position of IRS 5. Similarly the HCN J=4-3 transition was detected at the position of IRS 5 and also at a position close to HH29. However, the J=4-3 transition of H(13)CO(+) was bit detected at the position of IRS 5 even through it was observed at the position close to HH29 with a peak corrected antenna temperature of 0.23K at a V(LSR) of 1 km s(-1). The detection of the J=4-3 transitions of both HCO(+) and H(13)CO(+) close to the position of HH29 suggest the presence of very dense gas in this region. LVG analysis of the various molecular lines observed give a kinetic temperature between 10 and 15K and a density from 10(5) to 10(6) cm(-3) at the position of IRS 5 at the ambient cloud velocity. At the position close to HH29 LVG analysis of the CO observations gives a density between 10(3) and 10(4) cm(-3) at a kinetic temperature of 25k for a V(LSR) of 0 km s(-1). To the southwest of HH29 there is a large decrease in both the linewidth and intensity of CO emission. This may be due to the interaction between the outflow and a dense clump of gas which gives rise to HH29. The maps of the CO J=3-2 and CO J=2-1 emission integrated in 3.25 km s intervals show the shell structure postulated by Snell and Schloerb (1985).

Rainey, R.↗

Computational simulation of structural fracture in fiber composites

A methodology was developed for the computational simulation of structural fracture in fiber composites. This methodology consists of step-by-step procedures for mixed-mode fracture in generic components and an integrated computer code, Composite Durability Structural Analysis (CODSTRAN). The generic types of composite structural fracture include: (1) single and combined mode fracture in beams; 2) laminate free-edge delamination fracture; and (3) laminate center flaw progressive fracture. Structural fracture is identified by rapid changes in one or all of the following: (1) displacements, (2) frequencies, (3) the buckling loads, or (4) the strain energy release rate. These rapid changes are herein assumed to denote imminent structural fracture. Based on these rapid changes, parameters are identified which can be used as guidelines for structural fracture, inspection intervals and retirement for cause.

Chamis, Christos C.↗

Second coefficient of viscosity in air

Acoustic attenuation measurements in air were analyzed in order to estimate the second coefficient of viscosity. Data over a temperature range of 11 C to 50 C and at relative humidities between 6 percent and 91 percent were used. This analysis showed that the second coefficient of viscosity varied between 1900 and 20,000 times larger than the dynamic or first coefficient of viscosity over the temperature and humidity range of the data. In addition, the data showed that the molecular relaxation effects, which are responsible for the magnitude of the second coefficient of viscosity, place severe limits on the use of time-independent, thermodynamic equations of state. Compressible flows containing large streamwise velocity gradients, like shock waves, which cause significant changes in particle properties to occur during time intervals shorter than hundredths of seconds, must be modeled using dynamic equations of state. The dynamic model approach is described briefly.

Ash, Robert L.↗

Deimos: A featureless asteroid-like spectrum

High quality CCD spectra were obtained of Deimos from 0.5 to 1.0 micron at a spectral resolution of 15A at the time of the 1988 Mars opposition. The data acquisition and reduction methods allowed the quantitative prevention of scattered light from Mars contaminating the spectra. Solar analog stars BS560, BS2007, and BS8931 were observed the same night to allow removal of telluric absorptions. The ratio spectrum of Deimos has a red slope, increasing in reflectance by a factor of approx. 50 pct. over the one octave wavelength interval observed. Other than this slope, the spectrum is remarkably featureless. The absence of absorption bands in the spectrum of Deimos is in marked contrast with the spectra of Martian surface materials. No trace of the Fe(2+) charge transfer absorption band around 1 micron is observed, which rules out the presence of significant quantities of minerals such as the pyroxenes or olivine at the surface of Deimos. The featureless red spectrum of Deimos appears to be consistent with a surface composition of fine grained carbonaceous chondrite type material. An analysis is presented of the spectrum of Deimos which makes use of the Hapke scattering surface model.

Grundy, W. M.↗

On Geomagnetism and Paleomagnetism

A statistical description of Earth's broad scale, core-source magnetic field has been developed and tested. The description features an expected, or mean, spatial magnetic power spectrum that is neither "flat" nor "while" at any depth, but is akin to spectra advanced by Stevenson and McLeod. This multipole spectrum describes the magnetic energy range; it is not steep enough for Gubbins' magnetic dissipation range. Natural variations of core multipole powers about their mean values are to be expected over geologic time and are described via trial probability distribution functions that neither require nor prohibit magnetic isotropy. The description is thus applicable to core-source dipole and low degree non-dipole fields despite axial dipole anisotropy. The description is combined with main field models of modem satellite and surface geomagnetic measurements to make testable predictions of: (1) the radius of Earth's core, (2) mean paleomagnetic field intensity, and (3) the mean rates and durations of both dipole power excursions and durable axial dipole reversals. The predicted core radius is 0.7% above the 3480 km seismologic value. The predicted root mean square paleointensity (35.6 mu T) and mean Virtual Axial Dipole Moment (about 6.2 lx 1022 Am(exp 2)) are within the range of various mean paleointensity estimates. The predicted mean rate of dipole power excursions, as defined by an absolute dipole moment <20% of the 1980 value, is 9.04/Myr and 14% less than obtained by analysis of a 4 Myr paleointensity record. The predicted mean rate of durable axial dipole reversals (2.26/Myr) is 2.3% more than established by the polarity time-scale for the past 84 Myr. The predicted mean duration of axial dipole reversals (5533 yr) is indistinguishable from an observational value. The accuracy of these predictions demonstrates the power and utility of the description, which is thought to merit further development and testing. It is suggested that strong stable stratification of Earth's uppermost outer core leads to a geologically long interval of no dipole reversals and a very nearly axisymmetric field outside the core. Statistical descriptions of other planetary magnetic fields are outlined.

Voorhies, Coerte V.↗

Section on Observed Impacts on El Nino

Agricultural applications of El Nino forecasts are already underway in some countries and need to be evaluated or re-evaluated. For example, in Peru, El Nino forecasts have been incorporated into national planning for the agricultural sector, and areas planted with rice and cotton (cotton being the more drought-tolerant crop) are adjusted accordingly. How well are this and other such programs working? Such evaluations will contribute to the governmental and intergovernmental institutions, including the Inter-American Institute for Global Change Research and the US National Ocean and Atmospheric Agency that are fostering programs to aid the effective use of forecasts. As El Nino climate forecasting grows out of the research mode into operational mode, the research focus shifts to include the design of appropriate modes of utilization. Awareness of and sensitivity to the costs of prediction errors also grow. For example, one major forecasting model failed to predict the very large El Nino event of 1997, when Pacific sea-surface temperatures were the highest on record. Although simple correlations between El Nino events and crop yields may be suggestive, more sophisticated work is needed to understand the subtleties of the interplay among the global climate system, regional climate patterns, and local agricultural systems. Honesty about the limitations of an forecast is essential, especially when human livelihoods are at stake. An end-to-end analysis links tools and expertise from the full sequence of ENSO cause-and-effect processes. Representatives from many disciplines are needed to achieve insights, e.g, oceanographers and atmospheric scientists who predict El Nino events, climatologists who drive global climate models with sea-surface temperature predictions, agronomists who translate regional climate connections in to crop yield forecasts, and economists who analyze market adjustments to the vagaries of climate and determine the value of climate forecasts. Methods include historical studies to understand past patterns and to test hindcasts of the prediction tools, crop modeling, spatial analysis and remote sensing. This research involves expanding, deepening, and applying the understanding of physical climate to the fields of agronomy and social science; and the reciprocal understanding of crop growth and farm economics to climatology. Delivery of a regional climate forecast with no information about how the climate forecast was derived limits its effectiveness. Explanation of a region's major climate driving forces helps to place a seasonal forecast in context. Then, a useful approach is to show historical responses to previous El Nino events, and projections, with uncertainty intervals, of crop response from dynamic process crop growth models. Regional ID forecasts should be updated with real-time weather conditions. Since every El Nino event is different, it is important to track, report and advise on each new event as it unfolds. The stability of human enterprises depends on understanding both the potentialities and the limits of predictability. Farmers rely on past experience to anticipate and respond to fluctuations in the biophysical systems on which their livelihoods depend. Now scientists are improving their ability to predict some major elements of climate variability. The improvements in the reliability of El Nino forecasts are encouraging, but seasonal forecasts for agriculture are not, and will probably never be completely infallible, due to the chaotic nature of the climate system. Uncertainties proliferate as we extend beyond Pacific sea-surface temperatures to climate teleconnections and agricultural outcomes. The goal of this research is to shed as a clear light as possible on these inherent uncertainties and thus to contribute to the development of appropriate responses to El Nino and other seasonal forecasts for a range of stakeholders, which, ultimately, includes food consumers everywhere.

Rosenzweig, Cynthia↗

Improving the CERES SYN Cloud and Flux Products by Identifying GOES-17 Scan Anomalies Using a Convolutional Neural Network

The NASA Clouds and the Earth’s Radiant Energy System (CERES) project relies on top-of-atmosphere (TOA) broadband fluxes derived from geostationary (GEO) satellite imagery to account for the diurnal flux variations between the CERES observation intervals, and thereby produce a synoptic gridded (SYN1deg) product based on continuous temporal observations. Consistent broadband flux derivation depends on accurate radiative property measurements and cloud retrievals, which largely determine the radiance-to-flux conversion process. Therefore, it is important to ensure a high quality of cloud property input in order to maintain a reliable broadband flux record. In Edition 4 of the CERES SYN1deg product, a robust automated image anomaly detection algorithm based on inter-line and inter-pixel differences, spatial variance, and 2-D Fourier analysis has been successful in identifying imagery with linear artifacts, but the line-by-line inspection and cleaning process must still be performed by a human. Therefore, further automation of this quality assurance process is warranted, especially considering the excessive amount of additional cleaning necessitated by the GOES-17 Advance Baseline Imager (ABI) cooling system anomaly. As such, this article highlights advancement of the CERES GEO image artifact cleaning approach based on a convolutional neural network (CNN) for classification of bad scanlines. Once trained, the CNN approach is a computationally inexpensive means to ensure greater consistency in cloud retrievals, and therefore broadband flux derivation, based on GOES-17 measurements.

Benjamin Scarino↗

Pioneer 9 plasma wave and solar plasma measurements for the August 1972 storm period

The solar disturbances of August 1972 produced large-scale solar wind perturbations that were detected by the Pioneer 9 plasma probe, electric field detector, and magnetometer for an extended time period commencing early on August 3. During this ten-day interval the interplanetary plasma parameters at r approximately equal 0.8 AU varied over unusually wide ranges, so that the conditions for generation of high and low VLF wave levels could be identified fairly readily. It is demonstrated that no measurable signals were detected in the broadband electric field channel (sensitive to waves with f greater than or equal to 100 Hz in the spacecraft frame of reference) unless the proton density was high enough to yield a proton plasma frequency with f greater than or about equal to 100 Hz. The analysis suggests that waves related to ion acoustic oscillations were detected throughout the extended storm period.

Scarf, F. L.↗

Information Retrieval from SAGE II and MFRSR Multi-Spectral Extinction Measurements

Direct beam spectral extinction measurements of solar radiation contain important information on atmospheric composition in a form that is essentially free from multiple scattering contributions that otherwise tend to complicate the data analysis and information retrieval. Such direct beam extinction measurements are available from the solar occultation satellite-based measurements made by the Stratospheric and Aerosol Gas Experiment (SAGE II) instrument and by ground-based Multi-Filter Shadowband Radiometers (MFRSRs). The SAGE II data provide cross-sectional slices of the atmosphere twice per orbit at seven wavelengths between 385 and 1020 nm with approximately 1 km vertical resolution, while the MFRSR data provide atmospheric column measurements at six wavelengths between 415 and 940 nm but at one minute time intervals. We apply the same retrieval technique of simultaneous least-squares fit to the observed spectral extinctions to retrieve aerosol optical depth, effective radius and variance, and ozone, nitrogen dioxide, and water vapor amounts from the SAGE II and MFRSR measurements. The retrieval technique utilizes a physical model approach based on laboratory measurements of ozone and nitrogen dioxide extinction, line-by-line and numerical k-distribution calculations for water vapor absorption, and Mie scattering constraints on aerosol spectral extinction properties. The SAGE II measurements have the advantage of being self-calibrating in that deep space provides an effective zero point for the relative spectral extinctions. The MFRSR measurements require periodic clear-day Langley regression calibration events to maintain accurate knowledge of instrument calibration.

Lacis, Andrew A.↗

The Impact of the Evolving Satellite Data Record on Reanalysis Water and Energy Fluxes During the Past 30 Years

Retrospective analyses (reanalyses) use a fixed assimilation model to take diverse observations and synthesize consistent, time-dependent fields of state variables and fluxes (e.g. temperature, moisture, momentum, turbulent and radiative fluxes). Because they offer data sets of these quantities at regular space / time intervals, atmospheric reanalyses have become a mainstay of the climate community for diagnostic purposes and for driving offline ocean and land models. Of course, one weakness of these data sets is the susceptibility of the flux products to uncertainties because of shortcomings in parameterized model physics. Another issue, perhaps less appreciated, is the fact that the discreet changes in the evolving observational system, particularly from satellite sensors, may also introduce artifacts in the time series of quantities. In this paper we examine the ability of the NASA MERRA (Modern Era Retrospective Analysis for Research and Applications) and other recent reanalyses to determine variability in the climate system over the satellite record (~ the last 30 years). In particular we highlight the effect on reanalyses of discontinuities at the junctures of the onset of passive microwave imaging (Special Sensor Microwave Imager) in late 1987 as well as improved sounding and imaging with the Advanced Microwave Sounding Unit, AMSU-A, in 1998. We examine these data sets from two perspectives. The first is the ability to capture modes of variability that have coherent spatial structure (e.g. ENSO events and near-decadal coupling to SST changes) and how these modes are contained within trends in near global averages of key quantities. Secondly, we consider diagnostics that measure the consistency in energetic scaling in the hydrologic cycle, particularly the fractional changes in column-integrated water vapor versus precipitation as they are coupled to radiative flux constraints. These results will be discussed in the context of implications for science objectives and priorities of the NASA Energy and Water Cycle Study, NEWS.

Robertson, Franklin R.↗

The Effect of Satellite Observing System Changes on MERRA Water and Energy Fluxes

Because reanalysis data sets offer state variables and fluxes at regular space / time intervals, atmospheric reanalyses have become a mainstay of the climate community for diagnostic purposes and for driving offline ocean and land models. Although one weakness of these data sets is the susceptibility of the flux products to uncertainties because of shortcomings in parameterized model physics, another issue, perhaps less appreciated, is the fact that continual but discreet changes in the evolving observational system, particularly from satellite sensors, may also introduce artifacts in the time series of quantities. In this paper we examine the ability of the NASA MERRA (Modern Era Retrospective Analysis for Research and Applications) and other recent reanalyses to determine variability in the climate system over the satellite record (approximately the last 30 years). In particular we highlight the effect on the reanalysis of discontinuities at the junctures of the onset of passive microwave imaging (Special Sensor Microwave Imager) in late 1987 as well as improved sounding and imaging with the Advanced Microwave Sounding Unit, AMSU-A, in 1998. We first examine MERRA fluxes from the perspective of how physical modes of variability (e.g. ENSO events, Pacific Decadal Variability) are contaminated by artificial step-like trends induced by the onset of new moisture data these two satellite observing systems. Secondly, we show how Redundancy Analysis, a statistical regression methodology, is effective in relating these artifact signals in the moisture and temperature analysis increments to their presence in the physical flux terms (e.g. precipitation, radiation). This procedure is shown to be effective greatly reducing the artificial trends in the flux quantities.

Robertson, Franklin R.↗

The Effect of Satellite Observing System Changes on MERRA Water and Energy Fluxes

Because reanalysis data sets offer state variables and fluxes at regular space / time intervals, atmospheric reanalyses have become a mainstay of the climate community for diagnostic purposes and for driving offline ocean and land models. Although one weakness of these data sets is the susceptibility of the flux products to uncertainties because of shortcomings in parameterized model physics, another issue, perhaps less appreciated, is the fact that continual but discreet changes in the evolving observational system, particularly from satellite sensors, may also introduce artifacts in the time series of quantities. In this paper we examine the ability of the NASA MERRA (Modern Era Retrospective Analysis for Research and Applications) and other recent reanalyses to determine variability in the climate system over the satellite record (approx. the last 30 years). In particular we highlight the effect on the reanalysis of discontinuities at the junctures of the onset of passive microwave imaging (Special Sensor Microwave Imager) in late 1987 and, more prominently, with improved sounding and imaging with the Advanced Microwave Sounding Unit, AMSU-A, in 1998. We first examine MERRA fluxes from the perspective of how physical modes of variability (e.g. ENSO events, Pacific Decadal Variability) are contained by artificial step-like trends induced by the onset of new moisture data these two satellite observing systems. Secondly, we show how Redundancy Analysis, a statistical regression methodology, is effective in relating these artifact signals in the moisture and temperature analysis increments to their presence in the physical flux terms (e.g. precipitation, radiation). This procedure is shown to be effective greatly reducing the artificial trends in the flux quantities.

Robertson, Franklin R.↗

Probing the consistency of cosmological contours for supernova cosmology

As the scale of cosmological surveys increases, so does the complexity in the analyses. This complexity can often make it difficult to derive the underlying principles, necessitating statistically rigorous testing to ensure the results of an analysis are consistent and reasonable. This is particularly important in multi-probe cosmological analyses like those used in the Dark Energy Survey (DES) and the upcoming Legacy Survey of Space and Time, where accurate uncertainties are vital. In this paper, we present a statistically rigorous method to test the consistency of contours produced in these analyses and apply this method to the Pippin cosmological pipeline used for type Ia supernova cosmology with the DES. We make use of the Neyman construction, a frequentist methodology that leverages extensive simulations to calculate confidence intervals, to perform this consistency check. A true Neyman construction is too computationally expensive for supernova cosmology, so we develop a method for approximating a Neyman construction with far fewer simulations. We find that for a simulated dataset, the 68% contour reported by the Pippin pipeline and the 68% confidence region produced by our approximate Neyman construction differ by less than a percent near the input cosmology; however, they show more significant differences far from the input cosmology, with a maximal difference of 0.05 in $Ω$ M and 0.07 in w. In conclusion, this divergence is most impactful for analyses of cosmological tensions, but its impact is mitigated when combining supernovae with other cross-cutting cosmological probes, such as the cosmic microwave background.

79 ASTRONOMY AND ASTROPHYSICS↗

Congenital malformation and hemoglobin A1c in the first trimester among Japanese women with pregestational diabetes

Abstract Aim To investigate the incidence of major congenital malformations in Japanese women with pregestational diabetes, and to determine the cutoff value of hemoglobin A1c (HbA1c) in the first trimester associated with congenital malformations. Methods This retrospective cohort study included singleton pregnancies in Japanese women with pregestational diabetes, including type 1 and type 2 diabetes, and specific types of diabetes due to other causes. The primary outcome was the incidence of major congenital malformations. The secondary outcome was the incidence of all congenital malformations. The cutoff value of HbA1c for congenital malformations was calculated using receiver operating characteristic curve analysis. The adjusted odds ratios (aOR) of major congenital malformations were calculated using multiple logistic regression analyses. Results This study enrolled 292 patients, including 132 (45.2%) with type 1 diabetes, 156 (53.4%) with type 2 diabetes, and 4 (1.4%) with other specific types. The incidence rates of major congenital malformations and all congenital malformations were 7.2% (21/292) and 12.7% (37/292), respectively. The cutoff value of HbA1c in the first trimester for major malformations and for all congenital malformations was 6.5%. HbA1c ≥ 6.5% was significantly associated with major malformations (aOR 3.5; 95% confidence interval: 1.2–12.6; p = 0.018). Conclusion The incidence of major congenital malformations significantly increased in pregnant Japanese women with HbA1c values of 6.5% or higher. The recommended HbA1c value during the first trimester used in other countries can be applied to pregnant Japanese women.

Nakanishi, Kentaro↗