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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Identification of mosquito proteins that differentially interact with alphavirus nonstructural protein 3, a determinant of vector specificity

Chikungunya virus (CHIKV) and the closely related onyong-nyong virus (ONNV) are arthritogenic arboviruses that have caused significant, often debilitating, disease in millions of people. However, despite their kinship, they are vectored by different mosquito subfamilies that diverged 180 million years ago (anopheline versus culicine subfamilies). Previous work indicated that the nonstructural protein 3 (nsP3) of these alphaviruses was partially responsible for this vector specificity. To better understand the cellular components controlling alphavirus vector specificity, a cell culture model system of the anopheline restriction of CHIKV was developed along with a protein expression strategy. Mosquito proteins that differentially interacted with CHIKV nsP3 or ONNV nsP3 were identified. Six proteins were identified that specifically bound ONNV nsP3, ten that bound CHIKV nsP3 and eight that interacted with both. In addition to identifying novel factors that may play a role in virus/vector processing, these lists included host proteins that have been previously implicated as contributing to alphavirus replication.

Byers, Nathaniel M. (ORCID:0000000157725940)↗
DOE OSTI2022

Human behavior determinants of exposure to Anopheles vectors of malaria in Sumba, Indonesia

Malaria vector control interventions in Sumba, Indonesia, have not been able to eliminate malaria. Human drivers of exposure to Anopheles bites were investigated as part of a larger clinical trial evaluating the impact of a spatial repellent product on malaria incidence. Human behavioral observations (HBOs) evaluating temporal and spatial presence, sleeping behaviors, and insecticide treated net (ITN) use, were collected parallel to entomological collections—indoor and outdoor human landing catches (HLCs), and house hold surveys. Data demonstrates that mosquito access to humans, enabled by structurally open houses, is evident by the similar entomological landing rates both inside and outside households. The presence of animals inside houses was associated with increased mosquito entry–however, the number of humans present inside houses was not related to increased mosquito landing. Analyzing mosquito landing rates with human behavior data enables the spatial and temporal estimation of exposure to Anopheles bites, accounting for intervention (ITN) presence and usage. Human behavior adjusted exposure to Anopheles bites was found to be highest in the early in the evening, but continued at lower levels throughout the night. Over the night, most exposure (53%) occurred when people were indoors and not under the protection of nets (asleep or awake) followed by exposure outside (44%). Characterized gaps in protection are outdoor exposure as well as exposure indoors–when awake, and when asleep and not using ITNs. Interestingly, in the primary trial, even though there was not a significant impact of the spatial repellent on vector biting rates by themselves (16%), when factoring in human behavior, there was approximately 28% less exposure in the intervention arm than in the placebo arm. The treated arm had less human behavior adjusted bites in all spaces evaluated though there was proportionally higher exposure indoors. This analysis points to the importance of using HBOs both towards understanding gaps in protection as well as how interventions are evaluated. To mitigate ongoing transmission, understanding context specific spatial and temporal exposure based on the interactions of vectors, humans and interventions would be vital for a directed evidence-based control or elimination strategy.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2022

Magnetic Field Vector Measurements Using Doppler-Free Saturation Spectroscopy

Experimentally measuring the magnetic-field vector topology in low-cost fusion-concept devices will provide critical information required to optimize and accelerate the development of those concepts for economical fusion energy. The magnetic-field measurement techniques most commonly used in modern tokamaks, i.e., beam-emission spectroscopy and optical emission spectroscopy, are not suitable below 5000 Gauss due to a lack of sensitivity. To diagnose magnetic field relevant to some of the ARPA-E-supported fusion concepts (50 to 1000 Gauss), a novel approach is required. Doppler-free saturation spectroscopy (DFSS) is a pump/probe laser-based technique and has been successfully demonstrated in the laboratory to provide a magnetic-field measurement accuracy of <10 Gauss. DFSS is implemented to obtain ultra-high-resolution spectra at a localized point in space. The spectral data is then fit to the Schrödinger equation for determination of the magnetic-field vector. To obtain the magnetic-field topology, the measurement spatial location is scanned over the desired region of space by steering the DFSS pump laser beam. The goal of this project is to assemble and commission a portable DFSS diagnostic capable of 2-D magnetic-field vector measurements utilizing the Hα spectral line profile.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2020

A Vector Sensor-Based Acoustic Characterization System for Marine Renewable Energy

NoiseSpotter is a passive acoustic monitoring system that characterizes, classifies, and geo-locates anthropogenic and natural sounds in near real time. It was developed with the primary goal of supporting the evaluation of potential acoustic effects of offshore renewable energy projects. The system consists of a compact array of three acoustic vector sensors, which measures acoustic pressure and the three-dimensional particle velocity vector associated with the propagation of an acoustic wave, thereby inherently providing bearing information to an underwater source of sound. By utilizing an array of three vector sensors, the application of beamforming techniques can provide sound source localization, allowing for characterization of the acoustic signature of specific underwater acoustic sources. Here, performance characteristics of the system are presented, using data from controlled acoustic transmissions in a quiet environment and ambient noise measurements in an energetic tidal channel in the presence of non-acoustic flow noise. Data quality is demonstrated by the ability to reduce non-acoustic flow noise contamination, while system utility is shown by the ability to characterize and localize sources of sound in the underwater environment.

16 TIDAL AND WAVE POWER↗
DOE OSTI2021

Protection against Different Genotypes of Newcastle Disease Viruses (NDV) Afforded by an Adenovirus-Vectored Fusion Protein and Live NDV Vaccines in Chickens

The efficacy of an adenovirus-vectored Newcastle disease virus (NDV) vaccine expressing the fusion (F) NDV protein (adeno-F) was evaluated against challenges with virulent heterologous and homologous NDV strains to the F protein. In a preliminary study, two different doses (low and high) of adeno-F were tested against a virulent NDV strain containing the homologous NDV F protein, CA02. In a second study, at three weeks post-vaccination, the efficacy of the high dose of adeno-F was compared to a live attenuated NDV vaccine strain (LaSota) against three antigenically distinct virulent NDV challenge strains, one homologous (CA02) and two heterologous (TZ12, EG14) to F in the vectored vaccine. In both experiments, clinical signs, mortality, virus shedding, and humoral response were evaluated. In the first experiment, the survival rates from birds vaccinated with adeno-F at a high and low dose were 100% and 25%, respectively. In the second experiment, birds vaccinated with the high dose of adeno-F had a survival rate of 80%, 75%, and 65% after challenge with the CA02, TZ12, and EG14 viruses, respectively. All of the LaSota-vaccinated birds survived post-challenge no matter the NDV challenge strain. High antibody titers were detected after vaccination with LaSota by HI and ELISA tests. The majority of adeno-F-vaccinated birds had detectable antibodies using the ELISA test, but not using the HI test, before the challenge. The data show that both the similarity of the F protein of the adeno-F vaccine to the challenge virus and the adeno-F vaccination dose affect the efficacy of an adenovirus-vectored NDV vaccine against a virulent NDV challenge.

Ferreira, Helena L. (ORCID:0000000232613712)↗
DOE OSTI2023

Cloning and expression vectors and systems

Vectors for cloning, maintaining and expressing a wide range of coding sequences in inducible T7 expression systems in Escherichia coli expression hosts are disclosed herein. Target genes that can be stably maintained and expressed include those that specify proteins that are highly toxic to the host cell. Different configurations of vectors and expression hosts provide different rates of transcription and translation of target genes and therefore different rates of accumulation of target proteins. Methods for cloning by asymmetric ligation and co-expression of more than one target protein in a single vector are also disclosed, as are variants of BL21(DE3) having lower basal transcription by T7 RNA polymerase.

Studier, F. William↗
DOE OSTI2023

Comparative investigation of iterative solutions of the all-frequency stable formulation and its vector-potential-only variation

An all-frequency stable formulation has been proposed and applied to solve low-frequency and multiscale electromagnetic problems to avoid the low-frequency breakdown catastrophe of the traditional vector wave equation. Based on the potential representation of the fields, this formulation involves vector and scalar potentials, as well as an auxiliary potential to enforce the gauge condition. In this paper, such a formulation is first simplified to involve vector potential only. Their iterative solutions are then sought by using an incomplete LU preconditioner and an iterative solver. The iterative performance of both formulations are investigated in a comparative study.

Mekonnen, Minyechil↗
DOE OSTI2025

Search for single-production of vector-like quarks decaying into Wb in the fully hadronic final state in pp collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector

A search for T and Y vector-like quarks produced in proton-proton collisions at a centre-of-mass energy of 13 TeV and decaying into Wb in the fully hadronic final state is presented. The search uses 139 fb −1 of data collected by the ATLAS detector at the LHC from 2015 to 2018. The final state is characterised by a hadronically decaying W boson with large Lorentz boost and a b-tagged jet, which are used to reconstruct the invariant mass of the vector-like quark candidate. The main background is QCD multijet production, which is estimated using a data-driven method. Upon finding no significant excess in data, mass limits at 95% confidence level are obtained as a function of the global coupling parameter, κ. The observed lower limits on the masses of Y quarks with κ = 0.5 and κ = 0.7 are 2.0 TeV and 2.4 TeV, respectively. For T quarks, the observed mass limits are 1.4 TeV for κ = 0.5 and 1.9 TeV for κ = 0.7.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2026

Vector boson scattering and anomalous quartic couplings in final states with ℓνqq or ℓℓqq plus jets using proton-proton collisions at $\sqrt{s}=13$ TeV

A measurement is presented of the electroweak vector boson scattering production of ZV (V = W, Z) boson pairs associated with two jets in proton-proton collisions at a center-of-mass energy of 13 TeV. The data, corresponding to an integrated luminosity of 138 fb −1 , were collected at the CERN LHC with the CMS detector during the 2016–2018 data-taking period. The analysis targets final states with a pair of isolated electrons or muons from Z boson decays and three or four jets, depending on the momentum of the vector boson that decays into quarks. Signal strength is measured for events characterized by a large invariant mass of two forward jets with a wide pseudorapidity gap between them. The electroweak production of ZV in association with two jets is measured with an observed (expected) significance of 1.3 (1.8) standard deviations. A combination of the analyses of ZV channel and the previously published WV channel in the lepton plus jets final state places constraints on effective field theory parameters that describe anomalous electroweak production of WW, WZ, and ZZ boson pairs in association with two jets. Several world best limits are set on anomalous quartic gauge couplings in terms of dimension-8 standard model effective field theory operators.

Hadron-Hadron Scattering↗
DOE OSTI2023

Search for single production of vector-like T quarks decaying into Ht or Zt in pp collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector

This paper describes a search for the single production of an up-type vector-like quark (T) decaying as T → Ht or T → Zt. The search utilises a dataset of pp collisions at $\sqrt{s}$ = 13 TeV collected with the ATLAS detector during the 2015–2018 data-taking period of the Large Hadron Collider, corresponding to an integrated luminosity of 139 fb ₋1 . Data are analysed in final states containing a single lepton with multiple jets and b-jets. The presence of boosted heavy resonances in the event is exploited to discriminate the signal from the Standard Model background. No significant excess above the Standard Model expectation is observed, and 95% CL upper limits are set on the production cross section of T quarks in different decay channels. The results are interpreted in several benchmark scenarios to set limits on the mass and universal coupling strength (κ) of the vector-like quark. For singlet T quarks, κ values above 0.53 are excluded for all masses below 2.3 TeV. At a mass of 1.6 TeV, κ values as low as 0.35 are excluded. For T quarks in the doublet scenario, where the production cross section is much lower, κ values above 0.72 are excluded for all masses below 1.7 TeV, and this exclusion is extended to κ above 0.55 for low masses around 1.0 TeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2024

Search for Higgs boson pair production with one associated vector boson in proton-proton collisions at $ \sqrt{s} $ = 13 TeV

A search for Higgs boson pair (HH) production in association with a vector boson V (W or Z boson) is presented. The search is based on proton-proton collision data at a center-of-mass energy of 13 TeV, collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 138 fb$^{−1}$. Both hadronic and leptonic decays of V bosons are used. The leptons considered are electrons, muons, and neutrinos. The HH production is searched for in the $ \textrm{b}\overline{\textrm{b}}\textrm{b}\overline{\textrm{b}} $ decay channel. An observed (expected) upper limit at 95% confidence level of VHH production cross section is set at 294 (124) times the standard model prediction. Constraints are also set on the modifiers of the Higgs boson trilinear self-coupling, k$_{λ}$, assuming k$_{2V}$ = 1, and vice versa on the coupling of two Higgs bosons with two vector bosons, k$_{2V}$. The observed (expected) 95% confidence intervals of these coupling modifiers are −37.7 < k$_{λ}$ < 37.2 (−30.1 < k$_{λ}$ < 28.9) and −12.2 < k$_{2V}$ < 13.5 (−7.2 < k$_{2V}$ < 8.9), respectively.[graphic not available: see fulltext]

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2023

Search for single vector-like $B$ quark production and decay via $B$ → $bH$($b\overline{b}$) in $pp$ collisions at $\sqrt{s}$ = 13 TeV with the ATLAS detector

A search is presented for single production of a vector-like B quark decaying into a Standard Model b-quark and a Standard Model Higgs boson, which decays into a $b\overline{b}$ pair. The search is carried out in 139 fb -1 of $\sqrt{s}$ = 13 TeV proton-proton collision data collected by the ATLAS detector at the LHC between 2015 and 2018. No significant deviation from the Standard Model background prediction is observed, and mass-dependent exclusion limits at the 95% confidence level are set on the resonance production cross-section in several theoretical scenarios determined by the couplings c W , c Z and c H between the B quark and the Standard Model W, Z and Higgs bosons, respectively. For a vector-like B occurring as an isospin singlet, the search excludes values of c W greater than 0.45 for a B resonance mass (m B ) between 1.0 and 1.2 TeV. For 1.2 TeV < m B < 2.0 TeV, c W values larger than 0.50–0.65 are excluded. If the B occurs as part of a (B, Y) doublet, the smallest excluded c Z coupling values range between 0.3 and 0.5 across the investigated resonance mass range 1.0 TeV < m B < 2.0 TeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2022

Observation of Vector Spin Seebeck Effect in a Noncollinear Antiferromagnet

Spintronic phenomena to date have been established in magnets with collinear moments, where the spin injection through the spin Seebeck effect (SSE) is always along the out-of-plane direction. Here, we report the observation of a vector SSE in a noncollinear antiferromagnet (AF) LuFeO 3 , where temperature gradient along the out-of-plane and also the in-plane directions can both inject a pure spin current and generate a voltage in the heavy metal via the inverse spin Hall effect (ISHE). We show that the thermovoltages are due to the magnetization from canted spins in LuFeO 3 . Furthermore, in contrast to the challenges of generating, manipulating, and detecting spin current in collinear AFs, the vector SSE in LuFeO 3 is readily viable in zero magnetic field and can be controlled by a small magnetic field of about 150 Oe at room temperature. Furthermore, the noncollinear AFs expand new realms for exploring spin phenomena and provide a new route to low-field antiferromagnetic spin caloritronics and magnonics.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2021

Vector bosons and jets in proton collisions

Events with vector bosons produced in association with jets have been extensively studied at hadron colliders and provide high-accuracy tests of the standard model. A good understanding of these processes is of paramount importance for precision Higgs physics, as well as for searches for new physics. In particular, associated production of γ, W, or Z bosons with light-flavor and heavy-flavor jets is a powerful tool for testing perturbative QCD calculations, Monte Carlo event generators, and can also constrain the parametrizations used to describe the parton content of the proton. Furthermore, events with a W or Z boson produced with two well-separated jets can be used to distinguish between electroweak and strong production mechanisms, and to set limits on contributions of physics beyond the standard model. This review summarizes the historical theoretical developments and the state-of-the-art in the modeling of vector-boson-plus-jet physics while focusing on experimental results by the LHC collaborations in run 1 and run 2 and including comparisons with recent measurements at the Tevatron.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2025

Low-mass vector-meson production at forward rapidity in 𝑝 + 𝑝 and Au + Au collisions at $\sqrt{𝑠_{𝑁⁢𝑁}}$ = 200 GeV

The PHENIX experiment at the Relativistic Heavy Ion Collider has measured low-mass vector-meson (𝜔+𝜌 and 𝜙) production through the dimuon decay channel at forward rapidity (1.2 < |y| < 2.2) in 𝑝 + 𝑝 and Au + Au collisions at $\sqrt{𝑠_{𝑁⁢𝑁}}$ = 200 GeV. The low-mass vector-meson yield and nuclear-modification factor were measured as a function of the average number of participating nucleons, ⟨𝑁 part ⟩, and the transverse momentum 𝑝 𝑇 . These results were compared with those obtained via the kaon decay channel in a similar 𝑝 𝑇 range at midrapidity. The nuclear-modification factors in both rapidity regions are consistent within the uncertainties. A comparison of the 𝜔 + 𝜌 and 𝐽/𝜓 mesons reveals that the light and heavy flavors are consistently suppressed across both 𝑝 𝑇 and ⟨𝑁 part ⟩. Finally, in contrast, the 𝜙 meson displays a nuclear-modification factor consistent with unity, suggesting strangeness enhancement in the medium formed.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
DOE OSTI2023

A Six-Phase Space Vector PWM Technique for Wide Bandgap Device-Based Three-Level Inverters

This article presents a space vector pulsewidth modulation (SVPWM) technique for wide bandgap (WBG) device-based three-level (3L) six-phase inverters. Implementation of the SVPWM techniques for any six-phase inverter is complex for its high number of possible voltage vectors. Different six-phase load configurations are also possible depending on the angle between two consecutive phases and neutral point connections. The implementation techniques change depending on the load configuration. Moreover, a common neutral point for all six phases leads to circulating currents. Capacitor voltage balancing is also needed for 3L inverters. Capacitor voltage balancing and addressing the circulating current problem further increases the implementation complexity. In this article, a generalized SVPWM technique is proposed for the six-phase 3L inverters that is implementable using two three-phase 3L SVPWM blocks. The SVPWM technique also ensures dc bus capacitor voltage balancing and minimizes circulating current. Here, the SVPWM technique is experimentally verified using a GaN-based 3L six-phase active neutral point clamped (ANPC) inverter prototype, and the results are presented in this article.

42 ENGINEERING↗
DOE OSTI2023

Lost in transduction: Critical considerations when using viral vectors

The application of retroviral vectors in the laboratory requires considerations that often go overlooked but are often easy to circumvent. Here, we discuss the relationship between the observed transduction efficiency of a cell population and per-cell viral insertions—and describe how differential cell-type susceptibilities can confound results. We consider the math underlying this problem and review an alternative approach to the commonly used “multiplicity of infection” (MOI) method of titering and using viral vectors in the biomedical research laboratory.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2023

Sparse matrix‐vector and matrix‐multivector products for the truncated SVD on graphics processors

Summary Many practical algorithms for numerical rank computations implement an iterative procedure that involves repeated multiplications of a vector, or a collection of vectors, with both a sparse matrix and its transpose. Unfortunately, the realization of these sparse products on current high performance libraries often deliver much lower arithmetic throughput when the matrix involved in the product is transposed. In this work, we propose a hybrid sparse matrix layout, named CSRC, that combines the flexibility of some well‐known sparse formats to offer a number of appealing properties: (1) CSRC can be obtained at low cost from the popular CSR (compressed sparse row) format; (2) CSRC has similar storage requirements as CSR; and especially, (3) the implementation of the sparse product kernels delivers high performance for both the direct product and its transposed variant on modern graphics accelerators thanks to a significant reduction of atomic operations compared to a conventional implementation based on CSR. This solution thus renders considerably higher performance when integrated into an iterative algorithm for the truncated singular value decomposition (SVD), such as the randomized SVD or, as demonstrated in the experimental results, the block Golub–Kahan–Lanczos algorithm.

Aliaga, José I.↗