{sup 99}Mo Production at KIPT Neutron Source Facility
Argonne National Laboratory (ANL) and Kharkov Institute of Physics and Technology (KIPT) have cooperated on the construction of the Neutron Source Facility (NSF) at KIPT, Kharkov (Ukraine). The NSF facility consists of an electron accelerator driven system (ADS) generating 300 kW of thermal power for multiple applications, including medical isotope production. ANL performed extensive analyses including medical isotopes production, reactivity monitoring, operations and control, refueling, cold neutron source design, target design,and radiation shielding. The present study focuses on the use of the KIPT NSF for medical isotope production. Medical isotopes are radioactive isotopes with short half-lives used in diagnostic and therapeutic medical procedures. For example, brain cancer is difficult to treat by ordinary surgery and only brachytherapy with {sup 131}Cs, which has 9.7 days half-life, has shown effective results on the patients. {sup 99m}Tc is the most common medical isotope used in medical diagnoses because the wavelength of its gamma radiation (8.8 pm) is about the same as the conventional X-ray diagnostic devices. {sup 99m}Tc has 6 hours half-life, therefore it cannot be stored because it decays into {sup 99}Tc. The parent of {sup 99m}Tc is {sup 99}Mo, which has 66 hours half-life. Consequently, the delivery of {sup 99m}Tc occurs through shipping {sup 99}Mo samples to the medical facilities. The Neutron Source Facility of KIPT is the first ADS in the world operating at non-zero power and allows producing several isotopes for medical applications. The total power of the facility is about 300 kW, including ∼200 kW from fission reactions. The construction of the NSF has been already completed and operations will start during year 2016. After 20 irradiation days, {sup 82}Br, {sup 64}Cu, {sup 165}Dy, {sup 166}Ho, {sup 192}Ir, {sup 194}Ir, {sup 186}Re, {sup 188}Re and {sup 153}Sm have specific activities, larger than 100 MBq/mg without taking into account the self-shielding effect and therefore they are good candidates for production. The self-shielding effect plays an important role for all nuclide parents that have a large microscopic capture cross section. This effect reduces the reaction rate and therefore the specific activity. For instance, the analyses of molybdenum trioxide (MoO{sub 3}) irradiation samples have shown that the self-shielding effect may reduce the specific activity by a factor 1.4. The metallic form of natural molybdenum produces a higher specific activity, relative to the trioxide form. Analyses on the 6-day Ci {sup 99}Mo activity have shown that is possible to perform between 40 to 310 {sup 99m}Tc medical procedures per MoO{sub 3} irradiation week. The number of medical procedures depends on the diagnosed organ and the weight of the patient. (authors)