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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 577 records · Page 32
All sourcesNASA NTRSDOE OSTI
DOE OSTI2021

Magnetron R&D for high efficiency CW RF sources for industrial accelerators

The scheme of using high-efficiency magnetrons to drive radiofrequency accelerators has been demonstrated at 2450 MHz in CW mode *. Magnetron test stands at JLab and GA have been set up to further test the noise figure and the locking speed of the injection phase-lock method. For higher power applications, power combining experiments using a TM010 cavity-type combiner and a magic tee for the binary combiner while using a single clean injection signal has been carried out at 2450 MHz. The frequency pulling effect between the magnetron and a low-Q cavity has been shown to enhance the frequency locking bandwidth compared to the injection phase-lock alone. The principle has been studied by the equivalent circuit simulation, analytical model, and finally confirmed experimentally on the magnetrons. Due to the pandemic delay in 2020, the equivalent high power tests using a 75kW, 915MHz industrial magnetron will be done in 2021 and will be reported in a future paper.

Wang, H.↗
DOE OSTI2023

Improved measurements of nonlinear integrable optics at IOTA

Nonlinear integrable optics (NIO) are a promising novel approach at improving the stability of high intensity beams. Implementations of NIO based on specialized magnetic elements are being tested at the Integrable Optics Test Accelerator (IOTA) at Fermilab. One method of verifying proper implementation of these solutions is by measuring the analytic invariants predicted by theory. The initial measurements of nonlinear invariants were performed during IOTA run in 2019/20, however the covid-19 pandemic prevented the full-scale experimental program from being completed. Several important improvements were implemented in IOTA for the 2022/23 run, including the operation at higher beam energy of 150 MeV, improved optics control, and chromaticity correction. This report presents on the improved calibrations of the NIO for nonlinear invariant measurements.

43 PARTICLE ACCELERATORS↗
DOE OSTI2022

Single-molecule 3D imaging of HIV cellular entry by liquid-phase electron tomography

Enveloped viruses, including human immunodeficiency virus (HIV) and SARS-CoV-2, target cells through membrane fusion process. The detailed understanding of the process is sought after for vaccine development but remains elusive due to current technique limitations for direct three-dimensional (3D) imaging of an individual virus during its viral entry. Recently, we developed a simple specimen preparation method for real-time imaging of metal dynamic liquid-vaper interface at nanometer resolution by transmission electron microscopy (TEM). Here, we extended this method to study biology sample through snapshot 3D structure of a single HIV (pseudo-typed with the envelope glycoprotein of vesicular stomatitis virus, VSV-G) at its intermediate stage of viral entry to HeLa cells in a liquid-phase environment. By individual-particle electron tomography (IPET), we found the viral surface release excess lipids with unbound viral spike proteins forming ~50-nm nanoparticles instead of merging cell membrane. Moreover, the spherical-shape shell formed by matrix proteins underneath the viral envelope does not disassemble into a cone shape right after fusion. Further, the snapshot 3D imaging of a single virus provides us a direct structure-based understanding of the viral entry mechanism, which can be used to examine other viruses to support the development of vaccines combatting the current ongoing pandemic.

Kong, Lingli↗
DOE OSTI2020

COVID-19 LDRD Project Summaries

Sandia National Laboratories currently has 27 COVID-related Laboratory Directed Research & Development (LDRD) projects focused on helping the nation during the pandemic. These LDRD projects cross many disciplines including bioscience, computing & information sciences, engineering science, materials science, nanodevices & microsystems, and radiation effects & high energy density science.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Getting things done onsite: Heat Source production never ramps down

The COVID-19 pandemic has changed many norms in the world and at LANL. During the rapid transition of sending many to work from home in March, some programs were deemed mission critical, with the expectation to continue driving their missions forward. One of those essential programs is Heat Source Technologies, a group within the Actinide Material Power & Processing (AMPP) Division at TA-55. Within the Associate Laboratory Directorate of Weapons Production (ALDWP), the group responsible for the Pu-238 heat sources continued their work nearly uninterrupted as many others made the mandatory transition to work remotely. This group, known as AMPP-1, Heat Source Technologies, works on the production line producing heat sources from Plutonium (Pu)-238, which is an essential mission for National Security. This group is comprised of nearly 90 employees and operates out of the TA-55 Plutonium Facility (PF-4 and PF-5) producing heat sources. Heat source production includes the operations that purify, process, and weld Pu-238 oxide into encapsulated heat sources that are essential for space and defense missions.

45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEF↗
DOE OSTI2020

Uncertainty analysis of Resource Demand Model for Covid-19

As part of the Department of Energy response to the novel coronavirus pandemic of 2020, a modeling effort was sponsored by the DOE Office of Science. One task of this modeling effort at Sandia was to develop a model to predict medical resource needs given various patient arrival scenarios. Resources needed include personnel resources (nurses, ICU nurses, physicians, respiratory therapists), fixed resources (regular or ICU beds and ventilators), and consumable resources (masks, gowns, gloves, face shields, sedatives). This report documents the uncertainty analysis that was performed on the resource model. The uncertainty analysis involved sampling 26 input parameters to the model. The sampling was performed conditional on the patient arrival streams that also were inputs to the model. These patient arrival streams were derived from various epidemiology models and had a significant effect on the projected resource needs. In this report, we document the sampling approach, the parameter ranges used, and the computational workflow necessary to perform large-scale uncertainty studies for every county and state in the United States.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Variable Chain Length Carboxylic Acids as Modifiers to Enhance the Antiviral Efficacy of Sodium Dodecyl Sulfate.

Non-toxic disinfectants composed of readily available commodity chemicals are needed for immediate response to the current COVID-19 pandemic. One such area is the active research field for food-grade sanitization. Combinations of levulinic acid, a five-carbon ketocarboxylic acid, and sodium dodecyl sulfate, have been frequently described for antibacterial use on food contact surfaces. Levulinic acid has been identified as a renewable feedstock but is not presently in commodity production. Other carboxylic acids, such as acetic acid, may be equally usable and food-safe. Acidic and buffered solutions were highly effective, yielding no countable surviving organisms. The high efficacy of each acid may suggest that carboxylic acid sanitizers in general have potential use against viruses.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2020

Deuterium Concentration Effects on Cell Cycle Progression

Deuterium (D), which is found in natural water at ~ 150 ppm, seems to play an important role in biology. For example, D concentrations above 150 ppm are known to produce toxic effects in many organisms. There is also evidence to suggest D levels significantly less than 150 ppm can cause delays in progression through the normal mitotic cell cycle. Some have even theorized that the D:H ratio in cells may impact an organism’s radiation resistance. Therefore, evaluating the role of D and the D:H ratio in eukaryotic and prokaryotic cells should lead to a better understanding of cell cycle progression and radiation resistance in these organisms. Research in this field has likely been stalled by the limited availability of D 2 O with varying D concentrations needed to accurately study the deuterium effects. However, SRNL can currently manufacture D 2 O in varying concentrations, and we have assembled a unique team of radiation biologists, microbiologists, radiochemists, and health physics to form an interdisciplinary research group to study the cell cycle as a function of D concentration in order to address several fundamental science questions. Proposed work in FY20 was a collaborative effort with Augusta University to utilized BSL-2 mammalian cell lines. Lab work was halted due to the COVID-19 pandemic. An intensive literature review was performed and identified pertinent knowledge gaps that could be filled in future research efforts.

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEA↗
DOE OSTI2020

Efficiency of Room Air Cleaners for Removal of Bioaerosols From Ambient Air

The COVID-19 pandemic necessitated the evaluation of commercial air purification units to protect worker safety in indoor spaces. This project evaluated the efficacy of commercial off-the-shelf air purification systems that utilize electrostatic precipitation for the collection and removal of particulates (including bioaerosols) from ambient air. An aerosol mist containing Escherichia coli (E. coli) and bacteriophage surrogate virus, MS2, was produced using a nebulizer and delivered to the front intake of the commercial system with the ionizer ON and OFF. Removal efficiency was evaluated by colony/plaque formation assays using a small agar plate (60 X 15 mm) to passively collect E. coli and MS2 exhausting from the electrostatic precipitation cell. The system was determined to remove 98-99% of the microorganism introduced to the system. Testing was performed with all pre- and post-electrostatic cell filters removed so further removal is anticipated.

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
DOE OSTI2020

Safeguards by Design Projects (FY2020 Final Report)

This University Engagement project challenged engineering students at universities, that do not have Bachelor degrees in nuclear engineering but do have research reactors and some nuclear engineering coursework, to incorporate Safeguards by Design concepts into their Senior Capstone Design Project. This University Engagement project was part of the U. S. Department of Energy’s (DOE) National Nuclear Security Administration (NNSA), Office of Defense Nuclear Nonproliferation, Office of International Nuclear Safeguards, Next Generation Safeguards Initiative, Human Capital Development: University Engagement Program. This program exposed university students with Mechanical Engineering majors and Nuclear Engineering minors to the concepts of international nuclear safeguards. FY20, three teams at the University of Rhode Island and one team at the University of Texas - Austin participated in researching, designing, building, and testing projects to support international nuclear safeguards measurements or verification. The projects involved engaging in activities at the university’s research reactors. All the projects engaged students with prototyping a design and/or tool for application at the Universities’ reactor. At the end of the course, most of the students expressed the experience was a positive and they learned more about international nuclear safeguards and applying requirements than they had previously encountered. This school year the projects were further complicated by the COVID-19 pandemic. Both universities cancelled in class room classes, and limited direct student/professor interactions. Furthermore, Los Alamos National Laboratory (LANL) greatly restricted travel, therefore making it impossible to visit the students at the end of the semester for the review of their design projects. The final design and review meeting for the projects happened via the internet. Additionally, while the teams planned to build prototypes this did not happen since there was a social distancing ban on students meeting in person.

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
DOE OSTI2020

Terry Turbopump Expanded Operating Band Modeling and Simulation Efforts in Fiscal Year 2020 - Progress Report

The Terry Turbine Expanded Operating Band Project is currently conducting testing at Texas A&M University as part of a revised experimental program meant to supplant previous full-scale testing plans under the headings of Milestone 5 and Milestone 6. In consultation with Sandia National Laboratories technical staff and with modeling and simulation support from the same, the hybrid Milestone 5&6 plan is moving forward with experiments aimed at addressing knowledge gaps regarding scale, working fluid, and turbopump self-regulation. Modeling and simulation efforts at Sandia National Laboratories in FY20 fell under the broad umbrella of Milestone 7 and consisted exclusively of MELCOR-related tasks aimed at: 1) Constructing/improving input models of Texas A&M University experiments, 2) Constructing a generic boiling water reactor input model according to best practices with systems-level Teny turbine capabilities, and 3) Adding code capability in order to leverage experimental data/findings, address bugs, and improve general code robustness Project impacts of the Covid-19 pandemic have fortunately been minimal thus far but are mentioned as necessary when discussing the hybrid Milestone 5&6 progress as well as the corresponding Milestone 7 modeling and simulation progress.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2020

AMPP Newsletter (Sep 2020)

I am excited to introduce the third 2020 issue of Actinide Materials Processing and Power Division’s quarterly newsletter, with a focus on “excellence in mission operations.” Excellence in mission operations requires the execution of sustained operations that are reliable and responsive to mission needs across all work being performed in AMPP. For all of us, adherence to Conduct of Operations principles and strong work planning and execution is essential to achieving a safe and productive environment that enables overall excellence. Since the beginning of the COVID-19 pandemic response, you have all shown how AMPP has a division exemplifies this focus area. Highlights of our outstanding operational work under the threat of COVID-19 have been featured in our weekly newsletters.

36 MATERIALS SCIENCE↗
DOE OSTI2020

CPAP Ventilators Needed for Rapid Response to COVID-19 by Modification of CPAP Equipment

Early on in the COVID-19 pandemic, potential ventilator shortages were a critical issue identified by national health care providers. Capacity modeling at the time suggested patient demand may exceed ventilator supply. Thus, the challenge became finding an urgent interim solution to meet health care needs. Our initial hypothesis was that CPAP technology could be modified to provide similar functionality to a ventilator, relieving demand and allowing physicians to decide which patients need high end machines, ultimately saving lives. In conjunction with medical experts and pulmonologists, we were able to identify three key thrusts associated with this research problem: (1) modification of CPAP technology to allow for 02 input that would be capable of providing ventilation; (2) development of an alarming function that would provide real-time audible alarms to alert medical personnel to critical conditions, which would be used inline with CPAP technology; and (3) a method of sterilizing expiratory air from such a system in order to protect medical personnel from biohazard, since CPAPs vent to the atmosphere. We were unable to realize results for thrust 1 (CPAP modification for 02); we identified potential safety issues associated with utilizing medical grade oxygen with a common CPAP device. In order to characterize and mitigate these issues, we would need to partner closely with a device manufacturer; such a partnership could not be achieved in the timeframe needed for this rapid response work. However, we determined that some medical grade BiPAP devices do not need this modification and that the significant progress on thrusts 2 and 3 would be sufficient to buy down risk of a massive ventilator shortage. Our team built a prototype alarm system that can be utilized with any assistive respiratory device to alert on all key conditions identified by medical personnel (high pressure, low pressure, apnea, loss of power, low battery). Finally, our team made significant progress in the rapid prototyping and demonstration of an inline UV air purifier device. The device is cost efficient and can be manufactured at scale with both commercially available and additively manufactured parts. Initial tests with SARS-CoV-2 analog bacteriophage MS2 show 99% efficacy at reducing bioburden. Following a successful demonstration of the prototype device with medical personnel, we were able to obtain follow-on (non-LDRD) funding to provide additional device characterization, validation, and production in order to respond to an immediate regional need.

42 ENGINEERING↗
DOE OSTI2020

Quantifying Graph Uncertainty from Communication Data

Graphs are a widely used abstraction for representing a variety of important real-world problems including emulating cyber networks for situational awareness, or studying social networks to understand human interactions or pandemic spread. Communication data is often converted into graphs to help understand social and technical patterns in the underlying communication data. However, prior to this project, little work had been performed analyzing how best to develop graphs from such data. Thus, many critical, national security problems were being performed against graph representations of questionable quality. Herein, we describe our analyses that were precursors to our final statistically grounded technique for creating static graph snapshots from a stream of communication events. The first analyzes the statistical distribution properties of a variety of real-world communication datasets generally fit best by Pareto, log normal, and extreme value distributions. The second derives graph properties that can be estimated given the expected statistical distribution for communication events and the communication interval to be viewed node observability, edge observability, and expected accuracy of node degree. Unfortunately, as that final process is under review for publication, we can't publish it here at this time.

97 MATHEMATICS AND COMPUTING↗
DOE OSTI2020

Favipiravir Flow Synthesis

Researchers at Los Alamos have invented a novel flow/batch chemistry synthetic process to produce the small molecule anti-viral favipiravir more cheaply and rapidly to enable on-demand production for pandemic response. Current methods for synthesizing favipiravir are constrained by long reaction times and low yields. If ongoing clinical trials for favipiravir demonstrate its effectiveness as a COVID-19 antiviral, and as a broad spectrum anti-viral for treating future viral outbreaks, this synthesis would help alleviate potential drug shortages and supply chain issues for the manufacturing and availability of this small molecule anti-viral. This U.S.-based synthesis route would be capable of scale-up for making large (kilogram) amounts of favipiravir as needed to assist with clinical trial needs and demand for patient treatment, and can also produce isotopically labeled favipiravir. We are seeking a CRADA partner to finalize method development who has interest in licensing the method and employing it for domestic production.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
DOE OSTI2020

Impact of Proton Activity on Fuel-Cell Performance (CRADA Final Report)

The key attribute that is being investigated is the dependence of the oxygen-reduction and hydrogen-oxidation reaction kinetics on proton activity. The influence of proton activity on the kinetics is also important in the determination of limiting factors that impact overall fuel-cell performance. At lower humidities, which are required to simplify fuel-cell water and thermal management (especially for higher-temperature operation) and enable next generation fuel cells, the ionomer water content will be different than that in today’s fuel cells. Such changes in water content directly impact the activity and concentration of protons. Thus, it is necessary to quantify this impact of proton activity on the reaction kinetics, and to determine means to mitigate any detrimental impacts to enable high performance. To realize the above goals of understanding the intrinsic interactions of proton activity on hydrogen-oxidation and oxygen-reduction kinetics, systematic investigations were carried out and a novel technique, a rapid microelectrode with environmental control, was realized. The experimental campaign at LBNL worked alongside that of TokyoTech and both were complemented by mathematical modeling of the key phenomena. The results demonstrated a robust method to analyze the kinetic behavior and an impact of proton activity, although greater delineation in terms of ion concentration versus activity was not obtained fully due in part to limited lab access during the COVID pandemic.

30 DIRECT ENERGY CONVERSION↗