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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 505 records · Page 28
All sourcesNASA NTRSDOE OSTI
NASA NTRS2023

Thermomechanical Property Prediction of Amorphous and Crystal PEKK via Molecular Dynamics

Traditionally, advanced aerospace composites have been manufactured using thermoset resins. However, recently, thermoplastics have been investigated for use in the manufacturing of composite materials due to their unique manufacturing characteristics. Thermoplastic resins can be reshaped and formed, along with the added benefit of being recyclable, which thermoset resin cannot. Thermoplastic materials undergo a crystallization process during manufacturing which affects the percent crystallinity of the material. The crystallization needs to be understood better to maximize the potential of thermoplastic resins. PEKK is a thermoplastic material with good chemical, thermal, and mechanical loading resistance. PEKK is also a material NASA is interested in for developing new bonded joint technology. The crystalline microstructure of PEKK is at the micrometer length scale, and it is of interest to model the effects of the crystallinity structure on PEKK’s bulk properties. Molecular dynamics (MD) is a simulation tool that allows for property-structure relationships between atomistic structure and nanometer-length portions of a material. This makes MD a useful tool for developing the structure-property relationship of PEKK. However, the micrometer length scale of PEKK’s crystal structure is too large for MD. Thus, a hybrid approach to modeling PEKK’s microstructure is proposed in this work where MD models are built of both the amorphous and crystalline phases of PEKK. The engineering material properties can be obtained using MD at the nanometer length scale. A micromechanics approach can then generate the micrometer length scale of the crystallinity and the effective properties can be homogenized. The objective of this paper is to show the MD model workflow and the MD-predicted properties of PEKK. The properties can then be homogenized with different crystalline percentages to build design graphs that can be used to tailor PEKK for specific composite applications.

poly ether ketone ketone↗
NASA NTRSDate not supplied

Lean Model-Based Systems Engineering on the NASA High-Density Vertiplex Subproject

The High Density Vertiplex (HDV) subproject of NASA’s Advanced Air Mobility (AAM) project adopted Model-Based Systems Engineering (MBSE) in July of 2020, prior to subproject formulation. A small and lean team of HDV Systems Engineers (SE) are utilizing MagicDraw to execute NASA SE processes via MBSE. The SEs learned how to use MagicDraw from scratch and HDV is the first project for which the SEs have utilized MagicDraw. This presentation will demonstrate project technical execution via MBSE, utilizing the digital elements built into the SysML (Systems Modeling Language). SysML provides a model-centric means of carrying out the NASA SE common technical processes by providing tools for complete system modeling, including requirements and interface management and design capture. The authors also leverage and extend SysML to perform other SE tasks, such as Verification and Validation (V&V) tracking. MBSE has two main purposes for HDV: 1) documenting the subproject’s logical architecture for distribution outside of the subproject, 2) capturing the subproject’s physical architecture in a single-source-of-truth for use by the subproject’s members. This presentation details the challenges, lessons learned, and solutions that were encountered in implementing MBSE in the first iteration on a multi-iteration, full-lifecycle design, build, fly project.

systems engineering↗
NASA NTRS2023

Automated Fiber Placement Through Thickness Defect Stacking Optimization

In its 2022 commercial market outlook, Boeing forecasted an 80% increase in the global fleet through 2041 compared to 2019 pre-pandemic levels. This sharp rise in demand will drive pressure onto airframe manufacturers to ramp up production and find more efficient ways to design and manufacture airplanes. Complicating this challenge is the industry’s recent transformation from traditional metal-based airframes towards hybrid composite-metal aircraft. While composites have been used in aviation for decades, aircraft manufacturers are still struggling to design and manufacture quality parts at a high rate. Automated Fiber Placement (AFP) is one of the main manufacturing techniques used to produce large-scale composite parts. After a design has been created, a manufacturing strategy has to be developed based on the working material, part geometry, and machine capabilities. This process planning stage is essential to the AFP workflow and currently requires a high level of manual input from an experienced process planner. In an effort to automate and optimize this stage, the Computer Aided Process Planning (CAPP) module was developed. CAPP assists process planners in identifying optimal starting point location and layup strategy for each ply of a laminate. This Ply-Level Optimization (PLO) phase operates on the quantification of ply quality through predictable geometry-based defects such as gaps, overlaps, angle deviation, and steering. As you move from PLO to Laminate-Level Optimization (LLO) the design space grows exponentially, emphasizing the need for automated optimization. The work presented in this thesis expands CAPP’s functionality by comparing the planned fiber paths through the thickness of the laminate to mitigate stacked area defects and achieve an optimal laminate-level manufacturing strategy. Within CAPP, predicted gap and overlap defects are imported from Vericut Composites Programming (VCP) and then discretized to streamline the through-thickness comparison. Two objective functions are used to score different combinations of ply layup strategies based on defect stacking both globally and locally. Four combinatorial optimization algorithms were coupled with these objective functions to investigate the laminate-level manufacturing strategy design space and converge on the optimal plan. These algorithms were evaluated based on accuracy and efficiency through virtual testing on a complex tool surface. A separate LLO approach was developed to achieve near-optimal laminates in significantly less time. The end result is a software package which greatly reduces the required input from process planners, shortening the design-build cycle time and improving part quality.

AFP↗
NASA NTRS2024

Terrestrial Proving Ground Capabilities Needed for Lunar In Situ Resource Utilization (ISRU) & Construction Concepts of Operation

Incorporating any new technology or system into a human exploration mission or architecture requires development well in advance of the mission to eliminate technology, cost, and schedule risk concerns. It is often stated that technologies need to be at a Technology Readiness Level (TRL) of 6, i.e. ‘system/subsystem model or prototype demonstration in a relevant environment (ground or space)’, by Authority To Proceed (ATP) or by the Preliminary Design Review (PDR) for the mission at the latest. There are two game changing capabilities for sustained human exploration of space that can have a significant effect on the overall exploration architecture and the technologies and systems included in the architecture. The first game changing capability, known as In Situ Resource Utilization (ISRU), involves the search for, acquisition, and processing of resources on the Moon and Mars into mission consumables and usable products, and the second is the ability to utilize space resources in the construction of roads, structures, and surface infrastructure. ISRU and surface construction capabilities have the potential to greatly reduce the cost and risk of human exploration while enabling sustained lunar surface and commercial operations. However, ISRU and surface construction systems are complex and must operate in extremely harsh environments, with abrasive regolith and pervasive dust, for long-periods of time, with potentially limited opportunities for maintenance and repair by humans. The complexity of these capabilities and operations also means that there are a limited number of companies that can design, build, and operate end-to-end systems on their own. The majority of the technologies being developed for these systems are by small companies and at the component or subsystem level. With the overarching strategy of the United States National Aeronautics and Space Administration (NASA) Space Technology Mission Directorate (STMD) to enable industry to implement ISRU and surface infrastructure for Artemis and space commercialization, it is therefore important to establish processes and capabilities to promote and foster collaborations among large and small companies involved in ISRU and surface infrastructure development. For ISRU and infrastructure systems and capabilities to be used in Artemis missions and future commercial lunar surface operations, a coordinated framework with virtual/physical integration and testing locations, or ‘Proving Grounds’, needs to be established and operated on a regular basis and open to all. This paper will discuss the ISRU and surface construction near and long-term concepts of operations, and review operations and lessons-learned from the previous ISRU analog field tests. From this information, requirements and capabilities will be proposed to support and enable the integration and testing of ISRU and construction systems with industry, academia, and international agencies, as well as what facilities and organizations could help establish these Proving Grounds.

ISRU↗
NASA NTRSDate not supplied

Introduction to Metal Additive Manufacturing for Propulsion Applications: Part I and II

Additive Manufacturing (AM) has become a prominent technology of interest for manufacturing propulsion components and gaining attention across the aerospace industry. AM is maturing at a rapid pace and providing new design opportunities, novel materials, new industries and supply chains resulting in programmatic and technical performance improvements. The successful use of AM requires a methodical and intentional approach to understanding the concept to utilization lifecycle for AM. This course will provide an overview of the various steps in AM process trades, design, build process, post-processing, certification and infusion of AM. This will provide various lessons learned and experiences that were captured in a recent AIAA textbook titled "Metal Additive Manufacturing for Propulsion Applications" by the session chairs and industry colleagues. This course will include propulsion examples and that went through the AM lifecycle including hot-fire testing.

Additive Manufacturing↗
DOE OSTI2020

The Future of Zero Energy Buildings: Produce, Respond, Regenerate: Preprint

The zero energy buildings concept is more than 20 years old, and the paradigm shift from buildings as energy consumers to buildings as energy producers is underway. Buildings also consume land and material resources, however, with attendant environmental impacts. Another paradigm is emerging: a built environment that produces energy and is environmentally responsive and regenerative. This paper investigates an updated framework for thinking about zero energy buildings that includes discussions of prioritizing renewables; determining on-site versus off-site generation; exploring how and when buildings should use energy; and balancing renewables, storage, and energy efficiency. Buildings are typically connected to the utility grid and the utility grid develops largely in response to the built environment. If more buildings’ real time electricity use aligned with renewable generation, more renewables would be added to the grid. Ultimately, the goal for zero energy buildings will be to use 100% renewables, 100% of the time, matching loads with energy storage and renewable generation at each discrete timestep over a year. This target is beyond the current zero energy definitions, which focus on an annual balance of renewable supply and energy demand and use the grid to “store” excess production to make up for hours without sufficient on-site renewable generation. This paper expands this upgraded concept and outlines simple metrics to evaluate the alignment of renewable sources and storage with building loads. This process can provide insights on building design considerations, including the use of flexible loads and optimal resource management.

ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATION↗
DOE OSTI2022

2.2.5.401 - Ocean Observing Prize

The Powering the Blue Economy: Ocean Observing Prize is a $2.4M contest that challenges innovators to develop solutions that integrate marine renewable energy with ocean observation platforms to revolutionize our ability to monitor, manage, and understand the ocean. Competitors are challenged to design, build, and test novel, wave-powered, self-charging autonomous underwater vehicle (AUV) systems that could be suitable for a 6-month deployment in the Atlantic Ocean to monitor hurricane formation. Through engagement with the end user ocean observing community, the team identified challenges in a lack of data on storm intensity, endangering coastal communities. This challenge could be addressed by collecting data before, during, and after a hurricane develops and strengthens at sea. Amassing this data, however, requires an ocean observing system that can be deployed at sea for long periods, waiting for approaching storms. To help solve this problem, competitors are working to integrate wave energy capture with AUV systems to collect this data, helping to better protect coastal communities from oncoming storms. Solutions developed through this prize aim to enable long-term collection of data before, during, and after a hurricane that will help better forecast storm intensity. The prize mechanism provides an environment to accelerate technology development for innovators and helps to improve awareness of marine energy and its ability to provide power to blue economy applications.

coastal communities↗
DOE OSTI2023

ABF DFO with Technology Holding, Inc.

This Agile BioFoundry Directed Funding Opportunity project with Technology Holding and partners focuses on the development of both a strain of Pseudomonas putida KT2440 and a corresponding bioprocess to convert cellulosic sugars to beta-ketoadipic acid, which can be used in performance nylons and polyesters. Our approach follows the Design-Build-Test-Learn cycle wherein we have transferred learnings from muconic acid production in P. putida to develop a glucose and xylose-utilizing beta-ketoadipic acid production strain. This strain achieves 65 g/L of beta-ketoadipic acid at 0.7 g/L/hr and a C-mol yield of 0.40. We are currently on-boarding arabinose utilization as well. To identify non-intuitive strain modifications as well, we are deploying a beta-ketoadipic acid biosensor and building randomly barcoded transposon insertion sequencing (RB-TnSeq) libraries and gene over-expression libraries in beta-ketoadipic acid production strains. Moreover, we are using global metabolomics and other systems biology tools to identify off-target pathways. Lastly, we are scaling up beta-ketoadipic acid production to kg-scale production for Technology Holding to evaluate in performance polymers with their partners.

beta-ketoadipic acid↗
DOE OSTI2023

Investigating Marine Environmental Degradation of Additive Manufacturing Materials for Renewable Energy Applications: Preprint

Marine renewable energy is a relatively young industry where there is a great need for rapid prototyping in design-build-test campaigns to quickly mature groundbreaking technologies. Additive manufacturing has an important role to play in the industry; however, little information is available to marine energy developers to help inform them on which additive manufacturing materials are appropriate for harsh marine environments. This paper presents an initial study on the mechanical characterization of polymeric additive manufacturing materials and the degradation effects of marine environments. Ultem 9085, acrylonitrile styrene acrylate, and chopped carbon-filled nylon, as well as continuous carbon and glass fiber-reinforced nylon were chosen for this study. Samples were manufactured to perform a variety of tension, shear, and compression mechanical characterization tests on the materials. Half of the samples were conditioned in Pacific Ocean water for approximately 6 months at Pacific Northwest National Laboratory's Marine Sciences Laboratory before being returned for mechanical characterization. The mechanical testing results showed that the Ultem 9085 and acrylonitrile styrene acrylate materials experienced little to no degradation in stiffness or strength after exposure to the marine environment. On the other hand, the nylon-based materials suffered significant stiffness and strength degradation (over 50% in some cases) after environmental conditioning. Ultimately, these data sets should serve as starting points to allow marine renewable energy developers to make informed additive manufacturing material choices for their prototype deployments.

additive manufacturing↗
DOE OSTI2023

Investigating Marine Environmental Degradation of Additive Manufacturing Materials for Renewable Energy Applications

Marine renewable energy is a relatively young industry where there is a great need for rapid prototyping in design-build-test campaigns to quickly mature groundbreaking technologies. Additive manufacturing has an important role to play in the industry; however, little information is available to marine energy developers to help inform them on which additive manufacturing materials are appropriate for highly loaded structures in harsh marine environments. This paper presents an initial study on the mechanical characterization of polymeric additive manufacturing materials and the degradation effects due to the marine environment. Ultem 9085, acrylonitrile styrene acrylate, and chopped carbon-filled nylon, as well as continuous carbon and glass fiber-reinforced nylon were chosen for this study. Samples were manufactured to perform a variety of tension, shear, and compression mechanical characterization tests on the materials. Half of the samples were conditioned in Pacific Ocean water for approximately 6 months at the Pacific Northwest National Laboratory's Marine and Coastal Research Laboratory before being returned for mechanical characterization. The mechanical testing results showed that the Ultem 9085 and acrylonitrile styrene acrylate materials experienced little to no degradation in stiffness or strength after exposure to the marine environment. On the other hand, the nylon-based materials suffered significant stiffness and strength degradation (over 50% in some cases) after environmental conditioning. Ultimately, these data sets should serve as starting points to allow marine renewable energy developers to make informed additive manufacturing material choices for their prototype deployments.

additive manufacturing↗
DOE OSTI2020

Panel Session 34: US DOE Featured Site: Savannah River Operations Office: 70 Years of Service

The Savannah River Site celebrates its 70. anniversary on November 28, 2020. On this date in 1950, President Harry S. Truman requested the Dupont Company to design, build and operate what was then known as the Savannah River Plant in response to the Soviet Union's detonation of its first atomic weapon, which set the Cold War into motion. During the 1950's, six South Carolina towns were relocated for the construction of SRS and by 1953, the 310 square mile site was complete. Nearly 40,000 workers were employed t build five nuclear reactors and support facilities, two chemical separations plants, heavy water extraction plant, nuclear fuel and target fabrication facility tritium extraction facility and waste management facilities. SRS played a key role in winning the Cold War and for seven decades, SRS has been a leader within the DOE complex. Today, the site supports environmental stewardship and maintains the nation's nuclear deterrent while ensuring the safekeeping and disposal of domestic and international nuclear materials. The site continues to support the nation's nuclear defense as it explores new potential NNSA missions. SRS has a proud 70- year history and looks forward to a future of service as a national asset and strong community partner. The session was kicked off with a video message from Secretary of Energy, Dan Brouillette, who thanked employees past and current for their efforts. The video also provided an overview of the history and future of the Site. This panel provided an overview of the Savannah River Site's 70 years of service (history, challenges, opportunities, and future) presented by the SRS's Senior leadership and the local Aiken, South Carolina Mayor. Panelists with presentations: US DOE Secretary Dan Brouillette's Overview of DOE and SRS - A Legacy of 70 Years of Service (Amy Boyette); 70 Years of Service (Michael Budney); 70 Years of Service (Stuart MacVean); SRS Liquid Waste (Thomas Foster); National Nuclear Security Administration (Nicole Nelson-Jean)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
DOE OSTI2024

U.S. Department of Energy Collegiate Wind Competition 2025 Rules - Phase 1

The U.S. Department of Energy (DOE) Wind Energy Technologies Office's (WETO) Collegiate Wind Competition (CWC, also referred to as the "Competition" in this rules document) invites interdisciplinary teams of undergraduate students from a variety of academic programs to solve complex wind energy challenges. Through the competition, WETO intends to offer students direct industry experience, valuable exposure to wind energy career pathways, and greater knowledge of wind energy's potential to contribute to a clean energy future. The competition will select up to 35 teams to start, making them eligible to compete for a cash prize pool of up to $280,000 . Each year, the competition identifies a new challenge and set of activities that address real-world research questions, thus demonstrating skills that students will need to work in the wind or wider renewable energy industries. The Collegiate Wind Competition 2025 challenge requires participants to compete simultaneously in four contests: 1) Turbine Prototype Contest: Design, build, and present a unique, wind-driven power system based on market research; 2) Turbine Testing Contest: Test the wind turbine in a competition wind tunnel at the final event; 3) Project Development Contest: Research wind resource data, transmission infrastructure, and environmental factors to create a site plan and financial analysis for a hypothetical wind farm; and Connection Creation Contest: Partner with wind industry professionals, raise awareness of wind energy in your local community, and work with local media to promote your team's accomplishments. The competition does not prescribe a power system market or wind regime. It is expected that each team will participate in all four contests.

collegiate wind competition↗
DOE OSTI2023

Investigating Marine Environmental Degradation Of Additive Manufacturing Materials For Renewable Energy Applications

Marine renewable energy is a relatively young industry where there is a great need for rapid prototyping in design-build-test campaigns to quickly mature ground-breaking technologies. Additive manufacturing has an important role to play in the industry; however, little information is available to marine energy developers to help inform them on which additive manufacturing materials are appropriate for harsh marine environments. This paper presents an initial study on the mechanical characterization of polymeric additive manufacturing materials and degradation effects due to the marine environment. Ultem 9085, acrylonitrile styrene acrylate (ASA), and chopped carbon-filled Nylon, as well as continuous carbon and glass fiber reinforced Nylon were chosen for this study. Samples were manufactured to perform a variety of tension, shear, and compression mechanical characterization tests on the materials. Half of the samples were conditioned in Pacific Ocean water for approximately 6 months at the Pacific Northwest National Laboratory’s Marine and Coastal Research Laboratory before being returned for mechanical characterization. The mechanical testing results showed that the Ultem 9085 and ASA materials experienced little to no degradation in stiffness or strength after exposure to the marine environment. On the other hand, the Nylon-based materials suffered significant stiffness and strength degradation (over 50% in some cases) after environmental conditioning. Ultimately, these results should serve as starting points to allow marine renewable energy developers to make informed additive manufacturing material choices for their prototype deployments.

Murdy, Paul↗
DOE OSTI2024

U.S. Department of Energy Collegiate Wind Competition 2025: Rules - Phases 2 and 3

The U.S. Department of Energy (DOE) Wind Energy Technologies Office's (WETO) Collegiate Wind Competition (CWC, also referred to as the "competition" in this rules document) invites interdisciplinary teams of undergraduate students from a variety of academic programs to solve complex wind energy challenges. Through the competition, WETO intends to offer students direct industry experience, valuable exposure to wind energy career pathways, and greater knowledge of wind energy's potential to contribute to a clean energy future. The competition will select up to 35 teams to start, making them eligible to compete for a cash prize pool of up to $280,000. Each year, the competition identifies a new challenge and set of activities that address real-world research questions, thus demonstrating skills that students will need to work in the wind or wider renewable energy industries. The Collegiate Wind Competition 2025 challenge requires participants to compete simultaneously in four contests: 1) Turbine Design Contest: Design, build, and present a unique, wind-driven power system. 2) Turbine Testing Contest: Test the wind turbine in a competition wind tunnel at the final event. 3) Project Development Contest: Research wind resource data, transmission infrastructure, and environmental factors to create a site plan and financial analysis for a hypothetical wind farm. 4) Connection Creation Contest: Partner with wind industry professionals, raise awareness of wind energy in your local community, and work with local media to promote your team's accomplishments. The competition does not prescribe a power system market or wind regime. It is expected that each team will participate in all four contests.

Collegiate Wind Competition↗
DOE OSTI2024

Physical Properties of Hilti HIT-RE 500 V3 After Irradiation: Slant Shear, Tensile, Flexural, and Compressive

There are various applications in which epoxy adhesives may be used within hot-cell environments. These epoxies currently see limited use within hot cells since it is known that organics see degradation after small doses even as low as 50 kilogray (kGy). These losses in physical property strengths limit the use of these epoxies to non-structural applications. In modern construction, however, the use of epoxies to bond structural components such as rebar or threaded anchors is becoming increasingly prevalent. To employ these types of materials the Idaho National Laboratory (INL) has begun investigating the specific degradation properties of epoxies for use in structural applications in environments where radiation is present. Hilti HIT-RE 500 V3 is used extensively in new construction and renovation projects across the world. The INL has conducted various tests on this epoxy for low dose environments. These tests include tensile, flexural, compression, and slant shear tests following the American Society for Testing Material International (ASTM) standards D638, D790, D695, and C882/882M respectively. Two sample sets for each test were created where the baseline specimens were not irradiated, and another set was irradiated to an accumulated dose of approximately 50-60 kGy. All the samples were destructively tested and analyzed focusing on the change in physical properties, examples of these tests are shown in Figures 1-4. Tensile testing results indicate a 0.9% loss in maximum load capacity, a 0.5% loss in tensile stress at maximum load, a 1.4% loss in tensile strain at break, and a 15% decrease in modulus of elasticity. Flexural testing results display an increase in all the following: 12% in strain at maximum load, 10% in maximum load capacity, 5% in stress at maximum load, and 3% in young’s modulus. The compressive physical properties after irradiation display a 1% increase in maximum load, a 3% decrease in stress at yield, and a 5% decrease in modulus of elasticity. The maximum compressive stress saw no measurable change after irradiation. The slant shear specimens after irradiation displayed a 2% increase in maximum load capacity and maximum compressive stress. Though a structural analysis would have to be completed as is normal for building design the increases and decreases in the measured physical properties indicate that this material may be used for structural applications in low dose hot-cell environments without adhesive failure.

36 MATERIALS SCIENCE↗
DOE OSTI2024

Modernizing the Legacy Fission Wire Measurement System for the Advanced Test Reactor-Critical Facility

Operational lifetime extensions of existing research reactors have emphasized the need for refurbishment, replacements, and upgrades to supporting equipment and instrumentation. The Advanced Test Reactor (ATR) at Idaho National Laboratory (INL), which entered service in 1967, has recently completed the sixth core internals change-out and has scheduled operations until at least 2040. Reactor maintenance and operational risk management is critically important in the research reactor community, however supporting measurement systems sometimes get overlooked when maintenance is planned. The Fission Wire Measurement System (FWMS) is a custom measurement system designed in the 1960s to measure the beta-particle activity of irradiated uranium-aluminum fission wires. This measurement is conducted to determine the fission rate profile of the Advanced Reactor Test Critical (ATR-C) facility. The ATR-C is an open-pool, low-power test reactor that was purpose driven to resemble ATR and is used to qualify experiment configurations and verify core models prior to full-power experiment irradiations in ATR. A power distribution measurement in ATR-C uses uranium-aluminum wires that are distributed throughout the ATR-C core to validate simulation and modeling results. These measurements require 340 to 1500 wires to be irradiated and measured within a 12-hour window. The activity of the wires is measured in the required time with the FWMS, which was put into service in 1965 at the Radiation Measurements Laboratory (RML). The system consists of 4 measurement channels and one reference channel, each with a 2-pi proportional gas flow detector and the measurement channels each have an automated sample changer. This legacy system is crucial to the continued operations of ATR and has undergone some minor hardware upgrades since 1965, however the system presently relies on custom control boards, custom gas ion chambers, analog amplifiers/discriminators, and a user interface (UI) for the system written in outdated code. Much of the equipment and software is custom with no commercial replacements or support and limited documentation. The existing control software requires an operating system that is no longer supported, creating more vulnerabilities to continued operations. A project is underway with a third-party vendor to design, build, and document a new control and data acquisition system (CDAS) for the FWMS. The new upgrade will replace the control system, computer, UI, sample changer motors, and main power supply while maintaining the interface with existing detector hardware. The upgraded system will be operated in parallel with the current hardware and software to conduct validation testing. This equipment upgrade demonstrates the commitment at ATR to ensuring successful operations and potential future research reactors at INL.

46 - INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AN↗
DOE OSTI2022

Chapter 10: Advances in Protein Engineering and its Application in Synthetic Biology

Protein engineering has been used successfully in fields ranging from medicine to food science to biofuels. Applications of protein engineering include developing antiviral peptides or other protein therapeutics, antibody engineering, designing protein-based logic circuits, engineering enzymes to be more specific or to function under industrially relevant conditions such as at higher temperatures or high/low pH, modifying cell signaling or regulatory functions, and so on. Advances in recombinant DNA, "omics," and CRISPR-Cas (clustered regularly interspaced short palindromic repeats and its associated proteins) technologies, combined with high-throughput screening facilities, will lead to improved methods for protein engineering, enabling easy modification of more proteins/enzymes for new specific applications. New methods for rational design, directed evolution, and computer-aided protein design will further accelerate the speed of protein evolution and expand the scope for protein engineering. In this chapter we discuss general protein engineering strategies and advances in engineering proteins with desired functions, focusing on the "design" and "build" part of the design-build-test-learn cycle.

BIOMASS FUELS↗
DOE OSTI2020

An Integrated Computer-Aided Design and Manufacturing Workflow for Synthetic Biology

Biological computer-aided design and manufacturing (bioCAD/CAM) tools facilitate the design and build processes of engineering biological systems using iterative design-build-test-learn (DBTL) cycles. In this book chapter, we highlight some of the bioCAD/CAM tools developed and used at the US Department of Energy (DOE) Joint Genome Institute (JGI), Joint BioEnergy Institute (JBEI), and Agile BioFoundry (ABF). We demonstrate the use of these bioCAD/CAM tools on a common workflow for designing and building a multigene pathway in a hierarchical fashion. Additionally, each tool presented in this book chapter is specifically tailored to support one or more specific steps in a workflow, can be integrated with the others into design and build workflows, and can be deployed at academic, government, or commercial entities.

59 BASIC BIOLOGICAL SCIENCES↗