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At least 451 records · Page 25

A tool and a methodology to use macros for abstracting variations in code for different computational demands

Scientific software used on high-performance computing platforms is in a phase of transformation because of the combined increase in the heterogeneity and complexity of models and hardware platforms. Having separate implementations for different platforms can easily lead to combinatorial explosions; therefore, the computational science community has been looking for mechanisms to express code through abstractions that can be specialized for different platforms. Most existing approaches use template meta-programming in C++, and are, therefore language specific. Here, we have developed a tool that uses customized expansion of macros to mimic some of C++ behavior in other languages. It enables unification of any code variants that may be necessary to run efficiently on different target architectures and different computational environments through use of macros with multiple alternative definitions and ability to arbitrate on definition selection for expansion. Combined with two other tools, a custom runtime, and a user specified recipe translator, our custom macroprocessor becomes a part of an overall performance portability solution that does not depend on any specific programming language. We also use macros as code-shorthand that lets code snippets become building blocks that allow variations in control flow to explore performance options. We demonstrate use of macros in Flash-X, a multiphysics multicomponent code with many Fortran legacy components derived from an earlier community code FLASH.

Heterogenous computing↗

JENSA: Past, present, and future

Nuclear reaction studies rely on three main physical components: the beam of nuclei provided by the facility, the detector systems used to measure the outgoing particles of interest, and the target. Target fabrication is thus a critical aspect of studying the reactions that power stars and probe the evolution of nuclear structure. The Jet Experiments in Nuclear Structure and Astrophysics (JENSA) gas jet target is the most dense helium jet target for rare isotope beam reaction studies in the world, providing targets of gaseous elements such as helium, nitrogen, and neon. A brief overview of the design and operation of JENSA, including commissioning and recent science experiments, and a discussion the future of JENSA coupled to the dedicated recoil separator SECAR, are presented.

Chipps, Kelly [ORNL] (ORCID:0000000330501298)↗

Characterization of a widespread sugar phosphate-processing bacterial microcompartment

Many prokaryotes form Bacterial Microcompartments (BMCs) that encapsulate segments of specialized metabolic pathways to enhance catalysis. The various functions of metabolosomes, catabolic BMCs, are dictated by the signature enzyme that processes initial substrates of the confined pathway. The components and native functions of several metabolosomes have been experimentally characterized; however one of the most prevalent across all bacteria has yet to be studied. Sugar Phosphate Utilizing (SPU) BMC loci encode enzymes predicted to be involved in sugar phosphate metabolism. The SPU genetic loci are found in organisms occupying habitats ranging from soils to hot springs, highlighting the ubiquity of the SPU BMC. We bioinformatically characterized seven SPU subtypes, all which contain an enzyme unique to SPU BMCs, a deoxyribose 5-phosphate aldolase (DERA). Here, we define the fundamental characteristics of SPU BMCs and have expressed, purified, and characterized a set of SPU core enzymes. These include a protein-protein complex formed between a SPU BMC DERA and a predicted ribose 5-phosphate isomerase. Further, we show that the SPU BMC DERA is catalytically active and propose that it acts as the universal signature enzyme for the SPU BMC, with implications for fundamental understanding and biotechnological applications of SPU BMCs.

59 BASIC BIOLOGICAL SCIENCES↗

Bioinspired mineralizing microenvironments generated by liquid-liquid phase coexistence

Biominerals such as bones, teeth and shells exhibit improved mechanical properties and intricate morphologies not seen in nonbiologically-produced minerals of ostensibly the same composition. These remarkable properties of biogenic minerals are thought to arise due to precise local control over the mineral deposition process, including organic and inorganic inclusions. Understanding how Biology controls the local reaction environment during formation of these materials to control their composition, structure, and properties is a grand challenge that promises to enable new routes to high-performance materials. This project developed multi-compartment bioinspired microreactors as artificial mineralizing vesicles, and used them to understand and control formation of inorganic/organic composite solid materials. A major emphasis was on developing all-aqueous emulsions in which each droplet was a structured microreactor with two or more adjacent phases. This approach provided local control over reaction environment including availability of inclusions such as polypeptides and metal ions, while being sufficiently simple to produce large populations of essentially identical multiphase reactor droplets simultaneously within a batch. Organic/inorganic composite materials could be produced with very high organic content that stabilized the inorganic portions as amorphous materials (e.g., amorphous calcium carbonate) by preventing the typical conversion to more thermodynamically crystalline forms (e.g., calcite). These stabilized amorphous composites could be stored indefinitely and converted to crystalline forms later by removal of the organic inclusions via, for example, heating. Compositional gradients in the organic and inorganic components were embedded during synthesis due to the evolution of the reaction microenvironment, and despite the complexity of this process it occurred similarly across the population of reactive droplets and was hence encoded into the population of resulting composite particles. The approach developed here allows pre-structuring of reactive microenvironments to control the spatiotemporal reaction environment, which is an important step towards rational design and on-demand production of complex functional materials with desired composition, optical properties, and mechanical response.

36 MATERIALS SCIENCE↗

The first dedicated life sciences Spacelab mission

JIt is pointed out that the Shuttle-borne Spacelab provides the capability to fly large numbers of life sciences experiments, to retrieve and rescue experimental equipment, and to undertake multiple-flight studies. A NASA Life Sciences Flight Experiments Program has been organized with the aim to take full advantages of this capability. A description is provided of the scientific aspects of the most ambitious Spacelab mission currently being conducted in connection with this program, taking into account the First Dedicated Life Sciences Spacelab Mission. The payload of this mission will contain the equipment for 24 separate investigations. It is planned to perform the mission on two separate seven-day Spacelab flights, the first of which is currently scheduled for early 1986. Some of the mission objectives are related to the study of human and animal responses which occur promptly upon achieving weightlessness.

Perry, T. W.↗

CRYSTAL, EOS Validation, and CAMEX-5

CAMEX-5 is at an early phase of concept development. This future field deployment (2004 or 2005) concerning hurricanes could potentially benefit from collaboration with other programs within NASA. Specifically, the recently completed CRYSTAL- Florida Area Cirrus Experiment (FACE) offers a useful model of such a collaborative endeavor. CRYSTAL-FACE was concerned with deep tropical convection and its impact on the upper troposphere. Three separate NASA R&A Programs joined in supporting CRYSTAL-FACE, including the Radiation Sciences Program, the Atmospheric Chemistry, Modeling & Analysis Program, and the Upper Atmosphere Research Program as well as the EOS Validation Program. In addition, the National Science Foundation and the Department of Energy Atmospheric Measurements Programs were also substantive partners. Insights will be given into how this cooperative field experiment came to be and how it worked in the field. Possibilities for similar model for CAMEX-5 will be explored.

Starr, David↗

NASA Strategic Roadmap Summary Report

In response to the Vision, NASA commissioned strategic and capability roadmap teams to develop the pathways for turning the Vision into a reality. The strategic roadmaps were derived from the Vision for Space Exploration and the Aldrich Commission Report dated June 2004. NASA identified 12 strategic areas for roadmapping. The Agency added a thirteenth area on nuclear systems because the topic affects the entire program portfolio. To ensure long-term public visibility and engagement, NASA established a committee for each of the 13 areas. These committees - made up of prominent members of the scientific and aerospace industry communities and senior government personnel - worked under the Federal Advisory Committee Act. A committee was formed for each of the following program areas: 1) Robotic and Human Lunar Exploration; 2) Robotic and Human Exploration of Mars; 3) Solar System Exploration; 4) Search for Earth-Like Planets; 5) Exploration Transportation System; 6) International Space Station; 7) Space Shuttle; 8) Universe Exploration; 9) Earth Science and Applications from Space; 10) Sun-Solar System Connection; 11) Aeronautical Technologies; 12) Education; 13) Nuclear Systems. This document contains roadmap summaries for 10 of these 13 program areas; The International Space Station, Space Shuttle, and Education are excluded. The completed roadmaps for the following committees: Robotic and Human Exploration of Mars; Solar System Exploration; Search for Earth-Like Planets; Universe Exploration; Earth Science and Applications from Space; Sun-Solar System Connection are collected in a separate Strategic Roadmaps volume. This document contains memebership rosters and charters for all 13 committees.

Wilson, Scott↗

Attitude Ground System (AGS) for the Magnetospheric Multi-Scale (MMS) Mission

MMS Overview Recall from Conrads presentation earlier today MMS launch: March 13, 2015 on an Atlas V from Space Launch Complex 40, Cape Canaveral, Florida MMS Observatory Separation: five minute intervals spinning at 3 rpm approximately 1.5 hours after launch MMS Science Goals: study magnetospheric plasma physics and understand the processes that cause power grids, communication disruptions and Aurora formation Mission: 4 identical spacecraft in tetrahedral formation with variable size1.2 x 12 RE in Phase 1, with apogee on dayside to observe bow shock1.2 x 25 RE in Phase 2, with apogee on night side to observe magneto tail Challenges Tight attitude control box, orbit and formation maintenance requirements Maneuvers on thrusters every two weeks Delta-H Spin axis direction and spin rate maintenance Delta-V Orbit and Formation maintenance Mission phase transitions AGS support Smart targeting prediction of Spin-Axis attitude in the presence of environmental torques to stay within the science attitude Determination of the spacecraft attitude and spin rate (sensitive to knowledge of inertia tensor)Calibrations to improve attitude determination results and improve orbit maneuvers Mass properties (Center of Mass, and inertia tensor for nutation and coning) Accelerometer bias (sensitive to the accuracy of the rate estimates) Sensor alignments.

Estimation and Calibration Support↗

Mars Reconnaissance Orbiter Navigation Strategy for Dual Support of Insight and ExoMars Entry, Descent and Landing Demonstrator Module in 2016

Mars Reconnaissance Orbiter (MRO) will support NASA's InSight Mission and ESA's ExoMars Entry, Descent and Landing Demonstrator Module (EDM) in the fall of 2016 when both landers arrive at Mars. MRO provided relay support during the Entry, Descent and Landing (EDL) sequences of Mars Phoenix Lander in 2008 and the Mars Science Laboratory in 2012. Unlike these missions, MRO will coordinate between two EDL events separated by only three weeks: InSight on September 28, 2016 and EDM on October 19, 2016. This paper describes MRO Navigation's maneuver strategy to move MRO's ascending node to meet the In- Sight EDL phasing requirement and support EDM.

EDM↗

The CAESAR New Frontiers Comet Sample Return Mission

The Comet Astrobiology Exploration Sample Return (CAESAR) mission is one of two finalists selected by NASA for Phase A study in the New Frontiers program. CAESAR will acquire a minimum of 80 grams of material from the surface of comet 67P/Churuyumov-Gerasimenko and return it to Earth for laboratory analysis. CAESAR preserves much of the science of a cryogenic sample return by retaining volatiles in a dedicated reservoir securely separated from the solid sample. Comet 67P was selected based on its favorable orbital geometry and the risk reduction and scientific context provided by the ESA (European Space Agency)'s Rosetta mission. CAESAR's objectives are to understand the origins of the Solar System starting materials and how these components came together to form planets and give rise to life. We also seek to resolve the conflicting views of comet origins arising from the Stardust and Rosetta missions. While the greater than 1 micron solids returned by Stardust originated in the hot, inner solar nebula, measurements by Rosetta suggest 67P volatiles formed at cryogenic temperatures and remained unchanged for billions of years. This dichotomy provides the rationale for returning both solid and gaseous samples.

CAESAR New Frontiers↗

The Quickest, Lowest-cost Lunar Resource Assessment Program: Integrated High-tech Earth-based Astronomy

Science and technology applications for the Moon have not fully kept pace with technical advancements in sensor development and analytical information extraction capabilities. Appropriate unanswered questions for the Moon abound, but until recently there has been little motivation to link sophisticated technical capabilities with specific measurement and analysis projects. Over the last decade enormous technical progress has been made in the development of (1) CCD photometric array detectors; (2) visible to near-infrared imaging spectrometers; (3)infrared spectroscopy; (4) high-resolution dual-polarization radar imaging at 3.5, 12, and 70 cm; and equally important (5) data analysis and information extraction techniques using compact powerful computers. Parts of each of these have been tested separately, but there has been no programmatic effort to develop and optimize instruments to meet lunar science and resource assessment needs (e.g., specific wavelength range, resolution, etc.) nor to coordinate activities so that the symbiotic relation between different kinds of data can be fully realized. No single type of remotely acquired data completely characterizes the lunar environment, but there has been little opportunity for integration of diverse advanced sensor data for the Moon. Two examples of technology concepts for lunar measurements are given. Using VIS/near-IR spectroscopy, the mineral composition of surface material can be derived from visible and near-infrared radiation reflected from the surface. The surface and subsurface scattering properties of the Moon can be analyzed using radar backscattering imaging.

Pieters, Carle M.↗

Blood Plasma Self-Separation Technologies during the Self-Driven Flow in Microfluidic Platforms

Blood plasma is the most commonly used biofluid in disease diagnostic and biomedical analysis due to it contains various biomarkers. The majority of the blood plasma separation is still handled with centrifugation, which is off-chip and time-consuming. Therefore, in the Lab-on-a-chip (LOC) field, an effective microfluidic blood plasma separation platform attracts researchers’ attention globally. Blood plasma self-separation technologies are usually divided into two categories: active self-separation and passive self-separation. Passive self-separation technologies, in contrast with active self-separation, only rely on microchannel geometry, microfluidic phenomena and hydrodynamic forces. Passive self-separation devices are driven by the capillary flow, which is generated due to the characteristics of the surface of the channel and its interaction with the fluid. Comparing to the active plasma separation techniques, passive plasma separation methods are more considered in the microfluidic platform, owing to their ease of fabrication, portable, user-friendly features. We propose an extensive review of mechanisms of passive self-separation technologies and enumerate some experimental details and devices to exploit these effects. The performances, limitations and challenges of these technologies and devices are also compared and discussed.

59 BASIC BIOLOGICAL SCIENCES↗

Irregular Satellites of the Planets

This proposal is directed towards the observational exploration of the irregular satellite systems of the planets. Primarily we use large-format CCD cameras on the world's largest telescopes, on Mauna Kea, to discover new irregular satellites and then to monitor their positions in order to ascertain their orbital characteristics. Separate observations are taken to determine the physical properties of the irregular satellites. The big picture science objective is to determine how these satellites were captures, and to use the properties of the satellites and their orbits to place constraints on early solar system (including formation) processes. Work in the first year has focussed on a major investigation of the Saturn irregular satellite system. We secured observing time on the Subaru and Gemini 8-m diameter telescopes in December 2004, January, February and March 2005 for the conduct of a deep, wide-area survey. This has resulted in the detection and orbit determination for 12 new satellites to be announced in the next week or two. Additional satellites were lost, temporarily, due to unusually poor weather conditions on Mauna Kea. These objects will be recovered and their orbits published next year. A separate survey of the Uranus irregular satellites was published (Sheppard, Jewitt and Kleyna 2005). Away from the telescope, we have discovered the amazing result that the four giant planets possess similar numbers of irregular satellites. This flies in the face of the standard gas-drag model for satellite capture, since only two of the giant planets are gas giants and the others (Uranus and Neptune) formed by a different process and in the absence of much gas. The constancy of the satellite number (each giant holds approximately 100 irregular satellites measured down to the kilometer scale) is either a coincidence, with different capture mechanisms at different planets giving by chance the same total numbers of irregular satellites, or indicates that the satellites were captured by a completely different process. We favor the latter (Jewitt and Sheppard 2005).

Jewitt, David↗

Rodent Habitat on ISS: Advances in Capability for Determining Spaceflight Effects on Mammalian Physiology

Rodent research is a valuable essential tool for advancing biomedical discoveries in life sciences on Earth and in space. The National Research Counsel's Decadal survey (1) emphasized the importance of expanding NASAs life sciences research to perform long duration, rodent experiments on the International Space Station (ISS). To accomplish this objective, new flight hardware, operations, and science capabilities were developed at NASA ARC to support commercial and government-sponsored research. The flight phases of two separate spaceflight missions (Rodent Research-1 and Rodent Research-2) have been completed and new capabilities are in development. The first flight experiments carrying 20 mice were launched on Sept 21, 2014 in an unmanned Dragon Capsule, SpaceX4; Rodent Research-1 was dedicated to achieving both NASA validation and CASIS science objectives, while Rodent Reesearch-2 extended the period on orbit to 60 days. Groundbased control groups (housed in flight hardware or standard cages) were maintained in environmental chambers at Kennedy Space Center. Crewmembers previously trained in animal handling transferred mice from the Transporter into Habitats under simultaneous veterinary supervision by video streaming and were deemed healthy. Health and behavior of all mice on the ISS was monitored by video feed on a daily basis, and post-flight quantitative analyses of behavior were performed. The 10 mice from RR-1 Validation (16wk old, female C57Bl6/J) ambulated freely and actively throughout the Habitat, relying heavily on their forelimbs for locomotion. The first on-orbit dissections of mice were performed successfully, and high quality RNA (RIN values>9) and liver enzyme activities were obtained, validating the quality of sample recovery. Post-flight sample analysis revealed that body weights of FLT animals did not differ from ground controls (GC) housed in the same hardware, or vivarium controls (VIV) housed in standard cages. Organ weights analyzed post-flight showed that there were no differences between FLT and GC groups in adrenal gland and spleen weights, whereas FLT thymus and liver weights exceeded those of GC. Minimal differences between the control groups (GC and VIV) were observed. In addition, Over 3,000 aliquots collected post-flight from the four groups of mice were deposited into the Ames Life Science Data Archives for the Biospecimen Sharing Program and Genelab project. New capabilities recently developed include DEXA scanning, grip strength tests and male mice. In conclusion, new capability for long duration rodent habitation of group-housed rodents was developed and includes in-flight sample collection, thus avoiding the complication of reentry. Results obtained to date reveal the possibility of striking differences between the effects of short duration vs. long duration spaceflight. This Rodent Research system enables achievement of both basic science and translational research objectives to advance human exploration of space.

Bone Loss↗

Pore-Space Partition and Optimization for Propane-Selective High-Performance Propane/Propylene Separation

The development of effective propane (C 3 H 8 )-selective adsorbents for the purification of propylene (C 3 H 6 ) from C 3 H 8 /C 3 H 6 mixture is a promising alternative to replace the energy-intensive cryogenic distillation. However, few materials possess the dual desirable features of propane selectivity and high uptake capacity. Here, we report a family of pore-space-partitioned crystalline porous materials (CPM) with remarkable C 3 H 8 uptake capacity (up to 10.9 mmol/g) and the highly desirable, yet uncommon C 3 H 8 selectivity (up to 1.54 at 0.1 bar and 1.44 at 1bar). The selectivity-capacity synergy endows them with record-performing C 3 H 8 /C 3 H 6 separation potential (i.e., C 3 H 6 recovered from the mixture). Moreover, these CPMs exhibit outstanding properties including high stability, low regeneration energy, and multi-modular chemical and geometrical tunability within the same isoreticular framework. Furthermore, the high C 3 H 8 /C 3 H 6 separation performance was further confirmed by the breakthrough experiments.

36 MATERIALS SCIENCE↗

Polyphenol-Sensitized Atomic Layer Deposition for Membrane Interface Hydrophilization

Improvements in energy-water systems will necessitate fabrication of high-performance separation membranes. To this end, interface engineering is a powerful tool for tailoring properties, and atomic layer deposition (ALD) has recently emerged as a promising and versatile approach. However, most non-polar polymeric membranes are not amenable to ALD processing due to the absence of nucleation sites. Here, a sensitization strategy for ALD-coating is presented, illustrated by membrane interface hydrophilization. Facile dip-coating with polyphenols effectively sensitizes hydrophobic polymer membranes to TiO2 ALD coating. Tannic acid-sensitized ALD-coated membranes exhibit outstanding underwater crude oil repulsion and rigorous mechanical stability through bending and rinsing tests. As a result, these membranes demonstrate outstanding crude oil-in-water separation and reusability compared to untreated membranes or those treated with ALD without polyphenol pretreatment. A possible polyphenol-sensitized ALD mechanism is proposed involving initial island nucleation followed by film intergrowth. This polyphenol sensitization strategy enriches the functionalization toolbox in material science, interface engineering, and environmental science.

36 MATERIALS SCIENCE↗

Deep Space Navigation for the BioSentinel CubeSat Science Orbit

BioSentinel is a 6U CubeSat active in heliocentric orbit, as of April 2024. The spacecraft was launched aboard the first SLS flight as part of the Artemis-I campaign in November 2022. After successful separation from the upper stage of SLS, it performed a lunar flyby which provided the necessary energy to achieve an Earth-trailing heliocentric orbit. This paper includes a description of the final science orbit as well as its evolution, the techniques and procedures utilized to perform the orbit determination and a description of the overall navigation campaign, with emphasis on the heliocentric orbit operations.

Jose Alvarellos↗