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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 37 records · Page 2
All sourcesNASA NTRSDOE OSTI
NASA NTRS2018

Common-Mode Digital Holographic Microscope

A lens-less digital holographic microscope, a reflective digital holographic microscope, and a digital holographic microscope including a plurality of lenses. In one example, the digital holographic microscope includes a single mode fiber collimated light source which provides illumination for both the `science` and `reference` arms, a pair of microscope objectives located side-by side, and illuminated by the common beam, a relay lens whose center is between the two objectives, and a focal plane element where the interference pattern is measured.

Wallace, James K.↗
DOE OSTI2022

Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding

Opioid-related fatal overdoses have reached epidemic proportions. Because existing treatments for opioid use disorders offer limited long-term protection, accelerating the development of newer approaches is critical. Monoclonal antibodies (mAbs) are an emerging treatment strategy that targets and sequesters selected opioids in the bloodstream, reducing drug distribution across the blood-brain barrier, thus preventing or reversing opioid toxicity. We previously identified a series of murine mAbs with high affinity and selectivity for oxycodone, morphine, fentanyl, and nicotine. To determine their binding mechanism, we used X-ray crystallography to solve the structures of mAbs bound to their respective targets, to 2.2 Å resolution or higher. Structural analysis showed a critical convergent hydrogen bonding mode that is dependent on a glutamic acid residue in the mAbs’ heavy chain and a tertiary amine of the ligand. Further, characterizing drug-mAb complexes represents a significant step toward rational antibody engineering and future manufacturing activities to support clinical evaluation.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1989

Optoelectronic Technique Eliminates Common-Mode Voltages

Small signals transmitted between circuits at large differences of potential. Technique lends itself to accurate measurement of any electrical parameter and display of value. Accommodates broad range of measured values from millivolts to hundreds of volts and provides unlimited electrical isolation. Measured parameter converted to duration, proportional to value, of pulse of light. Transmitted along optical fiber to or from isolated circuit. Applications include operation of traveling-wave tubes or other electron-gun devices including filaments at cathode potential and measurement of current from, or control of series stacked power supplies. Used for optimization and testing of depressed-collector/microwave-tube combinations.

Lesny, Gary G.↗
DOE OSTI2021

Analysis and Optimization of a Multi-Layer Integrated Organic Substrate for High Current GaN HEMT-Based Power Module

In this paper, analysis and optimization of a multi-layer organic substrate for high current GaN HEMT based power module are discussed. The organic multi-layer substrates can provide high electrical performance in terms of low parasitic inductance in the power loop by providing vertical layout, and shielding for reduction of common-mode noise, a common problem in fast switching power converters. Furthermore, high performance cooling solutions, such as micro-channel heat sinks, can be directly bonded to the substrate for optimum thermal management. The structure of the proposed architecture, thermal analysis and optimization of layer thickness, thermo-mechanical stress analysis of the GaN HEMT and development of a high-performance heat sink are discussed.

47 OTHER INSTRUMENTATION↗
NASA NTRS2006

Spatiotemporal Filtering Using Principal Component Analysis and Karhunen-Loeve Expansion Approaches for Regional GPS Network Analysis

Spatial filtering is an effective way to improve the precision of coordinate time series for regional GPS networks by reducing so-called common mode errors, thereby providing better resolution for detecting weak or transient deformation signals. The commonly used approach to regional filtering assumes that the common mode error is spatially uniform, which is a good approximation for networks of hundreds of kilometers extent, but breaks down as the spatial extent increases. A more rigorous approach should remove the assumption of spatially uniform distribution and let the data themselves reveal the spatial distribution of the common mode error. The principal component analysis (PCA) and the Karhunen-Loeve expansion (KLE) both decompose network time series into a set of temporally varying modes and their spatial responses. Therefore they provide a mathematical framework to perform spatiotemporal filtering.We apply the combination of PCA and KLE to daily station coordinate time series of the Southern California Integrated GPS Network (SCIGN) for the period 2000 to 2004. We demonstrate that spatially and temporally correlated common mode errors are the dominant error source in daily GPS solutions. The spatial characteristics of the common mode errors are close to uniform for all east, north, and vertical components, which implies a very long wavelength source for the common mode errors, compared to the spatial extent of the GPS network in southern California. Furthermore, the common mode errors exhibit temporally nonrandom patterns.

displacement↗
NASA NTRS2011

High-Voltage-Input Level Translator Using Standard CMOS

proposed integrated circuit would translate (1) a pair of input signals having a low differential potential and a possibly high common-mode potential into (2) a pair of output signals having the same low differential potential and a low common-mode potential. As used here, "low" and "high" refer to potentials that are, respectively, below or above the nominal supply potential (3.3 V) at which standard complementary metal oxide/semiconductor (CMOS) integrated circuits are designed to operate. The input common-mode potential could lie between 0 and 10 V; the output common-mode potential would be 2 V. This translation would make it possible to process the pair of signals by use of standard 3.3-V CMOS analog and/or mixed-signal (analog and digital) circuitry on the same integrated-circuit chip. A schematic of the circuit is shown in the figure. Standard 3.3-V CMOS circuitry cannot withstand input potentials greater than about 4 V. However, there are many applications that involve low-differential-potential, high-common-mode-potential input signal pairs and in which standard 3.3-V CMOS circuitry, which is relatively inexpensive, would be the most appropriate circuitry for performing other functions on the integrated-circuit chip that handles the high-potential input signals. Thus, there is a need to combine high-voltage input circuitry with standard low-voltage CMOS circuitry on the same integrated-circuit chip. The proposed circuit would satisfy this need. In the proposed circuit, the input signals would be coupled into both a level-shifting pair and a common-mode-sensing pair of CMOS transistors. The output of the level-shifting pair would be fed as input to a differential pair of transistors. The resulting differential current output would pass through six standoff transistors to be mirrored into an output branch by four heterojunction bipolar transistors. The mirrored differential current would be converted back to potential by a pair of diode-connected transistors, which, by virtue of being identical to the input transistors, would reproduce the input differential potential at the output

Yager, Jeremy A.↗
NASA NTRS1992

Excitation of pressure modes in common envelopes

The excitation of oscillatory modes by a low-mass star orbiting inside a common envelope with a more massive star is investigated, with emphasis on adiabatic high spherical harmonic degree (l is much greater than 1) modes propagating outward in the envelope. The dominant oscillatory modes are those for which the spherical harmonic order is large, and thus the amplitudes are large close to the equatorial plane and small closer to the poles. A secondary of mass about 1 percent of the primary mass excites modes with relative surface amplitudes of a few x 10 percent. Even a Jupiter-like brown dwarf, when it is very deep in the envelope of an asymptotic giant branch star, can cause perturbations of relative surface amplitudes of about 10 percent near the equatorial plane. If mass loss is influenced by oscillation, then this mechanism can lead to higher mass loss in the equatorial plane. In case of an asymptotic giant branch primary, this might lead to the formation of an elliptical planetary nebula.

Soker, Noam↗
NASA NTRS2012

Common Cause Failures and Ultra Reliability

A common cause failure occurs when several failures have the same origin. Common cause failures are either common event failures, where the cause is a single external event, or common mode failures, where two systems fail in the same way for the same reason. Common mode failures can occur at different times because of a design defect or a repeated external event. Common event failures reduce the reliability of on-line redundant systems but not of systems using off-line spare parts. Common mode failures reduce the dependability of systems using off-line spare parts and on-line redundancy.

reliability↗
DOE OSTI2023

Correction of the baseline fluctuations in the GEM-based ALICE TPC

To operate the ALICE Time Projection Chamber in continuous mode during the Run 3 and Run 4 data-taking periods of the Large Hadron Collider, the multi-wire proportional chamber-based readout was replaced with gas-electron multipliers. As expected, the detector performance is affected by the so-called common-mode effect, which leads to significant baseline fluctuations. A detailed study of the pulse shape with the new readout has revealed that it is also affected by ion tails. Since reconstruction and data compression are performed fully online, these effects must be corrected at the hardware level in the FPGA-based common readout units. The characteristics of the common-mode effect and of the ion tail, as well as the algorithms developed for their online correction, are described in this paper. The common-mode dependencies are studied using machine-learning techniques. Toy Monte Carlo simulations are performed to illustrate the importance of online corrections and to investigate the performance of the developed algorithms.

47 OTHER INSTRUMENTATION↗