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CPGminer: An Interactive Dashboard to Explore the Genomic Features and Taxonomy of Complete Prokaryotic Genomes

Prokaryotes, the earliest forms of life on Earth, play crucial roles in global biogeochemical processes in virtually all ecosystems. The ever-increasing amount of prokaryotic genome sequencing data provides a wealth of information to examine fundamental and applied questions through systematic genome comparison. Genomic features, such as genome size and GC content, and taxonomy-centric genomic features of complete prokaryotic genomes (CPGs) are crucial for various fields of microbial research and education, yet they are often overlooked. Additionally, creating systematically curated datasets that align with research concerns is an essential yet challenging task for wet-lab researchers. In this study, we introduce CPGminer, a user-friendly tool that allows researchers to quickly and easily examine the genomic features and taxonomy of CPGs and curate genome datasets. We also provide several examples to demonstrate its practical utility in addressing descriptive questions.

59 BASIC BIOLOGICAL SCIENCES↗

Developing Integrated Taxonomies for a Tiered Information Architecture

This viewgraph presentation reviews the concept of developing taxonomies for an information architecture. In order to assist people in accessing information required to access information and retrieval, including cross repository searching, a system of nested taxonomies is being developed. Another facet of this developmental project is collecting and documenting attributes about people, to allow for several uses: access management, i.e., who are you and what can you see?; targeted content delivery i.e., what content helps you get your work done?; w ork force planning i.e., what skill sets do you have that we can appl y to work?; and IT Services i.e., How can we provision you with the proper IT services?

information architecture↗

A Proposed Taxonomy for Advanced Air Mobility

There has been a large growth in interest of utilizing new technologies—most notably electrified propulsion and automation—as well as new business models to bring aviation services into the daily lives of a greater segment of society. Generally, these services are envisioned to augment existing ground modes of transportation or to enable new operating capabilities for shorter-range aviation missions. These services, which have become known as advanced air mobility (AAM), include passenger transportation, cargo transportation, and aerial work missions, such as aerial photography. In this paper we describe advanced air mobility and provide a framework based on demand and supply concepts that can be used for developing a taxonomy for AAM with a focus on passenger applications. This taxonomy is intended to facilitate the nascent AAM stakeholder community in adopting a common terminology and to enable better coordination among disparate AAM research and development activities.

advanced air mobility↗

T-Rex: The NASA Technology Taxonomy Recommender System

NASA tracks over 16,000 technology projects across the Agency, from propulsion systems to software. These projects are classified according to NASA’s Technology Taxonomy to facilitate data search, extraction, and application. In 2020, the Taxonomy was revised to better align strategic goals with project technical disciplines. Manual re-classification of cur-rent and historical projects was estimated to take thousands of technologist labor hours. Instead of manual classification, our team developed T-Rex, a recommender engine, trained on just a small set of manually classified projects. T-Rex was used to classify the projects and then integrate the data into TechPort to recommend classes to users when updating projects. The system and methodology are used in other NASA projects, and T-Rex has achieved 95% accepted accuracy overall.

Space Technology↗

Unified epigenomic, transcriptomic, proteomic, and metabolomic taxonomy of Alzheimer’s disease progression and heterogeneity

Alzheimer’s disease (AD) is a heterogeneous disorder with abnormalities in multiple biological domains. In an advanced machine learning analysis of postmortem brain and in vivo blood multi-omics molecular data ( N = 1863), we integrated epigenomic, transcriptomic, proteomic, and metabolomic profiles into a multilevel biological AD taxonomy. We obtained a personalized multilevel molecular index of AD dementia progression that predicts severity of neuropathologies, and identified three robust molecular-based subtypes that explain much of the pathologic and clinical heterogeneity of AD. These subtypes present distinct patterns of alteration in DNA methylation, RNA, proteins, and metabolites, identifiable in the brain and subsequently in blood. In addition, the genetic variations that predispose to the various AD subtypes in brain predict distinct spatial patterns of alteration in cell types, suggesting a unique influence of each putative AD variant on neuropathological mechanisms. These observations support that an individually tailored multi-omics molecular taxonomy of AD may represent distinct targets for preventive or treatment interventions.

60 APPLIED LIFE SCIENCES↗

Prompt-Based Development of Domain-Specific Taxonomies

Framework for interacting with prompt-based LLMs (Large Language Models such as, but not limited to, ChatGPT) in order to develop domain specific taxonomies. The software itself is a series of prompts designed to extract hierarchical taxonomy categories from an LLM, as well as guidelines for how to fine-tune LLMs in order to provide better domain-specific taxonomic categories.

Grundy, Jon [Pacific Northwest National Laboratory↗

A new taxonomy for distributed computer systems based upon operating system structure

Characteristics of the resource structure found in the operating system are considered as a mechanism for classifying distributed computer systems. Since the operating system resources, themselves, are too diversified to provide a consistent classification, the structure upon which resources are built and shared are examined. The location and control character of this indivisibility provides the taxonomy for separating uniprocessors, computer networks, network computers (fully distributed processing systems or decentralized computers) and algorithm and/or data control multiprocessors. The taxonomy is important because it divides machines into a classification that is relevant or important to the client and not the hardware architect. It also defines the character of the kernel O/S structure needed for future computer systems. What constitutes an operating system for a fully distributed processor is discussed in detail.

Foudriat, E. C.↗

A knowledge engineering taxonomy for intelligent tutoring system development

This paper describes a study addressing the issue of developing an appropriate mapping of knowledge acquisition methods to problem types for intelligent tutoring system development. Recent research has recognized that knowledge acquisition methodologies are not general across problem domains; the effectiveness of a method for obtaining knowledge depends on the characteristics of the domain and problem solving task. Southwest Research Institute developed a taxonomy of problem types by evaluating the characteristics that discriminate between problems and grouping problems that share critical characteristics. Along with the problem taxonomy, heuristics that guide the knowledge acquisition process based on the characteristics of the class are provided.

Fink, Pamela K.↗

Molecular evolution inferred from small subunit rRNA sequences: what does it tell us about phylogenetic relationships and taxonomy of the parabasalids?

The Parabasala are a primitive group of protists divided into two classes: the trichomonads and the hypermastigids. Until recently, phylogeny and taxonomy of parabasalids were mainly based on the comparative analysis of morphological characters primarily linked to the development of their cytoskeleton. Recent use of molecular markers, such as small subunit (SSU) rRNA has led to now insights into the systematics of the Parabasala and other groups of prolists. An updated phylogeny based on SSU rRNA is provided and compared to that inferred from ultrastructural data. The SSU rRNA phylogeny contradicts the dogma equating simple characters with pumitive characters. Hypermastigids, possessing a hyperdeveloped cytoskeleton, exhibit the most basal emergence in the parabasalid lineage. Other observations emerge from the SSU rRNA analysis, such as the secondary loss of some cytoskeleton structures in all representatives of the Monocercomonadidae, the existence of secondarily free living taxa (reversibility of parasitism) and the evidence against the co-evolution of the endobiotic parabasalids and their animal hosts. According to phylogenies based on SSU rRNA, all the trichomonad families are not monophyletic groups, putting into question the validity of current taxonomic assignments. The precise branching order of some taxa remains unclear, but this issue can possibly be addressed by the molecular analysis of additional parabasalids. The goal of such additional analyses would be to propose, in a near future, a revision of the taxonomy of this group of protists that takes into account both molecular and morphological data.

NASA Discipline Exobiology↗

Taxonomy Working Group Final Report

The purpose of the Taxonomy Working Group was to develop a proposal for a common taxonomy to be used by all NASA projects in the classifying of nonconformances, anomalies, and problems. Specifically, the group developed a recommended list of data elements along with general suggestions for the development of a problem reporting system to better serve NASA's need for managing, reporting, and trending project aberrant events. The Group's recommendations are reported in this document.

Parsons, Vickie S.↗

Taxonomy, Ontology and Semantics at Johnson Space Center

At NASA Johnson Space Center (JSC), the Chief Knowledge Officer has been developing the JSC Taxonomy to capitalize on the accomplishments of yesterday while maintaining the flexibility needed for the evolving information environment of today. A clear vision and scope for the semantic system is integral to its success. The vision for the JSC Taxonomy is to connect information stovepipes to present a unified view for information and knowledge across the Center, across organizations, and across decades. Semantic search at JSC means seemless integration of disparate information sets into a single interface. Ever increasing use, interest, and organizational participation mark successful integration and provide the framework for future application.

Berndt, Sarah Ann↗

A Practitioner's Perspective on Taxonomy, Ontology and Findability

This slide presentation reviews the presenters perspective on developing a taxonomy for JSC to capitalize on the accomplishments of yesterday, while maintaining the flexibility needed for the evolving information of today. A clear vision and scope for the semantic system is integral to its success. The vision for the JSC Taxonomy is to connect information stovepipes to present a unified view for information and knowledge across the Center, across organizations, and across decades. Semantic search at JSC means seamless integration of disparate information sets into a single interface. Ever increasing use, interest, and organizational participation mark successful integration and provide the framework for future application.

Berndt, Sarah↗

A Software Safety Risk Taxonomy for Use in Retrospective Safety Cases

Safety standards contain technical and process-oriented safely requirements. The best time to include these requirements is early in the development lifecycle of the system. When software safety requirements are levied on a legacy system after the fact, a retrospective safety case will need to be constructed for the software in the system. This can be a difficult task because there may be few to no art facts available to show compliance to the software safely requirements. The risks associated with not meeting safely requirements in a legacy safely-critical computer system must be addressed to give confidence for reuse. This paper introduces a proposal for a software safely risk taxonomy for legacy safely-critical computer systems, by specializing the Software Engineering Institute's 'Software Development Risk Taxonomy' with safely elements and attributes.

Hill, Janice L.↗

Autonomous Systems Taxonomy

The purpose of this taxonomy is to provide common definitions and a functional decomposition of the technology that is required for NASA's autonomous systems. The taxonomy serves as a framework for: (1) assessing the state of NASA's autonomous systems capability (workforce, technology, etc.) and (2) assessing the state of the art in autonomy technology.

Fong, Terrence W.↗

2020 NASA Technology Taxonomy

This document is the final version of the 2020 NASA Technology Taxonomy that will be used to update NASA TechPort. The updated 2020 NASA Technology Taxonomy, or "technology dictionary", uses a technology discipline based approach that realigns like-technologies independent of their application within the NASA mission portfolio. This tool is meant to serve as a common technology discipline-based communication tool across the agency and with its partners in other government agencies, academia, industry, and across the world.

Miranda, David↗

2020 NASA Technology Taxonomy

This document is the final PDF version of the 2020 NASA Technology Taxonomy that will be available to download on the Office of the Chief Technologist (OCT) public website. The updated 2020 NASA Technology Taxonomy, or "technology dictionary", uses a technology discipline based approach that realigns like-technologies independent of their application within the NASA mission portfolio. This tool is meant to serve as a common technology discipline-based communication tool across the agency and with its partners in other government agencies, academia, industry, and across the world.

Miranda, David↗

2020 NASA Technology Taxonomy

This document is an update (new photos used) of the PDF version of the 2020 NASA Technology Taxonomy that will be available to download on the OCT Public Website. The updated 2020 NASA Technology Taxonomy, or "technology dictionary", uses a technology discipline based approach that realigns like-technologies independent of their application within the NASA mission portfolio. This tool is meant to serve as a common technology discipline-based communication tool across the agency and with its partners in other government agencies, academia, industry, and across the world.

Miranda, David↗

Who Controls Energy in the Smart Home? A Multidisciplinary Taxonomy

Advances in technology have begun to open new opportunities for behavior-based and technical approaches to managing residential energy use and meet sustainability-related objectives. Visions of the future predict homes with smart technologies delivering enhanced comfort and cost savings to residents; utility-partners who can remotely optimize energy resources to meet grid needs; and occupants who play more active roles in the energy system supported by advanced information communication technologies. Each of these scenarios implies augmented control over home energy use, yet uncertainties remain regarding which ones will deliver the greatest grid benefits and services to customers in a given situation. These scenarios also raise broader questions regarding customer agency and the relationship between customers and third parties moving forward. While both the provision of information to spur behavior change and automated technologies theoretically enhance control over energy use in the built environment, these strategies are not often studied from an integrated perspective. Seeking to address this gap and develop a deeper understanding of the evolving paradigm of control over home energy use, this paper presents a taxonomy to evaluate perspectives from public policy (ex. demand-side management), technological innovation (automated controls), and user-agency (ex. the role of behavior change) on approaches to managing home energy use. We draw on theoretical and empirical evidence from across disciplines to detail the dimensions and implications of deploying programs that incorporate various levels of control and anticipate such a taxonomy will help holistically map out and evaluate tradeoffs between different approaches to demand-side management moving forward.

McIlvennie, Claire↗