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All sources NASA NTRS DOE OSTI

DOE OSTI2024

Factorized visual representations in the primate visual system and deep neural networks

Object classification has been proposed as a principal objective of the primate ventral visual stream and has been used as an optimization target for deep neural network models (DNNs) of the visual system. However, visual brain areas represent many different types of information, and optimizing for classification of object identity alone does not constrain how other information may be encoded in visual representations. Information about different scene parameters may be discarded altogether (‘invariance’), represented in non-interfering subspaces of population activity (‘factorization’) or encoded in an entangled fashion. In this work, we provide evidence that factorization is a normative principle of biological visual representations. In the monkey ventral visual hierarchy, we found that factorization of object pose and background information from object identity increased in higher-level regions and strongly contributed to improving object identity decoding performance. We then conducted a large-scale analysis of factorization of individual scene parameters – lighting, background, camera viewpoint, and object pose – in a diverse library of DNN models of the visual system. Models which best matched neural, fMRI, and behavioral data from both monkeys and humans across 12 datasets tended to be those which factorized scene parameters most strongly. Notably, invariance to these parameters was not as consistently associated with matches to neural and behavioral data, suggesting that maintaining non-class information in factorized activity subspaces is often preferred to dropping it altogether. Thus, we propose that factorization of visual scene information is a widely used strategy in brains and DNN models thereof.

59 BASIC BIOLOGICAL SCIENCES↗

NASA NTRS1991

Automated information retrieval using CLIPS

Expert systems have considerable potential to assist computer users in managing the large volume of information available to them. One possible use of an expert system is to model the information retrieval interests of a human user and then make recommendations to the user as to articles of interest. At Cal Poly, a prototype expert system written in the C Language Integrated Production System (CLIPS) serves as an Automated Information Retrieval System (AIRS). AIRS monitors a user's reading preferences, develops a profile of the user, and then evaluates items returned from the information base. When prompted by the user, AIRS returns a list of items of interest to the user. In order to minimize the impact on system resources, AIRS is designed to run in the background during periods of light system use.

Raines, Rodney Doyle, III↗

NASA NTRS1999

Psychological Selection of NASA Astronauts for International Space Station Missions

During the relatively short-duration Space Shuffle missions, a psychological support program for the astronauts has not been required. Such missions primarily require providing occasional communication with family members by means of audio, video or e-mail, and some diversions such as CD players. During the NASA-Mir Program, conducted from March 1995 through June 1998, mission duration increased to 4-6 months. As a result of these changes it was necessary for NASA to establish an operational Human Behavior and Performance Group (HBPG) to develop and implement a comprehensive program of psychological support. The Mir experience provided the opportunity to develop and implement a psychological support program for long-duration space missions. Many factors influence the support program, including individual preferences, mission duration, and environmental factors such as habitable and personal areas. Lessons learned from the Mir experience are being applied to improve the ISS psychological support program plan. This presentation will address which includes various preflight, in-flight, and post-flight support activities and tools that NASA's HBPG will provide to astronauts and their families for ISS missions.

VanderArk, Steve↗

DOE OSTI2025

Structural differences between human and mouse neurons and their implementation in generative AIs

Mouse and human brains have different functions that depend on their neuronal networks. We analyzed nanometer-scale three-dimensional structures of brain tissues of the mouse medial prefrontal cortex and compared them with structures of the human anterior cingulate cortex. The obtained results indicated that mouse neuronal somata are smaller and neurites are thinner than those of human neurons. We implemented these characteristics of mouse neurons in convolutional layers of a generative adversarial network (GAN) and a denoising diffusion implicit model (DDIM), which were then subjected to image generation tasks using photo datasets of cat faces, cheese, human faces, birds, and automobiles. The mouse-mimetic GAN outperformed a standard GAN in the image generation task using the cat faces and cheese photo datasets, but underperformed for human faces and birds. The mouse-mimetic DDIM gave similar results, suggesting that the nature of the datasets affected the results. Analyses of the five datasets indicated differences in their image entropy, which should influence the number of parameters required for image generation. The preferences of the mouse-mimetic AIs coincided with the impressions commonly associated with mice. The relationship between the neuronal network and brain function should be investigated by implementing other biological findings in artificial neural networks.

generative AI↗

NASA NTRS1994

A Role for MST Neurons in Heading Estimation

A template model of human visual self-motion perception, which uses neurophysiologically realistic "heading detectors", is consistent with numerous human psychophysical results including the failure of humans to estimate their heading (direction of forward translation) accurately under certain visual conditions. We tested the model detectors with stimuli used by others in single-unit studies. The detectors showed emergent properties similar to those of MST neurons: (1) Sensitivity to non-preferred flow; Each detector is tuned to a specific combination of flow components and its response is systematically reduced by the addition of nonpreferred flow, and (2) Position invariance; The detectors maintain their apparent preference for particular flow components over large regions of their receptive fields. It has been argued that this latter property is incompatible with MST playing a role in heading perception. The model however demonstrates how neurons with the above response properties could still support accurate heading estimation within extrastriate cortical maps.

Stone, L. S.↗

NASA NTRS1983

Development and marketing of a prosthetic urinary control valve system

An implantable prosthetic for the control of urinary incontinence was developed and marketed. Three phases are presented: bench development studies, animal trials, and human clinical trials. This work was performed under the direction of a Research Team at Rochester General Hospital (RGH). Bench trials were completed on prototype hardware and provided early verification of the device's ability to withstand repeated cyclic testing. Configurational variants were evaluated and a preferred design concept was established. Silicone rubber (medical grade) was selected as the preferred material for the prosthesis.

Tenney, J. B., Jr.↗

NASA NTRS2010

NASA Astronauts on Soyuz: Experience and Lessons for the Future

The U. S., Russia, and, China have each addressed the question of human-rating spacecraft. NASA's operational experience with human-rating primarily resides with Mercury, Gemini, Apollo, Space Shuttle, and International Space Station. NASA s latest developmental experience includes Constellation, X38, X33, and the Orbital Space Plane. If domestic commercial crew vehicles are used to transport astronauts to and from space, Soyuz is another example of methods that could be used to human-rate a spacecraft and to work with commercial spacecraft providers. For Soyuz, NASA's normal assurance practices were adapted. Building on NASA's Soyuz experience, this report contends all past, present, and future vehicles rely on a range of methods and techniques for human-rating assurance, the components of which include: requirements, conceptual development, prototype evaluations, configuration management, formal development reviews (safety, design, operations), component/system ground-testing, integrated flight tests, independent assessments, and launch readiness reviews. When constraints (cost, schedule, international) limit the depth/breadth of one or more preferred assurance means, ways are found to bolster the remaining areas. This report provides information exemplifying the above safety assurance model for consideration with commercial or foreign-government-designed spacecraft. Topics addressed include: U.S./Soviet-Russian government/agency agreements and engineering/safety assessments performed with lessons learned in historic U.S./Russian joint space ventures

Source record↗

NASA NTRS1975

Human comfort in relation to sinusoidal vibration

An investigation was made to assess the overall subjective comfort levels to sinusoidal excitations over the range 1 to 19 Hz using a two axis electrohydraulic vibration simulator. Exposure durations of 16 minutes, 25 minutes, 1 hour, and 2.5 hours have been considered. Subjects were not exposed over such durations, but were instructed to estimate the overall comfort levels preferred had they been constantly subjected to vibration over such durations.

Jones, B.↗

NASA NTRS2016

Liquid Oxygen/Liquid Methane Integrated Power and Propulsion

The proposed paper will cover ongoing work at the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) on integrated power and propulsion for advanced human exploration. Specifically, it will present findings of the integrated design, testing, and operational challenges of a liquid oxygen / liquid methane (LOx/LCH4) propulsion brassboard and Solid Oxide Fuel Cell (SOFC) system. Human-Mars architectures point to an oxygen-methane economy utilizing common commodities, scavenged from the planetary atmosphere and soil via In-Situ Resource Utilization (ISRU), and common commodities across sub-systems. Due to the enormous mass gear-ratio required for human exploration beyond low-earth orbit, (for every 1 kg of payload landed on Mars, 226 kg will be required on Earth) increasing commonality between spacecraft subsystems such as power and propulsion can result in tremendous launch mass and volume savings. Historically, propulsion and fuel cell power subsystems have had little interaction outside of the generation (fuel cell) and consumption (propulsion) of electrical power. This was largely due to a mismatch in preferred commodities (hypergolics for propulsion; oxygen & hydrogen for fuel cells). Although this stove-piped approach benefits from simplicity in the design process, it means each subsystem has its own tanks, pressurization system, fluid feed system, etc. increasing overall spacecraft mass and volume. A liquid oxygen / liquid methane commodities architecture across propulsion and power subsystems would enable the use of common tankage and associated pressurization and commodity delivery hardware for both. Furthermore, a spacecraft utilizing integrated power and propulsion could use propellant residuals - propellant which could not be expelled from the tank near depletion due to hydrodynamic considerations caused by large flow demands of a rocket engine - to generate power after all propulsive maneuvers are complete thus utilizing previously wasted mass. Such is the case for human and robotic planetary landers. Although many potential benefits through integrated power & propulsion exist, integrated operations have yet to be successfully demonstrated and many challenges have already been identified the most obvious of which is the large temperature gradient. SOFC chemistry is exothermic with operating temperatures in excess of 1,000 K; however, any shared commodities will be undoubtedly stored at cryogenic temperatures (90-112 K) for mass efficiency reasons. Spacecraft packaging will drive these two subsystems in close proximity thus heat leak into the commodity tankage must be minimized and/or mitigated. Furthermore, commodities must be gasified prior to consumption by the SOFC. Excess heat generated by the SOFC could be used to perform this phase change; however, this has yet to be demonstrated. A further identified challenge is the ability of the SOFC to handle the sudden power spikes created by the propulsion system. A power accumulator (battery) will likely be necessary to handle these sudden demands while the SOFC thermally adjusts. JSC's current SOFC test system consists of a 1 kW fuel cell designed by Delphi. The fuel cell is currently undergoing characterization testing at the NASA JSC Energy Systems Test Area (ESTA) after which a Steam Methane Reformer (SMR) will be integrated and the combined system tested in closed-loop. The propulsion brassboard is approximately the size of what could be flown on a sounding rocket. It consists of one 100 lbf thrust "main" engine developed for NASA by Aerojet and two 10 lbf thrusters to simulate a reaction control system developed at NASA JSC. This system is also under development and initial testing at ESTA. After initial testing, combined testing will occur which will provide data on the fuel cell's ability to sufficiently handle the power spikes created by the propulsion system. These two systems will also be modeled using General-Use Nodal Network Solver (GUNNS) software. Once anchored with test data, this model will be used to extrapolate onto other firing profiles and used to size the power accumulator.

Banker, Brian↗

NASA NTRS2016

Risk of Performance Decrement and Crew Illness Due to an Inadequate Food System

NASA is preparing for long duration manned missions beyond low-Earth orbit that will be challenged in several ways, including long-term exposure to the space environment, impacts to crew physiological and psychological health, limited resources, and no resupply. The food system is one of the most significant daily factors that can be altered to improve human health, and performance during space exploration. Therefore, the paramount importance of determining the methods, technologies, and requirements to provide a safe, nutritious, and acceptable food system that promotes crew health and performance cannot be underestimated. The processed and prepackaged food system is the main source of nutrition to the crew, therefore significant losses in nutrition, either through degradation of nutrients during processing and storage or inadequate food intake due to low acceptability, variety, or usability, may significantly compromise the crew's health and performance. Shelf life studies indicate that key nutrients and quality factors in many space foods degrade to concerning levels within three years, suggesting that food system will not meet the nutrition and acceptability requirements of a long duration mission beyond low-Earth orbit. Likewise, mass and volume evaluations indicate that the current food system is a significant resource burden. Alternative provisioning strategies, such as inclusion of bioregenerative foods, are challenged with resource requirements, and food safety and scarcity concerns. Ensuring provisioning of an adequate food system relies not only upon determining technologies, and requirements for nutrition, quality, and safety, but upon establishing a food system that will support nutritional adequacy, even with individual crew preference and self-selection. In short, the space food system is challenged to maintain safety, nutrition, and acceptability for all phases of an exploration mission within resource constraints. This document presents the evidence for the Risk of Performance Decrement and Crew Illness Due to an Inadequate Food System and the gaps in relation to exploration, as identified by the NASA Human Research Program (HRP). The research reviewed here indicates strategies to establish methods, technologies, and requirements that increase food stability, support adequate nutrition, quality, and variety, enable supplementation with grow-pick-and-eat salad crops, ensure safety, and reduce resource use. Obtaining the evidence to establish an adequate food system is essential, as the resources allocated to the food system may be defined based on the data relating nutritional stability and food quality requirements to crew performance and health.

Douglas, Grace L.↗

NASA NTRS1997

A novel culture morphology resulting from applied mechanical strain

To demonstrate that cells both perceive and respond to external force, a strain/relaxation regimen was applied to normal human fetal and aged dermal fibroblasts cultured as monolayers on flexible membranes. The precisely controlled protocol of stretch (20% elongation of the culture membrane) at 6.67 cycles/min caused a progressive change in the monolayers, such that the original randomly distributed pattern of cells became a symmetric, radial distribution as the cell bodies aligned parallel to the applied force. High cell density interfered with the success of re-alignment in the fetal cell cultures observed, which may reflect a preference in this cell strain for cell-cell over cell-matrix contacts. The chronologically aged cells observed did not demonstrate this feature, aligning efficiently at all seeding densities examined. The role of microfilaments in force perception and transmission was investigated through the addition of cytochalasin D in graded doses. Both intercellular interactions and cytoskeletal integrity mediate the morphological response to mechanical strain.

NASA Discipline Cell Biology↗

DOE OSTI2020

Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence

Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce different clinical presentations. The PltB subunit of each toxin exhibits different glycan-binding preferences that correlate with glycan expression profiles of host cells targeted by each bacterium at the primary infection or intoxication sites. Through co-crystal structures of PltB subunits bound to specific glycan receptor moieties, we show that they induce markedly different glycan-binding preferences and virulence outcomes. Furthermore, immunization with the NTS S. Javiana or its toxin offers cross-reactive protection against lethal-dose typhoid toxin challenge. Cumulatively, these results offer insights into the evolution of host adaptations in Salmonella AB toxins, their cell and tissue tropisms, and the design for improved typhoid vaccines and therapeutics.

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2023

Method to Investigate Cognitive Aging Effects in Nuclear Operations Using the Rancor Microworld Simulator

Many nuclear power plant (NPP) operators are close to, or at retirement age. Since NPP operators are responsible for tasks that engage different and complex cognitive abilities, human factors researchers recently called for the need to examine cognitive aging effects and potential interactions with modernized control rooms. One way control rooms are being modernized is by replacing paper-based procedures with computer-based procedures (CBPs). This paper outlines a method for testing preference and usability of three types of CBPs as a function of age, in simulated NPP operations. The Rancor Microworld Simulator will be used, which mimics an NPP control room, allowing novices to learn to perform operator tasks quickly. The experiment will have two independent variables: age (young and old) and CBP-type (Type 1, Type 2, and Type 3). The three types of CBPs vary in levels of embedded instrumentation and controls. Adults aged 18–25 years (young group) and =60 years (older group) will be recruited from the general population. The dependent variables will be preference and usability metrics via survey and simulator logs. All participants will perform two scenario types (startup and loss of feedwater operations) and will be randomly assigned to one type of CBP to guide them through the scenario. Analyses of variance (ANOVAs) will be used to determine whether there is a main effect of age and any age x CBP-type interactions on the preference and usability dependent variables.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

NASA NTRS2011

Evolution of the Space Shuttle Primary Avionics Software and Avionics for Shuttle Derived Launch Vehicles

As a result of recommendation from the Augustine Panel, the direction for Human Space Flight has been altered from the original plan referred to as Constellation. NASA s Human Exploration Framework Team (HEFT) proposes the use of a Shuttle Derived Heavy Lift Launch Vehicle (SDLV) and an Orion derived spacecraft (salvaged from Constellation) to support a new flexible direction for space exploration. The SDLV must be developed within an environment of a constrained budget and a preferred fast development schedule. Thus, it has been proposed to utilize existing assets from the Shuttle Program to speed development at a lower cost. These existing assets should not only include structures such as external tanks or solid rockets, but also the Flight Software which has traditionally been a "long pole" in new development efforts. The avionics and software for the Space Shuttle was primarily developed in the 70 s and considered state of the art for that time. As one may argue that the existing avionics and flight software may be too outdated to support the new SDLV effort, this is a fallacy if they can be evolved over time into a "modern avionics" platform. The technology may be outdated, but the avionics concepts and flight software algorithms are not. The reuse of existing avionics and software also allows for the reuse of development, verification, and operations facilities. The keyword is evolve in that these assets can support the fast development of such a vehicle, but then be gradually evolved over time towards more modern platforms as budget and schedule permits. The "gold" of the flight software is the "control loop" algorithms of the vehicle. This is the Guidance, Navigation, and Control (GNC) software algorithms. This software is typically the most expensive to develop, test, and verify. Thus, the approach is to preserve the GNC flight software, while first evolving the supporting software (such as Command and Data Handling, Caution and Warning, Telemetry, etc.). This can be accomplished by gradually removing the "support software" from the legacy flight software leaving only the GNC algorithms. The "support software" could be re-developed for modern platforms, while leaving the GNC algorithms to execute on technology compatible with the legacy system. It is also possible to package the GNC algorithms into an emulated version of the original computer (via Field Programmable Gate Arrays or FPGAs), thus becoming a "GNC on a Chip" solution where it could live forever to be embedded in modern avionics platforms.

Ferguson, Roscoe C.↗

NASA NTRS2015

Space Wear Vision -Development of a Wardrobe for Life in Space Vehicles and Habitats

A new vision is needed for the development of a wardrobe for NASA's journey to Mars in the 2030s. All human space missions require significant logistical mass and volume that add an unprecedented burden on long-duration missions beyond low-Earth orbit. The logistical burden is at least twice as great for prolonged exploration and settlements on planetary surfaces compared to missions in low-Earth orbit. The space wear vision is to design apparel that uniquely meets criteria and constraints for sustaining human presence in space. For long duration missions without landing on planetary surface, humans can use only what they carry in their spacecraft, while for settlements, additional resources may be available. The immediate space wear goal is to develop those elements needed for prolonged manned exploration beyond low Earth orbit. Three major objectives have been identified for achieving this goal: satisfying crew preferences, logistics reduction and repurposing, and systems integration. Garments must be comfortable, durable, safe to wear, and aesthetically pleasing. In addition, with limited cleaning resources, garments must be developed to reduce the logistical burden by reducing clothing mass and extending clothing wear. Furthermore, garments must have minimal impact on the life support systems of spacecraft. The approach to achieving the immediate space wear goal is to conduct multiple studies on Earth and on the International Space Station (ISS), thus laying out the path for finding materials and designing garments that meet the three objectives of prolonged manned exploration. Several studies have been undertaken recently for the first time, namely, to ascertain garment length of wear and to assess the acceptance of such extended wear. Most garments in these studies have been exercise T-shirts and shorts, and routine-wear T-shirts. Eleven studies have been completed: five studies of exercise T-shirts, three of exercise shorts, two of routine wear T-shirts, and one of shirts used as sleep-wear. The IVA (Intra Vehicular Activity) Clothing Study has been the first study with Roscosmos under the "Utilization Sharing Plan On-Board ISS," while the other studies have been conducted at the Johnson Space Center in a controlled environment similar to the ISS. For exercise clothing, study participants wore garments during aerobic exercise. For routine wear clothing, study participants wore the T-shirts daily in an office or laboratory. Daily questionnaires collected data on ordinal preferences of nine sensory elements and on reasons for retiring a used garment. More studies have been initiated on Earth, and some should be planned to engage more astronauts and cosmonauts in the design of the new space wear. Future studies will extend to other types of garments in the wardrobe; another will address microbial growth on textiles. Others will address cleaning and sanitation of clothing in space vehicles. Efforts will be made for additional ISS studies with NASA's international partners.

Orndorff, Evelyne↗

DOE OSTI2024

Proactive and Reactive Thermal Comfort Behaviors

The expansion of renewable electricity generation, growing demands due to electrification, greater prevalence of working from home, and increasing frequency and severity of extreme weather events, will place new demands on the electric supply and distribution grid. Broader adoption of demand response programs (DRPs) for the residential sector may help meet these challenges; however, experience shows that occupant overrides in DRPs compromises their effectiveness. There is a lack of formal understanding of how discomfort, routines, and other motivations affect DRP overrides and other related human building interactions (HBI). This paper reports preliminary findings from a study of 20 households in Colorado and Massachusetts, US over three months. Participants responded to ecological momentary assessments (EMA) triggered by thermostat interactions and at random times throughout the day. EMAs included Likert-scale questions of thermal preference, preference intensity, and changes to 7 different activity types that could affect thermal comfort, and an opened ended question about motivations of such actions. Twelve tags were developed to categorize motivation responses and analyzed statistically to identify associations between motivations, preferences, and HBI actions. Reactions to changes in the thermal environment were the most frequently observed motivation (118 of 220 responses). On the other hand, almost half (47%) responses were at least partially motivated by non-thermal factors, suggesting limited utility for occupant behavior models founded solely on thermal comfort. Changes in activity level and clothing were less likely to be reported when EMAs were triggered by thermostat interactions, while fan interactions were more likely. Windows, shades, and portable heater interactions had no significant dependence on how the EMA was triggered. These results suggest that better understanding of motivations for HBI may improve effectiveness of demand response programs.

Pathak, Maharshi↗

NASA NTRS1994

A Role for MST Neurons in Heading Estimation

A template model of human visual self-motion perception (Perrone, JOSA, 1992; Perrone & Stone, Vis. Res., in press), which uses neurophysiologically realistic "heading detectors", is consistent with numerous human psychophysical results (Warren & Hannon, Nature, 1988; Stone & Perrone, Neuro. Abstr., 1991) including the failure of humans to estimate their heading (direction of forward translation) accurately under certain visual conditions (Royden et al., Nature, 1992). We tested the model detectors with stimuli used by others in- single-unit studies. The detectors showed emergent properties similar to those of MST neurons: 1) Sensitivity to non-preferred flow. Each detector is tuned to a specific combination of flow components and its response is systematically reduced by the addition of nonpreferred flow (Orban et al., PNAS, 1992), and 2) Position invariance. The detectors maintain their apparent preference for particular flow components over large regions of their receptive fields (e.g. Duffy & Wurtz, J. Neurophys., 1991; Graziano et al., J. Neurosci., 1994). It has been argued that this latter property is incompatible with MST playing a role in heading perception. The model however demonstrates how neurons with the above response properties could still support accurate heading estimation within extrastriate cortical maps.

Stone, Leland Scott↗

DOE OSTI2025

A generalized platform for artificial intelligence-powered autonomous enzyme engineering

Proteins are the molecular machines of life with numerous applications in energy, health, and sustainability. However, engineering proteins with desired functions for practical applications remains slow, expensive, and specialist-dependent. Here we report a generally applicable platform for autonomous enzyme engineering that integrates machine learning and large language models with biofoundry automation to eliminate the need for human intervention, judgement, and domain expertise. Requiring only an input protein sequence and a quantifiable way to measure fitness, this automated platform can be applied to engineer a wide array of proteins. As a proof of concept, we engineer Arabidopsis thaliana halide methyltransferase (AtHMT) for a 90-fold improvement in substrate preference and 16-fold improvement in ethyltransferase activity, along with developing a Yersinia mollaretii phytase (YmPhytase) variant with 26-fold improvement in activity at neutral pH. This is accomplished in four rounds over 4 weeks, while requiring construction and characterization of fewer than 500 variants for each enzyme. This platform for autonomous experimentation paves the way for rapid advancements across diverse industries, from medicine and biotechnology to renewable energy and sustainable chemistry.

59 BASIC BIOLOGICAL SCIENCES↗