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LY-CoV555, a SARS-CoV-2 spike protein–specific antibody, neutralizes SARS-CoV-2 and protects the airways of nonhuman primates against infection.
Purpose of Review: Minimally invasive vertebral augmentation procedures (VAP) have been first introduced to provide pain relief in patients with osteoporotic vertebral fractures (VF). However, in the last decade scientific literature revealed to be quite controversial about their efficacy. The aim of this review was to analyze clinical evidences from current literature, supported by our own experience. Recent Findings: Compared to conservative therapies, VAP represent an effective treatment for recent VF and, in elderly patients, reduce mortality and morbidity. Advances in technology have widened the fields of application towards other spine pathologies typical of elderly, such as primary and metastatic tumors. Summary: In patients with severe pain for recent or un-healed vertebral fracture, VAP are clinically more effective than conservative treatment. Accurate pain assessment and pre-procedural Magnetic Resonance Imaging are highly recommended to obtain optimal patient selection and best treatment results.
Advanced energy systems based on molten salt technologies have gained increasing interest, and their design and construction are likely going to involve the use of materials of dissimilar chemistries. With dissimilar materials being used, galvanic coupling induced corrosion acceleration is one of the mechanisms believed to be an issue for the deployment of molten salt systems. However, non-galvanic interaction mechanisms such as activity gradient mass transport have also been theorized to represent a potential challenge. Unfortunately, the two effects have often been compounded in the literature, such that it is still unclear which degradation mechanisms are at play in these systems. In the following study, electrochemical measurements are used to predict the effect that galvanic coupling would have on dissimilar materials submerged in the same molten salt medium. Dissimilar material salt exposure tests are then performed to investigate whether galvanic coupling or activity gradient driven processes account for the levels of materials degradation observed. Finally, these separate effect electrochemical and corrosion experiments uniquely elucidate the degradation mechanisms in dissimilar materials systems.
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A 1000 -h corrosion experiment of 316H stainless steel at 700 °C investigated the role of metal fluoride impurities CrF 2 and FeF 2 in LiF-BeF 2 (66-34 mole %) (FLiBe) salt. Inductively coupled plasma-optical emission spectroscopy (ICP-OES) demonstrated the ability to measure changes in the concentration of these fluorides in FLiBe salt. Cyclic voltammetry (CV) showed the potential for real-time quantitative concentration measurement of corrosion products in the molten salt. Materials characterization revealed that both impurity species influence the dissolution of Cr from the alloy. The collective results from these analysis methods advance the understanding of the influence impurities have on materials corrosion.
Mass transport of corrosion products between Ni-201 test samples and 316 L capsules in a 500-hour FLiNaK corrosion experiment has been investigated. In one experiment, the capsule and samples were electrically connected for galvanic coupling, while in the other they were electrically isolated using boron-nitride. Post-corrosion characterization of Ni-201 from the two experiments did not reveal any remarkable differences. Substantial transport of Fe and Cr from the 316 L to the Ni-201 via the salt was observed, with notable diffusion of these elements in the near-surface regions of the Ni-201 samples, while a Cr-rich film was also observed on their surfaces.
Corrosion of nickel and copper electroplated coatings on SS316H in molten FLiNaK salt was studied. 500- and 1000-hour static corrosion tests were performed in molten FLiNaK at 700 degrees Celsius. Characterization of the coatings following corrosion indicated that they did not degrade in the molten salt during the corrosion experiment and fully protected the underlying SS316H from chromium dissolution. Interdiffusion between the copper coating and SS316H was extremely limited, interdiffusion between the nickel coating and SS316H. Diffusion modelling revealed that the nickel coatings still significantly reduced chromium dissolution over 60 years despite the interdiffusion.
Future salt reactors like the Fluoride-salt-cooled-High Temperature Reactor require varying material flavors. Graphite is required for neutron moderation and potential fuel forms, while structural metals are required for containment. Studies show graphite/metal interactions exist when both materials share a salt medium. These interactions may accelerate the corrosion of the metal and change the surface of graphite materials. A novel pyrolytic boron nitride coating on graphite is investigated for reducing graphite/metal interactions. Finally, this is the first known application of such a coating, and salt exposure tests reveal the pyrolytic boron nitride coating reduces the interactions between stainless steel and uncoated graphite.
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We present experiments investigating dense carbon at pressures between 100 GPa and 200 GPa and temperatures between 5,000 K and 15,000 K. High-pressure samples with different temperatures were created by laser-driven shock compression of graphite and varying the initial density from 1.53 g/cm 3 to 2.21 g/cm 3 and the drive laser intensity from 7.1 TW/cm 2 to 14.2 TW/cm 2 . In order to deduce temperatures, spectrally resolved X-ray scattering was applied to determine ion-ion structure factors at a scattering vector of k = 4.12 ∙ 10 10 m -1 which shows high sensitivity to temperature for the investigated sample conditions. After comparison to corresponding DFT-MD simulations, we were able to assign each structure factor a temperature. This information is indicative of the expected temperature range for the melting line of carbon at high pressures and can be compared to theoretical predictions.
Synergizing wire arc-directed energy deposition (WA-DED) additive manufacturing (AM) with particle-strengthened creep strength-enhanced ferritic (CSEF) steels enables fabrication and repair of critical power-plant components. Investigations focused on fusion-welded particle-strengthened CSEF steels, such as Grade 91 steel, have linked microstructurally heterogeneous regions—forming due to heat affected zones (HAZ)—with premature failure during elevated temperature service. Fusion-based AM, including WA-DED, likewise generates microstructurally and plastically heterogeneous regions due to spatiotemporally varying thermokinetics during deposition. However, works investigating such microstructural heterogeneities, their implications for mechanical behavior, and strategies to mitigate their formation remain scarce. This work identifies microstructurally and plastically heterogeneous regions within the WA-DED-processed Grade 91 steel. Spatial microhardness variations in the as-fabricated specimen correlate with the variation in the attributes of grain, martensitic microstructure, and precipitates across the fusion zone and HAZ. Digital image correlation-enabled tensile tests performed at 500 °C revealed pronounced deformation localization and a wave-like strain distribution, with wavelength close to the melt pool depth, indicating susceptibility of the as-fabricated components to premature creep failure. Such heterogeneity in microstructural and mechanical behavior was attributed to recurring solid-state phase transformations. Subsequently, an interlayer temperature control strategy was implemented, wherein maintaining interlayer temperature above the martensitic start temperature mitigated the heterogeneous microstructural and plastic response in the as-fabricated condition. Findings open pathways to achieving deformation-localization- and creep-resistant microstructures in WA-DED fabricated particle-strengthened CSEF steel components, reducing reliance on post-welding heat treatments—conventionally required to enhance creep resistance—and enabling on-demand, short lead-time fabrication of next-generation power-plant components.
Additive manufacturing (AM) potentially enables fabrication and repair of plasma facing components (PFCs) of tungsten. However, deformation mechanisms in AM-fabricated tungsten under service-relevant thermomechanical conditions remain unknown majorly due to challenges in achieving crack-free W. This study reveals the deformation mechanisms operative under tension at 800 °C and 1200 °C in the electron beam melting powder bed fusion (EBM-PBF) fabricated W. Textured columnar grains with mixed <001 >/<111 >|| build-direction were observed. Strong anisotropy in tensile properties persisted across test temperatures, and all specimens exhibited extensive deformation-induced banding phenomena. Grain boundary character analysis of the deformed specimens indicated that these deformation bands were kink bands with tilt grain boundaries prominently present at the band-matrix interface. Interestingly, the material within the kink bands rotated toward higher resolved shear stress, providing insights into the origins of kink band formation in body-centered cubic refractory metals. Intragranular misorientation axis analysis revealed that plasticity was dominated by {110} <111 > slip at 800 °C, whereas additional (213)[11̄1] and (112)[11̄1] slip systems activated at 1200 °C. A dense low-angle boundary networks observed near fractured surface indicated the onset of dynamic recrystallization. Results reveal plasticity governing mechanisms in AM-fabricated W under power plant-relevant conditions, and provide insights into kink band attributes in refractory metals.
The corrosion behavior of 316L and 316H stainless steels (low and high carbon, respectively) in molten LiF-NaF-KF (FLiNaK) salt at 700 °C for 500 h has been investigated. Tests were performed in 316L stainless steel, pyrolytic boron nitride, and glassy carbon capsule materials. The capsule material had a notable effect on the corrosion behavior of the two stainless steels. Further, the modes of corrosion for the two types of stainless steel in various capsule materials were classified into three categories, namely, uniform surface recession, selective grain boundary Cr dissolution, and the dissolution of Cr in the bulk grains. By most metrics, the 316H stainless steel exhibited slightly superior corrosion resistance, while by others the two stainless steels were comparable. These differences in corrosion behavior are attributed to the differences in grain size and the degree of sensitization.
ICARUS T600 will operate at shallow depths as far detector for the Short Baseline Neutrino (SBN) program at FNAL taking data from the BNB and NuMI beams. The entire apparatus will be exposed to the huge cosmic background which can mimic genuine neutrino interactions. To distinguish the signals related to the neutrino beams from those induced by cosmic rays, the detector will be provided with a trigger system that will exploit the coincidence of the prompt signals from the liquid argon scintillation light, detected by 360 Photomultiplier Tubes (PMTs), with a beam gate window generated in correspondence to the expected arrival time of neutrinos in the T600.
The following Key Messages comprise the salient findings of this study: 1. Ambient energy (from sun, air, ground, and sky) can heat and cool buildings; provide hot water, ventilation and daylighting; dry clothes; and cook food. These services account for about three-quarters of building energy consumption and a third of total US demand. Biophilic design (direct and indirect connections with nature) is an intrinsic adjunct to ambient energy systems, and improves wellness and human performance. 2. The current strategy of electrification and energy efficiency for buildings will not meet our climate goals, because the transition to an all-renewable electric grid is too slow. Widespread adoption of ambient energy is needed. Solar-heated buildings also flatten the seasonal demand for electricity compared to all-electric buildings, reducing required production capacity and long-term energy storage. In addition, ambient-conditioned buildings improve resilience by remaining livable during power outages. 3. National policies, incentives, and marketing should be enacted to promote ambient energy use. Federal administrative priorities should reflect the importance of ambient energy for buildings. Use of ambient energy should be encouraged through existing and new building codes and standards. 4. Ambient energy system design tools are needed for architects, engineers, builders, building scientists, realtors, appraisers, and consumers. PVWatts is used over 100 million times per year for photovoltaic system design. A similar, simple, and accessible tool for ambient design is crucial. 5. Training on ambient energy is needed throughout secondary, post-secondary, and continuing education for workforce development. Currently, only about 10% of colleges teach courses on passive heating and cooling systems. 6. Ambient-conditioned buildings should be demonstrated in all US climate zones. Performance should be monitored and reported, with quantitative case studies made widely available. 7. While current technology is sufficient to build high-performance ambient buildings now, research is needed to develop new technologies to harness ambient energy more effectively and more economically. Such advancements will facilitate adoption of ambient energy technologies in a wider range of buildings, including retrofits. Examples include windows with much lower thermal losses, use of the building shell as thermal storage, alternative light-weight thermal storage systems, sky radiation cooling systems, automated controls for solar gains and passive cooling, and ground coupling.
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