NASA NTRS · 19880047909
Life sciences, biotechnology, and microgravity
Abstract
Growth hormone (GH) studies on rats flown aboard Spacelab 3 are discussed, and evidence for the direct effect of microgravity on cell function is reviewed. SL-3 rat GH cells were found to experience a secretory lesion (they contained more hormone per cell, but released less per cell relative to controls). Pituitary cell culture experiments on the STS-8 mission showed that GH cells did not subsequently release as much hormone as did control cells, indicating a secretory lesion. Changes in bone and muscle noted in SL-3 rats are related to GH cell findings.
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Hymer, W. C., Hayes, C., Grindeland, R., Lanhan, J. W., Morrison, D.. 1987-01-01. Life sciences, biotechnology, and microgravity. https://ntrs.nasa.gov/citations/19880047909
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