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Hayes, C.

Publications and source records attributed to Hayes, C..

18 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS1988

Heterogeneity in the growth hormone pituitary gland system of rats and humans: Implications to microgravity based research

The cell separation techniques of velocity sedimentation, flow cytometry and continuous flow electrophoresis were used to obtain enriched populations of growth hormone (GH) cells. The goal was to isolate a GH cell subpopulation which releases GH molecules which are very high in biological activity, it was important to use a method which was effective in processing large numbers of cells over a short time span. The techniques based on sedimentation are limited by cell density overlaps and streaming. While flow cytometry is useful in the analytical mode for objectively establishing cell purity, the numbers of cells which can be processed in the sort mode are so small as to make this approach ineffective in terms of the long term goals. It was shown that continuous flow electrophoresis systems (CFES) can separate GH cells from other cell types on the basis of differences in surface charge. The bioreactive producers appear to be more electrophoretically mobile than the low producers. Current ground based CFES efforts are hampered by cell clumping in low ionic strength buffers and poor cell recoveries from the CFES device.

Hymer, W. C.↗
NASA NTRS1987

Changes in pituitary growth hormone cells prepared from rats flown on Spacelab 3

The effect of exposure to microgravity on pituitary gland was investigated by examining cells isolated from anterior pituitaries of rats flown on the 7-day Spacelab 3 mission and, subsequently, cultured for 6 days. Compared with ground controls, flight cells contained more intracellular growth hormone (GH); however, the flight cells released less GH over the 6-day culture period and after implantation into hypophysectomized rats than did the control cells. Compared with control rats, glands from large rats (400 g) contained more somatotrophs (44 percent compared with 37 percent in control rats); small rats (200 g) showed no difference. No major differences were found in the somatotroph ultrastructure (by TEM) or in the pattern of the immunoactive GH variants. However, high-performance liquid chromatography fractionation of culture media indicated that flight cells released much less of a biologically active high-molecular weight GH variant, suggesting that space flight may lead to secretory dysfunction.

Grindeland, R.↗
NASA NTRS1987

Life sciences, biotechnology, and microgravity

Growth hormone (GH) studies on rats flown aboard Spacelab 3 are discussed, and evidence for the direct effect of microgravity on cell function is reviewed. SL-3 rat GH cells were found to experience a secretory lesion (they contained more hormone per cell, but released less per cell relative to controls). Pituitary cell culture experiments on the STS-8 mission showed that GH cells did not subsequently release as much hormone as did control cells, indicating a secretory lesion. Changes in bone and muscle noted in SL-3 rats are related to GH cell findings.

Hymer, W. C.↗
NASA NTRS1985

Microgravity associated changes in pituitary growth hormone (GH) cells prepared from rats flown on Space Lab 3

The effect of microgravity on the release of pituitary growth hormone (GH) in rats is studied. The pituitary glands from six adult rats exposed to microgravity are analyzed for in vitro and in vivo changes in pituitary growth hormone cells. The GH cell functions in the somatotrophs of flight rats are compared to a control group. The two assay procedures employed in the experiment are described. It is observed that intracellular levels of GH are two to three times greater in the flight rats than in the control group; however, the amount of GH released from the somatotrophs is 1.11 + or - 0.4 micrograms for the flight rats and 1.85 + or - 1.3 micrograms for the control rats.

Hymer, W. C.↗
NASA NTRS1983

Aerodynamic characteristics of a series of single-inlet air-breathing missile configurations

A series of air-breathing missile configurations was investigated to provide a data base for the design of such missiles. The model could be configured with either a single axisymmetric or a two dimensional inlet located at the bottom of the body. Two tail configurations were investigated: a tri-tail and an X-tail. The tail surfaces could be deflected to provide pitch control. A wing could be located above the inlet on the center line of the model. Tests were made at supersonic Mach numbers with the inlet open and internal flow, and at subsonic-transonic Mach numbers with the internal duct closed and no internal flow.

Hayes, C.↗
NASA NTRS1983

Aerodynamic characteristics of a series of twin-inlet air-breathing missile configurations. 2: Two-dimensional inlets at supersonic speeds

A series of air-breathing missile configurations was investigated to provide a data base for the design of such missiles. The model could be configured with either twin axisymmetric or two dimensional inlets. Three circumferential inlet locations were investigated: 90 deg, 115 deg, and 135 deg from the top center. Two vertical wing locations, as well as wingless configurations, were used. Three tail configurations were formed by locating the tail surfaces either on the inlet fairings or on fairings on the body. The surfaces were used to provide pitch control. Two dimensional inlets with extended compression surfaces, used to improve the angle-of-attack performance of the inlets for wingless configurations, were also investigated. The two dimensional inlet configurations are covered.

Hayes, C.↗
NASA NTRS1983

Aerodynamic characteristics of a series of twin-inlet air-breathing missile configurations. 3: Axisymmetric and two-dimensional inlets at subsonic-transonic speeds

A series of air-breathing missile configurations was investigated to provide a data base for the design of such missiles. The model could be configurated with either twin axisymmetric or two dimensional inlets. Three circumferential inlet locations were investigated: 90 deg, 115 deg, and 135 deg from the top center. Two vertical wing locations, as well as wingless configurations, were used. Three tail configurations were formed by locating the tail surfaces either on the inlet fairing or on the inlet fairing or on fairings on the body. The surfaces were used to provide pitch control. Two dimensional inlets with extended compression surfaces, used to improve the angle-of-attack performance of the inlets for wingless configurations, were also investigated. The twin axisymmetric two dimensional inlet types without internal flow are covered, and the boost configuration of an air-breathing missile is simulated.

Hayes, C.↗
NASA NTRS1981

Aerodynamic characteristics of a series of airbreathing missile configurations

Due to the interest in the application of airbreathing propulsion to missiles and the lack of a suitable data base, an experimental program has been conducted to contribute to such a data base. The configurations investigated were with twin-inlets, either two-dimensional or axisymmetric, each located at three circumferential locations. The effects of a wing located above the inlets and of tail configuration were investigated. Longitudinal stability and control and lateral-directional stability were included in the data obtained. This paper presents a summary of the program and some of the results obtained. Certain trends of the data, as well as problem areas, are discussed. Due to the large volume of data obtained, a detailed analysis is not presented.

Hayes, C.↗
NASA NTRS1981

Aerodynamic characteristics of a series of airbreathing missile configurations

The results of an experimental program conducted in order to compile a data base useful in the application of airbreathing propulsion to missiles are presented. The configurations investigated used two-dimensional or axisymmetric twin inlets located at three alternative circumferential positions: 90, 115 and 135 deg to the vertical centerline. The effects of a wing located above the inlets and of various tail configurations were investigated, with a view to longitudinal stability/control and lateral-directional stability characteristics. It is noted that of the three tail configurations tested, the 'X' tail showed (1) the most linear pitch-moment curve, (2) control effectiveness, and (3) positive lateral-directional stability.

Hayes, C.↗
NASA NTRS1979

Surface pressure data on a series of analytic forebodies at Mach numbers from 1.70 to 4.50 and combined angles of attack and sideslip

Tabulated surface pressure data for a series of four forebodies which have analytically defined cross sections and which are based on a parabolic arc profile having a 20 deg half angle at the nose are presented without analysis. The first forebody has a circular cross section, and the second has a cross section which is an ellipse with an axis ratio of 2/1. The third has a cross section defined by a lobed analytic curve. The fourth forebody has cross sections which develop smoothly from circular at the pointed nose through the lobed analytic curve and back to circular at the aft end. The data generally cover angles of attack from -5 deg to 20 deg at angles of sideslip from 0 deg to 5 deg for Mach numbers of 1.70, 2.50, 3.95, and 4.50 at a constant Reynolds number.

Townsend, J. C.↗
NASA NTRS1979

Surface pressure data on a series of conical forebodies at Mach numbers from 1.70 to 4.50 and combined angles of attack and sideslip

Tabulated surface pressure data for a series of forebodies which have analytically defined cross sections and are based on a 20 degs half-angle cone are presented without analysis. Five of the cross sections were ellipses having axis ratios of 3/1, 2/1, 1/1, 1/2, and 1/3. The sixth cross section was defined by a curve having a single lobe. The data generally cover angles of attack from -5 degs to 20 degs at angles of sideslip from 0 degs to 5 degs for Mach numbers of 1.70, 2.50, 3.95, and 4.50 at a constant Reynolds number.

Townsend, J. C.↗
NASA NTRS1977

Effect of a simulated engine jet blowing above an arrow wing at Mach 2.0

The effects of a gas jet simulating a turbojet engine exhaust blowing above a cambered and twisted arrow wing were investigated. Tests were conducted in the Langley 4-foot supersonic pressure tunnel at a Mach number of 2.0. Nozzle pressure ratios from 1 to 64 were tested with both helium and air used as jet gases. The tests were conducted at angles of attack from -2 deg to 8 deg at a Reynolds number of 9,840,000 per meter. Only the forces and moments on the wing were measured. Results of the investigation indicated that the jet blowing over the wing caused reductions in maximum lift-drag ratio of about 4 percent for helium and 6 percent for air at their respective design nozzle pressure ratios, relative to jet-off data. Moderate changes in the longitudinal, vertical, or angular positions of the jet relative to the wing had little effect on the wing aerodynamic characteristics.

Shrout, B. L.↗
NASA NTRS1976

Stability and control characteristics of an air-breathing missile configuration having a forward located inlet

An investigation was made to determine the aerodynamic characteristics of an airbreathing missile configuration having a forward located inlet. Control was provided by cruciform tail surfaces. Aerodynamic data were obtained for the body-tail configuration alone and with planar or cruciform wings. At Mach numbers from 2.86 to 4.63, the model had internal flow. At Mach numbers from 1.70 to 2.86, the internal duct was closed, and an inlet fairing was installed to simulate boost conditions.

Sawyer, W. C.↗