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Spence, J. H.

Publications and source records attributed to Spence, J. H..

New Light on Disordered Ensembles: Ab Initio Structure Determination of One Particle from Scattering Fluctuations of One Particular from Scattering Fluctuatins of Many Copies

We report on the first experimental ab initio reconstruction of an image of a single particle from fluctuations in the scattering from an ensemble of copies, randomly oriented about an axis. The method is applicable to identical particles frozen in space or time (as by snapshot diffraction from an x-ray free electron laser). These fluctuations enhance information obtainable from an experiment such as conventional small angle x-ray scattering.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Beyond small-angle x-ray scattering: Exploiting angular correlations

We propose a method for determining the projected electron density of an individual molecule from diffraction patterns of many such simultaneously illuminated molecules, randomly oriented about an axis parallel to an incident x-ray beam. We illustrate the idea with a simulation of a structure determination of a K-channel membrane protein in situ.

59 BASIC BIOLOGICAL SCIENCES↗