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Chen, Xi

Publications and source records attributed to Chen, Xi.

At least 145 records · Page 8
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

Silencing of Kangai 1 C-terminal interacting tetraspanin suppresses progression of cholangiocarcinoma

Highlights: • KITENIN is expressed in murine and human cholangiocarcinoma (CC). • Knockdown of KITENIN reduced proliferation, migration, invasion and colony formation in CC cells. • Silencing of KITENIN inhibited the expression of epithelial-mesenchymal transition markers. • Targeting of KITENIN might function as a new therapeutic strategy against CC. Cholangiocarcinoma (CC) is the second most common primary hepatic malignancy. CC treatment options are very limited especially for patients with distant metastasis. Kangai 1 C-terminal interacting tetraspanin (KITENIN) is highly expressed in numerous cancers, but the role of KITENIN in CC remains unknown. Here, we have investigated for the first time the function of KITENIN in human CC cell lines (TFK-1, SZ-1), tissues and a CC mouse model (Alb-Cre/LSL-KRAS{sup G12D}/p53{sup L/L}). KITENIN was expressed in 92.2% of human CC tissues, in murine CC samples and also in human CC cell lines. Knockdown of KITENIN by small interfering RNA (siRNA) effectively reduced proliferation, migration, invasion and colony formation in both intra- and extra-hepatic CC cells. The expression of epithelial-mesenchymal transition (EMT) markers like N-cadherin, Vimentin, Snail and Slug were suppressed in KITENIN knockdown CC cells. Our results indicate that KITENIN is crucial for cholangiocarcinogenesis and it might become a potential therapeutic target for human CC treatment.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2018

Study of Ion Conductivity and Chain Dynamics in Polymer-Ceramic Composite Electrolytes

We fabricated polymer-ceramic composite consisting of polyethylene oxide, lithium trifluoromethanesulfonate, and a lithium-conducting glass ceramic from Ohara corporation. We examined the ion conductivity of the composite electrolyte with high volume fractions of Ohara ceramic (30% to 60%) using various processing methods. In this composition range, the composite conductivity was less affected by the volume fraction of the ceramic. Instead, it was strongly affected by processing methods. We found that the composite showed lower ion conductivity than the conductivity of PEO and the Ohara ceramic. A trilayer experiment using polymer electrolyte/Ohara ceramic plate/polymer electrolyte design revealed a very large interfacial resistance between the polymer electrolyte and Ohara ceramic. Quasi-elastic neutron scattering measurements were performed on the system to shed light on underpinnings of the origin of this large interfacial resistance.

Chen, Xi↗
DOE OSTI2017

Direct observation of magnon-phonon coupling in yttrium iron garnet

The magnetic insulator yttrium iron garnet (YIG) with a ferrimagnetic transition temperature of ~ 560 K has been widely used in microwave and spintronic devices. Anomalous features in spin Seeback effect (SSE) voltages have been observed in Pt/YIG and attributed to magnon-phonon coupling. Here, we use inelastic neutron scattering to map out low-energy spin waves and acoustic phonons of YIG at 100 K as a function of increasing magnetic field. In this work, by comparing the zero and 9.1 T data, we find that instead of splitting and opening up gaps at the spin wave and acoustic phonon dispersion intersecting points, magnon-phonon coupling in YIG enhances the hybridized scattering intensity. These results are different from expectations of conventional spin-lattice coupling, calling for different paradigms to understand the scattering process of magnon-phonon interactions and the resulting magnon polarons.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗
DOE OSTI2017

Potential for natural evaporation as a reliable renewable energy resource

About 50% of the solar energy absorbed at the Earth’s surface drives evaporation, fueling the water cycle that affects various renewable energy resources, such as wind and hydropower. Recent advances demonstrate our nascent ability to convert evaporation energy into work, yet there is little understanding about the potential of this resource. Here in this paper we study the energy available from natural evaporation to predict the potential of this ubiquitous resource. We find that natural evaporation from open water surfaces could provide power densities comparable to current wind and solar technologies while cutting evaporative water losses by nearly half. We estimate up to 325 GW of power is potentially available in the United States. Strikingly, water’s large heat capacity is sufficient to control power output by storing excess energy when demand is low, thus reducing intermittency and improving reliability. Our findings motivate the improvement of materials and devices that convert energy from evaporation.

13 HYDRO ENERGY↗
DOE OSTI2017

A 6.7 GHz Methanol Maser Survey at High Galactic Latitudes

We performed a systematic 6.7 GHz Class II methanol maser survey using the Shanghai Tianma Radio Telescope toward targets selected from the all-sky Wide-Field Infrared Survey Explorer (WISE) point catalog. In this paper, we report the results from the survey of those at high Galactic latitudes, i.e., |b| > 2°. Of 1473 selected WISE point sources at high latitude, 17 point positions that were actually associated with 12 sources were detected with maser emission, reflecting the rarity (1%–2%) of methanol masers in the region away from the Galactic plane. Out of the 12 sources, 3 are detected for the first time. The spectral energy distribution at infrared bands shows that these new detected masers occur in the massive star-forming regions. Compared to previous detections, the methanol maser changes significantly in both spectral profiles and flux densities. The infrared WISE images show that almost all of these masers are located in the positions of the bright WISE point sources. Compared to the methanol masers at the Galactic plane, these high-latitude methanol masers provide good tracers for investigating the physics and kinematics around massive young stellar objects, because they are believed to be less affected by the surrounding cluster environment.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2017

Detection of 36 GHz Class I Methanol Maser Emission toward NGC 4945

We have searched for emission from the 36.2 GHz (4{sub −1}→3{sub 0}E) methanol transition toward NGC 4945, using the Australia Telescope Compact Array. 36.2 GHz methanol emission was detected offset southeast from the Galactic nucleus. The methanol emission is narrow, with a line width <10 km s{sup −1} and a luminosity five orders of magnitude higher than Galactic class I masers from the same transition. These characteristics combined the with physical separation from the strong central thermal emission suggests that the methanol emission is a maser. This emission is a factor of ∼90 more luminous than the widespread emission detected from the Milky Way central molecular zone. This is the fourth detection of extragalactic class I emission and the third detection of extragalactic 36.2 GHz maser emission. These extragalactic class I methanol masers do not appear to be simply highly luminous variants of Galactic class I emission and instead appear to trace large-scale regions of low-velocity shocks in molecular gas, which may precede, or be associated with, the early stages of large-scale star formation.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2017

A New 95 GHz Methanol Maser Catalog. I. Data

The Purple Mountain Observatory 13.7 m radio telescope has been used to search for 95 GHz (8{sub 0}–7{sub 1}A{sup +}) class I methanol masers toward 1020 Bolocam Galactic Plane Survey (BGPS) sources, leading to 213 detections. We have compared the line width of the methanol and HCO{sup +} thermal emission in all of the methanol detections, and on that basis, we find that 205 of the 213 detections are very likely to be masers. This corresponds to an overall detection rate of 95 GHz methanol masers toward our BGPS sample of 20%. Of the 205 detected masers, 144 (70%) are new discoveries. Combining our results with those of previous 95 GHz methanol maser searches, a total of 481 95 GHz methanol masers are now known. We have compiled a catalog listing the locations and properties of all known 95 GHz methanol masers.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2017

Protecting against damage from refraction of high power microwaves in the DIII-D tokamak

Here, several new protective systems are being installed on the DIII D tokamak to increase the safety margins for plasma operations with injected ECH power at densities approaching cutoff. Inadvertent overdense operation has previously resulted in reflection of an rf beam back into a launcher causing extensive arcing and melt damage on one waveguide line. Damage to microwave diagnostics, which are located on the same side of the tokamak as the ECH launchers, also has occurred. Developing a reliable microwave based interlock to protect the many vulnerable systems in DIII-D has proved to be difficult. Therefore, multiple protective steps have been taken to reduce the risk of damage in the future. Among these is a density interlock generated by the plasma control system, with setpoint determined by the ECH operators based on rf beam trajectories and plasma parameters. Also installed are enhanced video monitoring of the launchers, and an ambient light monitor on each of the waveguide systems, along with a Langmuir probe at the mouth of each launcher. Versatile rf monitors, measuring forward and reflected power in addition to the mode content of the rf beams, have been installed as the last miter bends in each waveguide line. As these systems are characterized, they are being incorporated in the interlock chains, which enable the ECH injection permits. The diagnostics most susceptible to damage from the ECH waves have also been fitted with a variety of protective devices including stripline filters, thin resonant notch filters tuned to the 110 GHz injected microwave frequency, blazed grating filters and shutters. Calculations of rf beam trajectories in the plasmas are performed using the TORAY ray tracing code with input from kinetic profile diagnostics. Using these calculations, strike points for refracted beams on the vacuum vessel are calculated, which allows evaluation of the risk of damage to sensitive diagnostics and hardware.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2017

Advances in the steady-state hybrid regime in DIII-D – a fully non-inductive, ELM-suppressed scenario for ITER

Here, the hybrid regime with beta, collisionality, safety factor and plasma shape relevant to the ITER steady-state mission has been successfully integrated with ELM suppression by applying an odd parity n=3 resonant magnetic perturbation (RMP). Fully non-inductive hybrids in the DIII-D tokamak with high beta (< β> ≤ 2.8%) and high confinement (H 98y2 ≤ 1.4) in the ITER similar shape have achieved zero surface loop voltage for up to two current relaxation times using efficient central current drive from ECCD and NBCD. The n=3 RMP causes surprisingly little increase in thermal transport during ELM suppression. Poloidal magnetic flux pumping in hybrid plasmas maintains q above 1 without loss of current drive efficiency, except that experiments show that extremely peaked ECCD profiles can create sawteeth. During ECCD, Alfvén eigenmode (AE) activity is replaced by a more benign fishbone-like mode, reducing anomalous beam ion diffusion by a factor of 2. While the electron and ion thermal diffusivities substantially increase with higher ECCD power, the loss of confinement can be offset by the decreased fast ion transport resulting from AE suppression. Extrapolations from DIII-D along a dimensionless parameter scaling path as well as those using self-consistent theory-based modeling show that these ELM-suppressed, fully non-inductive hybrids can achieve the Q fus = 5 ITER steady-state mission.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2017

Stripes developed at the strong limit of nematicity in FeSe film

A single monolayer of iron selenide grown on strontium titanate shows an impressive enhancement of superconductivity compared with the bulk, as well as a novel Fermi surface topology, extreme two-dimensionality, and the possibility of phonon-enhanced electron pairing. For films thicker than one unit cell, however, the electronic structure is markedly different, with a drastically suppressed superconductivity and strong nematicity appearing. The physics driving this extraordinary dichotomy of superconducting behaviour is far from clear. In this paper, we use low-temperature scanning tunnelling microscopy to study multilayers of iron selenide grown by molecular beam epitaxy, and find a stripe-type charge ordering instability that develops beneath the nematic state. The charge ordering is visible and pinned in the vicinity of impurities. And as it emerges in the strong limit of nematicity, it suggests that a magnetic fluctuation with a rather small wavevector may be competing with the ordinary collinear antiferromagnetic ordering in multilayer films. Finally, the existence of stripes in iron-based superconductors, which resemble the stripe order in cuprates, not only suggests that electronic anisotropy and correlation are playing an important role, but also provides a platform for probing the complex interactions between nematicity, charge ordering, magnetism and superconductivity in high-temperature superconductors.

36 MATERIALS SCIENCE↗
DOE OSTI2017

Bifurcation of quiescent H-mode to a wide pedestal regime in DIII-D and advances in the understanding of edge harmonic oscillations

New experimental studies and modelling of the coherent edge harmonic oscillation (EHO), which regulates the conventional Quiescent H-mode (QH-mode) edge, validate the proposed hypothesis of edge rotational shear in destabilizing the low-n kink-peeling mode as the additional drive mechanism for the EHO. The observed minimum edge E×B shear required for the EHO decreases linearly with pedestal collisionality $\nu _{\text{e}}^{\ast}$ , which is favorable for operating QH-mode in machines with low collisionality and low rotation such as ITER. In addition, the QH-mode regime in DIII-D has recently been found to bifurcate into a new 'wide-pedestal' state at low torque in double-null shaped plasmas, characterized by increased pedestal height, width and thermal energy confinement (Burrell 2016 Phys. Plasmas 23 056103, Chen 2017 Nucl. Fusion 57 022007). This potentially provides an alternate path for achieving high performance ELM-stable operation at low torque, in addition to the low-torque QH-mode sustained with applied 3D fields. Multi-branch low-k and intermediate-k turbulences are observed in the 'wide-pedestal'. New experiments support the hypothesis that the decreased edge E×B shear enables destabilization of broadband turbulence, which relaxes edge pressure gradients, improves peeling-ballooning stability and allows a wider and thus higher pedestal. In conclusion, the ability to accurately predict the critical E×B shear for EHO and maintain high performance QH-mode at low torque is an essential requirement for projecting QH-mode operation to ITER and future machines.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗