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Use of the Aromascan(TM) Instrument for Nonsubjective Evaluation of Rodent Spaceflight Hardware

This report describes the verification and utilization of the AromaScan(TM) (Hollis, NH) instrument for the ground-based evaluation of odor containment by various spaceflight habitats developed at NASA's Ames Research Center (ARC). The AromaScan(TM) instrument is an electronic odor detection system consisting of 32 polymer sensors that respond differentially to 10 different chemical groups present in an air sample. The AromaScan(TM) system also includes neural network software for constructing a database of known odors, against which an unknown odor can be compared. At present, the standard method for characterizing rodent odor containment during the development and testing of spaceflight hardware is the use of a human odor assessment panel. However, this can be a very time consuming and costly process, and the results are inherently subjective. The AromaScan(TM) system should produce more consistent and objective results, as well as a cost savings in the long term. To test and verify the AromaScan(TM) instrument, daily air samples will be collected from the exhaust port of rodent habitats, during experiment development tests, then injected into the instrument and used to create a database of recognizable odors. Human sniff tests will be performed in conjunction with the AromaScan(TM) analysis, and the results will be correlated. We will then teach the neural network to differentiate between an acceptable and an unacceptable odor profile, as defined by the human sniff test, and to be able to accurately identify an odor that would not pass a sniff panel. The results of our efforts will be to verify that the AromaScan(TM) system is a valuable alternative to human sniff panel assessments for the early iterative process of designing and testing rodent waste filters for spaceflight. Acceptance by a human panel will remain one of the final criteria for successful rodent habitat development.

Scribner, K. A.↗

Thermostable Shelf Life Study

The objective of this project is to determine the shelf life end-point of various food items by means of actual measurement or mathematical projection. The primary goal of the Advanced Food Technology Project in these long duration exploratory missions is to provide the crew with a palatable, nutritious and safe food system while minimizing volume, mass, and waste. The Mars missions could be as long as 2.5 years with the potential of the food being positioned prior to the crew arrival. Therefore, it is anticipated that foods that are used during the Mars missions will require a 5 year shelf life. Shelf life criteria are safety, nutrition, and acceptability. Any of these criteria can be the limiting factor in determining the food's shelf life. Due to the heat sterilization process used for the thermostabilized food items, safety will be preserved as long as the integrity of the package is maintained. Nutrition and acceptability will change over time. Since the food can be the sole source of nutrition to the crew, a significant loss in nutrition may determine when the shelf life endpoint has occurred. Shelf life can be defined when the food item is no longer acceptable. Acceptability can be defined in terms of appearance, flavor, texture, or aroma. Results from shelf life studies of the thermostabilized food items suggest that the shelf life of the foods range from 0 months to 8 years, depending on formulation.

Perchonok, M. H.↗

Thermostabilized Shelf Life Study

The objective of this project is to determine the shelf life end-point of various food items by means of actual measurement or mathematical projection. The primary goal of the Advanced Food Technology Project in these long duration exploratory missions is to provide the crew with a palatable, nutritious and safe food system while minimizing volume, mass, and waste. The Mars missions could be as long as 2.5 years with the potential of the food being positioned prior to the crew arrival. Therefore, it is anticipated that foods that are used during the Mars missions will require a 5 year shelf life. Shelf life criteria are safety, nutrition, and acceptability. Any of these criteria can be the limiting factor in determining the food's shelf life. Due to the heat sterilization process used for the thermostabilized food items, safety will be preserved as long as the integrity of the package is maintained. Nutrition and acceptability will change over time. Since the food can be the sole source of nutrition to the crew, a significant loss in nutrition may determine when the shelf life endpoint has occurred. Shelf life can be defined when the food item is no longer acceptable. Acceptability can be defined in terms of appearance, flavor, texture, or aroma. Results from shelf life studies of the thermostabilized food items suggest that the shelf life of the foods range from 0 months to 8 years, depending on formulation.

Perchonok, Michele H.↗

Design of a 2-Hour Prebreathe Protocol for Space Walks (EVAs) from the International Space Station (ISS)

The majority of extravehicular activities (EVAs) performed from the shuttle use a 10.2 psi staged decompression. The International Space Station (ISS) will operate at 14.7 psi, requiring crews to "campout" in the airlock at 10.2 psi. The constraints associated with campout (crew isolation, oxygen usage, and waste management), provided the rationale to develop a 2-hour prebreathe protocol from 14.7 psi. Previous studies on the affect of microgravity and exercise during prebreathe suggested the feasibility of this approach. Various combinations of adynamia (nonwalking subjects), prebreathe exercise doses, and space suit donning options (10.2 vs. 14.7 psi) were analyzed against timeline and consumable constraints. Prospective decompression sickness (DCS) and venous gas emboli (VGE) accept/reject criteria were defined from statistical analysis of historical DCS data, combined with risk management of DCS under ISS mission circumstances. Maximum operational DCS levels were defined based on protecting for EVA capability with two crew members at 95% confidence, throughout ISS lifetime (within the constraints of NASA DCS disposition policy JPG 1800.3). The accept / reject limits were adjusted for greater safety (including Grade IV VGE criteria) based on analysis of related medical factors. Monte-Carlo simulation was performed to design a closed sequential, multi-center laboratory trial, including the capability of rejecting the primary protocol and testing at least one alternate exercise dose, within the 2-hour prebreathe. The 2-hour protocol incorporates 0, breathing for 5 0 min at 14.7 psi, including 10 min dual cycle ergometry at 75%VO(2max). It requires an additional 30 minO2breathing during depress from 14.7 to 10.2 psi, followed by a 30-60 min suit donning break at 10.2 psi/26.5% O2. It concludes with a 40 min in-suit O2 prebreathe. The protocol would be accepted for operations, if the incidence of DCS was less than 15% and Grade IV VGE less than 20%, both at 95% confidence. The above protocol and accept/reject limits were implemented in a multi-center study.

Gernhardt, M. L.↗

Bio-Medical Factors and External Hazards in Space Station Design

The design of space-station configurations is influenced by many factors. Probably the most demanding and critical are the biomedical and external hazards requirements imposed to provide the proper environment and supporting facilities for the crew and the adequate protective measures necessary to provide a configuration'in which the crew can live and work efficiently in relative comfort and safety. The major biomedical factors, such as physiology, psychology, nutrition, personal hygiene, waste management, and recreation, all impose their own peculiar requirements. The commonality and integration of these requirements demand the utmost ingenuity and inventiveness be exercised in order to achieve effective configuration compliance. The relationship of biomedical factors for the internal space-station environment will be explored with respect to internal atmospheric constituency, atmospheric pressure levels, oxygen positive pressure, temperature, humidity, CO2 concentration, and atmospheric contamination. The range of these various parameters and the recommended levels for design use will be analyzed. Requirements and criteria for specific problem areas such as zero and artificial gravity and crew private quarters will be reviewed and the impact on the design of representative solutions will be presented. In the areas of external hazards, the impact of factors such as meteoroids, radiation, vacuum, temperature extremes, and cycling on station design will be evaluated. Considerations with respect to operational effectiveness and crew safety will be discussed. The impact of such factors on spacecraft design to achieve acceptable launch and reentry g levels, crew rotation intervals, etc., will be reviewed.

Olling, E. H.↗

Bio-Medical Factors and External Hazards in Space Station Design

The design of space-station configurations is influenced by many factors, Probably the most demanding and critical are the biomedical and external hazards requirements imposed to provide the proper environment and supporting facilities for the crew and the adequate protective measures necessary to provide a configuration in which the crew can live and work efficiently in relative comfort and safety. The major biomedical factors, such as physiology, psychology, nutrition, personal hygiene, waste management, and recreation, all impose their own peculiar requirements. The commonality and integration of these requirements demand the utmost ingenuity and inventiveness be exercised in order to achieve effective configuration compliance. The relationship of biomedical factors for the internal space-station environment will be explored with respect to internal atmospheric constituency, atmospheric pressure levels, oxygen positive pressure, temperature, humidity, CO2 concentration, and atmospheric contamination. The range of these various parameters and the recommended levels for design use will be analyzed. Requirements and criteria for specific problem areas such as zero and artificial gravity and crew private quarters will be reviewed and the impact on the design of representative solutions will be presented. In the areas of external hazards, the impact of factors such as meteoroids, radiation, vacuum, temperature extremes, and cycling on station design will be evaluated. Considerations with respect to operational effectiveness and crew safety will be discussed. The impact of such factors on spacecraft design to achieve acceptable launch and reentry g levels, crew rotation intervals, etc., will be reviewed. Examples of configurations, subsystems, and internal a arrangement and installations to comply with such biomedical factor requirements will ber presented. The effects of solutions to certain biomedical factors on configuration weight, operational convenience, and program costs will be compared.

Olling, Edward H.↗