Structural investigation of 2-naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Display format and highlight validity were shown to affect visual display search performance; however, these studies were conducted on small, artificial displays of alphanumeric stimuli. A study manipulating these variables was conducted using realistic, complex Space Shuttle information displays. A 2x2x3 within-subjects analysis of variance found that search times were faster for items in reformatted displays than for current displays. Responses to valid applications of highlight were significantly faster than responses to non or invalidly highlighted applications. The significant format by highlight validity interaction showed that there was little difference in response time to both current and reformatted displays when the highlight validity was applied; however, under the non or invalid highlight conditions, search times were faster with reformatted displays. A separate within-subject analysis of variance of display format, highlight validity, and several highlight methods did not reveal a main effect of highlight method. In addition, observed display search times were compared to search time predicted by Tullis' Display Analysis Program. Benefits of highlighting and reformatting displays to enhance search and the necessity to consider highlight validity and format characteristics in tandem for predicting search performance are discussed.
Identification of atmospheric conditions within a multivariate atmospheric dataset is a necessary step in the validation of wind plant control strategies. Most often, operating conditions are characterized in terms of aggregated observations and assume that the atmosphere is 'quasi-steady'. Aggregation of observations without regard to covariance between time series discounts the dynamical nature of the atmosphere and is not sufficiently representative of wind plant operating conditions. Identification and characterization of continuous time periods with atmospheric conditions that have a high value for analysis or simulation sets the stage for more advanced model validation and the development of real-time control and operation strategies. Controlling observational data for statistical stationarity highlights significant enhancements to the power production of waked turbines under wake steering wind plant control. Considering the combined energy ratio of the turbine to which yaw offsets are prescribed as well as the waked turbine show only moderate improvements when filtering for total validation. The same quality control that highlights wake steering also serves to underpin the off-nominal operation of the controlled turbine.
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In this overview talk, I have represented STAR to highlight the results of 19 parallels talks and 38 posters at this Quark Matter Conference. Overall, the contents have 8 major categories: 1. experimental measurements related to the BreitWheeler process and vacuum birefringence; 2. probes of initial states of heavy-ion collisions (parton distribution function and azimuthal correlations in small systems); 3. constraints on temperature-dependent viscosity (η/s(T)) with multiple flow harmonics and rapidity correlations; 4. hard probes using jet structures and heavy flavors; 5. exploration of the origin of global polarization and vorticity; 6. chiral and thermal properties of the QGP; 7. Beam Energy Scan (BES) and the critical point search; 8. upgrades and summary.
Not provided.
This report provides an overview of the new results obtained by the ATLAS Collaboration at the LHC, which were presented at the Quark Matter 2018 conference. Furthermore these measurements were covered in 12 parallel talks, one flash talk and 11 posters. In this document, a discussion of results is grouped into four areas: electromagnetic interactions, jet quenching, quarkonia and heavy-flavour production, and collectivity in small and larger systems. Measurements from the xenon-xenon collisions based on a short run collected in October 2017 are reported for the first time.
The design of the electron-ion collider (EIC) at Brookhaven National Laboratory is well underway, aiming at a peak electron-proton luminosity of 10e+34 cm^-1·sec^-1. This high luminosity, the wide center-of-mass energy range from 29 to 141 GeV (e-p) and the high level of polarization require innovative solutions to maximize the performance of the machine, which makes the EIC one of the most challenging accelerator projects to date. The complexity of the EIC will be discussed, and the project status and plans will be presented.
The videotape includes footage of the following: Voyagers to Jupiter, Pioneer to Saturn, High Energy Astronomy Observatory, space telescope, space shuttle, astronauts Young and Crippen, 10th anniversary of Apollo 11, Skylab reentry, Landsat, satellite freeze warning, Fire Fighting Module, SAGE, wind generators, Solar Energy Project, electric car research, XV-15, HiMAT, and crash worthiness tests.
Display format and highlight validity were shown to affect visual display search performance; however, these studies were conducted on small, artificial displays of alphanumeric stimuli. A study manipulating these variables was conducted using realistic, complex Space Shuttle information displays. A 2x2x3 within-subjects analysis of variance found that search times were faster for items in reformatted displays than for current displays. The significant format by highlight validity interaction showed that there was little difference in response time to both current and reformatted displays when the highlight validity was applied; however, under the non or invalid highlight conditions, search times were faster with reformatted displays. Benefits of highlighting and reformatting displays to enhance search and the necessity to consider highlight validity and format characteristics in tandem for predicting search performance are discussed.
A continuation of 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 1 of 2' (internal ID 2001096942), this video shows highlights from flight day five of STS-102, including the deployment of the Space Shuttle's Robotic Arm and the opening of the hatch between the Unity Module and Leonard Multipurpose Logistics Module by Expedition 1 Commander Bill Shepherd. The activities of flight days 6-14 can be seen on 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 1 of 2' (internal ID 2001096943) and 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 2 of 2' (internal ID 2001096940).
A continuation of 'STS 110 Mission Highlights Resource Tape'. This video, Part 3 of 4, shows footage from flight days 6 through 9 of STS-110. The spacecrew includes Michael J. Bloomfield, Commander Stephen N. Frick, Pilot; Jerry L. Ross, Mission Specialist; Steven L. Smith, Mission Specialist; Ellen Ochoa, Mission Specialist; Lee M.E. Morin, Mission Specialist; Rex J. Walheim, Mission Specialist. On flight day 6, Ross and Morin conduct an EVA (extravehicular activity) to secure a tripod like strut to the S0 Truss of the International Space Station (ISS). They also move the drag link and keel pins from one face of the Truss to the other to free the rail on the truss for a railcar to move. Smith installs a camera onto the CANADARM robotic arm on flight day 7, and on flight day 8 the restraints are removed from the railcar connected to the S0 Truss in preparation for checkout. The checkout of the railcar is shown, including its inaugural run. Ross and Morin conduct another EVA on flight day 9 to complete the outfitting of the S0 Truss Structure. Notable footage includes views of Ross and Morin at work from the helmet-mounted camera on Ross' EVA suit, including close-ups of the pistol grip tool, CANADARM 2 onboard the ISS lit at sunrise, a 'diamond ring' effect formed by the Sun between the Earth's limb and the ISS, a brief shot of the Yucatan peninsula, and a end-to-end pan down the length of the ISS. The activities from other flights days can be seen on "STS 110 Mission Highlights Resource Tape" Part 1 of 4 (internal ID 2002137575), "STS 110 Mission Highlights Resource Tape" Part 2 of 4 (internal ID 2002137573), and "STS 110 Mission Highlights Resource Tape" Part 4 of 4 (internal ID 2002137517).
A continuation of 'STS 110 Mission Highlights Resource Tape'. This video, Part 2 of 4, shows footage from flight days 3 through 5 of STS-110. The flight crew includes Michael J. Bloomfield, Commander; Stephen N. Frick, Pilot; Jerry L. Ross, Mission Specialist; Steven L. Smith, Mission Specialist; Ellen Ochoa, Mission Specialist; Lee M.E. Morin, Mission Specialist; Rex J. Walheim, Mission Specialist. The coverage from flight day 3 includes docking replays of Atlantis and the International Space Station (ISS), and postdocking procedures, as well as intermingling of the flight crew with the Expedition 4 crew (Yury I. Onufrienko, Commander; Daniel W. Bursch, Flight Engineer; Carl E. Walz, Flight Engineer) of the ISS. Flight day 4 includes an EVA (extravehicular activity) in which Walheim and Smith lift the S0 Truss from the payload bay, and temporarily clamp it onto the Destiny laboratory. On flight day 5 a suite of spaceborne experiments (not shown) arrives at Destiny, including protein crystal growth and wheat plant growth experiments. Notable footage includes Hawaii, New Zealand, and sunrise on Atlantis. An unknown object steaks across the field of view during the video, with the Earth in the background. The activities of the other flight days can be seen on 'STS 110 Mission Highlights Resource Tape, Part 1 of 4' (internal ID 2002137575), 'STS 110 Mission Highlights Resource Tape, Part 3 of 4' (internal ID 2002137574), and 'STS 110 Mission Highlights Resource Tape, Part 4 of 4' (internal ID 2002137517).
A continuation of 'STS 110 Mission Highlights Resource Tape'. This video, Part 4 of 4, shows footage from flight days 10 through 12 of STS-110. The spacecrew includes Michael J. Bloomfield, Commander; Stephen N. Frick, Pilot; Jerry L. Ross, Mission Specialist; Steven L. Smith, Mission Specialist; Ellen Ochoa, Mission Specialist; Lee M.E. Morin, Mission Specialist; Rex J. Walheim, Mission Specialist. Flight day 10 includes an exchange of farewells with the Expedition 4 crew (Yury I. Onufrienko, Commander; Daniel W. Bursch, Flight Engineer; Carl E. Walz, Flight Engineer) of the International Space Station (ISS), and undocking. The video includes many views of the ISS as Atlantis departs, including cloud cover and the Earth's limb as backgrounds. There is also a view of Atlantis with its payload bay open. On flight day 11, in preparation for landing, the crew conducts a checkout of flight controls and a test firing. A spaceborne wheat plant experiment onboard the ISS is briefly shown. Flight day 12 includes closing the payload bay, suit-up, and landing. Kennedy Space Center is seen from the air, and the video shows landing replays, as well as a heads-up display view of the landing. Earth views include clear views of Western Sahara, Morocco, Mauritania, and Algeria, with the Atlantic Ocean, a cloud obstructed view of Newfoundland and the Atlantic, Pacific Ocean sun glint, and an excellent view of the Chicago area and Lake Michigan at night. The activities from other flights days can be seen on "STS 110 Mission Highlights Resource Tape" Part 1 of 4 (internal ID 2002137575), "STS 110 Mission Highlights Resource Tape" Part 2 of 4 (internal ID 2002137573), and "STS 110 Mission Highlights Resource Tape" Part 3 of 4 (internal ID 2002137574).
The mission of the NASA Langley Research Center is to increase the knowledge and capability of the United States in a full range of aeronautics disciplines and in selected space disciplines. This mission is accomplished by performing innovative research relevant to national needs and Agency goals, transferring technology to users in a timely manner, and providing development support to other United States Government agencies, industry, other NASA Centers, the educational community, and the local community. This report contains highlights of the major accomplishments and applications that have been made by Langley researchers and by our university and industry colleagues during the past year. The highlights illustrate both the broad range of research and technology (R&T) activities carried out by NASA Langley Research Center and the contributions of this work toward maintaining United States leadership in aeronautics and space research. An electronic version of the report is available at URL http://techreports.larc.nasa.gov/RandT95. This color version allows viewing, retrieving, and printing of the highlights, searching and browsing through the sections, and access to an on-line directory of Langley researchers.
A continuation of 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 1 of 2' (internal ID 2001096942), 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 2 of 2' (internal ID 2001096941), and 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 1 of 2' (internal ID 2001096943), this video shows the activities of flight days 13 and 14 of the STS-102 mission. The landing of the Discovery orbiter is seen from several viewpoints, and the crew of STS-102 (Commander James Wetherbee, Pilot James Kelly, and Mission Specialists Andrew Thomas and Paul Richards) and the Expedition 1 crew (William Shepherd, Yuri Gidzenko, and Sergei Krikalev) are seen as they disembark from Discovery.
This video gives an overview of the first four flight days of the STS-102 mission through a compilation of footage from each day. The crew of STS-102 (Commander James Wetherbee, Pilot James Kelly, and Mission Specialists Andrew Thomas and Paul Richards) and the Expedition 2 crew (Commander Yuriy Usachev and Flight Engineers James Voss and Susan Helms) are seen during the ceremonial breakfast, suitup, and as they board Discovery. The orbiter's launch is seen from several different viewpoints, and various in-flight activities are shown, such as the opening of Discovery's payload bay doors, Helms preparing for the 'H-Reflex Experiment: Effects of Microgravity on the Spine', the rendezvous and docking of Discovery with the International Space Station (ISS), and Helms and Voss preparing for and performing their spacewalks. The crew of STS-102 and both Expedition crews (E1 crew William Shepherd, Yuri Gidzenko, and Sergei Krikalev) are seen in the Destiny Laboratory Module. Activities for flight day five can be seen on 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 2 of 2' (internal ID 2001096941). Flight days 6-14 activities can be seen on 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 1 of 2' (internal ID 2001096943) and 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 2 of 2' (internal ID 2001096940).
A continuation of 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 1 of 2' (internal ID 2001096942) and 'STS-102 Mission Highlight Resource Tape, Part 1 of 2, Tape 2 of 2' (internal ID 2001096941), this video shows the activities of flight days 6-12 of the STS-102 mission. Various on-orbit activities are seen, such as STS-102 Mission Specialists Andrew Thomas and Paul Richards suiting up and performing their spacewalks, Thomas in the Leonardo Multipurpose Logistics Module preparing for the unloading activities, the change of command from the International Space Station's (ISS's) Expedition 1 crew (William Shepherd, Yuri Gidzenko, and Sergei Krikalev) to the Expedition 2 crew (Yuriy Usachev, James Voss, and Susan Helms), and the undocking of the Discovery Orbiter from the ISS. Activities for flight days 13 and 14 can be found on 'STS-102 Mission Highlight Resource Tape, Part 2 of 2, Tape 2 of 2' (internal ID 2001096940).