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At least 19 records

Guiding Requirements for Designing Life Support System Architectures for Crewed Exploration Missions Beyond Low-Earth Orbit

The National Aeronautics and Space Administration's (NASA) technology development roadmaps provide guidance to focus technological development in areas that enable crewed exploration missions beyond low-Earth orbit. Specifically, the technology area roadmap on human health, life support and habitation systems describes the need for life support system (LSS) technologies that can improve reliability and in-flight maintainability within a minimally-sized package while enabling a high degree of mission autonomy. To address the needs outlined by the guiding technology area roadmap, NASA's Advanced Exploration Systems (AES) Program has commissioned the Life Support Systems (LSS) Project to lead technology development in the areas of water recovery and management, atmosphere revitalization, and environmental monitoring. A notional exploration LSS architecture derived from the International Space has been developed and serves as the developmental basis for these efforts. Functional requirements and key performance parameters that guide the exploration LSS technology development efforts are presented and discussed. Areas where LSS flight operations aboard the ISS afford lessons learned that are relevant to exploration missions are highlighted.

Perry, Jay L.

How Environment and Operational Considerations Guide Requirements Development for Clinical Decision Support Beyond Low Earth Orbit

The Aerospace Medical community is acutely aware of the need for automated cognitive systems to support astronauts in responding to and making critical decisions about assessing – and treating - medical conditions and assuring wellness during exploration spaceflight missions. Such systems will be critically important to mission success as we venture farther from terrestrial settings (particularly low-earth orbit platforms) and encounter increasingly Earth-independent medical decision-making scenarios and requirements. This need would likely be met through the development of a Clinical Decision Support System (CDSS) that assimilates information from various sources (e.g., vehicle environmental control system, blood pressure cuff, and heart rate monitor) integrated with medical and wellness data to provide detailed guidance tailored to individual crew member needs. This presentation will address some of the fundamental considerations and their implications that must be fully understood by CDSS requirement developers early in the system lifecycle.

B Burian

SEE Design Guide and Requirements for Electrical Deadfacing

The purpose of this design guide is to present information for understanding and mitigating the potential hazards associated with de-mating and mating powered electrical connectors on space flight vehicles. The process of staging is a necessary function in the launching of space vehicles and in the deployment of satellites, and now in manned assembly of systems in space. During this electrical interconnection process, various environments may be encountered that warrant the restriction of the voltage and current present across the pins of an electrical connector prior to separation, mating, or in a static open non-mated configuration. This process is called deadfacing. These potentially hazardous environments encompass the obvious explosive fuel vapors and human shock hazard, to multiple Electro-Magnetic Interference (EMI) phenomena related to the rapid rate of change in current as well as exposure to Radio Frequency (RF) fields.

Berki, Joe M.

Terrain Relative Navigation for Guided Descent on Titan

Titan’s dense atmosphere, low gravity, and high winds at high altitudes create descent times of >90 minutes with standard entry/descent/landing (EDL) architectures and result in large unguided landing ellipses, with 99% values of 110x110 km and 149x72 km in recent Titan lander proposals. Enabling precision landing on Titan could increase science return for the types of missions proposed to date and make additional types of landing sites accessible, opening up new possibilities for science investigations. Precision landing on Titan has unique challenges, because the hazy atmosphere makes it difficult to see the surface and because it requires guided descent with divert ranges that are one to two orders of magnitude larger than needed for other target bodies, i.e. up to on the order of 100 km. It is conceivable that such a divert capability could be provided economically by a parafoil or other steerable aerodynamic decelerator deployed several 10s of km above the surface. The long descent times lead to large inertial navigation errors, hence a need for terrain relative navigation (TRN). This would require a TRN capability that can operate at such altitudes, despite challenges of seeing the surface sufficiently clearly and of depending on map products that are two orders of magnitude lower in spatial resolution than those for Mars and airless bodies. We then develop algorithms for map matching and feature tracking with descent images and test these with synthetic images created from Cassini/Huygens data sets and our radiative transfer model. We also introduce new possibilities for TRN based on the potential to discriminate some specific types of terrain onboard in descent imagery, such as lake vs adjacent ground and dune vs interdune. We use sensor measurement noise models in simulations of state estimation with an extended Kalman filter that includes coordinates of a set of tracked features in the state vector. Case studies were done for two notional landing sites, one in a site with only dry ground and one in a Titan lake district. In both cases, the filter error model shows 3 position error at touchdown on the order of 2 km. More work is needed to validate these results with higher fidelity camera models and larger data sets, but this is very promising.

Matthies, Larry

BSMV-mediated genome editing exhibits host-specific heritability: germline transmission in barley and somatic edits in Nicotiana benthamiana

Plant RNA virus–mediated guide RNA (gRNA) delivery represents a transformative advance in genome editing technologies. Unlike conventional transformation methods that rely on labor-intensive tissue culture and regeneration for each individual gRNA delivery, viral vectors can rapidly and systemically transmit gRNAs into pre-established Cas-expressing plants, providing an accelerated route for functional genomics and trait discovery directly in planta . However, key design parameters, including subgenomic promoter choice, transcript architecture, and their effects on viral fitness and editing outcomes, remain to be elucidated for most viral platforms. We developed five Barley stripe mosaic virus (BSMV) vectors, each with distinct subgenomic promoter elements to drive single gRNA expression. These were initially evaluated in Cas9-expressing transgenic Nicotiana benthamiana plants targeting the Phytoene desaturase ( PDS ) gene to compare their editing efficiencies. Single gRNAs expressed under the duplicated γb subgenomic promoter or when fused directly to the γb genome achieved the highest mutation frequencies (up to 90% at 60 days post-inoculation), whereas β1- and β2-driven sgRNAs produced delayed and reduced editing. Thus, promoter selection critically determines gRNA accumulation and the efficacy of BSMV-mediated genome editing. The top-performing design was then applied to Cas9-expressing barley ( Hordeum vulgare ) targeting HvCMF7 (conferring green-white variegation) and HvGW2.1 (impacts grain width and weight). BSMV spread systemically throughout barley, inducing somatic and heritable mutations at frequencies up to 100%, with virus-free edited progeny. In contrast, despite robust somatic editing in N. benthamiana, no heritable mutations were detected indicating species-dependent limitations in germline transmission. Our systematic comparison of subgenomic promoter architectures establishes clear design principles for optimizing viral vector–mediated delivery. Promoter choice and transcript structure critically shape editing efficiency and viral stability. The host-specific boundary for germline editing, defined by efficient heritable editing in barley but not N. benthamiana , highlights where BSMV offers advantages and where alternative vectors or hybrid strategies are required, guiding rational platform selection for diverse crop species and applications. Collectively, these findings establish BSMV as a promising next-generation vector for rapid, tissue culture–free, and transformation-independent genome editing in cereals and other recalcitrant monocots.

barley

The moderate resolution imaging spectrometer (MODIS) science and data system requirements

The Moderate Resolution Imaging Spectrometer (MODIS) has been designated as a facility instrument on the first NASA polar orbiting platform as part of the Earth Observing System (EOS) and is scheduled for launch in the late 1990s. The near-global daily coverage of MODIS, combined with its continuous operation, broad spectral coverage, and relatively high spatial resolution, makes it central to the objectives of EOS. The development, implementation, production, and validation of the core MODIS data products define a set of functional, performance, and operational requirements on the data system that operate between the sensor measurements and the data products supplied to the user community. The science requirements guiding the processing of MODIS data are reviewed, and the aspects of an operations concept for the production of data products from MODIS for use by the scientific community are discussed.

Ardanuy, Philip E.

Systems Engineering

This short course provides information on what systems engineering is and how the systems engineer guides requirements, interfaces with the discipline leads, and resolves technical issues. There are many system-wide issues that either impact or are impacted by the thermal subsystem. This course will introduce these issues and illustrate them with real life examples.

Thermal

Functional Interface Considerations within an Exploration Life Support System Architecture

As notional life support system (LSS) architectures are developed and evaluated, myriad options must be considered pertaining to process technologies, components, and equipment assemblies. Each option must be evaluated relative to its impact on key functional interfaces within the LSS architecture. A leading notional architecture has been developed to guide the path toward realizing future crewed space exploration goals. This architecture includes atmosphere revitalization, water recovery and management, and environmental monitoring subsystems. Guiding requirements for developing this architecture are summarized and important interfaces within the architecture are discussed. The role of environmental monitoring within the architecture is described.

Perry, Jay L.

Introduction to Life Support Systems

This course provides an introduction to the design and development of life support systems to sustain humankind in the harsh environment of space. The life support technologies necessary to provide a respirable atmosphere and clean drinking water are emphasized in the course. A historical perspective, beginning with open loop systems employed aboard the earliest crewed spacecraft through the state-of-the-art life support technology utilized aboard the International Space Station today, will provide a framework for students to consider applications to possible future exploration missions and destinations which may vary greatly in duration and scope. Development of future technologies as well as guiding requirements for designing life support systems for crewed exploration missions beyond low-Earth orbit are also considered in the course.

Perry, Jay

Evaluating the Viability of Compact and Portable X-Ray Systems for an Exploration Medical System in a Ground Demonstration

MOTIVATION FOR INCLUDING X-RAY CAPABILITIES For upcoming exploration missions, the need for enhanced medical care becomes critical due to extended mission durations, significant communication delays, and minimal evacuation opportunities. Previous evidence by our team has revealed that among the 119 medical conditions targeted for management during spaceflight within NASA Exploration Medical Capability’s IMPACT Condition List, at least 36 could benefit from radiography (XR). Utilizing XR for diagnosis and management is hypothesized to significantly improve management of crew health by enabling the immediate evaluation and confirmation of potential injuries or illnesses. Beyond clinical applications, XR also holds potential for non-destructive testing (NDT). This includes applications such as assessing the structural integrity of the spacecraft, analyzing surface and meteorite samples, and inspecting onboard electronics. THREE CANDIDATE X-RAY SYSTEMS CHOSEN FOR GROUND DEMONSTRATION The Exploration Medical Capability Element (ExMC) and the Exploration Medical Integrated Product Team (XMIPT) of the Mars Campaign Office initiated early background work for ground demonstrations. In FY21, ExMC published a Concept of Operations to guide requirements development. By FY23, XMIPT and yet2, a technology scouting and open innovation consulting firm, had completed a market survey and trade study to identify potential miniature XR systems. Selection criteria included commercial-off-the-shelf availability, low mass and volume, and regulatory compliance. The top three candidate devices—Remedi REMEX-KA6, MinXray Impact, and FujiFilm Xair—were acquired to characterize the requirements and capabilities of each device. To facilitate testing, phantoms, and radiographic personal protective equipment (PPE) were purchased, and a dedicated space was designated for XRS usage at Glenn Research Center. During this presentation, the mass, volume, and power requirements for each of the three piloted devices are revealed, as well as information regarding the detector, mA, and kV of the devices. GOAL AND OBJECTIVES OF A MINI XRS GROUND DEMONSTRATION The primary goal of ExMC/XMIPT technology demonstrations is to bridge the gap in available, flight-ready medical device technology by flight-testing diagnostic and treatment technologies essential for managing medical conditions during exploration missions. These technologies must adhere to vehicle constraints such as mass, volume, power, and data requirements, integrate seamlessly with medical decision-support tools, and support increasingly Earth-independent operations. There are three main objectives for the future ground demonstration of these three devices. First, we aim to determine the full capabilities of these three miniature XR systems within the context of the spaceflight environment. While medical applications are the primary focus for the miniature XR, a comprehensive exploration of non-medical uses has been initiated by an XMIPT-sponsored NASA SPARK campaign to identify collaborators. Second, we plan to establish criteria and to use insights gained from evaluating each miniature XR against those criteria to select the most suitable system among the three candidates. Third, we intend to evaluate their suitability for flight certification, which includes assessing its durability for launch, reentry, and exposure to high background radiation, as well as its compatibility with existing data architecture systems. Numerous subject matter experts from NASA and partner institutions will support these objectives.

C A Haddix

Technical guide on documentation requirements for open market contract acquisitions of information resources

A guide is presented to assist requestors in formulating and submitting the required Complete Package for Information Resources (IR) acquisitions. Advance discussions with cognizant procurement personnel are strongly recommended for complex IR requirements or for those requestors new to the acquisition process. Open Market means the requirement either is not available on GSA Schedule Contract or exceeds the $300,000 threshold and/or the quantity Maximum Order Limitation of the GSA Schedule Contract. Only open market contract acquisitions (i.e., in excess of the $25,000 small purchase threshold), are addressed.

Shaw, Asa L., Jr.

Automated support requirement system user's guide for nondata entry personnel

ASRS provides the capability to process intercenter/agency support requirements and commitments necessary for support of the Space Shuttle Launch and Landing, Flight, and Cargo operations. The instructions and commands that users will be allowed to utilize are presented. ASRS utilizes a data base stored on Honeywell DPS8 computer. ASRS programs are written in COBOL 74 utilizing the Honeywell DMIV-TP Processing System and the GCOS8 Operating System; they can also be accessed through Telenet or Datanet.

Maryland, J. E., Jr.

Flight feeding systems design and evaluation. Supplement 1: Production guides

The requirements for processing, packaging, testing, and shipment of foods selected for use in the Apollo food system are presented. Specific foodstuffs chosen from the following categories are discussed: (1) soups; (2) juices; (3) breads; (4) meat and poultry products; (5) fruits and nuts; (6) desserts; and (7) beverages. Food procurement for the mobile quarantine facility and for Apollo preflight and postflight activities is also discussed.

Source record

Neural learning rules for the vestibulo-ocular reflex

Mechanisms for the induction of motor learning in the vestibulo-ocular reflex (VOR) were evaluated by recording the patterns of neural activity elicited in the cerebellum by a range of stimuli that induce learning. Patterns of climbing-fiber, vestibular, and Purkinje cell simple-spike signals were examined during sinusoidal head movement paired with visual image movement at stimulus frequencies from 0.5 to 10 Hz. A comparison of simple-spike and vestibular signals contained the information required to guide learning only at low stimulus frequencies, and a comparison of climbing-fiber and simple-spike signals contained the information required to guide learning only at high stimulus frequencies. Learning could be guided by comparison of climbing-fiber and vestibular signals at all stimulus frequencies tested, but only if climbing fiber responses were compared with the vestibular signals present 100 msec earlier. Computational analysis demonstrated that this conclusion is valid even if there is a broad range of vestibular signals at the site of plasticity. Simulations also indicated that the comparison of vestibular and climbing-fiber signals across the 100 msec delay must be implemented by a subcellular "eligibility" trace rather than by neural circuits that delay the vestibular inputs to the site of plasticity. The results suggest two alternative accounts of learning in the VOR. Either there are multiple mechanisms of learning that use different combinations of neural signals to drive plasticity, or there is a single mechanism tuned to climbing-fiber activity that follows activity in vestibular pathways by approximately 100 msec.

NASA Discipline Neuroscience

Bringing the Flight Surgeon Console Into the Artemis Era: Constructing A Quick Reference Guide for the Orion Vehicle

BACKGROUND: Historically, NASA flight surgeons working on control console have had access to a quick reference guide that provides tailored clinical information for a variety of medical conditions, symptoms, and events that crew members may experience on the International Space Station (ISS). With the development of the Orion vehicle and its new medical system intended for the Artemis missions, a new quick reference guide is required to reflect the capabilities of this new medical system. OVERVIEW: The Flight Surgeon Quick Reference Guide(FSQRG)offers a variety of information to flight surgeons. For each condition/symptom/event, the guide describes what actions and procedures crew members will perform either automatically or at the instruction of the flight surgeon. The guide describes what further information should be collected, lists potential diagnoses, and further actions available to be taken by the Flight Surgeon or crew. The guide also describes what medications are available to the crew, common clinical decision-making tools, and other terrestrial practices. Due to the significant differences between the ISS and the Orion vehicle in both structure and mission scope, Orion’s medical system is significantly smaller than the ISS’s. When constructing the new guide for the Orion vehicle we began with the ISS version of the guide as a template. We then replaced ISS crew procedure references with their Orion counterpart if one existed. We also added new Orion crew procedure references where clinically appropriate. Reductions or additions to the medical equipment/medication references were made until they were consistent with resources available on Orion. Finally, we constructed a resource matrix that allows flight surgeons to easily identify the location of medications and equipment required for crew procedures. DISCUSSION: The information provided in the updated FSQRG allows flight surgeons to make quick and clinically accurate decisions that can be accomplished within the scope of the Orion vehicle medical system. This timely and accurate decision making becomes more important as missions go beyond low earth orbit and communication becomes more delayed. Such quick reference guides also have the potential to reflect medical systems on future vehicles, missions, and partner vehicles.

Anderson carter

Magnetic Field Effects on Plasma Plumes

Here, we will discuss our numerical studies of plasma jets and loops, of basic interest for plasma propulsion and plasma astrophysics. Space plasma propulsion systems require strong guiding magnetic fields known as magnetic nozzles to control plasma flow and produce thrust. Propulsion methods currently being developed that require magnetic nozzles include the VAriable Specific Impulse Magnetoplasma Rocket (VASIMR) [1] and magnetoplasmadynamic thrusters. Magnetic nozzles are functionally similar to de Laval nozzles, but are inherently more complex due to electromagnetic field interactions. The two crucial physical phenomenon are thrust production and plasma detachment. Thrust production encompasses the energy conversion within the nozzle and momentum transfer to a spacecraft. Plasma detachment through magnetic reconnection addresses the problem of the fluid separating efficiently from the magnetic field lines to produce maximum thrust. Plasma jets similar to those of VASIMR will be studied with particular interest in dual jet configurations, which begin as a plasma loops between two nozzles. This research strives to fulfill a need for computational study of these systems and should culminate with a greater understanding of the crucial physics of magnetic nozzles with dual jet plasma thrusters, as well as astrophysics problems such as magnetic reconnection and dynamics of coronal loops.[2] To study this problem a novel, hybrid kinetic theory and single fluid magnetohydrodynamic (MHD) solver known as the Magneto-Gas Kinetic Method is used.[3] The solver is comprised of a "hydrodynamic" portion based on the Gas Kinetic Method and a "magnetic" portion that accounts for the electromagnetic behaviour of the fluid through source terms based on the resistive MHD equations. This method is being further developed to include additional physics such as the Hall effect. Here, we will discuss the current level of code development, as well as numerical simulation results

Ebersohn, F.

Evaluation of shoulder integrity in space: first report of musculoskeletal US on the International Space Station

Investigative procedures were approved by Henry Ford Human Investigation Committee and NASA Johnson Space Center Committee for Protection of Human Subjects. Informed consent was obtained. Authors evaluated ability of nonphysician crewmember to obtain diagnostic-quality musculoskeletal ultrasonographic (US) data of the shoulder by following a just-in-time training algorithm and using real-time remote guidance aboard the International Space Station (ISS). ISS Expedition-9 crewmembers attended a 2.5-hour didactic and hands-on US training session 4 months before launch. Aboard the ISS, they completed a 1-hour computer-based Onboard Proficiency Enhancement program 7 days before examination. Crewmembers did not receive specific training in shoulder anatomy or shoulder US techniques. Evaluation of astronaut shoulder integrity was done by using a Human Research Facility US system. Crew used special positioning techniques for subject and operator to facilitate US in microgravity environment. Common anatomic reference points aided initial probe placement. Real-time US video of shoulder was transmitted to remote experienced sonologists in Telescience Center at Johnson Space Center. Probe manipulation and equipment adjustments were guided with verbal commands from remote sonologists to astronaut operators to complete rotator cuff evaluation. Comprehensive US of crewmember's shoulder included transverse and longitudinal images of biceps and supraspinatus tendons and articular cartilage surface. Total examination time required to guide astronaut operator to acquire necessary images was approximately 15 minutes. Multiple arm and probe positions were used to acquire dynamic video images that were of excellent quality to allow evaluation of shoulder integrity. Postsession download and analysis of high-fidelity US images collected onboard demonstrated additional anatomic detail that could be used to exclude subtle injury. Musculoskeletal US can be performed in space by minimally trained operators by using remote guidance. This technique can be used to evaluate shoulder integrity in symptomatic crewmembers after strenuous extravehicular activities or to monitor microgravity-associated changes in musculoskeletal anatomy. Just-in-time training, combined with remote experienced physician guidance, may provide a useful approach to complex medical tasks performed by nonexperienced personnel in a variety of remote settings, including current and future space programs. (c) RSNA, 2004.

Space Flight/education