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At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2002

Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis

The specific biochemical steps required for glucose-regulated insulin exocytosis from beta-cells are not well defined. Elevation of glucose leads to increases in cytosolic [Ca2+]i and biphasic release of insulin from both a readily releasable and a storage pool of beta-granules. The effect of elevated [Ca2+]i on phosphorylation of isolated beta-granule membrane proteins was evaluated, and the phosphorylation of four proteins was found to be altered by [Ca2+]i. One (a 18/20-kDa doublet) was a Ca2+-dependent increase in phosphorylation, and, surprisingly, three others (138, 42, and 36 kDa) were Ca2+-dependent dephosphorylations. The 138-kDa beta-granule phosphoprotein was found to be kinesin heavy chain (KHC). At low levels of [Ca2+]i KHC was phosphorylated by casein kinase 2, but KHC was rapidly dephosphorylated by protein phosphatase 2B beta (PP2Bbeta) as [Ca2+]i increased. Inhibitors of PP2B specifically reduced the second, microtubule-dependent, phase of insulin secretion, suggesting that dephosphorylation of KHC was required for transport of beta-granules from the storage pool to replenish the readily releasable pool of beta-granules. This is distinct from synaptic vesicle exocytosis, because neurotransmitter release from synaptosomes did not require a Ca2+-dependent KHC dephosphorylation. These results suggest a novel mechanism for regulating KHC function and beta-granule transport in beta-cells that is mediated by casein kinase 2 and PP2B. They also implicate a novel regulatory role for PP2B/calcineurin in the control of insulin secretion downstream of a rise in [Ca2+]i.

NASA Discipline Neuroscience↗
NASA NTRS1976

The occultation of beta Scorpii by Jupiter. VII - The angular diameters of beta Scorpii A1 and A2

A new technique for measuring angular diameters of stars, which makes use of stellar images formed by planetary atmospheres during occultations, is described. This method has been applied to light curves of the 1971 May 13 occultation of beta Sco by Jupiter, yielding the angular diameters of the two early B stars comprising the spectroscopic binary beta Sco A. An angular diameter of about .000422 arcsec for beta Sco A1 and about .000264 arcsec is found for beta Sco A2. These angular diameters are in good agreement with that obtained with the intensity interferometer for beta Sco, a star of nearly the same magnitude and spectral type as beta Sco A1. If the distance to beta Sco A were precisely known, beta Sco A1 and A2 would become fundamental standards of mass, luminosity, and radius for early B stars. Present constraints on the distance and methods by which it could be accurately determined are discussed.

Elliot, J. L.↗
NASA NTRS1997

Local Interstellar Medium Properties and Deuterium Abundances for the Lines of Sight Toward HR 1099, 31 Comae, beta Ceti, and beta Cassiopeiae

We analyze Goddard High-Resolution Spectrograph data to infer the properties of local interstellar gas and the Deuterium/Hydrogen (D/H) ratio for lines of sight toward four nearby late-type stars-HR 1099, 31 Comae, beta Ceti, and beta Cassiopeiae. The data consist of spectra of the hydrogen and deuterium Lyman-(alpha) lines, and echelle spectra of the Mg IIh and k lines toward all stars except beta Cas. Spectra of the RS CVn-type spectroscopic binary system HR 1099 were obtained near opposite quadratures to determine the intrinsic stellar emission line profile and the interstellar absorption separately. Multiple-velocity components were found toward HR 1099 and beta Cet. The spectra of 31 Com and beta Cet are particularly interesting because they sample lines of sight toward the north and south Galactic poles, respectively, for which H I and D I column densities were not previously available. The north Galactic pole appears to be a region of low hydrogen density like the 'interstellar tunnel' toward epsilon CMa. The temperature and turbulent velocities of the Local InterStellar Medium (LISM) that we measure for the lines of sight toward HR 1099, 31 Com, beta Cet, and beta Cas are similar to previously measured values (T approx.7000 K and xi = 1.0-1.6 km/s). The deuterium/hydrogen ratios found for these lines of sight are also consistent with previous measurements of other short lines of sight, which suggest D/H approx. 1.6 x 10(sup -5). In contrast, the Mg abundance measured for the beta Cet line of sight (implying a logarithmic depletion of D(Mg) = +0.30 +/- 0.15) is about 5 times larger than the Mg abundance previously observed toward alpha Cen, and about 20 times larger than all other previous measurements for the LISM. These results demonstrate that metal abundances in the LISM vary greatly over distances of only a few parsecs.

Piskunov, Nikolai↗
NASA NTRS1993

The Beta Pictoris circumstellar disk. XV - Highly ionized species near Beta Pictoris

Temporal variations of the Fe II, Mg II, and Al III circumstellar lines towards Beta Pictoris have been detected and monitored since 1985. However, the unusual presence of Al III ions is still puzzling, since the UV stellar flux from an A5V star such as Beta Pic is insufficient to produce such an ion. In order to better define the origin of such a phenomenon, new observations have been carried out to detect faint signatures of other highly ionized species in the short UV wavelength range, where the stellar continuum flux is low. These observations reveal variations not only near the C IV doublet lines, but also in C I and Al II lines, two weakly ionized species, not clearly detectable until now. In the framework of an infalling body scenario, highly ionized species would be created in the tail, far from the comet head, by collisions with ambient gas surrounding the star, or a weak stellar wind. Spectral changes have also been detected near a CO molecular band location, which, if confirmed, would provide the first molecular signature around Beta Pictoris.

Deleuil, M.↗
NASA NTRS1975

Edge-defined film-fed growth of beta-alumina and Mg-substituted beta-alumina

High Na vapor pressure, peritectic decomposition, and high reactivity of the melt complicate the growth of beta-alumina crystals. These difficulties were overcome by using a high-pressure (300 psig) growth chamber, Na2O-rich melts, and Ir for all surfaces in contact with the melt. These procedures were combined with the edge-defined film-fed growth technique to produce single-crystal beta-alumina tubes and ribbons.

Morrison, A. D.↗
NASA NTRS1975

Occultation of beta Scorpii by Jupiter. V - The emersion of beta Scorpii C

Use of multicolor photometry to remove planetary limb contamination from occultation light curves is demonstrated. This color restoration procedure is shown to be more advantageous than limb scanning techniques since it allows continuous observation of the occultation. Sharp spikes appearing in the light curve of beta Sco C are compared with those observed during the occultation of beta Sco AB, and a model is developed for estimating the effects of all factors affecting the observed shape of a spike. The widths of the narrowest spikes are shown to correspond closely to the angular diameters of the occulted stars, suggesting that occultation spikes can be used to determine stellar diameters.

Elliot, J. L.↗
NASA NTRS2002

Multiperiodicity in the Light Variations of the Beta Cephei Star Beta Crucis

High-resolution spectroscopic observations have led recently to the discovery that the beta Cephei star beta Crucis (Mimosa) is multiperiodic with at least three non-radial pulsation modes. Data obtained by the star tracker of the WIRE satellite have now allowed us to confirm this multiperiodicity in the light variations. A total of 5 million observations covering 17 days was analyzed and the three main periods we find in this work are in perfect agreement with the results derived from the line profile variations. The photometric amplitudes are small (3, 2.7 and 0.6 millimag for the dominant modes), but this is not surprising in view of the mode identifications derived earlier from the line profiles. Additional periods of low-amplitude modes (between 0.2-0.3 mmag) are also derived, including one suggested earlier by the radial velocity data.

Cuypers, J.↗
NASA NTRS1972

Ultraviolet observations of beta Canis majoris and beta Cephei

Ultraviolet spectra of the two variables exhibit periodic variations in the H I, Si IV, and C IV resonance lines. Later scans of the beta Cep atmosphere show that the C IV line disappeared for short periods. Three possible mechanisms for this effect are: a beat phenomenon, shock waves, or tidal distortions. It is concluded that a tidal distortion is possible if the period of revolution is 12 days and if the inclination is sufficiently small to keep one tidal bulge out of sight and large enough to keep the secondary from eclipsing the primary bulge.

Fischel, D.↗
NASA NTRS1975

The occultation of beta Scorpii by Jupiter. VI - The masses of beta Scorpii A1 and A2

From images of the spectroscopic binary beta Sco A, formed by the Jovian atmosphere during its 1971 May 13 occultation by Jupiter, the angular separation of the binary components was found to be 0.001496 plus of minus 0.000018 arcsec. The combination of this measurement, the elements of the spectroscopic orbit, and the parallax determination of Bertiau (1958) yields masses of 21.1 plus or minus 3.2 solar masses for the primary (B0.5 V) and 12.7 plus or minus 1.9 solar masses for the secondary. New observations are suggested for improving the accuracy of the mass determinations.

Elliot, J. L.↗
NASA NTRS2002

Multiperiodicity in the Light Variations of the Beta Cephei Star Beta Crucis

High-resolution spectroscopic observations have led recently to the discovery that the P Cephei star Beta Crucis (Mimosa) is multiperiodic with at least three non-radial pulsation modes. Data obtained by the star tracker of the WIRE satellite have now allowed us to confirm this multiperiodicity in the light variations. A total of five million observations covering 17 days was analyzed and the three main periods we find in this work are in perfect agreement with the results derived from the line profile variations. The photometric amplitudes are small (3, 2.7 and 0.6 millimag for the dominant modes), but this is not surprising in view of the mode identifications derived earlier from the line profiles. Additional periods of low-amplitude modes (between 0.2-0.3 mmag) are also derived, including one suggested earlier by the radial velocity data.

Cuypers, J.↗
NASA NTRS1990

Isomerization of 1-O-indol-3-ylacetyl-beta-D-glucose. Enzymatic hydrolysis of 1-O, 4-O, and 6-O-indol-3-ylacetyl-beta-D-glucose and the enzymatic synthesis of indole-3-acetyl glycerol by a hormone metabolizing complex

The first compound in the series of reactions leading to the ester conjugates of indole-3-acetic acid (IAA) in kernels of Zea mays sweet corn is the acyl alkyl acetal, 1-O-indol-3-ylacetyl-beta-D-glucose (1-O-IAGlu). The enzyme catalyzing the synthesis of this compound is UDP-glucose:indol-3-ylacetate glucosyl-transferase (IAGlu synthase). The IAA moiety of the high energy compound 1-O-IAGlu may be enzymatically transferred to myo-inositol or to glycerol or the 1-O-IAGlu may be enzymatically hydrolyzed. Alternatively, nonenzymatic acyl migration may occur to yield the 2-O, 4-O, and 6-O esters of IAA and glucose. The 4-O and 6-O esters may then be enzymatically hydrolyzed to yield free IAA and glucose. This work reports new enzymatic activities, the transfer of IAA from 1-O-IAGlu to glycerol, and the enzyme-catalyzed hydrolysis of 4-O and 6-O-IAGlu. Data is also presented on the rate of non-enzymatic acyl migration of IAA from the 1-O to the 4-O and 6-O positions of glucose. We also report that enzymes catalyzing the synthesis of 1-O-IAGlu and the hydrolysis of 1-O, 4-O, and 6-O-IAGlu fractionate as a hormone metabolizing complex. The association of synthetic and hydrolytic capabilities in enzymes which cofractionate may have physiological significance.

Non-NASA Center↗
NASA NTRS1995

Expression of S100 beta in sensory and secretory cells of the vertebrate inner ear

We evaluated anti-S100 beta expression in the chick (Gallus domesticus) inner ear and determined that: 1) the monomer anti-S100 beta is expressed differentially in the vestibular and auditory perikarya; 2) expression of S100 beta in the afferent nerve terminals is time-related to synapse and myelin formation; 3) the expression of the dimer anti-S100 alpha alpha beta beta and monomer anti-S100 beta overlaps in most inner ear cell types. Most S100 alpha alpha beta beta positive cells express S100 beta, but S100 beta positive cells do not always express S100 alpha alpha beta beta. 4) the expression of S100 beta is diffused over the perikaryal cytoplasm and nuclei of the acoustic ganglia but is concentrated over the nuclei of the vestibular perikarya. 6) S100 beta is expressed in secretory cells, and it is co-localized with GABA in sensory cells. 7) Color thresholding objective quantitation indicates that the amount of S100 beta was higher (mean 22, SD +/- 4) at E19 than at E9 (mean 34, SD +/- 3) in afferent axons. 8) Moreover, S100 beta was unchanged between E11-E19 in the perikaryal cytoplasm, but did change over the nuclei. At E9, 74%, and at E21, 5% of vestibular perikarya were positive. The data suggest that S100 beta may be physically associated with neuronal and ionic controlling cells of the vertebrate inner ear, where it could provide a dual ionic and neurotrophic modulatory function.

NASA Discipline Number 40-10↗
NASA NTRS1995

Immunohistochemical detection of active transforming growth factor-beta in situ using engineered tissue

The biological activity of transforming growth factor-beta 1 (TGF-beta) is governed by dissociation from its latent complex. Immunohistochemical discrimination of active and latent TGF-beta could provide insight into TGF-beta activation in physiological and pathological processes. However, evaluation of immunoreactivity specificity in situ has been hindered by the lack of tissue in which TGF-beta status is known. To provide in situ analysis of antibodies to differentiate between these functional forms, we used xenografts of human tumor cells modified by transfection to overexpress latent TGF-beta or constitutively active TGF-beta. This comparison revealed that, whereas most antibodies did not differentiate between TGF-beta activation status, the immunoreactivity of some antibodies was activation dependent. Two widely used peptide antibodies to the amino-terminus of TGF-beta, LC(1-30) and CC(1-30) showed marked preferential immunoreactivity with active TGF-beta versus latent TGF-beta in cryosections. However, in formalin-fixed, paraffin-embedded tissue, discrimination of active TGF-beta by CC(1-30) was lost and immunoreactivity was distinctly extracellular, as previously reported for this antibody. Similar processing-dependent extracellular localization was found with a neutralizing antibody raised to recombinant TGF-beta. Antigen retrieval recovered cell-associated immunoreactivity of both antibodies. Two antibodies to peptides 78-109 showed mild to moderate preferential immunoreactivity with active TGF-beta only in paraffin sections. LC(1-30) was the only antibody tested that discriminated active from latent TGF-beta in both frozen and paraffin-embedded tissue. Thus, in situ discrimination of active versus latent TGF-beta depends on both the antibody and tissue preparation. We propose that tissues engineered to express a specific form of a given protein provide a physiological setting in which to evaluate antibody reactivity with specific functional forms of a protein.

NASA Discipline Radiation Health↗
NASA NTRS1996

Redox-mediated activation of latent transforming growth factor-beta 1

Transforming growth factor beta 1 (TGF beta) is a multifunctional cytokine that orchestrates response to injury via ubiquitous cell surface receptors. The biological activity of TGF beta is restrained by its secretion as a latent complex (LTGF beta) such that activation determines the extent of TGF beta activity during physiological and pathological events. TGF beta action has been implicated in a variety of reactive oxygen-mediated tissue processes, particularly inflammation, and in pathologies such as reperfusion injury, rheumatoid arthritis, and atherosclerosis. It was recently shown to be rapidly activated after in vivo radiation exposure, which also generates reactive oxygen species (ROS). In the present studies, the potential for redox-mediated LTGF beta activation was investigated using a cell-free system in which ROS were generated in solution by ionizing radiation or metal ion-catalyzed ascorbate reaction. Irradiation (100 Gray) of recombinant human LTGF beta in solution induced 26% activation compared with that elicited by standard thermal activation. Metal-catalyzed ascorbate oxidation elicited extremely efficient recombinant LTGF beta activation that matched or exceeded thermal activation. The efficiency of ascorbate activation depended on ascorbate concentrations and the presence of transition metal ions. We postulate that oxidation of specific amino acids in the latency-conferring peptide leads to a conformation change in the latent complex that allows release of TGF beta. Oxidative activation offers a novel route for the involvement of TGF beta in tissue processes in which ROS are implicated and endows LTGF beta with the ability to act as a sensor of oxidative stress and, by releasing TGF beta, to function as a signal for orchestrating the response of multiple cell types. LTGF beta redox sensitivity is presumably directed toward recovery of homeostasis; however, oxidation may also be a mechanism of LTGF beta activation that can be deleterious during disease mechanisms involving chronic ROS production.

Non-NASA Center↗
NASA NTRS2010

High LET Radiation Can Enhance TGF(Beta) Induced EMT and Cross-Talk with ATM Pathways

The TGF(Beta) pathway has been shown to regulate or directly interact with the ATM pathway in the response to radiation in mammary epithelial cells. We investigated possible interactions between the TGF(Beta) and ATM pathways following simulated space radiation using hTERT immortalized human esophageal epithelial cells (EPC-hTERT), mink lung epithelial cells (Mv1lu), and several human fibroblast cell lines. TGF(Beta) is a key modulator of the Epithelial-Mesenchymal Transition (EMT), important in cancer progression and metastasis. The implication of EMT by radiation also has several lines of developing evidence, however is poorly understood. The identification of TGF(Beta) induced EMT can be shown in changes to morphology, related gene over expression or down regulation, which can be detected by RT-PCR, and immunostaining and western blotting. In this study, we have observed morphologic and molecular alternations consistent with EMT after Mv1lu cells were treated with TGF(Beta) High LET radiation enhanced TGF(Beta) mediated EMT with a dose as low as 0.1Gy. In order to consider the TGF(Beta) interaction with ATM we used a potent ATM inhibitor Ku55933 and investigated gene expression changes and Smad signaling kinetics. Ku559933 was observed to reverse TGF(Beta) induced EMT, while this was not observed in dual treated cells (radiation+TGF(Beta)). In EPC-hTERT cells, TGF(Beta) alone was not able to induce EMT after 3 days of application. A combined treatment with high LET, however, significantly caused the alteration of EMT markers. To study the function of p53 in the process of EMT, we knocked down P53 through RNA interference. Morphology changes associated with EMT were observed in epithelial cells with silenced p53. Our study indicates: high LET radiation can enhance TGF(Beta) induced EMT; while ATM is triggering the process of TGF(Beta)-induced EMT, p53 might be an essential repressor for EMT phenotypes.

Wang, Minli↗
NASA NTRS1993

Beta Regio rift system on Venus: Geologic interpretation of Magellan images

Magellan SAR images and altimetric data were used to produce a new geologic map of the Northern part of Beta Regio within the frames of C1-30N279 mapsheet. It was part of our contributions into C1-formate geologic mapping efforts. The original map is at 1:8,000,000 scale. The rift structures are typical for Beta Regio on Venus. There are many large uplifted tessera areas on Beta upland. They occupy areas of higher topography. These tessera are partly burried by younger volcanic cover of plain material. These observations show that Beta upland was formed mainly due to lithospheric tectonical uplifting, and only partly was constructed by volcanic activity. A number of rift valleis traverse Beta upland and spread to the surrounding lowlands. The largest rift crosses Beta N to S. Typical width of rifts is 40 to 160 km. Rift valleis in this region are structurally represented by crustal grabens and half-grabens. There are symmetrical and asymmetrical rifts. A lot of them have shoulder uplifts with the relative high up to 0.5-1 km and width 40 to 60 km. Preliminary analysis of the largest rift valley structural cross-sections leads to the conclusion that it originated due to a 5-10 percent crustal extension. The prominent shield volcano - Theia Mons - is located at the center of Beta rift system. It could be considered as the surface manifestation of the upper mantle hot spot. Most of the rift belts are located radially to Theia Mons. The set of these data leads to conclusion that Beta rift system has an 'active-passive' origin. It was formed due to the regional tectonic lithospheric extension. Rifting was accelerated by the upper mantle hot spot located under the center of passive extension (under Beta Regio).

Nikishin, A. M.↗
NASA NTRS1999

Beta in Streamers

Streamers are often described as regions of the corona in which the density is higher than in coronal holes because the plasma is trapped by closed loops of magnetic flux. In contrast, Magnetohydrodynamics (MHD) models of the global corona show that the plasma beta identically equal to 8(pi)p/B(exp 2) > 1 in streamers above approximately 1.2Rs heliocentric height (p=pressure, B=magnetic field strength). There are three recent contributions to this topic. The first is that heating near the cusp further drives Beta up and can result in release of new slow solar wind from the top of the streamer. The second is SOHO/UVCS observations, in combination with a potential field/source surface model of the magnetic field, show beta > 1 above 1.2Rs in a streamer observed near solar sunspot minimum. The third is a magnetic field reconstruction technique (using field deforming algorithms) which was applied both to an isolated active region (AR 7999) and to the Pneuman & Kopp global MHD model. In the active region, beta becomes larger than unity at approximately 1.2Rs. In the Pneuman & Kopp model, beta = 1.0 at the base of the streamer and rises with increasing height, becoming 15-20 at 1.6Rs and 35-55 at 1.7RS. The collective implication of these three results is that beta > 1 everywhere in streamers above approximately 1.2 Rs. Global simulations go on to show that the reason streamers do not simply explode under such high beta conditions is that they are held down by pressure from the sides due to the magnetic fields (and low beta) in adjacent coronal holes. The main role of the closed magnetic loops near the cusp is to keep the streamer from continuously leaking plasma, as otherwise happens in a magnetic pinch which is similar but has no closed loops. The purpose of this note is to summarize the results implying that beta > 1 is a general property of streamers above 1.2 Rs.

Suess, Steven T.↗