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At least 19 records

Trending in Probability of Collision Measurements via a Bayesian Zero-Inflated Beta Mixed Model

We investigate the performance of a generalized linear mixed model in predicting the Probabilities of Collision (Pc) for conjunction events. Specifically, we apply this model to the log(sub 10) transformation of these probabilities and argue that this transformation yields values that can be considered bounded in practice. Additionally, this bounded random variable, after scaling, is zero-inflated. Consequently, we model these values using the zero-inflated Beta distribution, and utilize the Bayesian paradigm and the mixed model framework to borrow information from past and current events. This provides a natural way to model the data and provides a basis for answering questions of interest, such as what is the likelihood of observing a probability of collision equal to the effective value of zero on a subsequent observation.

Conjuction Assessment↗

A Bayesian nonparametric analysis for zero-inflated multivariate count data with application to microbiome study

High-throughput sequencing technology has enabled researchers to profile microbial communities from a variety of environments, but analysis of multivariate taxon count data remains challenging. Here, we develop a Bayesian nonparametric (BNP) regression model with zero inflation to analyse multivariate count data from microbiome studies. A BNP approach flexibly models microbial associations with covariates, such as environmental factors and clinical characteristics. The model produces estimates for probability distributions which relate microbial diversity and differential abundance to covariates, and facilitates community comparisons beyond those provided by simple statistical tests. We compare the model to simpler models and popular alternatives in simulation studies, showing, in addition to these additional community-level insights, it yields superior parameter estimates and model fit in various settings. The model's utility is demonstrated by applying it to a chronic wound microbiome data set and a Human Microbiome Project data set, where it is used to compare microbial communities present in different environments.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Trending in Pc Measurements via a Bayesian Zero-Inflated Mixed Model

Two satellites predicted to come within close proximity of one another, usually a high-value satellite and a piece of space debris moving the active satellite is a means of reducing collision risk but reduces satellite lifetime, perturbs satellite mission, and introduces its own risks. So important to get a good statement of the risk of collision in order to determine whether a maneuver is truly necessary. Two aspects of this Calculation of the Probability of Collision (Pc) based on the most recent set of position velocity and uncertainty data for both satellites. Examination of the changes in the Pc value as the event develops. Events should follow a canonical development (Pc vs time to closest approach (TCA)). Helpful to be able to guess where the present data point fits in the canonical development in order to guide operational response.

Conjuction Assessment↗

Deep structural clustering for single-cell RNA-seq data jointly through autoencoder and graph neural network

Abstract Single-cell RNA sequencing (scRNA-seq) permits researchers to study the complex mechanisms of cell heterogeneity and diversity. Unsupervised clustering is of central importance for the analysis of the scRNA-seq data, as it can be used to identify putative cell types. However, due to noise impacts, high dimensionality and pervasive dropout events, clustering analysis of scRNA-seq data remains a computational challenge. Here, we propose a new deep structural clustering method for scRNA-seq data, named scDSC, which integrate the structural information into deep clustering of single cells. The proposed scDSC consists of a Zero-Inflated Negative Binomial (ZINB) model-based autoencoder, a graph neural network (GNN) module and a mutual-supervised module. To learn the data representation from the sparse and zero-inflated scRNA-seq data, we add a ZINB model to the basic autoencoder. The GNN module is introduced to capture the structural information among cells. By joining the ZINB-based autoencoder with the GNN module, the model transfers the data representation learned by autoencoder to the corresponding GNN layer. Furthermore, we adopt a mutual supervised strategy to unify these two different deep neural architectures and to guide the clustering task. Extensive experimental results on six real scRNA-seq datasets demonstrate that scDSC outperforms state-of-the-art methods in terms of clustering accuracy and scalability. Our method scDSC is implemented in Python using the Pytorch machine-learning library, and it is freely available at https://github.com/DHUDBlab/scDSC.

Gan, Yanglan↗

Zero-Truncated Poisson Tensor Decomposition for Sparse Count Data

We propose a novel statistical inference paradigm for zero-inflated multiway count data that dispenses with the need to distinguish between true and false zero counts. Our approach ignores all zero entries and applies zero-truncated Poisson regression on the positive counts. Inference is accomplished via tensor completion that imposes low-rank structure on the Poisson parameter space. Our main result shows that an $\textit{N}$-way rank-R parametric tensor 𝓜 ϵ (0, ∞) $I$Χ∙∙∙Χ$I$ generating Poisson observations can be accurately estimated from approximately $IR^2 \text{log}^2_2(I)$ non-zero counts for a nonnegative canonical polyadic decomposition. Several numerical experiments are presented demonstrating that our zero-truncated paradigm is comparable to the ideal scenario where the locations of false zero counts are known $\textit{a priori}$.

97 MATHEMATICS AND COMPUTING↗

Investigating the impact of environmental factors on West Nile virus human case prediction in Ontario, Canada

West Nile virus is the most common mosquito borne disease in North America and the leading cause of viral encephalitis. West Nile virus is primarily transmitted between birds and mosquitoes while humans are incidental, dead-end hosts. Climate change may increase the risk of human infections as climatic variables have been shown to affect the mosquito life cycle, biting rate, incubation period of the disease in mosquitoes, and bird migration patterns. We develop a zero-inflated Poisson model to investigate how human West Nile virus case counts vary with respect to mosquito abundance and infection rates, bird abundance, and other environmental covariates. We use a Bayesian paradigm to fit our model to data from 2010–2019 in Ontario, Canada. Our results show mosquito infection rate, temperature, precipitation, and crow abundance are positively correlated with human cases while NDVI and robin abundance are negatively correlated with human cases. We find the inclusion of spatial random effects allows for more accurate predictions, particularly in years where cases are higher. Our model is able to accurately predict the magnitude and timing of yearly West Nile virus outbreaks and could be a valuable tool for public health officials to implement prevention strategies to mitigate these outbreaks.

60 APPLIED LIFE SCIENCES↗

Territory and Population Attributes Affect Florida Scrub-Jay Fecundity in Fire Adapted Ecosystems

Fecundity, the number of young produced by a breeding pair during a breeding season, is a primary component in evolutionary and ecological theory and applications. Fecundity can be influenced by many environmental factors and requires long-term study due to the range of variation in ecosystem dynamics. Fecundity data often include a large proportion of zeros when many pairs fail to produce any young during a breeding season due to nest failure or when all young die independently after fledging. We conducted color banding and monthly censuses of Florida scrub-jays (Aphelocoma coerulescens) across 31 years, 15 populations, and 761 territories along central Florida’s Atlantic coast. We quantified how fecundity (juveniles/pair-year) was influenced by habitat quality, presence/absence of nonbreeders, population density, breeder experience, and rainfall, with a zero-inflated Bayesian hierarchical model including both a Bernoulli (e.g., brood success) and a Poisson (counts of young) submodel, and random effects for year, population, and territory. The results identified the importance of increasing “strong” quality habitat, which was a mid-successional state related to fire frequency and extent, because strong territories, and the proportion of strong territories in the overall population, influenced fecundity of breeding pairs. Populations subject to supplementary feeding also had greater fecundity. Territory size, population density, breeder experience, and rainfall surprisingly had no or small effects. Different mechanisms appeared to cause annual variation in fecundity, as estimates of random effects were not correlated between the success and count submodels. The increased fecundity for pairs with nonbreeders, compared to pairs without, identified empirical research needed to understand how the proportion of low-quality habitats influences population recovery and sustainability, because dispersal into low-quality habitats can drain nonbreeders from strong territories and decrease overall fecundity. We also describe how long term study resulted in reversals in our understanding because of complications involving habitat quality, sociobiology, and population density.

Long-term studies↗

Seasonal variation in methane ebullition in a temperate hydropower reservoir impacts annualized estimates

Estimates of ebullitive methane (CH4) emissions from reservoirs are highly uncertain, often based on spatial and temporal upscaling from a limited number of sampling sites and periods. While some of these estimates may adjust for seasonal variation in temperature, they rarely account for drawdown and the resulting changes in site depth and the areal extent of the reservoir. In Douglas Reservoir (Tennessee, USA), we conducted monthly sampling of 20 sites over 1 year to capture temporal and spatial variation in CH4 ebullition. We then compared various approaches for obtaining annualized, whole-reservoir ebullition estimates. CH4 ebullition fluxes were zero-inflated and highly skewed, with fluxes rising appreciably above zero in July and peaking in autumn. Estimates that did not account for drawdown overestimated annualized rates by 20%, though with high uncertainty. Seasonal variability and hotspots strongly influence annualized ebullition estimates and are important to account for in inventories and global upscaling.

Cardall, Anna [Brigham Young University]↗

Spatial patterns in occupancy and density of larval lampreys in freshwater habitats restored to a Stage 0 condition

Abstract We examined occupancy and density of larval lampreys ( Entosphenus tridentatus and Lampetra spp.) in two rivers in Oregon (USA) restored to a Stage 0 condition 1–5 years prior, using a multiscale occupancy model and a zero‐inflated Poisson mixture model. We sampled lampreys using backpack electrofishing in randomly distributed, paired, 1‐m 2 quadrats and recorded environmental data. Probabilities of occupancy and density were higher when water velocity was low, the substrate was noncompacted, and sediment was dominated by fines (<4 mm). At mean water depth (0.34 m) and velocity (0.09 m/s), estimated densities in occupied quadrats were 4.8 lampreys/m 2 (95%: 3.4–6.9) when the substrate was compacted, and fines were not dominant, and 21.1 lampreys/m 2 (95%: 17.7–25.3) when the substrate was noncompacted and fines were dominant. Probabilities of detecting occupancy in a 1‐m 2 quadrat sampled by backpack electrofishing were 0.76 (95%: 0.64–0.87) when captured after visual observation and 0.80 (95%: 0.71–0.88) with blind sweeps (i.e., constantly moving the net regardless of observation). The probability of capturing a single lamprey in a quadrat sampled by blind sweeps was 0.32 (95%: 0.27–0.37). Sampling in paired 1‐m 2 quadrats facilitated concurrent examination of patterns in occupancy and density while accounting for capture probability, which could aid temporal monitoring of restored habitats. To the best of our knowledge, this is the first study to document occupancy and estimate densities of larval lampreys in habitats that underwent valley floor restoration to Stage 0. We observed both lamprey genera within 5 years of restoration. Aquatic restoration that increases low‐velocity, noncompacted, fine sediment habitats could benefit lampreys.

Harris, Julianne E.↗

Prescribed fires, smoke exposure, and hospital utilization among heart failure patients

Abstract Background Prescribed fires often have ecological benefits, but their environmental health risks have been infrequently studied. We investigated associations between residing near a prescribed fire, wildfire smoke exposure, and heart failure (HF) patients’ hospital utilization. Methods We used electronic health records from January 2014 to December 2016 in a North Carolina hospital-based cohort to determine HF diagnoses, primary residence, and hospital utilization. Using a cross-sectional study design, we associated the prescribed fire occurrences within 1, 2, and 5 km of the patients’ primary residence with the number of hospital visits and 7- and 30-day readmissions. To compare prescribed fire associations with those observed for wildfire smoke, we also associated zip code-level smoke density data designed to capture wildfire smoke emissions with hospital utilization amongst HF patients. Quasi-Poisson regression models were used for the number of hospital visits, while zero-inflated Poisson regression models were used for readmissions. All models were adjusted for age, sex, race, and neighborhood socioeconomic status and included an offset for follow-up time. The results are the percent change and the 95% confidence interval (CI). Results Associations between prescribed fire occurrences and hospital visits were generally null, with the few associations observed being with prescribed fires within 5 and 2 km of the primary residence in the negative direction but not the more restrictive 1 km radius. However, exposure to medium or heavy smoke (primarily from wildfires) at the zip code level was associated with both 7-day (8.5% increase; 95% CI = 1.5%, 16.0%) and 30-day readmissions (5.4%; 95% CI = 2.3%, 8.5%), and to a lesser degree, hospital visits (1.5%; 95% CI: 0.0%, 3.0%) matching previous studies. Conclusions Area-level smoke exposure driven by wildfires is positively associated with hospital utilization but not proximity to prescribed fires.

Raab, Henry↗

Social Disparities of Pain and Pain Intensity Among Women Diagnosed With Early Stage Breast Cancer

Background: Breast cancer is one of the most commonly diagnosed cancers among women in the United States and pain is the most common side effect of breast cancer and its treatment. Yet, the relationships between social determinants of pain and pain experience/intensity remain under-investigated. We examined the associations between social determinants of pain both at the individual level and the neighborhood level to understand how social conditions are associated with pain perception among early stage breast cancer patients. Methods: We conducted integrated statistical analysis of 1,191 women with early stage breast cancer treated at a large cancer center in Memphis, Tennessee. Combining electronic health records, patient-reported data and census data regarding residential address at the time of first diagnosis, we evaluated the relationships between social determinants and pain perception. Pain responses were self-reported by a patient as a numerical rating scale score at the patient’s initial diagnosis and follow-up clinical visits. We implemented two sets of statistical analyses of the zero-inflated Poisson model and estimated the associations between neighborhood poverty prevalence and breast cancer pain intensity. After adjustment for demographic characteristics, cancer stage, and chemotherapy, pain perception was significantly associated with poverty and blight level of the neighborhood. Results: Among women living in the highest-poverty areas, the odds of reporting pain were 2.48 times higher than those in the lowest-poverty area. Women living in the highest-blight area had 5.43 times higher odds of reporting pain than those in the lowest-blight area. Neighborhood-level social determinants were significantly associated with pain intensity among women diagnosed with early-stage breast cancer. Conclusions: Distressed neighborhood conditions are significantly associated with higher pain perception. Breast cancer patients living in socio-economically disadvantaged neighborhoods and in poor environmental conditions reported higher pain severity compared to patients from less distressed neighborhoods. Therefore, post-diagnosis pain treatment design needs to be tailored to the social determinants of the breast cancer patients.

60 APPLIED LIFE SCIENCES↗

Tire footprint studies

This presentation covers the results of tire footprint studies conducted in the Landing Gear Development Facility of the USAF Wright Laboratory at the Wright Patterson Air force Base, OH. Tire footprint studies are essential in understanding tire wear mechanisms and computing tire tread wear rates. The power input into the tread is the driving force for tread wear. Variables needed for power input calculations include the footprint pressure and slip velocity distributions. Studies were performed on the effects of power input distributions due to vertical load, camber, yaw, inflation pressure, and tire construction. For the present study, two tire constructions, one radial and the other bias, were selected. These tires were for the F-16 Block 30 fighter aircraft, both of which were previously worn. The present study was limited to steady straight roll with a 14,000 lb vertical load, a 310 psi inflation pressure, and zero yaw and camber. All tests were conducted on the Tire Force Machine (TFM) with a specialized sensor plate with embedded pressure sensors (X, Y, and Z) and slip sensors (X and Y). All tests were conducted for a table speed of 1 in/s. Tests on the TFM show that the power intensity distributions and total power for both tire constructions are quite similar for straight roll. Later on, tests were also conducted on a modified dynamometer which was overlaid with a grit wear surface. The tire speed was maintained at 40 miles per hour and yaw was set to four degrees. Dynamometer tests showed that radial tires have more tread wear than the bias tire; however, in the field, radial tires have longer life.

Chawla, Mangal↗

Quick-disconnect inflatable seal assembly

A zero-leak cryogenic coupling includes a polymeric seal clamped to a male bayonet member with two pairs of tightening rings. The tightening rings threadably engage each other in respective pairs around tapered ends of the inflatable seal member so that a wedging action tightness the seal member about the male bayonet. Once in place, the seal may be inflated via an inflation port so that its expansion provides a pressure contact with the inside surface of a coaxial female member.

Kurt D Buehler↗

Evaluation of Design Concepts for Collapsible Cryogenic Storage Vessels

Future long-duration missions to Mars using in situ resource production to obtain oxygen from the Martian atmosphere for use as a propellant or for life support will require long term oxygen storage facilities. This report describes preliminary analysis of design concepts for lightweight, collapsible liquid oxygen storage tanks to be used on the surface of Mars. With storage at relatively low pressures, an inflatable tank concept in which the cryogen is stored within a fiber-reinforced Teflon FEP bladder is an efficient approach. The technology required for such a tank is well-developed through similar previous applications in positive expulsion bladders for zero-g liquid fuel rocket tanks and inflatable space habitat technology, though the liquid oxygen environment presents unique challenges. The weight of the proposed structure is largely dominated by the support structure needed to hold the tank off the ground and permit a vacuum insulation space to be maintained around the tank. In addition to the inflatable tank concept, telescoping tank concepts are studied. For a telescoping tank, the greatest difficulty is in making effective joints and seals. The use of shape memory alloy to produce a passive clamping ring is evaluated. Although the telescoping tank concepts are a viable option, it appears that inflatable tank concepts will be more efficient and are recommended.

Fleming, David C.↗

Policy implications of net-zero emissions: A multi-model analysis of United States emissions and energy system impacts

Many countries, subnational jurisdictions, and companies are setting net-zero emissions goals; however, questions remain about strategies to reach these targets, policy measures, technology gaps, and economic impacts. Here, we investigate the potential policy implications of reaching economy-wide net-zero CO 2 emissions across the United States by 2050 using results from a multi-model comparison with 14 energy-economic models. Model results suggest that achieving net-zero CO 2 targets depends on policies that accelerate deployment of zero- and low-emitting technologies that have seen rapid cost reductions in recent years (including wind, solar, battery storage, and electric vehicles) as well as relatively nascent options (including carbon capture and storage, advanced biofuels, low-carbon hydrogen, advanced nuclear, and long-duration energy storage). While net-zero policies are likely to lower fossil fuel consumption, including considerable coal and petroleum reductions, achieving net-zero emissions does not necessarily mean phasing out all fossil fuels. Model results indicate that the Inflation Reduction Act’s energy and climate provisions amplify near-term decarbonization but that net-zero policies have larger impacts on long-run outcomes. Stringent climate policy can have large fiscal impacts on tax revenue and government spending—revenues from carbon pricing and subsidies for carbon removal range from 0.1 % to 3.7 % of GDP in 2050 across models. Each dollar per metric ton carbon price leads to a 0.06 % to 0.31 % reduction in economy-wide CO 2 emissions relative to a reference scenario with current policies. Spending on energy across the economy decreases relative to today for many models under reference and net-zero policies, especially as a share of GDP, due primarily to end-use electrification and energy efficiency.

54 ENVIRONMENTAL SCIENCES↗

Inflatable Re-Entry Vehicle Experiment (IRVE) Design Overview

Inflatable aeroshells offer several advantages over traditional rigid aeroshells for atmospheric entry. Inflatables offer increased payload volume fraction of the launch vehicle shroud and the possibility to deliver more payload mass to the surface for equivalent trajectory constraints. An inflatable s diameter is not constrained by the launch vehicle shroud. The resultant larger drag area can provide deceleration equivalent to a rigid system at higher atmospheric altitudes, thus offering access to higher landing sites. When stowed for launch and cruise, inflatable aeroshells allow access to the payload after the vehicle is integrated for launch and offer direct access to vehicle structure for structural attachment with the launch vehicle. They also offer an opportunity to eliminate system duplication between the cruise stage and entry vehicle. There are however several potential technical challenges for inflatable aeroshells. First and foremost is the fact that they are flexible structures. That flexibility could lead to unpredictable drag performance or an aerostructural dynamic instability. In addition, durability of large inflatable structures may limit their application. They are susceptible to puncture, a potentially catastrophic insult, from many possible sources. Finally, aerothermal heating during planetary entry poses a significant challenge to a thin membrane. NASA Langley Research Center and NASA's Wallops Flight Facility are jointly developing inflatable aeroshell technology for use on future NASA missions. The technology will be demonstrated in the Inflatable Re-entry Vehicle Experiment (IRVE). This paper will detail the development of the initial IRVE inflatable system to be launched on a Terrier/Orion sounding rocket in the fourth quarter of CY2005. The experiment will demonstrate achievable packaging efficiency of the inflatable aeroshell for launch, inflation, leak performance of the inflatable system throughout the flight regime, structural integrity when exposed to a relevant dynamic pressure and aerodynamic stability of the inflatable system. Structural integrity and structural response of the inflatable will be verified with photogrammetric measurements of the back side of the aeroshell in flight. Aerodynamic stability as well as drag performance will be verified with on board inertial measurements and radar tracking from multiple ground radar stations. The experiment will yield valuable information about zero-g vacuum deployment dynamics of the flexible inflatable structure with both inertial and photographic measurements. In addition to demonstrating inflatable technology, IRVE will validate structural, aerothermal, and trajectory modeling techniques for the inflatable. Structural response determined from photogrammetrics will validate structural models, skin temperature measurements and additional in-depth temperature measurements will validate material thermal performance models, and on board inertial measurements along with radar tracking from multiple ground radar stations will validate trajectory simulation models.

Hughes, Stephen J.↗

Suppressing the enhancement of stimulated Raman scattering in inhomogeneous plasmas by tuning the modulation frequency of a broadband laser

The stimulated Raman scattering (SRS) instability can inhibit the performance of laser driven inertial confinement fusion (ICF) implosions by scattering light into unwanted directions or by generating hot electrons that preheat the target fuel. In principle, ICF target designs can avoid parameter regimes conducive to large, linear SRS gains. In practice, kinetic inflation—the nonlinear enhancement of SRS due to electron trapping in the excited plasma wave—makes this difficult. Here we show that laser bandwidth in the form of frequency modulation can either decrease or increase the inflationary SRS (iSRS) threshold in inhomogeneous plasmas depending on the maximum chirp of the laser pulse. The threshold, mapped out by a series of particle-in-cell simulations, exhibits a minimum when the frequency change within the pulse cancels the spatial detuning due to density inhomogeneities along the trajectory of the scattered light. In conclusion, by tuning the pump laser parameters away from this minimum, the iSRS threshold can be larger than at zero bandwidth, providing a path to mitigating kinetic inflation in ignition relevant plasmas.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗