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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 19 records

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NASA NTRS2001

YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components

YC-1 [3-(5'-hydroxymethyl-2'furyl)-1-benzyl indazole] is an allosteric activator of soluble guanylyl cyclase (sGC). YC-1 increases the catalytic rate of the enzyme and sensitizes the enzyme toward its gaseous activators nitric oxide or carbon monoxide. In other studies the administration of YC-1 to experimental animals resulted in the inhibition of the platelet-rich thrombosis and a decrease of the mean arterial pressure, which correlated with increased cGMP levels. However, details of YC-1 interaction with sGC and enzyme activation are incomplete. Although evidence in the literature indicates that YC-1 activation of sGC is strictly heme-dependent, this report presents evidence for both heme-dependent and heme-independent activation of sGC by YC-1. The oxidation of the sGC heme by 1H-(1,2,4)oxadiazole(4,3-a)quinoxalin-1-one completely inhibited the response to NO, but only partially attenuated activation by YC-1. We also observed activation by YC-1 of a mutant sGC, which lacks heme. These findings indicate that YC-1 activation of sGC can occur independently of heme, but that activation is substantially increased when the heme moiety is present in the enzyme.

NASA Discipline Cardiopulmonary↗

NASA NTRS1976

Results of static tests of a 1/4 scale model of the Boeing YC-14 powered-lift system

One quarter scale static ground tests of the Boeing YC-14 powered lift system were conducted for correlation with full scale test results. The 1/4 scale model utilized a JT-15D turbofan engine to represent the CF6-50D engine employed on the YC-14 advanced medium STOL transport prototype aircraft. The tests included evaluation of static turning performance, static surface pressure and temperature distributions, fluctuating loads, and accelerations of portions of the wing, flaps, and fuselage. Results are presented for the landing flap configuration over an appropriate range of fan pressure ratio as affected by several variables including ground height and vortex generator modifications. Static turning angles of the order of 60 deg were obtained. The highest surface pressures and temperatures were concentrated over the upper surface of the flaps in the region immediately aft of the upper surface blown nozzle.

Hassell, J. L., Jr.↗

NASA NTRS1977

Surface fluctuating pressure measurements on a 1/4-scale YC-14 boilerplate model

A research program is conducted for the study of the fluctuating loads imposed on both upper-surface blown-flap and externally blown-flap powered-lift STOL aircraft configurations by the impingement of the jet engine exhaust flow. Attention is given to the measurement of the unsteady pressures at 30 positions in the vicinity of the jet exhaust on the surface of a NASA 1/4-scale YC-14 boilerplate wing and fuselage section.

Pappa, R. S.↗

NASA NTRS1979

Investigation of surface fluctuating pressures on a 1/4 scale YC-14 upper surface blown flap model

Fluctuating pressures were measured at 30 positions on the surface of a 1/4-scale YC-14 wing and fuselage model during an outdoor static testing program. These data were obtained as part of a NASA program to study the fluctuating loads imposed on STOL aircraft configurations and to further the understanding of the scaling laws of unsteady surface pressure fields. Fluctuating pressure data were recorded at several discrete engine thrust settings for each of 16 configurations of the model. These data were reduced using the technique of random data analysis to obtain auto-and cross-spectral density functions and coherence functions for frequencies from 0 to 10 kHz, and cross-correlation functions for time delays from 0 to 10.24 ms. Results of this program provide the following items of particular interest: (1) Good collapse of normalized PSD functions on the USB flap was found using a technique applied by Lilley and Hodgson to data from a laboratory wall-jet apparatus. (2) Results indicate that the fluctuating pressure loading on surfaces washed by the jet exhaust flow was dominated by hydrodynamic pressure variations, loading on surface well outside the flow region dominated by acoustic pressure variations, and loading near the flow boundaries from a mixture of the two.

Pappa, R. S.↗

NASA NTRS1979

QCSEE - The key to future short-haul air transport

The paper describes the design and test procedure for the QCSEE (quiet, clean, short-haul experimental engine). The engines designed for the YC-14 and YC-15 STOL aircraft, both use a very low fan pressure ratio to keep jet-flap noise about 3 dB below total system noise. Other noise reducing features discussed are the low tip speed fans and a carefully selected number of fan blades and vanes with adequate spacing between them. Attention is also given to the development of a low emissions combustor, and reduction of fan frame weight, through the use of graphite/epoxy material. The YC-15 engine also employs variable pitch fans to provide thrust reversal, thus saving weight. Finally, it is noted that the tests have proven that the engines could be configurated to meet the needs of a powered lift system without excessively compromising performance or weight.

Ciepluch, C. C.↗

NASA NTRS1976

Overview of powered-lift technology

The concept and application of powered lift and the effects of some fundamental design variables are discussed. A brief chronology of significant developments in the field is also presented and the direction of research efforts in recent years is indicated. All powered lift concepts are included, but emphasis is on the two externally blown schemes which involve blowing either above or below the wing and which are utilized in the YC-14 and YC-15 aircraft. Aerodynamics and vehicle design are emphasized. The areas of acoustics, propulsion, and loads are briefly considered.

Campbell, J. P.↗

NASA NTRS1976

NASA participation in the AMST program

The objectives of the NASA Advanced Medium STOL Transport Experiments Program are discussed and several of the NASA experiments currently implemented and conducted on the YC-14 and YC-15 prototype aircraft are described. Emphasis is placed on experiments related to powered lift aerodynamics and acoustics.

Montoya, E. J.↗

NASA NTRS1979

Quiet powered-lift propulsion

Latest results of programs exploring new propulsion technology for powered-lift aircraft systems are presented. Topics discussed include results from the 'quiet clean short-haul experimental engine' program and progress reports on the 'quiet short-haul research aircraft' and 'tilt-rotor research aircraft' programs. In addition to these NASA programs, the Air Force AMST YC 14 and YC 15 programs were reviewed.

Source record↗

NASA NTRS1981

Prediction of jet exhaust noise on airframe surfaces during flight

The behavior of pressure fluctuations measured on the airframe of a prototype high lift jet transport (YC-14) is presented. The data are characterized in terms of a particular jet exhaust flow field idealization, jet mixing noise, and exhaust shock noise. Generalized spectrum shapes and scaling relations for peak level and frequency of peak level are developed, and the frequency is found to depend on jet exhaust velocity and aircraft velocity. Comparisons are made with near-field engine exhaust noise of a conventional jet, and results suggest that the same two exhaust noises are important for both aircraft types. Surface fluctuating pressure data are assessed, and results suggest that the jet mixing and exhaust shock noise source characterizations for the YC-14 have useful applicability to conventionally configured jets.

Butzel, L. M.↗

NASA NTRS1987

The ground effects of a powered-lift STOL aircraft during landing approach

The effects of ground proximity on a powered lift STOL aircraft are presented. The data are from NASA's Quiet Short Haul Research Aircraft (QSRA) flown at landing approach airspeeds of less than 60 knots with an 80 lb/sq ft wing loading. These results show that the ground effect change in lift is positive and does significantly reduce the touchdown sink rate. These results are compared to those of the YC-14 and YC-15. The change in drag and pitching moment caused by ground effects is also presented.

Stevens, Victor C.↗

NASA NTRS1997

Deoxypyridinoline in the Urine of Rats with Unloaded Hindlimbs

The urinary excretion of deoxypyridinoline (U-Dpd), a nonreducible collagen crosslink in bone released by osteoclastic activity, is thought to be an accurate marker of bone resorption. The role of increased resorption in the osteopenia of a space flight model which unloads the hindlimbs by suspending the tail is controversial. To assess skeletal resorption in the model we measured U-Dpd (Pyrilinks-D, Metro Biosystems, Inc.) in serial 24 hour urine specimens collected from 250 a (Y) and 450 a (M) male rats with unloaded hindlimbs for four weeks. Both groups of rats were fed AIN76 diets with calcium restricted to 0.2% in Y and to 0.1 % in M. Blood was obtained after 28 days for parathyroid hormone (PTH), 1,25-dihydroxyvitamin D (1,25-D) and alkaline phosphatase (Alkptase). Basal U-Dpd was higher and more variable in Y than M (475+/-200 vs 67+/-9, nM/mM creatinine, p<.001). Repeated measures ANOVA in Y revealed decreases in U-Dpd, 36% in control (C) and 24% in unloaded (S) rats (p<.005). There was a nadir in YS on the 14th day not observed in YC (p<.05). U-Dpd in MC showed no change, but increased in MS by the 14th day and remained elevated. At the end of the experiment, body weights in both Y and M were less in S than C (337+/-16 vs 306+/-12g and 485+/-10 vs 461+/-6g, p=.002). Bill was inversely related to U-Dpd only in M (r=0.699, p=.024). PTH, similar in C and S in Y (52+/-15 vs 42+/-7pg/ml, NS) and M (68+/-13 vs 61+/-12, NS), was unrelated to U-Dpd. 1,25-D tended toward higher values in YC than YS (197+/-103 vs 119+/-30, NS) and correlated with U-Dpd (0.773, p=.015). Alkptase, 1.3 times higher in Y than M, was similar in C and S at the end of unloading. These findings indicate that bone resorption, as reflected by U-Dpd, is suppressed in young and stimulated in mature rats exposed to a space flight model. U-Dpd reflects reduced growth from the diet change in young control and experimental rats and loss of Bill in mature animals exposed to the space flight model, 2 situations with opposite effects on bone resorption.

Arnaud, Sara B.↗

NASA NTRS2000

Human recombinant soluble guanylyl cyclase: expression, purification, and regulation

The alpha1- and beta1-subunits of human soluble guanylate cyclase (sGC) were coexpressed in the Sf9 cells/baculovirus system. In addition to the native enzyme, constructs with hexahistidine tag at the amino and carboxyl termini of each subunit were coexpressed. This permitted the rapid and efficient purification of active recombinant enzyme on a nickel-affinity column. The enzyme has one heme per heterodimer and was readily activated with the NO donor sodium nitroprusside or 3-(5'-hydroxymethyl-2'furyl)-1-benzyl-indazole (YC-1). Sodium nitroprusside and YC-1 treatment potentiated each other in combination and demonstrated a remarkable 2,200-fold stimulation of the human recombinant sGC. The effects were inhibited with 1H-(1,2, 4)oxadiazole(4,3-a)quinoxalin-1one (ODQ). The kinetics of the recombinant enzyme with respect to GTP was examined. The products of the reaction, cGMP and pyrophosphate, inhibited the enzyme. The extent of inhibition by cGMP depended on the activation state of the enzyme, whereas inhibition by pyrophosphate was not affected by the enzyme state. Both reaction products displayed independent binding and cooperativity with respect to enzyme inhibition. The expression of large quantities of active enzyme will facilitate structural characterization of the protein.

NASA Discipline Cardiopulmonary↗

NASA NTRS1976

USB environment measurements based on full-scale static engine ground tests

Flow turning parameters, static pressures, surface temperatures, surface fluctuating pressures and acceleration levels were measured in the environment of a full-scale upper surface blowing (USB) propulsive-lift test configuration. The test components included a flightworthy CF6-50D engine, nacelle and USB flap assembly utilized in conjunction with ground verification testing of the USAF YC-14 Advanced Medium STOL Transport propulsion system. Results, based on a preliminary analysis of the data, generally show reasonable agreement with predicted levels based on model data. However, additional detailed analysis is required to confirm the preliminary evaluation, to help delineate certain discrepancies with model data and to establish a basis for future flight test comparisons.

Sussman, M. B.↗

NASA NTRS1976

Transient excitation and data processing techniques employing the fast fourier transform for aeroelastic testing

The development of testing techniques useful in airplane ground resonance testing, wind tunnel aeroelastic model testing, and airplane flight flutter testing is presented. Included is the consideration of impulsive excitation, steady-state sinusoidal excitation, and random and pseudorandom excitation. Reasons for the selection of fast sine sweeps for transient excitation are given. The use of the fast fourier transform dynamic analyzer (HP-5451B) is presented, together with a curve fitting data process in the Laplace domain to experimentally evaluate values of generalized mass, model frequencies, dampings, and mode shapes. The effects of poor signal to noise ratios due to turbulence creating data variance are discussed. Data manipulation techniques used to overcome variance problems are also included. The experience is described that was gained by using these techniques since the early stages of the SST program. Data measured during 747 flight flutter tests, and SST, YC-14, and 727 empennage flutter model tests are included.

Jennings, W. P.↗

NASA NTRS1977

V/STOL Conference, Palo Alto, Calif., June 6-8, 1977, Technical Papers

Papers are presented on practical aspects of commercial STOL operations, a Vertical Attitude Takeoff and Landing (VATOL) program, powered-lift STOL ground effects, conceptual design studies of Navy Type A V/STOL aircraft, and a V/STOL shaft propulsion system analytical performance model. Also considered are the management of swirling flows with application to wind tunnel design and V/STOL testing, flight control testing of the VAK-191B, and surface fluctuating pressure measurements on a 1/4-scale YC-14 boilerplate model.

Source record↗

NASA NTRS1976

USB environment measurements based on full-scale static engine ground tests

Flow turning parameters, static pressures, surface temperatures, surface fluctuating pressures and acceleration levels were measured in the environment of a full-scale upper surface blowing (USB) propulsive lift test configuration. The test components included a flightworthy CF6-50D engine, nacelle, and USB flap assembly utilized in conjunction with ground verification testing of the USAF YC-14 Advanced Medium STOL Transport propulsion system. Results, based on a preliminary analysis of the data, generally show reasonable agreement with predicted levels based on model data. However, additional detailed analysis is required to confirm the preliminary evaluation, to help delineate certain discrepancies with model data, and to establish a basis for future flight test comparisons.

Sussman, M. B.↗

NASA NTRS1977

Flight-test measurements of ground effect - STOL airplanes

Powered-lift STOL aircraft exhibit special aerodynamic characteristics that necessitate changes in established procedures of flight testing. Methods used in ground-effect flight testing of STOL-configured aircraft are described, with special emphasis on results obtained from tests of the YC-15 AMST prototype aircraft. Ground effect on lift and on drag is theoretically analyzed in terms of trailing vortices, bound vortex, and flight-path angle. Airspeed static source position errors are induced by ground constraint and must be considered in the data reduction. Flight-test results show a positive lift increment due to ground proximity.

Parks, E. K.↗

NASA NTRS1980

Theoretical and Experimental studies of aerodynamic interference effects

Theoretical studies of aerodynamic forces on winglets shed considerable light on the mechanism by which these devices can reduce drag at constant total lift and on the necessity for proper alignment and cambering to achieve optimum favorable interference. Results of engineering studies, wind tunnel tests and performance predictions are reviewed for installations proposed for the AMST YC-14 and the KC-135 airplanes. The other major area of aerodynamic interference discussed is that of engine nacelle installations. Slipper and overwing nacelles have received much attention because of their potential for noise reduction, propulsive lift and improved ground clearance. A major challenge is the integration of such nacelles with the supercritical flow on the upper surface of a swept wing in cruise at high subsonic speeds.

Rettie, I. H.↗