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Measurements of gluon–gluon fusion and vector-boson fusion Higgs boson production cross-sections in the H → WW ∗ → eνμν decay channel in pp collisions at s = 13 TeV with the ATLAS detector
Higgs boson production cross-sections in proton–proton collisions are measured in the H → WW ∗ → eνμν decay channel. The proton–proton collision data were produced at the Large Hadron Collider at a centre-of-mass energy of 13 TeV and recorded by the ATLAS detector in 2015 and 2016, corresponding to an integrated luminosity of 36.1fb -1 . The product of the H→WW ∗ branching fraction times the gluon–gluon fusion and vector-boson fusion cross-sections are measured to be 11.4$_{-1.1}^{+1.2}$(stat.)$_{-1.7}^{+1.8}$(syst.) pb and 0.50$_{-0.22}^{+0.24}$(stat.)±0.17(syst.) pb, respectively, in agreement with Standard Model predictions.
A short hepatitis C virus NS5A peptide expression by AAV vector modulates human T cell activation and reduces vector immunogenicity
Viral vector-mediated gene therapies have the potential to treat many human diseases; however, host immune responses against the vector and/or the transgene pose a safety risk to the patients and can negatively impact product efficacy. Thus, novel strategies to reduce vector immunogenicity are critical for the advancement of these therapies. T cell activation (TCA) is required for the development of immune responses during gene therapy. We hypothesized that modulation of TCA by incorporating a novel viral immunomodulatory factor into a viral vector may reduce unwanted TCA and immune responses during gene therapy. To test this hypothesis, we identified an immunomodulatory domain of the hepatitis C virus (HCV) NS protein 5A (NS5A) protein and studied the effect of viral vectors expressing NS5A peptide on TCA. Lentiviral vector-mediated expression of a short 20-mer peptide derived from the NS5A protein in human T cells was sufficient to inhibit TCA. Synthetic 20-mer NS5A peptide also inhibited TCA in primary human T cells. Mechanistically, the NS5A protein interacted with Lck and inhibited proximal TCR signaling. Importantly, NS5A peptide expression did not cause global T cell signaling dysfunction as distal T cell signaling was not inhibited. Finally, recombinant adeno-associated virus (AAV) vector expressing the 20-mer NS5A peptide reduced both the recall antigen and the TCR-mediated activation of human T cells and did not cause global T cell signaling dysfunction. Together, these data suggest that expression of a 20-mer NS5A peptide by an AAV vector may reduce unwanted TCA and may contribute to lower vector immunogenicity during gene therapy.
Search for pair production of heavy vector-like quarks decaying into high-p T W bosons and top quarks in the lepton-plus-jets final state in pp collisions at $ \sqrt{s}=13$ TeV with the ATLAS detector
A search is presented for the pair production of heavy vector-like B quarks, primarily targeting B quark decays into a W boson and a top quark. The search is based on 36.1 fb -1 of pp collisions at s√=13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider. Data are analysed in the lepton-plus-jets final state, characterised by a high-transverse-momentum isolated electron or muon, large missing transverse momentum, and multiple jets, of which at least one is b-tagged. No significant deviation from the Standard Model expectation is observed. The 95% confidence level lower limit on the B mass is 1350 GeV assuming a 100% branching ratio to Wt. In the SU(2) singlet scenario, the lower mass limit is 1170 GeV. The 100% branching ratio limits are found to be also applicable to heavy vector-like X production, with charge +5/3, that decay into Wt. In conclusion, this search is also sensitive to a heavy vector-like B quark decaying into other final states (Zb and Hb) and thus mass limits on B production are set as a function of the decay branching ratios.
Wave vector and field vector orientation dependence of Fe K pre-edge X-ray absorption features in clinopyroxenes
Abstract Pre-edge X-ray absorption features are commonly used to derive redox states for transition metal oxides in crystals and glasses. Several calibrations for Fe2+ and Fe3+ in silicate glasses have utilized the general relationships among pre-edge peak intensity, energy, and redox state. However, absorption variations complicate those relationships in anisotropic crystals. Although absorption anisotropy at and above the energy of the rising edge adheres to the typical cos2 relationship observed in absorption spectroscopies at other energies, the anisotropy of the pre-edge is far more complicated. Prior studies focusing on pre-edge absorption anisotropy demonstrate a 1-cos4φ dependence of absorption magnitudes with rotation. Experiments presented here show that absorption magnitudes of the pre-edge vary as a function of both electric field vector orientation and wave vector direction. However, rotations around the field vector axis or wave vector axis individually result in cos2 dependence of absorption magnitudes. Rotations where both wave vector and field vector orientation are varied are not well fit by either model in the pre-edge. The resulting anisotropy complicates the process of measuring characteristic absorption in the pre-edge, making valence state determinations challenging for strongly anisotropic crystal structures such as pyroxene.
A Digital Three Level Space Vector Modulator for High Frequency Vector Sequence Generation
This letter proposes a digital high-speed three-level space vector pulse width modulator (3L-SVPWM). A conventional 3L-SVPWM is typically computation-based, involving a sequential execution of sub-tasks on a digital signal processor (DSP) based controller. The resulting high computation time of 5.4 μs limits the implementation of additional control blocks for switching frequencies greater than 100 kHz. This is overcome by transforming sub-tasks into digital blocks with 1-0 decisions and simpler arithmetic operations. The sub-task blocks are executed concurrently on a programmable logic device (PLD). Hence, a fast 3L-SVPWM execution in 140 ns is achieved. The proposed digital 3L-SVPWM enables high switching frequency operation of wide bandgap (WBG) device-based 3 L inverters to generate high fundamental frequency waveforms. A finite state machine is an integral part of the proposed implementation with the ability to generate any vector sequence, maximizing the usage of redundant vector states in 3L-SVPWM. Here, the proposed digital 3L-SVPWM operation is demonstrated with a GaN-based 3 L active neutral point clamped (3L-ANPC) inverter. Experimental results are presented at 250 kHz switching frequency to generate vector sequences for center-aligned SVPWM (CA-SVPWM) and common mode voltage reduced SVPWM (CMVR-SVPWM). The results also showcase a high fundamental frequency generation capability of 10 kHz.
Search for pair production of up-type vector-like quarks and for four-top-quark events in final states with multiple b-jets with the ATLAS detector
A search for pair production of up-type vector-like quarks ( T ) with a significant branching ratio into a top quark and either a Standard Model Higgs boson or a Z boson is presented. The same analysis is also used to search for four-top-quark production in several new physics scenarios. The search is based on a dataset of pp collisions at $\sqrt{s}$ =13 TeV recorded in 2015 and 2016 with the ATLAS detector at the CERN Large Hadron Collider and corresponds to an integrated luminosity of 36.1 fb -1 . Data are analysed in the lepton+jets final state, characterised by an isolated electron or muon with high transverse momentum, large missing transverse momentum and multiple jets, as well as the jets + E T miss final state, characterised by multiple jets and large missing transverse momentum. The search exploits the high multiplicity of jets identified as originating from b -quarks, and the presence of boosted, hadronically decaying top quarks and Higgs bosons reconstructed as large-radius jets, characteristic of signal events. No significant excess above the Standard Model expectation is observed, and 95% CL upper limits are set on the production cross sections for the different signal processes considered. These cross-section limits are used to derive lower limits on the mass of a vector-like T quark under several branching ratio hypotheses assuming contributions from T → W b , Zt , Ht decays. The 95% CL observed lower limits on the T quark mass range between 0 . 99 TeV and 1 . 43 TeV for all possible values of the branching ratios into the three decay modes considered, significantly extending the reach beyond that of previous searches. Additionally, upper limits on anomalous four-top-quark production are set in the context of an effective field theory model, as well as in an universal extra dimensions model.
Search for pair production of vector-like top quarks in events with one lepton, jets, and missing transverse momentum in $ \sqrt{s}=13 $ TeV $pp$ collisions with the ATLAS detector
The results of a search for vector-like top quarks using events with exactly one lepton, at least four jets, and large missing transverse momentum are reported. The search is optimised for pair production of vector-like top quarks in the Z(→vv) t + X decay channel. LHC pp collision data at a centre-of-mass energy of √s=13 TeV recorded by the ATLAS detector in 2015 and 2016 are used, corresponding to an integrated luminosity of 36.1 fb -1 . No significant excess over the Standard Model expectation is seen and upper limits on the production cross-section of a vector-like T quark pair as a function of the T quark mass are derived. The observed (expected) 95% CL lower limits on the T mass are 870 GeV (890 GeV) for the weak-isospin singlet model, 1.05 TeV (1.06 TeV) for the weak-isospin doublet model and 1.16 TeV (1.17 TeV) for the pure Zt decay mode. Limits are also set on the mass as a function of the decay branching ratios, excluding large parts of the parameter space for masses below 1 TeV.
Generation of arbitrary vector beams with liquid crystal polarization converters and vector-photoaligned q-plates
Arbitrary vector beams (VBs) are realized by the designed polarization converters and corresponding vector-photoaligned q-plates. The polarization converter is a specific twisted nematic cell with one substrate homogeneously aligned and the other space-variantly aligned. By combining a polarization-sensitive alignment agent with a dynamic micro-lithography system, various categories of liquid crystal polarization converters are demonstrated. Besides, traditional radially/azimuthally polarized light, high-order and multi-ringed VBs, and a VB array with different orders are generated. The obtained converters are further utilized as polarization masks to implement vector-photoaligning. The technique facilitates both the volume duplication of these converters and the generation of another promising optical element, the q-plate, which is suitable for the generation of VBs for coherent lasers. The combination of proposed polarization converters and correspondingly fabricated q-plates would drastically enhance the capability of polarization control and may bring more possibilities for the design of photonic devices.
Radial coordinate maps, radial vectors, and binormal vectors for 5/6, 5/5 and 5/4 edge island domains in W7-X
Abstract The edge island domain in Wendelstein 7-X consists of divertor islands whose position coincide with the location of rational values of the rotational transform - ι ≈ ( 5 / 6 , 5 / 5 , 5 / 4 ) and surround the main confinement volume (the ‘main plasma’), providing the magnetic topology for an island divertor. The 5/5 edge consists of five individual islands that are unconnected. In contrast, a single island connects onto itself after 6 or 4 toroidal transits in the 5/6 or 5/4 edge, respectively. Many interesting phenomena are related to these islands and diagnostic analyses require a mapping from ‘laboratory’ or real space coordinates to the island coordinate system (ICS). A procedure is described here to calculate several scalar and vector quantities for closed island structures which can be utilized in fast interpolation schemes for inverse maps. For the 5/5 edge, a fixed-boundary vacuum (zero beta) magneto-hydrodynamic solution of the 5/5 island is found with the Variational Moments Equilibrium Code, VMEC. The solution is compatible with already existing routines which determine the radial and binormal vectors of VMEC solutions at arbitrary laboratory coordinates. VMEC does not support solutions for the 5/4 and 5/6 islands, but the radial and binormal vectors are available in a local 2D Fourier ICS.
Search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector boson pairs in proton–proton collisions at $\sqrt{s} = 13\,{\text {TeV}} $
A search for charged Higgs bosons produced in vector boson fusion processes and decaying into vector bosons, using proton–proton collisions at √s = 13 TeV at the LHC, is reported. The data sample corresponds to an integrated luminosity of 137 fb -1 collected with the CMS detector. Events are selected by requiring two or three electrons or muons, moderate missing transverse momentum, and two jets with a large rapidity separation and a large dijet mass. No excess of events with respect to the standard model background predictions is observed. Model independent upper limits at 95% confidence level are reported on the product of the cross section and branching fraction for vector boson fusion production of charged Higgs bosons as a function of mass, from 200 to 3000GeV. The results are interpreted in the context of the Georgi–Machacek model.
Review of searches for vector-like quarks, vector-like leptons, and heavy neutral leptons in proton-proton collisions at $\sqrt{s}$ = 13 TeV at the CMS experiment
The LHC has provided an unprecedented amount of proton-proton collision data, bringing forth exciting opportunities to address fundamental open questions in particle physics. These questions can potentially be answered by performing searches for very rare processes predicted by models that attempt to extend the standard model of particle physics. The data collected by the CMS experiment in 2015-2018 at a center-of-mass energy of 13 TeV can be used to test the standard model with high precision and potentially uncover evidence for new particles or interactions. An interesting possibility is the existence of new fermions with masses ranging from the MeV to the TeV scale. Such new particles appear in many possible extensions of the standard model and are well motivated theoretically. New fermions may explain the appearance of three generations of leptons and quarks, the mass hierarchy across the generations, and the nonzero neutrino masses. In this report, the results of searches targeting vector-like quarks, vector-like leptons, and heavy neutral leptons at the CMS experiment are summarized. The complementarity of current searches for each type of new fermion is discussed, and combinations of several searches for vector-like quarks are presented. The discovery potential for some of these searches at the High-Luminosity LHC is also discussed.
A Short-Term and High-Resolution System Load Forecasting Approach Using Support Vector Regression with Hybrid Parameters Optimization
This work proposes an approach for distribution system load forecasting, which aims to provide highly accurate short-term load forecasting with high resolution utilizing a support vector regression (SVR) based forecaster and a two-step hybrid parameters optimization method. Specifically, because the load profiles in distribution systems contain abrupt deviations, a data normalization is designed as the pretreatment for the collected historical load data. Then an SVR model is trained by the load data to forecast the future load. For better performance of SVR, a two-step hybrid optimization algorithm is proposed to determine the best parameters. In the first step of the hybrid optimization algorithm, a designed grid traverse algorithm (GTA) is used to narrow the parameters searching area from a global to local space. In the second step, based on the result of the GTA, particle swarm optimization (PSO) is used to determine the best parameters in the local parameter space. After the best parameters are determined, the SVR model is used to forecast the short-term load deviation in the distribution system.
Inclusive τ lepton hadronic decay in vector and axial-vector channels within dispersive approach to QCD
The dispersive approach to QCD, which properly embodies the intrinsically nonperturbative constraints originating in the kinematic restrictions on relevant physical processes and extends the applicability range of perturbation theory towards the infrared domain, is briefly overviewed. The study of OPAL (update 2012) and ALEPH (update 2014) experimental data on inclusive τ lepton hadronic decay in vector and axial-vector channels within dispersive approach is presented.
Global constraints on vector-like WIMP effective interactions
In this work we combine information from relic abundance, direct detection, cosmic microwave background, positron fraction, gamma rays, and colliders to explore the existing constraints on couplings between Dark Matter and Standard Model constituents when no underlying model or correlation is assumed. For definiteness, we include independent vector-like effective interactions for each Standard Model fermion. Our results show that low Dark Matter masses below 20 GeV are disfavoured at the 3 σ level with respect to higher masses, due to the tension between the relic abundance requirement and upper constraints on the Dark Matter couplings. Lastly, large couplings are typically only allowed in combinations which avoid effective couplings to the nuclei used in direct detection experiments.
Search for the production of single vector-like and excited quarks in the Wt final state in pp collisions at root s=8 TeV with the ATLAS detector
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Search for the Standard Model Higgs boson produced by vector-boson fusion and decaying to bottom quarks in $ \sqrt{s}=8 $ TeV pp collisions with the ATLAS detector
A search with the ATLAS detector is presented for the Standard Model Higgs boson produced by vector-boson fusion and decaying to a pair of bottom quarks, using 20.2 fb -1 of LHC proton-proton collision data at √s=8 TeV. The signal is searched for as a resonance in the invariant mass distribution of a pair of jets containing b-hadrons in vector-boson-fusion candidate events. The yield is measured to be -0.8 ± 2.3 times the Standard Model cross-section for a Higgs boson mass of 125 GeV. The upper limit on the cross-section times the branching ratio is found to be 4.4 times the Standard Model cross-section at the 95% confidence level, consistent with the expected limit value of 5.4 (5.7) in the background-only (Standard Model production) hypothesis.[Figure not available: see fulltext.]