Results for “Staggered SAR” | Engineering Papers

NASA NTRS2016

Nisar L-band Digital Electronics Subsystem

The NASA-ISRO Synthetic Aperture Radar (NISAR) L-band SAR instrument employs multiple digital channels to optimize resolution while keeping a large swath on a single pass. High-speed digitization with fine synchronization and digital beam forming are necessary in order to facilitate this new technique called SweepSAR. An architecture employing multiple FPGA based digital signal processors has been conceived to facilitate digital calibration on an individual channel basis as well as digital signal processing to optimize the receive signal. On-board processing and data compression has been implemented to reduce the volume of data in order to satisfy the operational requirements of near global coverage for the desired science targets. A novel command and timing architecture was developed to manage this complex system to meet the challenging project requirements. The NISAR L-band Digital Electronics Subsystem is the combination of the hardware, firmware and software components architected and implemented to operate this radar and return the desired quantity and quality of data for the science community.

SweepSAR↗

DOE OSTI2021

Evolution of the SARS-CoV -2 proteome in three dimensions (3D) during the first 6 months of the COVID -19 pandemic

Understanding the molecular evolution of the SARS-CoV-2 virus as it continues to spread in communities around the globe is important for mitigation and future pandemic preparedness. Three-dimensional structures of SARS-CoV-2 proteins and those of other coronavirusess archived in the Protein Data Bank were used to analyze viral proteome evolution during the first 6 months of the COVID-19 pandemic. Analyses of spatial locations, chemical properties, and structural and energetic impacts of the observed amino acid changes in >48 000 viral isolates revealed how each one of 29 viral proteins have undergone amino acid changes. Catalytic residues in active sites and binding residues in protein–protein interfaces showed modest, but significant, numbers of substitutions, highlighting the mutational robustness of the viral proteome. Energetics calculations showed that the impact of substitutions on the thermodynamic stability of the proteome follows a universal bi-Gaussian distribution. Here detailed results are presented for potential drug discovery targets and the four structural proteins that comprise the virion, highlighting substitutions with the potential to impact protein structure, enzyme activity, and protein–protein and protein–nucleic acid interfaces. Characterizing the evolution of the virus in three dimensions provides testable insights into viral protein function and should aid in structure-based drug discovery efforts as well as the prospective identification of amino acid substitutions with potential for drug resistance.

59 BASIC BIOLOGICAL SCIENCES↗