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At least 19 records

Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness

Light can elicit both circadian and acute physiological responses in humans. In a dose response protocol men and women were exposed to illuminances ranging from 3 to 9100 lux for 6.5 h during the early biological night after they had been exposed to <3 lux for several hours. Light exerted an acute alerting response as assessed by a reduction in the incidence of slow-eye movements, a reduction of EEG activity in the theta-alpha frequencies (power density in the 5-9 Hz range) as well as a reduction in self-reported sleepiness. This alerting response was positively correlated with the degree of melatonin suppression by light. In accordance with the dose response function for circadian resetting and melatonin suppression, the responses of all three indices of alertness to variations in illuminance were consistent with a logistic dose response curve. Half of the maximum alerting response to bright light of 9100 lux was obtained with room light of approximately 100 lux. This sensitivity to light indicates that variations in illuminance within the range of typical, ambient, room light (90-180 lux) can have a significant impact on subjective alertness and its electrophysiologic concomitants in humans during the early biological night.

Clinical Trial

Land mobile satellite demonstration system

A land mobile satellite demonstration system is described. It ulilizes the INMARSAT MARECS B2 satellite at 26 degrees W. The system provides data transmission using a poll-response protocol with error detection and retransmission at 200 b/s rate. For most tests a 1.8 inch monopole antenna was used, along with a satellite EIRP normally used for four voice channels. A brief summary of the results are given and the overall system consisting of three elements in addition to the satellite (the mobile unit, the base station, and the office terminal and map display) is described. Throughput statistics from one trip are summarized.

Gooch, Guy M.

Building a Real-Time Flood Prediction Model for Improving Early Warning Systems in Ellicott City, Maryland

As flood events in the United States grow in frequency and intensity, the use of applied remote sensing analyses is increasingly necessary for effective flood monitoring and warning systems. The NASA DEVELOP National Program partnered with the local government of Howard County, Maryland, to investigate the use of machine learning for advanced flood risk detection, and to test the feasibility of integrating this approach into the county’s flood early warning system. To strengthen the efforts of the Howard County Office of Emergency Management (OEM), the project developed a statistical model capable of hindcasting the two severe flash flood events that devastated Ellicott City and transitioned to a ‘Long Short-Term Memory’ based sequence-to-sequence deep learning model with 8-hour forecast capability. The team combined data inputs from public sources including river and precipitation gauges, NASA and NOAA Earth observations, and numerical weather model products using scripts written in the Google Colaboratory Python scripting environment. In addition to designing the deep learning architecture, the team trained and tested the model, and evaluated its performance using Nash-Sutcliffe Efficiency. The final product, the Sequentially Trained Real-time EstimAted Model (STREAM) predicts stage height for the Hudson Branch gauge in Ellicott City using data products available in near real-time, including the High-Resolution Rapid Refresh model’s accumulated precipitation forecasts supplemented by stream gauge data from the OEM and the U.S. Geological Survey. STREAM was incorporated into an online dashboard in a user-friendly interface capable of triggering the alarms that initiate emergency response protocols up to 8 hours in advance of a predicted severe flood event. The project demonstrated the potential for the integration of open data and Earth observations into a flood risk forecasting tool capable of informing near real-time decision making.

NASA DEVELOP

Building a Real-Time Predictive Flood Model for Improving Early Warning Systems in Ellicott City, Maryland

As flood events in the United States grow in frequency and intensity, the use of applied remote sensing analyses is increasingly necessary for effective flood monitoring and warning systems. The NASA DEVELOP National Program partnered with the Howard County government in Maryland to investigate the use of machine learning for advanced flood risk detection, and to test the feasibility of integrating this approach into the county’s flood early warning system. To strengthen the efforts of the Howard County Office of Emergency Management (OEM), the project developed a prediction model capable of hindcasting the two severe flash flood events that devastated Ellicott City, and transitioned to an Long Short-Term Memory (LSTM) based sequence-to-sequence deep learning model with 8-hour forecast capability. The team combined data inputs from public sources including river and precipitation gauges, NASA and NOAA Earth observations, and numerical weather model products using scripts written in the Google Colaboratory Python scripting environment. In addition to designing the deep learning architecture, the team trained and tested the model, and evaluated its performance using the Nash-Sutcliffe Efficiency (NSE). The final product, called the Sequentially Trained Real-time EstimAted Model (STREAM), predicts stage height for the Hudson Branch gauge in Ellicott City using data products available in near real-time, including the High-Resolution Rapid Refresh (HRRR) model’s accumulated precipitation forecasts supplemented by stream gauge data from the OEM and the U.S. Geological Survey. STREAM was incorporated into an online dashboard in a user-friendly interface capable of triggering the alarms that initiate the OEM’s emergency response protocols up to 8 hours in advance of a predicted severe flood event. The project demonstrated the potential for the integration of open data and Earth observations into a flood risk forecasting tool capable of informing near real-time decision making.

Ryan Hammock

Hypovolemia Induced Orthostatic Hypotension in Presyncopal Astronauts and Normal Subjects Related to Hypoadrenergic Responsiveness

Circulating blood volume is reduced during spaceflight, making astronauts hemodynamically compromised. After landing, astronauts separate into two groups. One group compensates for the hypovolemia with a hyper-sympathetic response during upright tilt testing and can complete a tilt test with few symptoms. The other group is unable to mount a hyper-sympathetic response and experiences orthostatic hypotension and presyncope during upright tilt tests. We tested the hypothesis that hypovolemia alone, in the absence of spaceflight, also would cause subjects to separate into presyncopal and non-presyncopal groups according to their sympathetic responses during tilt. We studied 20 subjects, including 10 veteran astronauts, on three occasions. On Days 1 (normovolemia) and 3 (hypovolemia), plasma volume, tilt tolerance and supine and standing plasma norepinephrine levels were measured. Forty hours prior to Day 3, subjects were given intravenous furosemide, followed by 36 hours of a 10MEq Na diet. Statistical comparisons were made between normovolemia and hypovolemia responses. This protocol reproduced landing day tilt test outcomes with 100% fidelity in the astronauts. Similarly to patterns reported after flight, non-presyncopal subjects had greater norepinephrine responses to tilt during hypovolemia compared to normovolemia (580 plus or minus 79 vs. 298 plus or minus 37 pg/ml, P less than 0.05), but presyncopal subjects had no increase (180 plus or minus 44 vs. 145 plus or minus 32 pg/ml, P=NS). This model can be used to predict astronauts who will become presyncopal on landing day, so that prospective, individualized countermeasures can be developed. Within patient populations, it can be used to study the interaction of volemic state and the sympathetic nervous system.

Meck, Janice V.

Effect of whole-body and local heating on cutaneous vasoconstrictor responses in humans

Animal studies suggest that alpha-adrenergic-mediated vasoconstriction is compromised during whole-body heating. The purpose of this study was to identify whether whole-body heating and/or local surface heating reduce cutaneous alpha-adrenergic vasoconstrictor responsiveness in human skin. Protocol I: Six subjects were exposed to neutral skin temperature (i.e., 34 degrees C), whole-body heating, and local heating of forearm skin to increase skin blood flow to the same relative magnitude as that observed during whole-body heating. Protocol II: In eight subjects forearm skin was locally heated to 34, 37, 40, and 42 degrees C. During both protocols, alpha-adrenergic vasoconstrictor responsiveness was assessed by local delivery of norepinephrine (NE) via intradermal microdialysis. Skin blood flow was continuously monitored over each microdialysis membrane via laser-Doppler flowmetry. In protocol I, whole-body and local heating caused similar increases in cutaneous vascular conductance (CVC). The EC50 (log NE dose) of the dose-response curves for both whole body (-4.2 +/- 0.1 M) and local heating (-4.7 +/- 0.4 M) were significantly greater (i.e., high dose required to cause 50% reduction in CVC) relative to neutral skin temperature (- 5.6 +/- 0.0 M; P<0.05 for both). In both local and whole-body heated conditions CVC did not return to pre-heating values even at the highest dose of NE. In protocol II, calculated EC50 for 34, 37, 40, and 42 degrees C local heating was - 5.5 +/- 0.4, -4.6 +/- 0.3, -4.5 +/- 0.3, - 4.2 +/- 0.4 M, respectively. Statistical analyses revealed that the EC50 for 37,40 and 42 degrees C were significantly greater than the EC50 for 34 degrees C. These results indicate that even during administration of high concentrations of NE, alpha-adrenergic vasoconstriction does not fully compensate for local heating and whole-body heating induced vasodilatation in young, healthy subjects. Moreover, these data suggest that elevated local temperatures, above 37 degrees C, and whole-body heating similarly attenuate cutaneous alpha-adrenergic vasoconstriction responsiveness.

Non-NASA Center

Next Steps: Laying the Groundwork for Bundle Protocol v7

Delay/Disruption Tolerant Networking (DTN) is a networking model and protocol suite that extends the terrestrial internet to the challenging communication environments of space. These environments are typically subject to frequent disruptions, which can cause delays or errors. DTN protects data transmission by wrapping data into bundles (similar to Internet Protocol packets), storing them until a connection can be established between two nodes (similar to terrestrial routers or computers), and forwarding them to their destinations. Bundle Protocol (BP) is responsible for generating those bundles and creates the transport layer of DTN, much like how Transmission Control Protocol (TCP) and User Datagram Protocol (UDP) create the transport layer of the Internet Protocol. BPv6 is the current, accepted version of the Bundle Protocol standard. However, recent missions and test implementations have revealed missing components and areas for improvement in the standard. Using lessons learned from NASA missions and gathering inspiration from the Internet Protocol, BPv7 is intended to be a more robust Bundle Protocol that improves upon its predecessor and increases the technology readiness level of the DTN architecture. The DTN Standard Interface Design team, a sub-team of the DTN Infusion Project at the Goddard Space Flight Center, worked to create a dictionary of terms for bundle components and functional decomposition of the protocol. These efforts aided in the standardization of BP interfaces, something missing from BPv6, and supported parallel network management and configuration work. This standardization will ultimately contribute to LunaNet (a lunar communications and navigation architecture that will bring networking, positioning, navigation, timing and science services to the Moon), the Solar System Internet (SSI), and expand crewed and uncrewed space exploration opportunities.

DTN

Next Steps: Laying the Groundwork for Bundle Protocol v7

Delay/Disruption Tolerant Networking (DTN) is a networking model and protocol suite that extends the terrestrial internet to the challenging communication environments of space. These environments are typically subject to frequent disruptions, which can cause delays or errors. DTN protects data transmission by wrapping data into bundles (similar to Internet Protocol packets), storing them until a connection can be established between two nodes (similar to terrestrial routers or computers), and forwarding them to their destinations. Bundle Protocol (BP) is responsible for generating those bundles and creates the transport layer of DTN, much like how Transmission Control Protocol (TCP) and User Datagram Protocol (UDP) create the transport layer of the Internet Protocol. BPv6 is the current, accepted version of the Bundle Protocol standard. However, recent missions and test implementations have revealed missing components and areas for improvement in the standard. Using lessons learned from NASA missions and gathering inspiration from the Internet Protocol, BPv7 is intended to be a more robust Bundle Protocol that improves upon its predecessor and increases the technology readiness level of the DTN architecture. The DTN Standard Interface Design team, a sub-team of the DTN Infusion Project at the Goddard Space Flight Center, worked to create a dictionary of terms for bundle components and functional decomposition of the protocol. These efforts aided in the standardization of BP interfaces, something missing from BPv6, and supported parallel network management and configuration work. This standardization will ultimately contribute to LunaNet (a lunar communications and navigation architecture that will bring networking, positioning, navigation, timing and science services to the Moon), the Solar System Internet (SSI), and expand crewed and uncrewed space exploration opportunities.

dtn

A proposed group management scheme for XTP multicast

The purpose of a group management scheme is to enable its associated transfer layer protocol to be responsive to user determined reliability requirements for multicasting. Group management (GM) must assist the client process in coordinating multicast group membership, allow the user to express the subset of the multicast group that a particular multicast distribution must reach in order to be successful (reliable), and provide the transfer layer protocol with the group membership information necessary to guarantee delivery to this subset. GM provides services and mechanisms that respond to the need of the client process or process level management protocols to coordinate, modify, and determine attributes of the multicast group, especially membership. XTP GM provides a link between process groups and their multicast groups by maintaining a group membership database that identifies members in a name space understood by the underlying transfer layer protocol. Other attributes of the multicast group useful to both the client process and the data transfer protocol may be stored in the database. Examples include the relative dispersion, most recent update, and default delivery parameters of a group.

Dempsey, Bert J.

Standard formatted data units-control authority procedures

The purpose of this document is to establish a set of minimum and optional requirements for the implementation of Control Authority (CA) organizations within and among the Agencies participating in the Consultative Committee for Space Data Systems (CCSDS). By satisfying these requirements, the resultant cooperating set of CA organizations will produce a global CA service supporting information transfer with digital data under the Standard Formatted Data Unit (SFDU) concept. This service is primarily accomplished through the registration, permanent archiving, and dissemination of metadata in the form of Metadata Objects (MDO) that assist in the interpretation of data objects received in SFDU form. This Recommendation addresses the responsibilities, services, and interface protocols for a hierarchy of CA organizations. The top level, consisting of the CCSDS Secretariat and its operational agent, is unique and primarily provides a global coordination function. The lower levels are Agency CA organizations that have primary responsibility for the registration, archiving, and dissemination of MDOs. As experience is gained and technology evolves, the CA Procedures will be extended to include enhanced services and their supporting protocols. In particular, it is anticipated that eventually CA organizations will be linked via networks on a global basis, and will provide requestors with online automated access to CA services. While this Recommendation does not preclude such operations, it also does not recommend the specific protocols to be used to ensure global compatibility of these services. These recommendations will be generated as experience is gained.

Source record

CERES FM-5 on the NPP Spacecraft: Continuing the Earth Radiation Budget Climate Data Record

The Clouds and the Earth's Radiant Energy System (CERES) Flight Model-5 (FM-5) instrument will fly on the NPOESS Preparatory Project (NPP) spacecraft, which has a launch-readiness date in June, 2010. This mission will continue the critical Earth Radiation Budget Climate Data Record (CDR) begun by the Earth Radiation Budget Experiment (ERBE) instruments in the mid 1980 s and continued by the CERES instruments currently flying on the EOS Terra and Aqua spacecraft. Ground calibrations have been completed for FM-5 and the instrument has been delivered for integration to the spacecraft Rigorous pre-launch ground calibration is performed on each CERES unit to achieve an accuracy goal of 1% for SW flux and 0.5% for outgoing LW flux. Any ground to flight or in-flight changes in radiometer response is monitored using a protocol employing both onboard and vicarious calibration sources and experiments. Recent studies of FM-1 through FM-4 data have shown that the SW response of space based broadband radiometers can change dramatically due to optical contamination. With these changes having most impact on optical response to blue-to UV radiance, where tungsten lamps are largely devoid of output, such changes are hard to monitor accurately using existing on-board sources. This paper outlines the lessons learned on the existing CERES sensors from 30+ years of flight experience and presents a radiometric protocol to be implemented on the FM-5 instrument to ensure that its performance exceeds the stated calibration and stability goals.

Priestly, Kory

Tradeoffs in implementing primary-backup protocols

One way to implement a fault-tolerant service is by using multiple servers that fail independently. The state of the service is replicated and distributed among these servers, and updates are coordinated so that even when a subset of the servers fail, the service remains available. A common approach to structuring such replicated services is to designate one server as the primary and all the others as backups. Clients make requests by sending messages only to the primary. If the primary fails, then a failover occurs and one of the backups takes over. This service architecture is commonly called the primary-backup or the primary-copy approach. In most such primary-backup protocols, when the primary receives a client request, it informs the backups about the request, and then responds to the client. Informally, this primary-backup protocol is non-blocking if the primary does not wait for an acknowledgement from the backups before it sends the response; otherwise, it is blocking. Most of the existing protocols are blocking as non-blocking protocols cannot be constructed for some kinds of failures. However, it is shown that non-blocking protocols can be constructed for most of the process and communication failures that are expected to occur in the primary-backup systems of the future. Since non-blocking protocols can theoretically achieve the smallest possible response time, this paper analyzes these protocols under various system parameters. Two kinds of non-blocking protocols are analyzed: one in which the processes use point-to-point communication to exchange messages, and the other in which processes use hardware broadcasts.

Budhiraja, Navin

Space Station Freedom: Dynamic instrumentation for a large space structure

A proposed approach called Modal Identification Experiment (MIE) for obtaining on-orbit dynamic response measurements on Space Station Freedom, the first of a family of large, flexible space structures is discussed. The Phase 2 conceptual design study which provides a conceptual design of a proposed measurement system and an experimental protocol for inobstrusively collecting dynamic response data critical to characterizing important vibration modes of Space Station Freedom were recently concluded. The case for conducting such a measurement program is presented and the specific MIE objectives that were identified, are listed. The sequence of discrete Space Station Freedom assembly configurations is described, and the Phase 2 conceptual design of the experiment and instrumentation system are defined. In addition, a plan to utilize a space station hydrid scale model in laboratory simulations as part of the design process are discussed.

Raney, John P.

Blood flow dynamics in heart failure

BACKGROUND: Exercise intolerance in heart failure (HF) may be due to inadequate vasodilation, augmented vasoconstriction, and/or altered muscle metabolic responses that lead to fatigue. METHODS AND RESULTS: Vascular and metabolic responses to rhythmic forearm exercise were tested in 9 HF patients and 9 control subjects (CTL) during 2 protocols designed to examine the effect of HF on the time course of oxygen delivery versus uptake (protocol 1) and on vasoconstriction during exercise with 50 mm Hg pressure about the forearm to evoke a metaboreflex (protocol 2). In protocol 1, venous lactate and H+ were greater at 4 minutes of exercise in HF versus CTL (P<0.05) despite similar blood flow and oxygen uptake responses. In protocol 2, mean arterial pressure increased similarly in each group during ischemic exercise. In CTL, forearm blood flow and vascular conductance were similar at the end of ischemic and ambient exercise. In HF, forearm blood flow and vascular conductance were reduced during ischemic exercise compared with the ambient trial. CONCLUSIONS: Intrinsic differences in skeletal muscle metabolism, not vasodilatory dynamics, must account for the augmented glycolytic metabolic responses to moderate-intensity exercise in class II and III HF. The inability to increase forearm vascular conductance during ischemic handgrip exercise, despite a normal pressor response, suggests that enhanced vasoconstriction of strenuously exercising skeletal muscle contributes to exertional fatigue in HF.

NASA Discipline Cardiopulmonary

Exercise response

The bicycle ergometer and a graded stress protocol were used to conduct exercise stress tests for the Apollo project. The graded exercise tests permitted a progressive evaluation of physiological control system response and provided a better understanding of safe stress limits; heart rate was used for determining stress levels. During each test, workload, heart rate, blood pressure, and respiratory gas exchange (oxygen consumption, carbon dioxide production, and minute volume) measurements were made. The results are presented and discussed.

J.A. Rummel

Globalizing animal care and use: making the dream a reality

What will drive the globalization of animal care in the 21st century? Will targeted concerns from privately funded groups be the motivating factors? Will the threat of disease, and the concomitant hue and cry from a threatened public, be responsible for bringing nations together to collaborate on rules and regulations? The author, who is responsible for the animal use protocols on NASA's space station, explains why globalization on Planet Earth may be guided by what happens in outer space.

Animal Welfare/standards

A New View of Radiation-Induced Cancer: Integrating Short-and Long-Term Processes. Part I: Approach

Mathematical models of radiation carcinogenesis are important for understanding mechanisms and for interpreting or extrapolating risk. There are two classes of such models: (1) long-term formalisms that track premalignant cell numbers throughout an entire lifetime but treat initial radiation dose-response simplistically and (2) short-term formalisms that provide a detailed initial dose-response even for complicated radiation protocols, but address its modulation during the subsequent cancer latency period only indirectly. We argue that integrating short- and long-term models is needed. As an example of this novel approach, we integrate a stochastic short-term initiation/ inactivation/repopulation model with a deterministic two-stage long-term model. Within this new formalism, the following assumptions are implemented: radiation initiates, promotes, or kills pre-malignant cells; a pre-malignant cell generates a clone, which, if it survives, quickly reaches a size limitation; the clone subsequently grows more slowly and can eventually generate a malignant cell; the carcinogenic potential of pre-malignant cells decreases with age.

Shuryak, Igor

The Living With a Star Program Space Environment Testbed

This viewgraph presentation describes the objective, approach, and scope of the Living With a Star (LWS) program at the Marshall Space Flight Center. Scientists involved in the project seek to refine the understanding of space weather and the role of solar variability in terrestrial climate change. Research and the development of improved analytic methods have led to increased predictive capabilities and the improvement of environment specification models. Specifically, the Space Environment Testbed (SET) project of LWS is responsible for the implementation of improved engineering approaches to observing solar effects on climate change. This responsibility includes technology development, ground test protocol development, and the development of a technology application model/engineering tool.

Barth, Janet