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All sourcesNASA NTRSDOE OSTI
DOE OSTI2020

Materials Data on ReC2(IO)2 by Materials Project

ReC2(OI)2 crystallizes in the trigonal R-3 space group. The structure is zero-dimensional and consists of three ReC2(OI)2 clusters. there are two inequivalent Re6+ sites. In the first Re6+ site, Re6+ is bonded to three equivalent C and three equivalent I1- atoms to form distorted face-sharing ReC3I3 octahedra. All Re–C bond lengths are 1.91 Å. All Re–I bond lengths are 2.85 Å. In the second Re6+ site, Re6+ is bonded to six equivalent I1- atoms to form face-sharing ReI6 octahedra. All Re–I bond lengths are 2.74 Å. C is bonded in a linear geometry to one Re6+ and one O2- atom. The C–O bond length is 1.17 Å. O2- is bonded in a single-bond geometry to one C atom. I1- is bonded in a distorted L-shaped geometry to two Re6+ atoms.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on ReC2 by Materials Project

ReC2 crystallizes in the tetragonal P4/mmm space group. The structure is three-dimensional. Re6+ is bonded in a body-centered cubic geometry to eight equivalent C3- atoms. All Re–C bond lengths are 2.26 Å. C3- is bonded in a 5-coordinate geometry to four equivalent Re6+ and one C3- atom. The C–C bond length is 1.42 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on ReC2 by Materials Project

ReC2 is Corundum-like structured and crystallizes in the hexagonal P-6m2 space group. The structure is three-dimensional. Re6+ is bonded to six equivalent C3- atoms to form distorted edge-sharing ReC6 pentagonal pyramids. All Re–C bond lengths are 2.13 Å. C3- is bonded in a rectangular see-saw-like geometry to three equivalent Re6+ and one C3- atom. The C–C bond length is 1.39 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on ReC2 by Materials Project

ReC2 crystallizes in the tetragonal I4/mmm space group. The structure is three-dimensional. Re6+ is bonded in a distorted q6 geometry to ten equivalent C3- atoms. There are two shorter (2.25 Å) and eight longer (2.26 Å) Re–C bond lengths. C3- is bonded in a 5-coordinate geometry to five equivalent Re6+ atoms.

36 MATERIALS SCIENCE↗
DOE OSTI2020

Materials Data on ReC2 by Materials Project

ReC2 is Corundum-like structured and crystallizes in the hexagonal P6_3/mmc space group. The structure is three-dimensional. Re6+ is bonded to six equivalent C3- atoms to form distorted edge-sharing ReC6 pentagonal pyramids. All Re–C bond lengths are 2.14 Å. C3- is bonded in a rectangular see-saw-like geometry to three equivalent Re6+ and one C3- atom. The C–C bond length is 1.38 Å.

36 MATERIALS SCIENCE↗
DOE OSTI2021

Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules

Proteins evolve through the modular rearrangement of elements known as domains. Extant, multidomain proteins are hypothesized to be the result of domain accretion, but there has been limited experimental validation of this idea. Here, we introduce a technique for genetic minimization by iterative size-exclusion and recombination (MISER) for comprehensively making all possible deletions of a protein. Using MISER, we generate a deletion landscape for the CRISPR protein Cas9. We find that the catalytically-dead Streptococcus pyogenes Cas9 can tolerate large single deletions in the REC2, REC3, HNH, and RuvC domains, while still functioning in vitro and in vivo, and that these deletions can be stacked together to engineer minimal, DNA-binding effector proteins. In total, our results demonstrate that extant proteins retain significant modularity from the accretion process and, as genetic size is a major limitation for viral delivery systems, establish a general technique to improve genome editing and gene therapy-based therapeutics.

59 BASIC BIOLOGICAL SCIENCES↗