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At least 19 records

Metronomic Adjuvant Chemotherapy Improves Treatment Outcome in Nasopharyngeal Carcinoma Patients With Postradiation Persistently Detectable Plasma Epstein-Barr Virus Deoxyribonucleic Acid

Purpose: To investigate the effects of adjuvant chemotherapy in nasopharyngeal carcinoma (NPC) patients with persistently detectable plasma Epstein-Barr virus DNA (pEBV DNA) after curative radiation therapy plus induction/concurrent chemotherapy. Methods and Materials: The study population consisted of 625 NPC patients with available pEBV DNA levels before and after treatment. Eighty-five patients with persistently detectable pEBV DNA after 1 week of completing radiation therapy were eligible for this retrospective study. Of the 85 patients, 33 were administered adjuvant chemotherapy consisting of oral tegafur-uracil (2 capsules twice daily) for 12 months with (n=4) or without (n=29) preceding intravenous chemotherapy of mitomycin-C, epirubicin, and cisplatin. The remaining 52 patients who did not receive adjuvant chemotherapy served as the control group. Results: Baseline patient characteristics at diagnosis (age, sex, pathologic type, performance status, T classification, N classification, and overall stage), as well as previous treatment modality, were comparable in both arms. After a median follow-up of 70 months for surviving patients, 45.5% (15 of 33 patients) with adjuvant chemotherapy and 71.2% (37 of 52 patients) without adjuvant chemotherapy experienced tumor relapses (P=.0323). There were a significant reduction in distant failure (P=.0034) but not in local or regional recurrence. The 5-year overall survival rate was 71.6% for patients with adjuvant chemotherapy and 28.7% for patients without adjuvant chemotherapy (hazard ratio 0.27; 95% confidence interval 0.17-0.55; P<.0001). Conclusions: Our retrospective data showed that adjuvant chemotherapy can reduce distant failure and improve overall survival in NPC patients with persistently detectable pEBV DNA after curative radiation therapy plus induction/concurrent chemotherapy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Persistence of uranium emission in laser-produced plasmas

Detection of uranium and other nuclear materials is of the utmost importance for nuclear safeguards and security. Optical emission spectroscopy of laser-ablated U plasmas has been presented as a stand-off, portable analytical method that can yield accurate qualitative and quantitative elemental analysis of a variety of samples. In this study, optimal laser ablation and ambient conditions are explored, as well as the spatio-temporal evolution of the plasma for spectral analysis of excited U species in a glass matrix. Various Ar pressures were explored to investigate the role that plasma collisional effects and confinement have on spectral line emission enhancement and persistence. The plasma-ambient gas interaction was also investigated using spatially resolved spectra and optical time-of-flight measurements. The results indicate that ambient conditions play a very important role in spectral emission intensity as well as the persistence of excited neutral U emission lines, influencing the appropriate spectral acquisition conditions.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Investigation and quantification of nonlinearity using surrogate data in a glow discharge plasma

Detection of nonlinearity has been carried out in periodic and aperiodic floating potential fluctuations of DC glow discharge plasma by generating surrogate data using iterative amplitude adjusted Fourier transform method. We introduce “delay vector variance” analysis (DVV) for the first time, which allows reliable detection of nonlinearity and provides some easy to interpret diagram conveying information about the nature of the experimental floating potential fluctuations (FPF). The method of false nearest neighbourhood is deployed on the FPF's to find a good embedding so as to be acquainted with the precise knowledge of m, which is desirable for carrying out DVV analysis. The emergence of nonlinearity with increase in discharge voltage has been ensured by taking into consideration the total energy present in different band of frequencies excited due to nonlinear processes. Rejection of null hypothesis has been verified by performing the rank test method that confirms the presence of nonlinearity quantitatively.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Gravitational wave detection with plasma haloscopes

Searches for high frequency gravitational waves using cavities based on the Gertsenshtein effect were recently proposed, building off existing axion dark matter experiments. In particular, the sensitivity of axion dark matter experiments using metamaterial plasmas (tunable plasma haloscopes) to gravitational waves has not been explored in detail. Here we perform a full analysis of gravitational wave detection in plasma haloscopes, showing that the baseline design of experiments such as ALPHA is several orders of magnitude less sensitive than previously thought. We show how simple changes to the experiment can recover that sensitivity and lead to a powerful gravitational wave detector in the 𝒪⁡(10–50) GHz frequency range.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Dynamic measurement of the helium concentration of evolving tungsten nanostructures using Elastic Recoil Detection during plasma exposure

Helium (He) concentration depth profiles of evolving tungsten (W) nanostructures have been measured for the first time using in situ Elastic Recoil Detection (ERD) throughout plasma irradiation. In this work, exposures resulting in fuzzy and non-fuzzy surfaces were analyzed in order to illuminate the role of He during the development of these surface morphologies. ERD was performed on samples with surface temperatures from $T_s$ = 530–1100 K and irradiated by He flux densities of $Γ_{\text{He}}$ ~ 10 20 –10 22 m –2 s –1 . He concentration profiles in samples that developed either non-fuzzy or fuzzy surfaces are uniformly shaped with concentrations of 1.5–7 at.%, which is presumed to be too low for pressure driven growth models. Therefore, surface morphology changes are not perpetuated by continuous bubble bursting deformation. Also, a threshold in He flux density above 10 20 m –2 s –1 is suggested by using in situ ERD to monitor the depth profile evolution of the He-rich layer while changing the flux during exposure.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

In situ Detection of Plasma Induced Surface Interaction based on Deep Learning based Visual Diagnostics (Technical Report)

It is characteristic for many plasma devices to undergo plasma-material interaction leading to surface erosion. These processes, often not easily detectable, lead to changes in device performance and lifespan. State-of-the-art lifetime tests and wear experiments require over 1000s hours. A self-consistent model for accurately predicting the erosion's effects is not available. In situ detection of these processes is not a trivial task since the surface variations at the early stages have a micron scale. Such limitations not only restrict testing and prediction capabilities but also slow the development of new thrusters and limit mission duration. To address these challenges, an in-situ diagnostic for real-time erosion assessment has been developed, aiming to expedite lifetime testing and broaden experimental campaigns. Several works were dedicated to real-time and in situ monitoring of material erosion during plasma exposure using laser holography, microscopy, and with telemicroscopes. However, the applicability of these approaches is limited due to complexity, cost and less flexibility as they often require placing diagnostic equipment inside the vacuum chamber. In collaboration with Princeton Collaborative Research Facility (PCRF), Princeton Plasma Physics Laboratory (PPPL), a new diagnostic approach is developed, where geometry modifications to the ceramic channel walls were introduced that would result in accelerated channel erosion. We employed Long-distance microscope (LDM) imagery, combined with Deep-Learning based Shape from focus or depth from focus (DFF or SFF) approach, that provides an accessible and cost-effective solution. LDM employs focus variation techniques to continuously capture multiple images of the target object at distinct focal planes. DFF, an optical focus variation method, generates a 3D topographical surface depth map from a sequence of variably focused images. Combined with the developed diagnostic, this approach offers a controllable means to study erosion under accelerated conditions. In this work, we develop Neural Network-based DFF algorithm applicable for LDM data to quantitatively evaluate plasma induced surface modification from LDM data. Next, we develop Deep Learning-based super-resolution depth map image reconstruction technique to increase the resolution of depth maps obtained from DFF algorithm to improve the accuracy of erosion measurements. Thirdly, we develop several image processing techniques to remove noise and improve the quality of depth map image. Here we report the results of initial tests for this approach. An experimental setup designed and built in PPPL was employed that consists of a 3-cm gridded ion source that produces a neutralized argon beam with energies up to 600 eV. A hexagonal boron nitride (h-BN) ceramic target, designed based on computational predictions, was used. Tests were conducted to reconstruct the complex geometry of the target under the lighting conditions of the operated ion source.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Origin of electrical signals for plasma etching endpoint detection

Electrical signals are used for endpoint detection in plasma etching, but the origin of the electrical changes observed at endpoint is not known. They may be caused by changes in the gas-phase densities of etch products and reactants or by changes in substrate surface properties such as photoemitted or ion-induced electron yield. To investigate these effects, experiments were performed in an inductively coupled, rf-biased reactor, during CF{sub 4}/Ar etches of SiO{sub 2} films on Si wafers. The rf bias impedance was measured vs. time during etching, simultaneous with Langmuir probe measurements. At endpoint, a decrease in impedance coincided with increases in ion current and electron energy. The data, analyzed by a numerical model of the discharge, indicate that changes in electron emission yield were relatively insignificant or entirely absent. Thus the impedance change is not a surface effect but is, instead, predominantly or entirely a gas-phase phenomenon.

36 MATERIALS SCIENCE↗

DETECTION OF PLASMA FLUCTUATIONS IN WHITE-LIGHT IMAGES OF THE OUTER SOLAR CORONA: INVESTIGATION OF THE SPATIAL AND TEMPORAL EVOLUTION

This work focuses on the first results from the identification and characterization of periodic plasma density fluctuations in the outer corona, observed in STEREO-A COR1 white-light image time series. A two-dimensional reconstruction of the spatial distribution and temporal evolution of the coronal fluctuation power has been performed over the whole plane of the sky, from 1.4 to 4.0 R{sub Sun }. The adopted diagnostic tool is based on wavelet transforms. This technique, with respect to the standard Fourier analysis, has the advantage of localizing non-persistent fluctuating features and exploring variations of the relating wavelet power in both space and time. The map of the variance of the coronal brightness clearly outlines intermittent spatially coherent fluctuating features, localized along, or adjacent to, the strongest magnetic field lines. In most cases, they do not correspond to the visible coronal structures in the brightness maps. The results obtained provide a scenario in which the solar corona shows quasi-periodic, non-stationary density variations characterized by a wide range of temporal and spatial scales and strongly confined by the magnetic field topology. In addition, structures fluctuating with larger power are larger in size and evolve more slowly. The characteristic periodicities of the fluctuations are comparable to their lifetimes. This suggests that plasma fluctuations lasting only one or two wave periods and initially characterized by a single dominant periodicity either rapidly decay into a turbulent mixed flow via nonlinear interactions with other plasma modes, or they are damped by thermal conduction. The periodic non-stationary coronal fluctuations outlined by the closed field lines at low and mid latitudes might be associated with the existence of slow standing magneto-acoustic waves excited by the convective supergranular motion. The fluctuating ray-like structures observed along open field lines appear to be linked either to the intermittent nature of the processes underlying the generation of magnetic reconnection in the polar regions or to the oscillatory transverse displacements of the coronal ray itself.

79 ASTRONOMY AND ASTROPHYSICS↗

Use of Sonification for Analysis and Detection of Plasma Bubbles at 21 MHz

This research explores sonification as a useful tool for space science data exploration. Our interest lies in basic scientific analysis of plasmas of the ionosphere, of interplanetary space and of the interstellar medium. These plasmas all contain irregularities. Propagation of electromagnetic waves, like optical or radio waves, through a medium with random fluctuations in refractive index results in amplitude and phase fluctuations (Scheuer 1968). These variations may be displayed via sonification, using changes in sounds to represent the data variations. This is particularly useful extending science to the visually-impaired. The xSonify Java-based tool was developed to explore sonification techniques and its value for general science analysis and also assistive technology.

Wanda, Diaz↗

Charge collection during hypervelocity penetrations of thin foils

The following represents trajectory sensor development work for the space-station-based Cosmic Dust Collection Facility (CDCF). This facility-class payload was to expose some 7 sq m of NASA-provided general-user instruments in addition to three instruments provided by formally selected principal investigators. The preferred trajectory sensor for this general-user instrument envisioned the detection of impact-triggered plasma for both velocity measurement and location instruments. Space station developments in late 1992/early 1993 lead to cancellation of this potential flight project, for both technical and fiscal reasons. This precipitated termination of all plasma detection work at JSC on behalf of CDCF's general-user instrument. The following comprises three informal reports that summarize the CDCF efforts regarding plasma sensing for trajectory determinations. The reports were initially written for internal CDCF use and were not widely distributed. Because no formal publications are envisioned at present, the three reports are included in full in this document. They not only demonstrate that substantial progress was accomplished in the development of plasma trajectory sensors during 1990-1992, but the results are hopefully of interest and use to others who may continue these developments. The chronological sequence of these three reports is reversed, with the first containing the latest information.

Peterson, Robert B.↗

Plasma ignition and detection for in-situ cleaning of 1.3 GHz 9-cell cavities

Superconducting Radio Frequency (SRF) cavities performance preservation is crucial, from vertical test to accelerator operation. Field Emission (FE) is still one of the performance limiting factors to overcome and plasma cleaning has been proven successful by the Spallation Neutron Source (SNS), in cleaning field emitters and increasing the work function of Nb. A collaboration has been established between Fermi National Accelerator Laboratory (FNAL), SLAC National Accelerator Laboratory and Oak Ridge National Laboratory (ORNL) with the purpose of applying plasma processing to the Linac Coherent Light Source-II (LCLS-II) cavities, in order to minimize and overcome field emission without affecting the high Q of nitrogen-doped cavities. The cleaning for LCLS-II will follow the same plasma composition adopted at SNS, which allows in-situ processing of cavities installed in cryomodules from hydrocarbon contaminants. A novel method for plasma ignition has been developed at FNAL: a plasma glow discharge is ignited using high order modes to overcome limitations imposed by the fundamental power coupler, allowing in-situ cleaning for cavities in cryomodule. The plasma can be easily ignited and tuned in each of the cavity cells using low RF power. A method for plasma detection has been developed as well, which allows the detection of the plasma location in the cavity without the need of cameras at both cavity ends. The presented method can be applied to other multi-cell cavity designs, even for accelerators where the coupling for the fundamental modes at room temperature is very weak.

43 PARTICLE ACCELERATORS↗

Low RF Power Plasma Ignition and Detection for In-Situ Cleaning of 1.3 GHz 9-Cell Cavities

Superconducting Radio Frequency (SRF) cavities performance preservation is crucial, from vertical test to accelerator operation. Field Emission (FE) is still one of the performance limiting factors to overcome and plasma cleaning has been proven successful by the Spallation Neutron Source (SNS), in cleaning field emitters and increasing the work function of Nb. A collaboration has been established between Fermi National Accelerator Laboratory (FNAL), SLAC National Accelerator Lab- oratory and Oak Ridge National Laboratory (ORNL) with the purpose of applying plasma processing to the Linac Coherent Light Source-II (LCLS-II) cavities, in order to minimize and overcome field emission without affecting the high Q of nitrogen-doped cavities. The cleaning for LCLS-II will follow the same plasma composition adopted at SNS, which allows in-situ processing of cavities installed in cryomod-ules from hydrocarbon contaminants. A novel method for plasma ignition has been developed at FNAL: a plasma glow discharge is ignited using high order modes to overcome limitations imposed by the fundamental power coupler, allowing in-situ cleaning for cavities in cryomodule. The plasma can be easily ignited and tuned in each of the cavity cells using low RF power. A method for plasma detection has been developed as well, which allows the detection of the plasma location in the cavity without the need of cameras at both cavity ends. The presented method can be applied to other multi-cell cavity designs, even for accelerators where the coupling for the fundamental modes at room temperature is very weak.

43 PARTICLE ACCELERATORS↗

A Detection of the Same Hot Plasma in the Corona: During a CME and Later at Ulysses

We show direct evidence for the same very hot plasma being detected remotely from SOHO in the corona and subsequently, at Ulysses in the solar wind. This is, to our knowledge, the first time that such an unambiguous identification has been made in the case of hot plasma. This detection complements studies correlating other plasma and field properties observed to the properties measured at the source in the corona. This observation takes advantage of a SOHO-Sun-Ulysses quadrature, during which the Sun-Ulysses included angle is $90^\circ$ and it is possible to observe with Ulysses instruments the same plasma that has previously been remotely observed with SOHO instruments in the corona on the limb of the Sun. The identification builds on an existing base of separate SOHO and interplanetary detections of hot plasma. SOHO/UVCS has found evidence for very hot coronal plasma in current sheets in the aftermath of CMEs in the [Fe XVIII] $\lambda$ \AA\ line, implying a temperature on the order of $6\times 10(exp 6)$ K. This temperature is unusually high even for active regions, but is compatible with the high temperature predicted in current sheets. In the solar wind, ACE data from early 1998 to middle 2000 revealed high frozen-in Fe charge state in many cases to be present in interplanetary plasma.

Suess, S. T.↗

Distributed Magnetic Measurements Using Fiber Optic Pulsed Polarimetry (Final Report)

Measurement of the magnetic fields surrounding magnetic fusion energy (MFE) devices, such as tokamaks, is critical for characterizing and monitoring the plasma inside these devices, and it is especially important for detecting plasma instabilities, which can lead to the plasma damaging the inside of these devices. This program successfully demonstrated a new type of magnetic field diagnostic that is capable for the first time of measuring simultaneously the spatial and temporal magnetic field distributions of MFE devices in real-time and with high resolution. This is a capability not feasible with existing magnetic field diagnostics and, moreover, the technique we developed provides other advantages, such as less susceptibility to noise, the ability to operate during both pulsed and steady-state plasma conditions, the ability to detect relatively weak poloidal fields, and potentially lower costs. This new capability of being able in real-time to detect anomalies in the magnetic field distribution corresponding to the onset of plasma instabilities offers the ability to automatically shut down the MFE device before the plasma can damage the machine. Hence, this machine protection capability can be vital for future fusion power stations. Our technique uses optical fibers where changes in the polarization of the laser light traveling through the fiber provide a direct measurement of the magnetic field at any point along the fiber. The small size of the fibers allows them to be easily installed either outside or inside the MFE vacuum vessel, and in any direction one wishes (e.g., poloidal or toroidal). We demonstrated the basic capabilities of our new diagnostic during a proof-of-principle experiment performed on the General Atomics DIII-D tokamak, and published the results in: W. D. Kimura, D. S. Dhillon, S. Munaretto, E. J. Strait, D. Du, S. Loranger, J.-S. Boisvert, and R. Kashyap, “Measurements of DIII-D poloidal field by fiber-optic pulsed polarimetry,” Rev. Sci, Inst. 89, 10J102 (2018).

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗