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Results for “PLASMON RULER”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sources NASA NTRS DOE OSTI

DOE OSTI2015

Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules

Plasmon rulers, consisting of pairs of gold nanoparticles, allow single-molecule analysis without photobleaching or blinking; however, current plasmon rulers are irreversible, restricting detection to only single events. Here, we present a reversible plasmon ruler, comprised of coupled gold nanoparticles linked by a single aptamer, capable of binding individual secreted molecules with high specificity. We show that the binding of target secreted molecules to the reversible plasmon ruler is characterized by single-molecule sensitivity, high specificity, and reversibility. Lastly, such reversible plasmon rulers should enable dynamic and adaptive live-cell measurement of secreted single molecules in their local microenvironment.

77 NANOSCIENCE AND NANOTECHNOLOGY↗

DOE OSTI2011

3D Plasmon Ruler

In this animation of a 3D plasmon ruler, the plasmonic assembly acts as a transducer to deliver optical information about the structural dynamics of an attached protein. (courtesy of Paul Alivisatos group)

59 BASIC BIOLOGICAL SCIENCES↗

DOE OSTI2014

Symmetry Breaking in Tetrahedral Chiral Plasmonic Nanoparticle Assemblies

Self-assembled plasmonic structures combine the specificity and tunability of chemical synthesis with collective plasmonic properties. In this work we systematically explore the effects of symmetry breaking on the chiroptical response of an assembly of plasmonic nanoparticles using simulation. The design is based on a tetrahedral nanoparticle frame with two different types of nanoparticles, where chirality is induced by targeted stimuli that change the distance along one edge of the assembly. Here, we show that the intensity, spectral position, and handedness of the CD response are tunable with small structural changes, making it usable as a nanoscale plasmonic ruler. We then build upon this initial design to show that the symmetry breaking principle may also be used to design a chiral pyramid using a mixture of different nanoparticle materials, which affords tunability over a broad spectral range, and retrieves nanoscale conformational changes over a range of length scales.

36 MATERIALS SCIENCE↗

DOE OSTI2013

Nanoplasmonic molecular ruler for nuclease activity and DNA footprinting

This invention provides a nanoplasmonic molecular ruler, which can perform label-free and real-time monitoring of nucleic acid (e.g., DNA) length changes and perform nucleic acid footprinting. In various embodiments the ruler comprises a nucleic acid attached to a nanoparticle, such that changes in the nucleic acid length are detectable using surface plasmon resonance. The nanoplasmonic ruler provides a fast and convenient platform for mapping nucleic acid-protein interactions, for nuclease activity monitoring, and for other footprinting related methods.

59 BASIC BIOLOGICAL SCIENCES↗