Structure and Function of Proteins and Nucleic Acids Semiannual Progress Report, 1 Jan. - 30 Jun. 1966
Potential applications to planetary explorations of research techniques and findings related to structure of proteins and nucleic acids
PROTEIN↗
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Structure and function of proteins and nucleic acid Progress report, 1 Jul. - 31 Dec. 1967
Conformation of pyridine nucleotide coenzymes by rotary dispersion and dichroism
Stryer, L.↗
Some recent work on prebiological synthesis of organic compounds.
Origin of constituents of nucleic acid and protein molecules, noting biological molecules synthesis under conditions similar to those prevailing in prebiotic Earth, following Oparin-Haldane hypothesis
ABIOGENESIS↗
Inferences from protein and nucleic acid sequences - Early molecular evolution, divergence of kingdoms and rates of change
Description of new sensitive, objective methods for establishing the probable common ancestry of very distantly related sequences and the quantitative evolutionary change which has taken place. These methods are applied to four families of proteins and nucleic acids and evolutionary trees will be derived where possible. Of the three families containing duplications of genetic material, two are nucleic acids: transfer RNA and 5S ribosomal RNA. Both of these structures are functional in the synthesis of coded proteins, and prototypes must have been present in the cell at the inception of the fundamental coding process that all living things share. There are many types of tRNA which recognize the various nucleotide triplets and the 20 amino acids. These types are thought to have arisen as a result of many gene duplications. Relationships among these types are discussed. The 5S ribosomal RNA, presently functional in both eukaryotes and prokaryotes, is very likely descended from an early form incorporating almost a complete duplication of genetic material. The amount of evolution in the various lines can again be compared. The other two families containing duplications are proteins; ferredoxin and cytochrome c.
Dayhoff, M. O.↗
Cell fine structure and function - Past and present
Electron microscopic studies of nerve membrane fine structure, discussing cell membrane multienzyme and macromolecular energy and information transduction, protein synthesis and nucleic acids interrelations
Fernandez-Moran, H.↗