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At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

Can synthetic lethality approach be used with DNA repair genes for primary and secondary MDS?

Cancer-specific defects in DNA repair pathways create the opportunity to employ synthetic lethality approach. Recently, GEMA (gene expression and mutation analysis) approach detected insufficient expression of BRCA or NHEJ (non-homologous end joining) to predict PARP inhibitors response. We evaluated a possible role of DNA repair pathways using gene expression of single-strand break (XPA, XPC, XPG/ERCC5, CSA/ERCC8, and CSB/ERCC6) and double-strand break (ATM, BRCA1, BRCA2, RAD51, XRCC5, XRCC6, LIG4) in 92 patients with myelodysplastic syndrome (73 de novo, 9 therapy-related (t-MDS). Therapy-related MDS (t-MDS) demonstrated a significant downregulation of axis BRCA1-BRCA2-RAD51 comparing to normal controls (p = 0.048, p = 0.001, p = 0.001). XRCC6 showed significantly low expression in de novo MDS comparing to controls (p = 0.039) and for patients who presented chromosomal abnormalities (p = 0.047). Downregulation of LIG4 was consistently associated with poor prognostic markers in de novo MDS (hemoglobin < 8 g/dL (p = 0.040), neutrophils < 800/mm{sup 3} (p < 0.001), patients with excess of blasts (p = 0.001), very high (p = 0.002)/high IPSS-R (p = 0.043) and AML transformation (p < 0.001). We also performed an evaluation of GEPIA Database in 30 cancer types and detected a typical pattern of downregulation as here presented in primary or secondary MDS. All these results suggest synthetic lethality approach can be tested with DNA repair genes (beyond that of BRCA1/2 status) for de novo and therapy-related myelodysplastic syndrome and may encourage clinical trials evaluating the use of PARP1 inhibitors in MDS. Graphic Abstract: .

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRS1990

Attitude Determination and Control System (ADCS) and Maintenance and Diagnostic System (MDS): A maintenance and diagnostic system for Space Station Freedom

The Maintenance and Diagnostic System (MDS) that is being developed at Honeywell to enhance the Fault Detection Isolation and Recovery system (FDIR) for the Attitude Determination and Control System on Space Station Freedom is described. The MDS demonstrates ways that AI-based techniques can be used to improve the maintainability and safety of the Station by helping to resolve fault anomalies that cannot be fully determined by built-in-test, by providing predictive maintenance capabilities, and by providing expert maintenance assistance. The MDS will address the problems associated with reasoning about dynamic, continuous information versus only about static data, the concerns of porting software based on AI techniques to embedded targets, and the difficulties associated with real-time response. An initial prototype was built of the MDS. The prototype executes on Sun and IBM PS/2 hardware and is implemented in the Common Lisp; further work will evaluate its functionality and develop mechanisms to port the code to Ada.

Toms, David↗
NASA NTRS2000

The MDS autonomous control architecture

We describe the autonomous control architecture for the JPL Mission Data System (MDS). MDS is a comprehensive new software infrastructure for supporting unmanned space exploration. The autonomous control architecture is one component of MDS designed to enable autonomous operations.

MDS autonomous control unmanned space exploration↗
DOE OSTI2018

Water Film Structure during Rupture as Revealed by MDS Image Analysis

The structure of thin water films during the rupture process was investigated by a new approach, which combines molecular dynamics simulation (MDS) with image processing analysis. The analysis procedure was developed to convert MDS trajectories to readable 3D images. The water films were studied at different thicknesses by MDS to determine the critical thickness at which the film ruptures. The potential energy of each specific film thickness during the simulation time was analyzed, and the results showed that the potential energy of stable films remained unchanged while the potential energy kept decreasing for films which ruptured during the simulation time. By applying the new procedure, the molecular porosity, which is defined as the void fraction between the volume of molecular pores in the water film and the total volume of the water film, was calculated. The results of molecular porosity for different film thicknesses during the simulation time suggested a critical molecular porosity as 49%. In other words, stable films have a molecular porosity of less than 49%. If a water film has a molecular porosity greater than 49%, rupture occurs during the simulation. This research was supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences.

molecular dynamics simulation, film stability, ima↗
DOE OSTI2025

Materials Data Science Ontology(MDS-Onto): Unifying Domain Knowledge in Materials and Applied Data Science

Ontologies have gained popularity in the scientific community as a way to standardize terminologies in organizations’ data. Although certain cohorts have created frameworks with rules and guidelines on creating ontologies, there exist significant variations in how Materials Science ontologies are currently developed. We seek to provide guidance in the form of a unified automated framework for developing interoperable and modular ontologies for Materials Data Science that simplifies the ontology terms matching by establishing a semantic bridge up to the Basic Formal Ontology(BFO). This framework provides key recommendations on how ontologies should be positioned within the semantic web, what knowledge representation language is recommended, and where ontologies should be published online to boost their findability and interoperability. Two fundamental components of the MDS-Onto framework are the bilingual package called FAIRmaterials for ontology creation and FAIRLinked, for FAIR data creation. To showcase the practical capabilities of FAIRmaterials, we present two exemplar domain ontologies of MDS-Onto: Synchrotron X-Ray Diffraction and Photovoltaics.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2018

FACE-MDS Phase 2: Data from Six US-Located Elevated CO2 Experiments

This dataset contains measured ecosystem data from four Free Air CO2 Enrichment (FACE) experiments–Duke, Oak Ridge (ORNL), and Rhinelander -- and one Open Top Chamber (OTC) experiment -- Kennedy Space Center (KSCO). The sites were located in the United States and contain data from 1996-2009. These sites were the study sites of the FACE Model Data Synthesis (FACE-MDS) project phase 2. The file naming convention can be found in the file 'facemds-file-table-sitedata.xml' and information about variable naming convention can be found in the file 'facemds-standard-name-table-modvars.xml'. We followed the ALMA v3 convention for meteorological variables and developed a hierarchical naming scheme for ecosystem variables. Additional info can be found in the protocols in the accompanying meteorological dataset (Walker et al. 2018: doi:10.15485/1480328). We replaced the original naming convention mentioned in the protocol with the one described in 'facemds-standard-name-table-modvars.xml'. The outputs of the FACE-MDS phase 2 are in Walker et al (2018: doi:10.15485/1480327). The dataset contains 18 data files that are available in comma-separate (*.csv), and 18 R Data Serialization (*.rds) format. 2 XML (*.xml) companion files and additional metadata are provided: 2 data dictionaries and a file-level metadata file in comma-separate (.csv) format and a user guide in PDF (*.pdf) format. This dataset was updated on 2019-06-28 to fix daily files at Duke and ORNL were incorrectly labelled and were standard error files instead of plot level data. Now corrected and all three (plot, mean, standard error) daily data files for both sites have been added. This dataset was updated on 2026-06-08 to add a user guide, data dictionary file, and a file-level metadata file. DUKE_ax_v2.csv was added to match the no data value format of other files in this dataset. DUKE_ax.csv is maintained as a data file. No previously released data values were changed.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2018

FACE-MDS Phase 2: Meteorological Data and Protocols

This dataset contains meteorological data, site parameterization data, and protocols for simulation of the five Free Air CO2 Enrichment (FACE) experiments and one Open Top Chamber (OTC) experiment that were the study sites of the FACE Model Data Synthesis (FACE-MDS) project. This dataset should contain everything necessary to simulate these six CO2 enrichment experiments -- Duke, Kennedy Space Center, NDFF, ORNL, PHACE, and Rhinelander -- following the FACE-MDS simulation protocol. Data cover 1998-2008 (1998-01-01 to 2008-12-31). File naming convention can be found in the file 'facemds-file-table-metdata.xml' and information about variable naming convention can be found in the file 'facemds-standard-name-table-metvars.xml'. Where possible, Assistance for the Land-surface Modelling Activities (ALMA) v3 convention for meteorological variables naming ontology was followed. Additional info can be found in the user guide, protocol documents, and readmes in this dataset. The original naming convention mentioned in the protocol was replaced with the one described in 'facemds-standard-name-table-modvars.xml' in the accompanying dataset (doi:10.15485/1480327). The dataset contains 21 data files that are available in comma-separate (*.csv), plain text (*.txt), and NetCDF (*.nc) format. Nine companion files and additional metadata are provided: three data dictionaries and a file-level metadata file in comma separate (.csv) format and a user guide in PDF (*.pdf) format. This dataset was updated on 2026-06-02 to add a version of the data files in comma separate (.csv) format, a user guide, data dictionary files, and a file-level metadata file. No previously released data values were changed.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1997

Calibrating the WFPC2 astrometry for MDS

The Hubble Space Telescope (HST) Medium Deep Survey has optimized an automated procedure to associate and stack WFPC2 data. The coordinates listed in HST WFPC2 image and/or jitter file headers are often found to be insufficient to stack images for cosmic ray removal. We discuss results from software developed for the HST Medium Deep Survey (MDS) pipeline to evaluate these shifts by cross-correlation of the images. We will also discuss the distortion of the pre-cool-down WFPC2 field and attempts to derive absolute coordinates for MDS WFPC2 observations using the USNO-Al.0 half billion object catalog.

Ratnatunga, Kavan U.↗
NASA NTRS2006

MDS MIC Catalog Inputs

This viewgraph presentation reviews the inputs to the MDS Medical Information Communique (MIC) catalog. The purpose of the group is to provide input for updating the MDS MIC Catalog and to request that MMOP assign Action Item to other working groups and FSs to support the MITWG Process for developing MIC-DDs.

Johnson-Throop, Kathy A.↗
DOE OSTI2015

Phase 1 Free Air CO2 Enrichment Model-Data Synthesis (FACE-MDS): Model Output Data (2015)

These datasets comprise the model output from phase 1 of the FACE-MDS. These include simulations of the Duke and Oak Ridge experiments and also idealised long-term (300 year) simulations at both sites (please see the modelling protocol for details). Included as part of this dataset are modelling and output protocols. The model datasets are formatted according to the output protocols. Phase 1 datasets are reproduced here for posterity and reproducibility although the model output for the experimental period have been somewhat superseded by the Phase 2 datasets.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2023

Electrokinetic comparison of CaF 2 and AgCl from a MDS perspective

CaF 2 has limited electrokinetic sensitivity to fluoride ions in solution and the positive CaF 2 surface charge is not reversed at high fluoride ion concentration. Similar insensitivity of surface charge to high fluoride ion concentration has been observed for other alkali and alkaline earth fluoride salts. On the contrary, chloride ions act as potential determining ions for AgCl and reverse the surface charge, as expected. FTIR-IRS results indicate that the AgCl/water interface has a water structure-breaking tendency, whereas the CaF 2 /water interface has a structure-making tendency. Here, it is speculated that the strong hydrogen bonding between fluoride ions and water prevents the accommodation of excess fluoride ions at surface lattice sites of fluorite, and therefore explains the low sensitivity of the fluorite surface charge sign and magnitude to fluoride ion concentration. However, this speculation has not been examined at the molecular level and is evaluated by molecular dynamics simulations (MDS) in the research presented in this paper. Higher hydrogen bond density at the CaF 2 mineral/water interface confirms that the water structure has stronger hydrogen bonding at both the CaF 2 mineral surface and with the F - ion in solution. In this way, the interaction of the F - ion with the CaF 2 surface is inhibited.

36 MATERIALS SCIENCE↗
DOE OSTI2018

FACE-MDS Phase 2: Model Output

Model output from Phase 2 of the Free Air CO2 Enrichment Model Data Synthesis (FACE-MDS) project. Results from 12 models simulating six elevated CO2 experiments using the protocols, met data, and other data supplied in the accompanying dataset: Phase 2 Free Air CO2 Enrichment Model-Data Synthesis: Meteorological Data and Protocols. File naming convention can be found in the file 'facemds-file-table-modeldata.xml' and information about variable naming convention can be found in the file 'facemds-standard-name-table-modvars.xml'. We followed the ALMA v3 convention for meteorological variables and developed a hierarchical naming scheme for ecosystem variables. Additional info can be found in the protocols in the accompanying meteorological dataset (doi:10.15485/1480328). We replaced the original naming convention mentioned in the protocol with the one described in 'facemds-standard-name-table-modvars.xml'.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1988

A lower bound for the decoder error probability of the linear MDS code

A lower bound for the decoder error probability (P sub E (u)) of a linear maximum distance separable (MDS) code is derived by counting the dominant types of decoding words around code words. It is shown that the lower bound derived is similar in form, and close numerically, to the upper bound derived.

Cheung, K.-M.↗
NASA NTRS2018

Additive Construction with Mobile Emplacement (ACME) / Automated Construction of Expeditionary Structures (ACES) Materials Delivery System (MDS)

The purpose of the Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) project is to incorporate the Liquid Goods Delivery System (LGDS) into the Dry Goods Delivery System (DGDS) structure to create an integrated and automated Materials Delivery System (MDS) for 3D printing structures with ordinary Portland cement (OPC) concrete. ACES 3 is a prototype for 3-D printing barracks for soldiers in forward bases, here on Earth. The LGDS supports ACES 3 by storing liquid materials, mixing recipe batches of liquid materials, and working with the Dry Goods Feed System (DGFS) previously developed for ACES 2, combining the materials that are eventually extruded out of the print nozzle. Automated Construction of Expeditionary Structures, Phase 3 (ACES 3) is a project led by the US Army Corps of Engineers (USACE) and supported by NASA. The equivalent 3D printing system for construction in space is designated Additive Construction with Mobile Emplacement (ACME) by NASA.

Mueller, R. P.↗
DOE OSTI2015

Phase 1 Free Air CO2 Enrichment Model-Data Synthesis (FACE-MDS): Meteorological Data

These datasets comprise the meteorological, CO2 and N deposition data used to run models for the Duke and Oak Ridge FACE experiments. Phase 1 datasets are reproduced here for posterity and reproducibility although these meteorological datasets are superseded by the Phase 2 datasets. If you would like to use the meteorological datasets to run your own model or for any other purpose please use the Phase 2 datasets.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS1977

Tracking system performance tests in the MDS era

Tracking system performance tests as developed to support DSN Mark III Data Subsystem implementation project and prepass readiness tests are described. The system test design, the rationale chosen for implementation, and the inevitable compromises imposed by schedule constraints and reserves are discussed.

Buckles, B. J.↗