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At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2025

Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13

Sperm IZUMO1 binds to egg JUNO, and this interaction is essential for mammalian fertilization. Isolated from a female mouse immunized with syngeneic sperm, the antisperm antibody OBF13 recognizes IZUMO1 and inhibits murine fertilization. How OBF13 interferes with sperm–egg interactions was unknown. Here, we present the X-ray crystal structure of IZUMO1 in complex with OBF13. OBF13 binds to the apex of the four-helix domain of IZUMO1, distant from the JUNO-binding site. Our crystal structure of OBF13-bound IZUMO1 resembles apo-IZUMO1 and differs from the structure of IZUMO1 in complex with JUNO. We identify that OBF13 carries a low level of somatic hypermutation, and through deep mutational scanning, we engineer an affinity-enhanced OBF13 variant. This OBF13 variant single-chain fragment variable decreases the apparent affinity of IZUMO1 for membrane-bound murine JUNO and blocks the binding of acrosome-reacted sperm to eggs, thereby preventing fertilization. We propose allostery between the OBF13 epitope and the JUNO-binding site. OBF13 inhibits a conformational change in IZUMO1, preventing fusion-competent sperm from adhering to murine eggs during fertilization. Surprisingly, murine IZUMO1 binds to hamster JUNO with an affinity ~20-fold higher than to murine JUNO. The decreased affinity caused by OBF13 of murine IZUMO1 for hamster JUNO is sufficient for murine sperm to bind to and fuse with hamster eggs. Our studies provide a structural and mechanistic framework for species-specific, allosteric inhibition of IZUMO1 by a naturally occurring antisperm antibody and offer insights into the development of immunocontraceptives.

Science & Technology - Other Topics↗
DOE OSTI2020

Why matter effects matter for JUNO

In this paper we focus on the Earth matter effects for the solar parameter determination by a medium baseline reactor experiment such as JUNO. We derive perturbative expansions for the mixing angles θ 12 and θ 13 as well as the Δm$^{2}_{21}$ and Δm$^{2}_{31}$ in terms of the matter potential relevant for JUNO. These expansions, up to second order in the matter potential, while simple, allow one to calculate the electron antineutrino survival probability to a precision much better than needed for the JUNO experiment. We use these perturbative expansions to semi-analytically explain and confirm the shift caused by the matter effects on the solar neutrino mixing parameters θ 12 and Δm$^{2}_{21}$ which were previously obtained by a purely numerical χ 2 analysis. Since these shifts do not satisfy the naive expectations and are significant given the precision that can be achieved by the JUNO experiment, a totally independent cross check using a completely different method is of particular importance. We find that these matter effect shifts do not depend on any of the details of the detector characteristics apart from the baseline and earth mass density between reactor(s) and detector, but do depend on the normalized product of reactor neutrino spectrum times the inverse-beta decay cross-section. The results of this manuscript suggests an alternative analysis method for measuring sin 2 θ 12 and Δm$^{2}_{21}$ in JUNO which would be a useful cross check of the standard analysis and for the understanding of the Wolfenstein matter effect. The explanation of these shifts together with a quantitative understanding, using a semi-analytical method, is the principal purpose of this paper.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2020

Optimization of the JUNO liquid scintillator composition using a Daya Bay antineutrino detector

To maximize the light yield of the liquid scintillator (LS) for the Jiangmen Underground Neutrino Observatory (JUNO), a 20 t LS sample was produced in a pilot plant at Daya Bay. The optical properties of the new LS in various compositions were studied by replacing the gadolinium-loaded LS in one antineutrino detector. The concentrations of the fluor, PPO, and the wavelength shifter, bis-MSB, were increased in 12 steps from 0.5 g/L and 0.01 mg/L to 4 g/L and 13 mg/L, respectively. The numbers of total detected photoelectrons suggest that, with the optically purified solvent, the bis-MSB concentration does not need to be more than 4 mg/L. In order to bridge the one order of magnitude in the detector size difference between Daya Bay and JUNO, the Daya Bay data were used to tune the parameters of a newly developed optical model. Then, the model and tuned parameters were used in the JUNO simulation. Overall, this enabled to determine the optimal composition for the JUNO LS: purified solvent LAB with 2.5 g/L PPO, and 1 to 4 mg/L bis-MSB.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2024

Exploring solar neutrino oscillation parameters with the liquid scintillator counter at Yemilab with a comparison to JUNO

We investigate the sensitivities of the liquid scintillator counter (LSC) at Yemilab and JUNO to solar neutrino oscillation parameters, focusing on θ 12 and Δ m 21 2 . We compare the potential of JUNO with LSC at Yemilab utilizing both reactor and solar data in determining those parameters. We find that the solar neutrino data of LSC at Yemilab is highly sensitive to θ 12 enabling its determination with a higher precision compared to reactor experiments. Our study also reveals that if Δ m 21 2 is larger, with a value close to the best-fit value of KamLAND, JUNO reactor data will have about two times better precision than the reactor LSC at Yemilab. On the other hand, if Δ m 21 2 is smaller and closer to the best-fit value of solar neutrino experiments, the precision of the reactor LSC at Yemilab will be better than JUNO. Published by the American Physical Society 2024

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2026

Impact of new physics on the JUNO-long-baseline synergy in the neutrino mass ordering determination

The determination of the neutrino mass ordering is one of the flagship goals in particle physics. A well-known and powerful synergy emerges when combining high-precision measurements of the effective atmospheric mass-squared splitting from electron antineutrino disappearance in reactor experiments with that from muon (anti)neutrino disappearance in accelerator-based long-baseline experiments. To fully exploit this synergy, percent-level precision in the atmospheric mass splitting is required—a target that JUNO is expected to achieve within a few months of data taking. This motivated the formulation of a mass ordering sum rule for neutrino disappearance channels, which shows that by combining data from T2K and NOvA with JUNO after one year of operation, the neutrino mass ordering can be determined at the 3⁢𝜎 confidence level. Since JUNO has recently started taking data, it is timely to ask whether this sum rule remains robust in the presence of new physics. We identify the necessary conditions for new physics to affect the sum rule and demonstrate that, in some cases, such effects could lead to an incorrect inference of the mass ordering. As concrete examples, we consider scalar nonstandard interactions (SNSI) and neutrinos coupled to an ultralight scalar field. We find that, for SNSI, current constraints render any modification of the sum rule negligible, whereas in the latter case, the inference of the ordering requires caution. Nevertheless, these effects can be disentangled, illustrating how the sum rule can also be used to search for new physics.

Alves, Gustavo F. S. [Fermi National Accelerator L↗
DOE OSTI2024

Pulse shape discrimination technique for diffuse supernova neutrino background search with JUNO

Pulse shape discrimination (PSD) is widely used in particle and nuclear physics. Specifically in liquid scintillator detectors, PSD facilitates the classification of different particle types based on their energy deposition patterns. This technique is particularly valuable for studies of the diffuse supernova neutrino background (DSNB), nucleon decay, and dark matter searches. This paper presents a detailed investigation of the PSD technique, applied in the DSNB search performed with the Jiangmen Underground Neutrino Observatory (JUNO). Instead of using conventional cut-and-count methods, we employ methods based on boosted decision trees and neural networks and compare their capability to distinguish the DSNB signals from the atmospheric neutrino neutral-current background events. The two methods demonstrate comparable performance, resulting in a 50–80% improvement in signal efficiency compared to a previous study performed for JUNO (An et al. [JUNO] in J Phys G 43(3):030401, 2016). Moreover, we study the dependence of the PSD performance on the visible energy and final state composition of the events and find a significant dependence on the presence/absence of 11 C. Finally, we evaluate the impact of the detector effects (photon propagation, PMT dark noise, and waveform reconstruction) on the PSD performance.

FOS: Physical sciences↗
DOE OSTI2026

Impact of New Physics on the JUNO-Long-Baseline Synergy in Neutrino Mass Ordering Determination

The determination of the neutrino mass ordering is one of the flagship goals in particle physics. A well-known and powerful synergy emerges when combining high-precision measurements of the effective atmospheric mass-squared splitting from electron antineutrino disappearance in reactor experiments with that from muon (anti)neutrino disappearance in accelerator-based long-baseline experiments. To fully exploit this synergy, percent-level precision in the atmospheric mass splitting is required-a target that JUNO is expected to achieve within a few months of data taking. This motivated the formulation of a mass ordering sum rule for neutrino disappearance channels, which shows that by combining data from T2K and NOvA with JUNO after one year of operation, the neutrino mass ordering can be determined at the $3σ$ confidence level. Since JUNO has recently started taking data, it is timely to ask whether this sum rule remains robust in the presence of new physics. We identify the necessary conditions for new physics to affect the sum rule and demonstrate that, in some cases, such effects could lead to an incorrect inference of the mass ordering. As concrete examples, we consider Scalar Non-Standard Interactions (SNSI) and neutrinos coupled to an ultralight scalar field. We find that, for SNSI, current constraints render any modification of the sum rule negligible, whereas in the latter case, the inference of the ordering requires caution. Nevertheless, these effects can be disentangled, illustrating how the sum rule can also be used to search for new physics.

Alves, Gustavo F.S. [Fermilab; Northwestern U.; Sa↗
DOE OSTI2025

The Juno mission as a probe of long-range new physics

Orbits of celestial objects, especially the geocentric and heliocentric ones, have been well explored to constrain new long-range forces beyond the Standard Model (SM), often referred to as fifth forces. In this paper, for the first time, we apply the motion of a spacecraft around Jupiter to probe fifth forces that don’t violate the equivalence principle. The spacecraft is the Juno orbiter, and ten of its early orbits already allow a precise determination of the Jovian gravitational field. We use the shift in the precession angle as a proxy to test non-gravitational interactions between Juno and Jupiter. Requiring that the contribution from the fifth force does not exceed the uncertainty of the precession shift inferred from data, we find that a new parameter space with the mass of the fifth-force mediator around 10 −14 eV is excluded at 95% C.L.

new light particles↗
DOE OSTI2025

Mass ordering sum rule for the neutrino disappearance channels in T2K, NOvA, and JUNO

We revisit, reformulate, and extend a method for determining the neutrino mass ordering by using precision measurements of the atmospheric Δ m 2 s in both electron and muon neutrino disappearance channels, first proposed by the authors in 2005 [H. Nunokawa , Phys. Rev. D 72, 013009 (2005)]. The mass ordering is a very important outstanding question for our understanding of the elusive neutrino and determination of the mass ordering has consequences to particle physics, nuclear physics, and cosmology. The JUNO reactor experiment will start data taking this year, and the precision of the atmospheric Δ m 2 s from electron antineutrino measurements will improve by a factor of 3 from Daya Bay’s 2.4% to 0.8% within a year. This measurement, when combined with the atmospheric Δ m 2 ’s measurements from T2K and NOvA for muon neutrino disappearance, will contribute substantially to the Δ χ 2 between the two remaining neutrino mass orderings. In this paper we derive for the first time a mass ordering sum rule that can be used to address the possibility that JUNO’s atmospheric Δ m 2 ’s measurement, when combined with other experiments in particular T2K and NOvA, can determine the neutrino mass ordering at the 3 σ confidence level within one year of operation. For a confidence level of 5 σ in a single experiment, we will have to wait until the middle of the next decade when the DUNE experiment is operating.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
DOE OSTI2026

Determining Neutrino Mass Ordering with NOvA and Upcoming JUNO Measurements

NOvA has reported a significance of mass ordering determination using ten years of data together with external constraints from reactor-based experiments. The JUNO collaboration is poised to provide a more precise reactor-based constraint on $|Δm^2_{32}|$. In this Letter, we explore the potential impact of this anticipated measurement on the determination of the neutrino mass ordering by NOvA. We find that $3σ$ evidence of the normal ordering is achievable over a range of plausible JUNO measurements within the next five years.

Abubakar, S. [Erciyes U.]↗
DOE OSTI2023

Plasma Wave and Particle Dynamics During Interchange Events in the Jovian Magnetosphere Using Juno Observations

Abstract Interchange instability is known to drive fast radial transport of particles in Jupiter's inner magnetosphere. Magnetic flux tubes associated with the interchange instability often coincide with changes in particle distributions and plasma waves, but further investigations are required to understand their detailed characteristics. We analyze representative interchange events observed by Juno, which exhibit intriguing features of particle distributions and plasma waves, including Z‐mode and whistler‐mode waves. These events occurred at an equatorial radial distance of ∼9 Jovian radii on the nightside, with Z‐mode waves observed at mid‐latitude and whistler‐mode waves near the equator. We calculate the linear growth rate of whistler‐mode and Z‐mode waves based on the observed plasma parameters and electron distributions and find that both waves can be locally generated within the interchanged flux tube. Our findings are important for understanding particle transport and generation of plasma waves in the magnetospheres of Jupiter and other planetary systems.

Geology↗
DOE OSTI2020

Probing neutrino quantum decoherence at reactor experiments

We explore how well reactor antineutrino experiments can constrain or measure the loss of quantum coherence in neutrino oscillations. We assume that decoherence effects are encoded in the size of the neutrino wave-packet, σ . We find that the current experiments Daya Bay and the Reactor Experiment for Neutrino Oscillation (RENO) already constrain σ > 1 . 0 × 10 - 4 nm and estimate that future data from the Jiangmen Underground Neutrino Observatory (JUNO) would be sensitive to σ < 2 . 1 × 10 - 3 nm. If the effects of loss of coherence are within the sensitivity of JUNO, we expect σ to be measured with good precision. The discovery of nontrivial decoherence effects in JUNO would indicate that our understanding of the coherence of neutrino sources is, at least, incomplete.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
DOE OSTI2024

Neutrino charge radius and additional one-loop radiative corrections at ultranear reactor experiments

We scrutinize the potential of upcoming ultranear reactor neutrino experiments to detect radiative corrections in the elastic neutrino-electron scattering channel, focusing on the JUNO-TAO and CLOUD detectors, which employ advanced scintillator detection technologies. Previous reactor experiments have already constrained the electron neutrino charge radius, which is a neutrino property associated with a certain subset of the total radiative corrections, and have achieved limits that are only about an order of magnitude away from the Standard Model prediction. Our study demonstrates that JUNO-TAO and CLOUD could discover the neutrino charge radius in the near future, considering the established treatment of the charge radius. However, we show that it is necessary to go beyond this standard treatment. By including the complete set of one-loop level radiative corrections, we find a partial cancellation with the charge radius effect, reducing the experimental sensitivity to this quantity. Nevertheless, JUNO-TAO and CLOUD still have the potential to achieve a 5 σ discovery but over longer timescales within a reasonable operational time frame. Published by the American Physical Society 2024

Brdar, Vedran (ORCID:0000000170275104)↗
DOE OSTI2019

Luminous signals of inelastic dark matter in large detectors

In this work, we study luminous dark matter signals in models with inelastic scattering. Dark matter $\chi_1$ that scatters inelastically off elements in the Earth is kicked into an excited state $\chi_2$ that can subsequently decay into a monoenergetic photon inside a detector. The photon signal exhibits large sidereal-daily modulation due to the daily rotation of the Earth and anisotropies in the problem: the dark matter wind comes from the direction of Cygnus due to the Sun's motion relative to the galaxy, and the rock overburden is anisotropic, as is the dark matter scattering angle. This allows outstanding separation of signal from backgrounds. We investigate the sensitivity of two classes of large underground detectors to this modulating photon line signal: large liquid scintillator neutrino experiments, including Borexino and JUNO, and the proposed large gaseous scintillator directional detection experiment CYGNUS. Borexino's (JUNO's) sensitivity exceeds the bounds from xenon experiments on inelastic nuclear recoil for mass splittings $\delta \gtrsim 240 (180)$ keV, and is the only probe of inelastic dark matter for ${350 \text{ keV} \lesssim \delta \lesssim 600 \text{ keV}}$. CYGNUS's sensitivity is at least comparable to xenon experiments with $\sim 10 \; {\rm m}^3$ volume detector for $\delta \lesssim 150$ keV, and could be substantially better with larger volumes and improved background rejection. Such improvements lead to the unusual situation that the inelastic signal becomes the superior way to search for dark matter even if the elastic and inelastic scattering cross sections are comparable.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗