Engineering Papers⌕ Search

SEARCH · Engineering Papers

Results for “INTERNATIONAL ORGANIZATIONS”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2013

Critical Dose of Internal Organs Internal Exposure - 13471

The health threat posed by radionuclides has stimulated increased efforts to developed characterization on the biological behavior of radionuclides in humans in all ages. In an effort motivated largely by the Chernobyl nuclear accident, the International Commission on Radiological Protection (ICRP) is assembling a set of age specific biokinetic models for environmentally important radioelements. Radioactive substances in the air, mainly through the respiratory system and digestive tract, is inside the body. Radioactive substances are unevenly distributed in various organs and tissues. Therefore, the degree of damage will depend not only on the dose of radiation have but also on the critical organ, which is the most accumulation of radioactive substances, which leads to the defeat of the entire human body. The main objective of radiation protection, to avoid exceeding the maximum permissible doses of external and internal exposure of a person to prevent the physical and genetic damage people. The maximum tolerated dose (MTD) of radiation is called a dose of radiation a person in uniform getting her for 50 years does not cause changes in the health of the exposed individual and his progeny. The following classification of critical organs, depending on the category of exposure on their degree of sensitivity to radiation: First group: the whole body, gonads and red bone marrow; Second group: muscle, fat, liver, kidney, spleen, gastrointestinal tract, lungs and lens of the eye; The third group: bone, thyroid and skin; Fourth group: the hands, forearms, feet. MTD exposure whole body, gonads and bone marrow represent the maximum exposures (5 rem per year) experienced by people in their normal activities. The purpose of this article is intended dose received from various internal organs of the radionuclides that may enter the body by inhalation, and gastrointestinal tract. The biokinetic model describes the time dependent distribution and excretion of different radionuclides that have intake into the organism or absorbed into blood. Transport of different radionuclides between compartments is assumed to follow first order kinetics provided the concentration in red blood cells (RBCs) stays below a nonlinear threshold concentration. When the concentration in RBCs exceeds that threshold, the transfer rate from diffusible plasma to RBCs is assumed to decrease as the concentration in RBCs increases. For the calculations used capabilities AMBER by using the traces of radionuclides in the body. Model for the transfer of radionuclides in the body has been built on the basis of existing models at AMBER for lead. (authors)

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2015

SU-E-T-508: Internal Organ Motion Effect On Radiation Dose to a Point Under Half-Beam Block Match Line

Purpose Half-beam block is a field matching technique frequently used in radiotherapy. With no setup error, a well calibrated linac, and no internal organ motion, two photon fields can be matched seamlessly dosimetry-wise with their central axes passing the match line. However, in actual clinical situations, internal organ motion is often inevitable. This study was conducted to investigate its influence on radiation dose to patient internal points directly under the matching line. Methods A clinical setting is modeled as two half-space (x<0 and x<0) radiation fields that are turned on sequentially with a time gap of integer times of the patient internal organ motion period (T{sub 0}). Our point of interest moves with patient internal organs periodically and evenly in and out of the radiation fields, resulting in an average location at x=0. When the fields are delivered without any motion management, the initial phase of the point’s movement is unknown. Statistical methods are used to compute the expected value ( ) and variance (σ) of the point dose given the uncertainty. Results Analytical solutions are obtained for and s of dose received by a point directly under the match line. is proportional to the total beam-on time (T1), and σ demonstrates previously unknown periodic behavior. /<Dσ has local maximums (minimums) when T{sub 1} is 2n*T{sub 0} ((2n+1)*T{sub 0}) (n is an integer) with an upper envelope scales as 1/T{sub 1}. Worst case scenario the point dose can be zero or double of the expected value. Conclusion We have analytically analyzed the internal organ motion effect on radiation dose received by a patient internal point directly under a half-beam block match line. Our results help us to better understand this phenomenon and facilitate the reduction of point dosimetric uncertainties in our clinical practice.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2014

DNA damage in internal organs after cutaneous exposure to sulphur mustard

Sulphur mustard (SM) is a chemical warfare agent that attacks mainly skin, eye and lungs. Due to its lipophilic properties, SM is also able to diffuse through the skin and reach internal organs. DNA represents one of the most critical molecular targets of this powerful alkylating agent which modifies DNA structure by forming monoadducts and biadducts. These DNA lesions are involved in the acute toxicity of SM as well as its long-term carcinogenicity. In the present work we studied the formation and persistence of guanine and adenine monoadducts and guanine biadducts in the DNA of brain, lungs, kidneys, spleen, and liver of SKH-1 mice cutaneously exposed to 2, 6 and 60 mg/kg of SM. SM-DNA adducts were detected in all studied organs, except in liver at the two lowest doses. Brain and lungs were the organs with the highest level of SM-DNA adducts, followed by kidney, spleen and liver. Monitoring the level of adducts for three weeks after cutaneous exposure showed that the lifetime of adducts were not the same in all organs, lungs being the organ with the longest persistence. Diffusion from skin to internal organs was much more efficient at the highest compared to the lowest dose investigated as the result of the loss of the skin barrier function. These data provide novel information on the distribution of SM in tissues following cutaneous exposures and indicate that brain is an important target. - Highlights: • Sulphur mustard reaches internal organs after skin exposure • Adducts are detected in the DNA of internal organs • Brain is the organ with the highest level of DNA damage • The barrier function of skin is lost at high dose of sulphur mustard • DNA adducts persist in organs for 2 or 3 weeks.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2013

Monitoring internal organ motion with continuous wave radar in CT

Purpose: To avoid motion artifacts in medical imaging or to minimize the exposure of healthy tissues in radiation therapy, medical devices are often synchronized with the patient's respiratory motion. Today's respiratory motion monitors require additional effort to prepare the patients, e.g., mounting a motion belt or placing an optical reflector on the patient's breast. Furthermore, they are not able to measure internal organ motion without implanting markers. An interesting alternative to assess the patient's organ motion is continuous wave radar. The aim of this work is to design, implement, and evaluate such a radar system focusing on application in CT.Methods: The authors designed a radar system operating in the 860 MHz band to monitor the patient motion. In the intended application of the radar system, the antennas are located close to the patient's body inside the table of a CT system. One receive and four transmitting antennas are used to avoid the requirement of exact patient positioning. The radar waves propagate into the patient's body and are reflected at tissue boundaries, for example at the borderline between muscle and adipose tissue, or at the boundaries of organs. At present, the authors focus on the detection of respiratory motion. The radar system consists of the hardware mentioned above as well as of dedicated signal processing software to extract the desired information from the radar signal. The system was evaluated using simulations and measurements. To simulate the radar system, a simulation model based on radar and wave field equations was designed and 4D respiratory-gated CT data sets were used as input. The simulated radar signals and the measured data were processed in the same way. The radar system hardware and the signal processing algorithms were tested with data from ten volunteers. As a reference, the respiratory motion signal was recorded using a breast belt simultaneously with the radar measurements.Results: Concerning the measurements of the test persons, there is a very good correlation (ρ= 0.917) between the respiratory motion phases received by the radar system and the external motion monitor. Our concept of using an array of transmitting antennas turned out to be widely insensitive to the positioning of the test persons. A time shift between the respiratory motion curves recorded with the radar system and the motion curves from the external respiratory monitor was observed which indicates a slight difference between internal organ motion and motion detected by the external respiratory monitor. The simulations were in good accordance with the measurements.Conclusions: A continuous wave radar operating in the near field of the antennas can be used to determine the respiratory motion of humans accurately. In contrast to trigger systems used today, the radar system is able to measure motion inside the body. If such a monitor was routinely available in clinical CT, it would be possible optimizing the scan start with respect to the respiratory state of the patient. Breathing commands would potentially widely be avoided, and as far as uncooperative patients or children are concerned, less sedation might be necessary. Further applications of the radar system could be in radiation therapy or interventional imaging for instance.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
NASA NTRS1991

An international organization for remote sensing

A recommendation is presented for the formation of a new commercially oriented international organization to acquire or develop, coordinate or manage, the space and ground segments for a global operational satellite system to furnish the basic data for remote sensing and meteorological, land, and sea resource applications. The growing numbers of remote sensing programs are examined and possible ways of reducing redundant efforts and improving the coordination and distribution of these global efforts are discussed. This proposed remote sensing organization could play an important role in international cooperation and the distribution of scientific, commercial, and public good data.

Helm, Neil R.↗
DOE OSTI2014

Self-organized internal architectures of chiral micro-particles

The internal architecture of polymeric self-assembled chiral micro-particles is studied by exploring the effect of the chirality, of the particle sizes, and of the interface/surface properties in the ordering of the helicoidal planes. The experimental investigations, performed by means of different microscopy techniques, show that the polymeric beads, resulting from light induced polymerization of cholesteric liquid crystal droplets, preserve both the spherical shape and the internal self-organized structures. The method used to create the micro-particles with controlled internal chiral architectures presents great flexibility providing several advantages connected to the acquired optical and photonics capabilities and allowing to envisage novel strategies for the development of chiral colloidal systems and materials.

36 MATERIALS SCIENCE↗
DOE OSTI2015

International organization for standardization on the topic of nuclear criticality safety (ISO TC85/SC5/WG8) - 14244

This paper is a four-year update (i.e. 2011 - 2015) about the progress and activities of the International Organization for Standardization (ISO), Technical Committee 85 (TC85) on Nuclear energy, Subcommittee 5 (SC5) on Nuclear fuel cycle, Working Group 8 (WG8) on Nuclear criticality safety. The update provides a brief summary of historic standards developed by ISO TC85/SC5/WG8 and descriptions about evolving standards for nuclear criticality safety. The update describes the potential value and relevance of indigenous standards and technological developments by OECD regarding nuclear criticality safety standards. Elements of the published WG8 ISO standards that have been incorporated into International Atomic Energy Agency non-consensus guides and standards are provided. A review of international participation and needed participation is also addressed along with the benefits to ISO participating member countries. (authors)

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗
DOE OSTI2011

A Pelvic Phantom for Modeling Internal Organ Motions

A pelvic phantom was developed for use in testing image-guided radiation therapy (IGRT) and adaptive applications in radiation therapy (ART) with simulating the anterior-posterior internal organ motions during prostate radiotherapy. Measurements could be done with an ionization chamber (IC) in the simulated prostate. The rectum was simulated by air-equivalent material (AEM). The volume superior to the IC placement was considered as the bladder. The extension of AEM volume could be varied. The vertical position of the IC placement could be shifted by {+-}1 cm to simulate the prostate motion parallel to the changes in bladder volume. The reality of the simulation was inspected. Three-millimeter-slice-increment computed tomography (CT) scans were taken for irradiation planning. The structure set was adapted to the phantom from a treated patient. Planning target volume was delineated according to the RTOG 0126 study. IMRT and 3D conformal radiation therapy (3D-CRT) plans were made. Prostate motion and rectum volume changes were simulated in the phantom. IC displacement was corrected by phantom shifting. The delivered dose was measured with IC in 7 cases using intensity-modulated radiation therapy (IMRT) and 3D-CRT fractions, and single square-shaped beams: anteroposterior (AP), posteroanterior (PA), and lateral (LAT). Variations from the calculated doses were slightly below 1% at IMRT and around 1% at 3D-CRT; below 4.5% at square AP beam; up to 9% at square PA beam; and around 0.5% at square LAT beam. Other authors have already shown that by using planning systems and ultrasonic and cone beam CT guidance, correction of organ motions in a real patient during prostate cancer IGRT does not have a significant dosimetric effect. The inspection of our phantom-as described here-ended with similar results. Our team suggested that our model is sufficiently realistic and can be used for IGRT and ART testing.

61 RADIATION PROTECTION AND DOSIMETRY↗
DOE OSTI2015

Controlling Internal Organization of Multilayer Poly(methacrylic acid) Hydrogels with Polymer Molecular Weight

Here, we report on tailoring the internal architecture of multilayer-derived poly(methacrylic acid) (PMAA) hydrogels by controlling the molecular weight of poly(N-vinylpyrrolidone) (PVPON) in hydrogen-bonded (PMAA/PVPON) layer-by-layer precursor films. The hydrogels are produced by cross-linking PMAA in the spin-assisted multilayers followed by PVPON release. We found that the thickness, morphology, and architecture of hydrogen-bonded films and the corresponding hydrogels are significantly affected by PVPON chain length. For all systems, an increase in PVPON molecular weight from M w = 2.5 to 1300 kDa resulted in increased total film thickness. We also show that increasing polymer M w smooths the hydrogen-bonded film surfaces but roughens those of the hydrogels. Using deuterated dPMAA marker layers in neutron reflectometry measurements, we found that hydrogen-bonded films reveal a high degree of stratification which is preserved in the cross-linked films. We observed dPMAA to be distributed more widely in the hydrogen-bonded films prepared with small M w PVPON due to the greater mobility of short-chain PVPON. Furthermore, these variations in the distribution of PMAA are erased after cross-linking, resulting in a distribution of dPMAA over about two bilayers for all M w but being somewhat more widely distributed in the films templated with higher M w PVPON. Finally, our results yield new insights into controlling the organization of nanostructured polymer networks using polymer molecular weight and open opportunities for fabrication of thin films with well-organized architecture and controllable function.

36 MATERIALS SCIENCE↗
NASA NTRS1993

International organizations to enable world-wide mobile satellite services

Numbers of systems exist or have been proposed to provide world-wide mobile satellite services (MSS). Developers of these systems have formulated institutional structures they consider most appropriate for profitable delivery of these services. MSS systems provide niche services and complement traditional telecommunications networks; they are not integrated into world-wide networks. To be successful, MSS system operators must be able to provide an integrated suite of services to support the increasing globalization, interconnectivity, and mobility of business. The critical issue to enabling 'universal roaming' is securing authority to provide MSS in all of the nations of the world. Such authority must be secured in the context of evolving trends in international telecommunications, and must specifically address issues of standardization, regulation and organization. Today, only one existing organization has such world-wide authority. The question is how proponents of new MSS systems and services can gain similar authority. Securing the appropriate authorizations requires that these new organizations reflect the objectives of the nations in which services are to be delivered.

Anglin, Richard L., Jr.↗
DOE OSTI2018

Roles of Interfacial Tension in Regulating Internal Organization of Low Bandgap Polymer Bulk Heterojunction Solar Cells by Polymer Additives

The role of a tertiary polymer-based additive is investigated in increasing the efficiency of inverted low bandgap polymer:fullerene bulk heterojunction (BHJ) solar cells. Charge separation in polymer BHJ solar cells relies on the phase separation between electron accepting fullerene derivatives and photoactive polymers. Proper distribution of individual phases of suitable crystallinities within the active layer is a key factor for efficient charge transport/extraction and high photovoltaic performance. Here in this paper, it is demonstrated that the minor addition of a tertiary amorphous polymer, polystyrene (PS), with optimized molecular weights can increase the overall photovoltaic efficiency of poly[N-9-heptadecanyl-2,7-carbazole-alt-5,5-(4,7-di-2-thienyl-2,1,3-benzothiadiazole)]:phenyl-C 61 butyric acid methyl ester (PCDTBT:PCBM) inverted BHJ solar cells, through the interfacial-tension-driven increase in crystallinities of photoactive phases and redistribution of PCBM molecules away from the top hole-collecting anode interface. Complementary studies correlating polymer interfacial tension, blend internal structure, charge transport, and photovoltaic characteristics show that tertiary, high molecular-weight polymers can serve as effective additives for improving the performance of low bandgap polymer solar cells.

25 ENERGY STORAGE↗