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At least 19 records

Effects of heavy ion radiation on the brain vascular system and embryonic development

The present investigation is concerned with the effects of heavy-ion radiation on the vascular system and the embryonic development, taking into account the results of experiments with neonatal rats and mouse embryos. It is found that heavy ions can be highly effective in producing brain hemorrhages and in causing body deformities. Attention is given to aspects of methodology, the induction of brain hemorrhages by X-rays and heavy ions, and the effect of iron particles on embryonic development. Reported results suggest that high linear energy transfer (LET) heavy ions can be very effective in producing developmental abnormalities.

Yang, T. C.↗

Life sciences and space research XXI(1); Proceedings of the Topical Meeting, Graz, Austria, June 25-July 7, 1984

Space research in biology is presented with emphasis on flight experiment results and radiation risks. Topics discussed include microorganisms and biomolecules in the space-environment experiment ES 029 on Spacelab-1, the preliminary characterization of persisting circadian rhythms during space flight; plant growth, development, and embryogenesis during the Salyut-7 flight, and the influence of space-flight factors on viability and mutability of plants. Consideration is also given to radiation-risk estimation and its application to human beings in space, the radiation situation in space and its modification by the geomagnetic field and shielding, the quantitative interpretation of cellular heavy-ion action, and the effects of heavy-ion radiation on the brain vascular system and embryonic development.

Klein, H. P.↗

Acceleration of heavy ions by radiation pressure.

The possible acceleration of heavy ions by the resonance scattering of radiation near bright stellar objects is examined. Planck spectra are assumed. At any radiation temperature, heavy-ion energies are found to be limited by aberration and Doppler effects. Photoionization is found to limit maximum radiation temperatures and energies for each ion. Collisional ionization by ambient electrons and ions may further limit heavy-ion energies. Because of these limitations, the production of the more energetic cosmic rays by this mechanism appears to be very improbable. If supernova radiation temperatures are high enough, they may produce heavy ions with energies up to several hundreds of MeV per nucleon. O and B stars appear to be able to accelerate certain heavy ions to 200 and 80 MeV per nucleon, respectively.

Nakada, M. P.↗

Radiation protection guidelines for space missions

The current radiation protection guidelines of the National Aeronautics and Space Administration (NASA) were recommended in 1970. The career limit was set at 4.0 Sv (400 rem). Using the same approach as in 1970 but current risk estimates, a considerably lower career limit would obtain today. Also, there is now much more information about the radiation environments that will be experienced in different missions. Furthermore, since 1970 women have joined the ranks of the astronauts. For these and other reasons, it was considered necessary to re-examine the radiation protection guidelines. This task has been undertaken by the National Council on Radiation Protection and Measurements Scientific Committee 75. Within the magnetosphere, the radiation environment varies with altitude and inclination of the orbit. In outer space missions, galactic cosmic rays, with the small but important heavy-ion component, determine the radiation environment. The new recommendations for career dose limits, based on lifetime excess risk of cancer mortality, take into account age at first exposure and sex. The career limits range from 1.0 Sv (100 rem) for a 24-y-old female up to 4.0 Sv (400 rem) for a 55-y-old male, compared with the previous single limit of 4.0 Sv (400 rem). The career limit for the lens of the eye has been reduced from 6.0 Sv (600 rem) to 4.0 Sv (400 rem).

NASA Discipline Radiation Health↗

Funduscopic alterations in the rhesus monkey induced by exposure to heavy ions /0+8/ 250 MeV/nucleon

A heavy-ion, high-energy beam has been extracted from the Lawrence Radiation Laboratory Bevatron, making controlled exposure of biological systems feasible, and a series of experiments have been undertaken to determine the possible deleterious effects of such irradiation upon the primate retina. The left eyes of 54 rhesus monkeys have been exposed to accelerated 0+8 (250 MeV/nucleon). Beam flux ranged from 1.3 x 10 to the 7th particles/ sq cm (171 rads) to 5.9 x 10 to the 8th particles/sq cm (7740 rads). Fundus photography was performed immediately prior to and immediately following exposure, at 24 to 48 hours postexposure and at 1, 2, and 5 weeks postexposure. Punctate hemorrhages of the retina were visible at 1.3 x 10 to the 7th particles/sq cm (171 rads), the lowest exposure level utilized in this study. Acute radiation retinopathy, consisting of geographic retinal hemorrhage and ischemic necrosis of the retina, was not seen until total flux reached 7.7 x 10 to the 7th particles/sq cm (1000 rads).

Beckman, F. N.↗

Physical considerations relevant to HZE-particle transport in matter

High-energy, highly charged (HZE) heavy nuclei may seem at first sight to be an exotic type of radiation, only remotely connected with nuclear power generation. On closer examination it becomes evident that heavy-ion accelerators are being seriously considered for driving inertial confinement fusion reactors, and high-energy heavy nuclei in the cosmic radiation are likely to place significant constraints on satellite power system deployment and space-based power generation. The use of beams of heavy nuclei in an increasing number of current applications, as well as their importance for the development of the state of the art of the future, makes it necessary to develop at the same time a good understanding of their transport through matter.

NASA Program Biomedical Research↗

Assessing the SEU resistance of CMOS latches using alpha-particle sensitive test circuits

The importance of Cosmic Rays on the performance of integrated circuits (IC's) in a space environment is evident in the upset rate of the Tracking and Data Relay Satellite (TDRS) launched in Apr. 1983. This satellite experiences a single-event-upset (SEU) per day which must be corrected from the ground. Such experience caused a redesign of the Galileo spacecraft with SEU resistant IC's. The solution to the SEU problem continues to be important as the complexity of spacecraft grows, the feature size of IC's decreases, and as space systems are designed with circuits fabricated at non-radiation hardened foundries. This paper describes an approach for verifying the susceptibility of CMOS latches to heavy-ion induced state changes. The approach utilizes alpha particles to induce the upsets in test circuits. These test circuits are standard cells that have offset voltages which sensitize the circuits to upsets. These results are then used to calculate the upsetability at operating voltages. In this study results are presented for the alpha particle upset of a six-transistor static random access memory (SRAM) cell. Then a methodology is described for the analysis of a standard-cell inverter latch.

Buehler, M.↗

Field Funneling and Range Straggling in Silicon Detectors

Magnitudes of field funneling and range straggling determined in silicon-surface-barrier (Schottky-barrier) charged-particle detectors (SSBD's) through meaurement of charges collected from alpha-particle tracks. Method used extended to straightforward measurement of charge collection from heavy-ion tracks in these and other semiconductor devices. Such measurements used to assess single-event upsets in integratedcircuit chips, with view toward making them resistant to radiation. Field funneling and range straggling measured with electronic system in which charge collected from individual ions measured and recorded by multichannel analyzer.

Zoutendyk, J. A.↗

Free-flyer biostack experiment

The free-flyer biostack experiment is part of a radiobiological space research program that includes experiments in space as well as in accelerators on Earth. The program has been specially designed to increase knowledge concerning the importance, effectiveness, and hazards of the structured components of cosmic radiation to man and to any biological specimen in space. Up to now, our understanding of the ways in which HZE particles might affect biological matter is based on a few spaceflight experiments from the last Apollo missions and on the limited data available from heavy-ion irradiation from accelerators. In the near future, accelerators capable of accelerating particles up to higher atomic numbers and higher energies will promote increased activity in ground-based studies on biological effects of HZE particles. Comparison of data from such irradiation experiments on Earth with those from an actual spaceflight experiment will show any potential influence of the inevitably attendant spaceflight factors (e.g., weightlessness) on the radiobiological events.

Buecker, H.↗

Latest trends in parts SEP susceptibility from heavy ions

JPL and Aerospace have collected a third set of heavy-ion single-event phenomena (SEP) test data since their last joint IEEE publications in December 1985 and December 1987. Trends in SEP susceptibility (e.g., soft errors and latchup) for state-of-the-art parts are presented. Results of the study indicate that hard technologies and unacceptably soft technologies can be flagged. In some instances, specific tested parts can be taken as candidates for key microprocessors or memories. As always with radiation test data, specific test data for qualified flight parts is recommended for critical applications.

Nichols, Donald K.↗

Quantum mechanical signature in exclusive coherent pion production

We calculate the coherent production of pions from subthreshold to relativistic energies in heavy-ion collisions using a quantum, microscopic, many-body model. For the first time, in this approach, we use harmonic oscillator wave functions to describe shell-model information. The theoretical quantum mechanical results obtained for the pion spectra represent an important improvement over our previous microscopic, many-body calculations.

NASA Discipline Radiation Health↗

Theoretical contributions to coherent pion production in subthreshold and relativistic heavy-ion collisions

The analytic results from a microscopic calculation for pion production in heavy-ion collisions at intermediate to relativistic energies both above and below pion threshold are presented and the most important terms that contribute to the pion spectrum are determined. The energy dependence and the effects on the pion spectrum due to the various parameters in the theory are examined. The model is applied to coherent pion-production in 16O + 12C collisions.

NASA Discipline Number 22-70↗

Delta excitations and shell-model information in heavy-ion, charge-exchange reactions

We calculate total cross sections for coherent pion production using localized plane-wave approximations for the shell-structure of valence nucleons that are excited to delta particles in the intermediate state in the (12C, 12B) and (12C, 12N) charge-exchange, heavy-ion reactions. We find comparable agreement to projectile downshift data for 12C(12C, 12B)12N. Then we improve the formalism by replacing the localized plane wave bound states with harmonic oscillator states which are imbedded in a multipole expansion approach and calculate pion differential cross sections to test for the sensitivity of the spectra to the single-particle mass parameter.

NASA Program Space Medicine↗

Heavy ions from interplanetary dust.

Most atoms that are evaporated from interplanetary dust near the sun are quickly ionized and are probably carried away by the interplanetary magnetic field and the solar wind. The contribution of these heavy ions to the solar-wind flux has been estimated by using estimates of the mass required to maintain the zodiacal cloud. This contribution appears to be small compared with the heavy-ion flux of coronal origin. Many ions from dust remain singly ionized; some of these, such as Ca(+), can resonantly scatter solar radiation. The contribution of this interplanetary glow to the background of twilight glow has been estimated. Interplanetary glow may be detectable. Some atoms from dust may be accelerated by radiation pressure before being ionized. Estimates of velocities and fluxes for Fe indicate that this acceleration is not very effective.

Nakada, M. P.↗

Quiet time observations of equatorially trapped megaelectronvolt radiation belt ions with nuclear charge Z greater than or equal to 4

Data from the equatorial satellite Explorer 45 were used to study ion fluxes during the geomagnetically quiescent period June 1-15, 1972. A heavy-ion solid-state ion detector system obtained count rates close to the equatorial plane in the energy passband 1.82-4.8 MeV per ion during a single satellite pass through the radiation belts. Fluxes of these ions are interpreted as oxygen ions and are found to maximize in the L shell range 3-3.5 with peak equatorially mirroring flux of 0.38 ions/(sq cm s sr keV). This peak is not as sharply confined in L shell as is the helium ion peak.

Spjeldvik, W. N.↗

Late degeneration in rabbit tissues after irradiation by heavy ions

Results are presented for investigations of the late effects of heavy-ion irradiation on rabbit tissues which were undertaken to assess the hazards associated with the long-term exposure of humans to heavy ions in space during such activities as the construction of solar power stations or voyages to Mars. White rabbits approximately six weeks old were exposed to various doses of collimated beams of 400-MeV/n Ne ions, 570 MeV/n Ar ions and Co-60 gamma rays directed through both eyes, and the responses of the various tissues (hair follicles, skin, cornea, lens, retina, Harderian glands, bone and forebrain) were examined. Proliferating tissues are found to exhibit high damage levels in the early and late periods following irradiation, while terminally differentiating tissues repond to radiation most intensely in the late period, years after irradiation, with no intermediate recovery. The results obtained from rabbits are used to predict the occurrence of late tissue degeneration in the central nervous system, terminally differentiating systems and stem cells of humans one or more decades following exposure to radiation levels anticipated during long-duration space flights. The studies also indicate that tissues may be prematurely aged in the sense that tissue life spans may be shortened without the development of malignancies.

Lett, J. T.↗

The non-Z-squared response of the heavy nuclei cosmic ray detector on HEAO-3

A combination of ion chambers and Cerenkov radiators similar to the Heavy Nuclei Experiment flown on HEAO-3 was calibrated at the Bevalac heavy-ion accelerator using beams of Mn-25 nuclei at kinetic energies up to about 1700 MeV/nucleon and Au-79 nuclei up to about 1000 MeV/nucleon. The data show only a small deviation (about 2-3 charge units at Au) from the Z-squared scaling used previously (Binns et al., 1981, 1982, 1983) to analyze the HNE data. Although at lower energy, the calibration indicates that the published relative abundances of the Sn-50/Ba-56 group and the published upper-limit actinide abundances are not likely to be significantly affected by non-Z-squared effects.

Garrard, T. L.↗