2.4 Å Crystal Structure of an Oxaliplatin 1,2-d(GpG) Intrastrand Cross-Link in a DNA Dodecamer Duplex
Abstract not provided
Spingler, Bernhard↗
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Results for “GPG”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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Wood Pellet-Fired Biomass Boiler Project at the Ketchikan Federal Building
Biomass boiler systems have existed for many years, but the technology has advanced in recent decades and can now provide automated and efficient operation for a relatively modest investment. Key advances in system monitoring and control allow for lower operating costs, since the control systems run all aspects of the boiler, including feed, load reduction and even tube cleaning. These advances have made such systems economical on a small scale in situations where inexpensive fuels like natural gas are not available. This creates an opportunity for building operators in remote, cold-climate locations to reduce the use of expensive fuels for heating buildings. GSA Region 10 installed the system at the federal building in Ketchikan, Alaska and submitted the project to the Green Proving Ground (GPG) program. GSA's GPG program contracted with the National Renewable Energy Laboratory (NREL) to assess the installation and the technology. The system serves as a demonstration to assess actual system efficiencies, as well as operating characteristics and financial benefits. In addition to installation and operational issues, the project team/researchers examined other issues, including fuel transportation costs, building energy savings, and overall economics.
09 BIOMASS FUELS↗
Field Validation of a Grid-Interactive Efficient Building Software Solution
The U.S. General Services Administration's (GSA's) Green Proving Ground (GPG) program, in partnership with the National Laboratory of the Rockies (NLR), completed a field study of a Grid-Interactive Efficient Buildings (GEB) software solution. The study focused on a single testbed facility to test the GEB functionality of the software solution, along with other features. The testbed facility - a courthouse - is a common building type in GSA's vast building portfolio, offering potentially impactful findings on a scalable level. The study evaluated Prescriptive Data's technology, Nantum OS, a connected building operating system ("GEB Solution") which aggregates multiple sources of previously siloed building data and combines that data with external sources, such as weather information or utility signals, into a single integrated platform. A GEB Solution is a type of Energy Management Information System (EMIS). EMIS is defined as a system of devices, data services, and software applications that communicates with any building system or third-party data source to aggregate and transform data into new capabilities to aid in the optimization of energy use at the building, campus, or agency level. This specific GEB Solution is an EMIS with ASO, automated system optimization, offering supervisory control of certain aspects of the Building Automation System (BAS). Multiple features were evaluated including, but not limited to, Continuous Demand Management to avoid setting new monthly kilowatt (kW) peaks, energy efficiency for reduction of kilowatt hours (kWh) and natural gas consumption, and automated demand response (ADR) for purposes of lowering demand during a utility called Demand Response (DR) event. The testbed facility was the Foley Federal Building and US Courthouse ("Foley Federal Building") located in Las Vegas, NV. This is a 209,496 sq. ft. building constructed in the 1960s with major renovations in 2004. The facility was a good candidate due to the large prevalence of office and courthouse spaces in the GSA portfolio of buildings. It also has many features which allow integration into and control of the building and a strong facilities team to assist with the study. Quantitative and qualitative performance objectives were developed using GSA's GPG GEB project template along with input from the vendor and building facility staff; these are outlined in Table 1. The quantitative performance objectives focused on continuous demand management, energy efficiency, and automated demand response. The qualitative performance objectives focused on the ease of installation and commissioning as well as the operability of the GEB solution. Other performance metrics that are reported on include carbon reduction, cost effectiveness, and occupant acceptance.
32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
Photovoltaic-Thermal New Technology Demonstration
Photovoltaic-thermal (PV-T) hybrid solar systems offer increased electricity production by cooling the PV panel, and using the removed thermal energy to heat water - all in the same footprint as a standard PV system. GPG's assessment of the nation's first large-scale PV-T system installed at the Thomas P. O'Neill, Jr. Federal Building in Boston, MA, provided numerous lessons learned in system design, and identified a target market of locations with high utility costs and electric hot water backup.
14 SOLAR ENERGY↗
High Performance Circulator Pump Demonstration
In commercial buildings, smaller circulator pumps are typically overlooked for energy efficiency upgrades due to their smaller size (typically less than 2.5 hp) and due to the lack of commercially available products that can simultaneously provide a combination of integrated controls and variable speed operation that is required to achieve acceptable energy savings and life cycle cost effectiveness. This General Services Administration (GSA) Green Proving Ground (GPG) project assessed the performance of a new high performance circulator pump (HPCP) at one heating hot water (HHW) application and two domestic hot water (DHW) application at the Denver Federal Center in Denver, Colorado.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Plug Load Management System Field Study: Wireless Meter and Controls
This presentation offers background on GSA's Green Proving Ground (GPG) and DOE's High Impact Technology (HIT) Catalyst work, and a field study that assessed a plug load management (PLM) system in two commercial building applications. The Ibis InteliNetwork (TM) PLM system enables users to measure and analyze device energy use and identify opportunities for reduction of plug load energy use, and set times for individual devices (or groups of devices) to turn off when not in use. The presentation gives an overview of the PLM demonstration project, its results, and lessons learned.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Lovastatin prevents cisplatin-induced activation of pro-apoptotic DNA damage response (DDR) of renal tubular epithelial cells
The platinating agent cisplatin (CisPt) is commonly used in the therapy of various types of solid tumors. The anticancer efficacy of CisPt largely depends on the formation of bivalent DNA intrastrand crosslinks, which stimulate mechanisms of the DNA damage response (DDR), thereby triggering checkpoint activation, gene expression and cell death. The clinically most relevant adverse effect associated with CisPt treatment is nephrotoxicity that results from damage to renal tubular epithelial cells. Here, we addressed the question whether the HMG-CoA-reductase inhibitor lovastatin affects the DDR of renal cells by employing rat renal proximal tubular epithelial (NRK-52E) cells as in vitro model. The data show that lovastatin has extensive inhibitory effects on CisPt-stimulated DDR of NRK-52E cells as reflected on the levels of phosphorylated ATM, Chk1, Chk2, p53 and Kap1. Mitigation of CisPt-induced DDR by lovastatin was independent of the formation of DNA damage as demonstrated by (i) the analysis of Pt-(GpG) intrastrand crosslink formation by Southwestern blot analyses and (ii) the generation of DNA strand breaks as analyzed on the level of nuclear γH2AX foci and employing the alkaline comet assay. Lovastatin protected NRK-52E cells from the cytotoxicity of high CisPt doses as shown by measuring cell viability, cellular impedance and flow cytometry-based analyses of cell death. Importantly, the statin also reduced the level of kidney DNA damage and apoptosis triggered by CisPt treatment of mice. The data show that the lipid-lowering drug lovastatin extensively counteracts pro-apoptotic signal mechanisms of the DDR of tubular epithelial cells following CisPt injury. - Highlights: • Lovastatin blocks ATM/ATR-regulated DDR of tubular cells following CisPt treatment. • Lovastatin attenuates CisPt-induced activation of protein kinase ATM in vitro. • Statin-mediated DDR inhibition is independent of initial DNA damage formation. • Statin-mediated blockage of CisPt-triggered DDR leads to cytoprotection. • Lovastatin attenuates CisPt-induced kidney DNA damage and apoptosis in vivo.
60 APPLIED LIFE SCIENCES↗
Synchronous and Cogged Fan Belt Performance Assessment
The GSA Regional GPG Team commissioned the National Renewable Energy Laboratory (NREL) to perform monitoring of cogged V-belts and synchronous belts on both a constant volume and a variable air volume fan at the Byron G. Rodgers Federal Building and U.S. Courthouse in Denver, Colorado. These motor/fan combinations were tested with their original, standard V-belts (appropriately tensioned by an operation and maintenance professional) to obtain a baseline for standard operation. They were then switched to the cogged V-belts, and finally to synchronous belts. The power consumption by the motor was normalized for both fan speed and air density changes. This was necessary to ensure that the power readings were not influenced by a change in rotational fan speed or by the power required to push denser air. Finally, energy savings and operation and maintenance savings were compiled into an economic life-cycle cost analysis of the different belt options.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Electrochromic Window Demonstration at the John E. Moss Federal Building, 650 Capitol Mall, Sacramento, California
Dynamic windows have the potential to provide real-time optimization of perimeter zone energy use, peak demand, comfort, amenity, and cost criteria on a seasonal or even minute-to- minute basis in response to weather, occupant or regional grid demands. Electrochromic (EC) windows, a type of dynamic window, have the ability to adjust their tint dynamically in response to a small applied voltage. In previous studies, they have shown potential to reduce heating, ventilation and air conditioning (HVAC) energy consumption and increase occupant satisfaction. This technology is available in the U.S. as a commercial product from multiple vendors with high-capacity manufacturing facilities, and could be broadly deployed if successful in a pilot test. This Green Proving Ground (GPG) program study examines the energy and comfort performance of EC windows in south-facing perimeter zones of a typical U.S. General Services Administration GSA office building.
32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
Non-Invasive, Low-Cost Gas Submeter [Slides]
This is a presentation for the Green Proving Ground (GPG) within GSA for a non-invasive low-cost strap on gas submeter.
24 POWER TRANSMISSION AND DISTRIBUTION↗
Downlight LED Lighting Form-Factor Assessment
This report provides information about the evaluation of a field installation of a one-for-one Light Emitting Diode (LED) lamp replacement that uses the existing fluorescent ballast. The evaluation was part of a study conducted by Pacific Northwest National Laboratory (PNNL) for the Green Proving Ground program (GPG). The evaluation includes field-collected energy data, light-level data, and occupant and system installer survey responses. The report also provides recommendations based on the data collected during this field evaluation as well as other research-based sources, for applying this technology to other locations.
32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
Demonstration and Evaluation of an Advanced Oxidation Technology for Cooling Tower Water Treatment
A cooling tower is a heat rejection device that uses an evaporative cooling process to reject heat to the atmosphere from water cooled chilled water plant. Cooling towers are commonly applied to water cooled chilled water plants in large commercial buildings. The Silver Bullet alternative water treatment (AWT) technology is a non-chemical-based cooling tower water treatment technology. It is advertised as a simpler water treatment technology that can reduce cooling tower blowdown by increasing the CoC, which reduces monthly chemical costs, monthly operation and maintenance costs, and the amount of scale that collects on condenser water tubes and cooling towers. The primary focus of this evaluation was measuring cooling tower make up water usage pre- and post- installation of the AWT. In addition, annual reductions in cooling tower chemical costs, monthly water chemistry reports, ease of installation, and overall cost effectiveness were evaluated.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Alternative Water Treatment Technologies for Cooling Tower Applications
The current state of water treatment in GSA buildings is to use conventional chemical maintenance for water quality and contract out this specialized service, for a fixed fee, to a third-party company specializing in such service. Traditional water treatment approaches rely on chemicals to extend the ability of the water to hold scaling minerals in suspension and kill off biological growth. This project assesses the effectiveness of three different technologies provided by three different manufacturers. Each system uses some sort of proprietary device, technology, or chemical. This report addresses both water and cost savings associated with Alternative Water Treatment (AWT) technologies, and the water quality provided by the AWT technologies.
42 ENGINEERING↗
Blowdown Recovery System for Cooling Tower Water Treatment
From 2014-2017, the U.S. General Services Administration's (GSA's) average nationwide water rates increased 41%. Rapidly escalating costs, mandated water-reduction targets, and the fact that an average of 28% of commercial office building water use is associated with heating and cooling led the GSA Green Proving Ground program to select alternative water treatment technologies for in-field validation. This report summarizes the latest alternative water treatment evaluation completed in 2022 - a Blowdown Recovery System for Cooling Tower Water Treatment. This Green Proving Ground program project assessed the performance of an alternative water treatment system provided by Aqualogix for treating cooling tower blowdown at the Lloyd D. George U.S. Courthouse in Las Vegas, Nevada.
13 HYDRO ENERGY↗