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At least 19 records

System and method for liquid crystal display system incorporating wire grid polarizers for large scale and large volume stereolithography

The present disclosure relates to a liquid crystal display (LCD) system. The system in one example has a light source for generating unpolarized light, and an LCD screen arranged in a path of transmittance of the unpolarized light. First and second wire grid polarizers are arranged adjacent to the LCD screen and each have a plurality of nano-scale wires, with the first and second wire grid polarizers have differing polarizations. A pitch of each of the nano-scale wires is no larger than one-third a wavelength of the unpolarized light from the light source. The wire grid polarizers create, in connection with operation of the LCD screen, a 2D light mask suitable for initiating the polymerization of an optically curable material.

Duoss, Eric B.↗

Development of a cell surface display system in Chlamydomonas reinhardtii

Cell-surface display systems are biotechnological techniques used to express heterologous proteins on the cell surface. Their application depends directly on the cell system used, as well as on the anchoring point for the surface displayed protein. To meet most application demands an inexpensive, safe, and scalable production platform, that reduces the economic barriers for large scale use is needed. Toward this goal, we screened three possible cell surface anchoring points in the green algae Chlamydomonas by fusing mVenus to prospective anchors moieties. The vectors harboring mVenus:anchor were screened for mVenus fluorescence and tested for cellular localization by confocal laser scanning microscopy. This strategy allowed the identification of two functional anchors, one for the cytoplasmic membrane using the MAW8 GPI-anchor signal, and one for the cell wall using the GP1 protein. We also exploited GP1 chemical and biological traits to release the fused proteins efficiently during cell wall shedding. Our work provides a foundation for surface engineering of C reinhardtii supporting both cell biology studies and biotechnology applications.

59 BASIC BIOLOGICAL SCIENCES↗

Exploring the Use of Large Immersive Display Systems in the Nuclear Industry

Large immersive display systems play a critical role in the nuclear industry by enabling advanced training, design reviews, scientific visualization, and safety simulations. These systems, such as CAVE and powerwalls, allow engineers and operators to interact with virtual nuclear environments in real-time, providing a deeper understanding of complex systems. Their ability to simulate real-world scenarios for testing and optimization in a safe, controlled environment ensures that operators and engineers can refine process, enhance safety protocols, and troubleshoot complex challenges. This article outlines key lessons learned from deploying these systems, practical insights into their applications, and considerations for future improvements, aiming to guide their broader adoption and effective use in the nuclear industry.

99 - GENERAL AND MISCELLANEOUS↗

Qualified display system architecture - 246

There is a need in the nuclear industry for a Qualified Display System (QDS) architecture as described in this paper. The function of the QDS is to process and display Regulatory Guide 1.97 post accident monitoring parameters. The QDS is implemented on the Lockheed Martin Field-Programmable Gate Array (FPGA) based Nuclear Protection and Control (NuPAC) digital platform, coupled with a Qualified Display Controller (QDC) and a Safety Display Unit (SDU). The QDS is designed to meet the requirements of IEEE 603-1991 (endorsed by Regulatory Guide 1.153, Rev. 1), IEEE 497-2002 (endorsed by Regulatory Guide 1.97, Rev. 4), and IEEE 7-4.3.2- 2003 (endorsed by Regulatory Guide 1.152, Rev. 3). The QDS is designed with flexibility such that it can be implemented in an advanced reactor design, Small Modular Reactor (SMR) with any cooling medium, or digital upgrade project for an operating nuclear plant. The QDS has four independent and redundant divisions. Each division has five layers in the architecture: Process variable input signals; Process Protection Logic (PPL); Algorithm Logic (AL), Interface Panel (IP); and Safety Display Unit (SDU). The QDS meets the following design criteria: redundancy, independence, predictability and repeatability, and diversity capability. The QDS architecture also meets the simplicity design principle. The QDS architecture design provides flexibility in the implementation in a plant. The QDS can be implemented in the design of a new advanced plant or as a digital upgrade in an operating plant. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Development of cyber security test scenario for non-safety display system - 226

In order to test the cyber security of NPP related to safety, the results of probabilistic safety assessment were used. The fault tree (FT) is used to reflect the impact of the cyber-attack on the operator. The cyber security test should be performed focusing on the scenario derived from the FT. The concept of a security case has been introduced. (authors)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

Three-dimensional radiograph security system

A method and apparatus for displaying a three-dimensional radiograph in a security scanner. A first X-ray image of an object is generated by the security scanner from a first viewpoint. A second X-ray image of the object is generated by the security scanner from a second viewpoint. The first X-ray image and the second X-ray image form a stereogram. The stereogram is displayed by the security scanner on a display system for the security scanner such that a first eye of a viewer sees the first X-ray image in the stereogram and a second eye of the viewer sees the second X-ray image in the stereogram. A parallax between the first viewpoint and the second viewpoint in the stereogram results in a three-dimensional visualization of the object on the display system for the security scanner.

Jimenez, Jr., Edward Steven↗

Phage display and other peptide display technologies

ABSTRACT Phage display technology, which is based on the presentation of peptide sequences on the surface of bacteriophage virions, was developed over 30 years ago. Improvements in phage display systems have allowed us to employ this method in numerous fields of biotechnology, as diverse as immunological and biomedical applications, the formation of novel materials and many others. The importance of phage display platforms was recognized by awarding the Nobel Prize in 2018 ‘for the phage display of peptides and antibodies’. In contrast to many review articles concerning specific applications of phage display systems published in recent years, we present an overview of this technology, including a comparison of various display systems, their advantages and disadvantages, and examples of applications in various fields of science, medicine and the broad sense of biotechnology. Other peptide display technologies, which employ bacterial, yeast and mammalian cells, as well as eukaryotic viruses and cell-free systems, are also discussed. These powerful methods are still being developed and improved; thus, novel sophisticated tools based on phage display and other peptide display systems are constantly emerging, and new opportunities to solve various scientific, medical and technological problems can be expected to become available in the near future.

Jaroszewicz, Weronika (ORCID:0000000302948682)↗

A regional comparison of sub-daily flow variability in regulated and unregulated rivers in the United States

Regulating rivers for hydropower or other purposes can dramatically alter river flow patterns, including creating substantial changes in flow over short, minutes-to-hours-long timespans known as sub-daily flow variability (SDFV). The impacts of flexible hydropower production on flow and aquatic organisms are increasingly documented in research. However, the degree to which flow alteration relates to different hydropower operational modes in distinct geographical regions and seasons is not well understood. This study offers a methodology for regional- and species-appropriate evaluations of potential impacts of flow on fish based on sub-daily flow characteristics of hydropower operational modes. We analyzed 15-min discharge data between 2018 and 2021 from 69 USGS stream gages to compare SDFV in hydropeaking, run-of-river, and unregulated systems in the US Southeast and Pacific Northwest. Regulated systems exhibited significant SDFV downstream from hydropower facilities relative to unregulated systems, but specific impacts differed between regions. Regulated systems in the Southeast were characterized by high flow coefficients of variation and ratios (hydropeaking only) and extended durations of daily upramping flow phases. Regulated systems in the Pacific Northwest were characterized by many short flow phases per day and large portions of the day spent upramping. Pacific Northwest unregulated systems displayed the strongest seasonal flow patterns while Southeastern hydropeaking systems displayed the greatest SDFV. Given that SDFV impacts multiple dimensions of fish ecology, region-specific sub-daily flow signatures have important implications for understanding and mitigating potential community-, species-, and age-specific effects on fish in different parts of the country.

Fish↗

Yeast cell surface display for lipase whole cell catalyst and its applications

The cell surface display technique allows for the expression of target proteins or peptides on the microbial cell surface by fusing an appropriate protein as an anchoring motif. Yeast display systems, such as Pichia pastoris, Yarowia lipolytica and Saccharomyces cerevisiae, are ideal, alternative and extensive display systems with the advantage of simple genetic manipulation and post-translational modification of expressed heterologous proteins. Engineered yeasts show high performance characteristics and variant utilizations. Herein, we comprehensively summarize the variant factors affecting lipase whole cell catalyst activity and display efficiency, including the structure and size of target proteins, screening anchor proteins, type and chain length of linkers, and the appropriate matching rules among the above-mentioned display units. Furthermore, we also address novel approaches to enhance stability and activity of recombinant lipases, such as VHb gene co-expression, multi-enzyme co-display technique, and the micro-environmental interference and self-assembly techniques. Finally, we represent the variety of applications of whole cell surface displayed lipases on yeast cells in non-aqueous phases, including synthesis of esters, PUFA enrichment, resolution of chiral drugs, organic synthesis and biofuels. We demonstrate that the lipase surface display technique is a powerful tool for functionalizing yeasts to serve as whole cell catalysts, and increasing interest is providing an impetus for broad application of this technique.

Application↗

Acousto-optic laser projection systems for displaying TV information

This review addresses various approaches to television projection imaging on large screens using lasers. Results are presented of theoretical and experimental studies of an acousto-optic projection system operating on the principle of projecting an image of an entire amplitude-modulated television line in a single laser pulse. We consider characteristic features of image formation in such a system and the requirements for its individual components. Particular attention is paid to nonlinear distortions of the image signal, which show up most severely at low modulation signal frequencies. We discuss the feasibility of improving the process efficiency and image quality using acousto-optic modulators and pulsed lasers. Real-time projectors with pulsed line imaging can be used for controlling high-intensity laser radiation. (review)

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Interaction-induced transition in the quantum chaotic dynamics of a disordered metal

We demonstrate that a weakly disordered metal with short-range interactions exhibits a transition in the quantum chaotic dynamics when changing the temperature or the interaction strength. For weak interactions, the system displays exponential growth of the out-of-time-ordered correlator (OTOC) of the current operator. The Lyapunov exponent of this growth is temperature-independent in the limit of vanishing interaction. With increasing the temperature or the interaction strength, the system undergoes a transition to a non-chaotic behaviour, for which the exponential growth of the OTOC is absent. We conjecture that the transition manifests itself in the quasiparticle energy-level statistics and also discuss ways of its explicit observation in cold-atom setups.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Closing the Gap Between Modeling and Experiments in the Self-assembly of Biomolecules at Interfaces and in Solution

Molecular self-assembly is a powerful tool in materials design, wherein non-covalent interactions like electrostatic, hydrophobic, hydrogen bonding, and van der Waals can be exploited to produce supramolecular nanostructures that are functional and highly tunable. Biomolecules are attractive building blocks, as they are biocompatible, biodegradable and adopt a wide array of higher order structures. Moreover, naturally occurring protein systems display a manifold of structures and interactions that can be replicated in synthetic biomolecules. In this perspective, we highlight advances in multiscale simulation techniques across broad spatiotemporal scales that can aid in characterizing self-assembly of hybrid and hierarchical bionanomaterial systems, with an emphasis on physics-based simulation approaches currently employed to study biomolecules at mineral interfaces. The power of these approaches is highlighted across a few recent areas where molecular simulations have advanced our understanding of self-assembly spanning peptides to protein self-assembly. Looking forward, we discuss how in the near future emerging methods in statistical and machine learning will advance this research field in all areas from expanding the capabilities of physics-based simulation methods to enabling new analyses of high throughput experiments. These advances will pave the way for understanding the molecular recognition patterns in systems that are dictated by self-assembly - biomineralizing peptides, hierarchical peptoids, and large protein assemblies, and will aid in the development of a new synthesis science for achieving precise molecular control in materials design

Sampath, Janani↗

Numerical study of the temperature dependence of the NMR relaxation rate across the superfluid–Bose glass transition in one dimension

Here, we study the nuclear magnetic resonance (NMR) spin-lattice relaxation rate 1/ T 1 1 in random one-dimensional spin chains as a function of the temperature and disorder strength. In the zero temperature limit, the system displays a disorder-induced quantum phase transition between a critical Tomonaga-Luttinger liquid (TLL) phase and a localized Bose glass phase. The 1/ T 1 is investigated across this transition using large-scale simulations based on matrix product state techniques. We find that this quantity can detect the transition and probe the value of the dimensionless TLL parameter K . We also compute the NMR relaxation rate distributions for each temperature and disorder strength considered. In particular, we discuss the applicability of the stretched exponential fit to the return-to-equilibrium function to extract the 1/ T 1 experimentally. The results presented here should provide valuable insights in regards of future NMR experiments in realistic disordered spin compounds.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

The problem analysis of data processing performance in nuclear power plant computerized information and control system - 288

This paper is based on the data processing performance problems of operating command delay and system display not updating real-time for nuclear power plant computerized information and control system. The plant computerized information and control system is responsible for monitoring and controlling the plant operation, and it is a key part in the plant DCS system. Its data processing performance will affect the operation stability of nuclear power plant. The architecture, hardware configuration and data communication for plant computerized information and control system among the different levels in DCS are described. The main reasons affecting data processing performance in different signal channels are analyzed according to the plant load test results. The CPU load curves for real time server and central processing server are displayed, although the detailed cause for operating command delay and system display not updating realtime are not found, central processing server load is heavier than real time server which remind us to analyze the data processing of software resource scheduling deeply. So the resource distribution problem of software execution task is also analyzed according to CPU load test results. This paper provides the optimization analysis for data processing performance, and it is available and effective according to the latest test results. (authors)

22 GENERAL STUDIES OF NUCLEAR REACTORS↗