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At least 19 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2016

Impact of The Protective Renin-Angiotensin System (RAS) on The Vasoreparative Function of CD34+ CACs in Diabetic Retinopathy

Purpose: In diabetes, the impaired vasoreparative function of Circulating Angiogenic Cells (CACs) is believed to contribute to the progression of diabetic retinopathy (DR). Accumulating evidence suggests that the protective arm of renin-angiotensin system (RAS) ACE2 Angiotensin-(1-7) Mas plays an important role in restoring the function of diabetic CACs. We examined the protective RAS in CACs in diabetic individuals with different stages of retinopathy. Methods: Study subjects (n43) were recruited as controls or diabetics with either no DR, mild non-proliferative DR (NPDR), moderate NPDR, severe NPDR or proliferative DR (PDR). Fundus photography and fluorescein angiograms were analyzed using Vessel Generation Analysis (VESGEN) software in a cohort of subjects. CD34+ CACs were isolated from peripheral blood of diabetics and control subjects. RAS gene expressions in CACs were measured by qPCR. The vasoreparative function of CACs was assessed by migration ability toward CXCL12 using the QCM 5M 96-well chemotaxis cell migration assay. Results: ACE2 gene is a key enzyme converting the deleterious Angiotensin II to the beneficial Angiotensin-(1-7). ACE2 expression in CACs from diabetic subjects without DR was increased compared to controls, suggestive of compensation (p0.0437). The expression of Mas (Angiotensin-(1-7) receptor) in CACs was also increased in diabetics without DR, while was reduced in NPDR compared to controls (p0.0002), indicating a possible loss of compensation of the protective RAS at this stage of DR. The presence of even mild NPDR was associated with CD34+ CAC migratory dysfunction. When pretreating CACs of DR subjects with Angiotensin-(1-7), migratory ability to a chemoattractant CXCL12 was restored (p0.0008). By VESGEN analysis, an increase in small vessel density was observed in NPDR subjects when compared with the controls. Conclusions: These data suggest the protective RAS axis within diabetic CACs may help maintain their vasoreparative potential. The VESGEN analysis supports the presence of retinal repair in small vessels. The loss of the protective arm of RAS may predict the progression of DR.

diabetes↗
NASA NTRS1999

Evaluation of the Hydrodynamic Focusing Bioreactor (HDFB) and the Centrifugal Absorption Cartridge System (CACS) Performance Under Micro G

The Hydrodynamic Focusing Bioreactor (HDFB) technology is designed to provide a flow field with nearly uniform shear force throughout the vessel, which can provide the desired low shear force spatial environment to suspend three-dimensional cell aggregates while providing optimum mass transfer. The reactor vessel consists of a dome-shaped cell culture vessel, a viscous spinner, an access port, and a rotating base. The domed vessel face has a radius of R(o). and rotates at 0mega(o) rpm, while the internal viscous spinner has a radius of R(i) and rotates at 0mega(i) rpm. The culture vessel is completely filled with cell culture medium into which three-dimensional cellular structures are introduced. The HDFB domed vessel and spinner were driven by two independent step motors,

Gonda, Steve↗
NASA NTRS2007

Cylindrical Asymmetrical Capacitors for Use in Outer Space

A report proposes that cylindrical asymmetrical capacitors (CACs) be used to generate small thrusts for precise maneuvering of spacecraft on long missions. The report notes that it has been known for decades that when high voltages are applied to CACs in air, thrusts are generated - most likely as a result of ionization of air molecules and acceleration of the ions by the high electric fields. The report goes on to discuss how to optimize the designs of CACs for operation as thrusters in outer space. Components that could be used to enable outerspace operation include a supply of gas and a shroud, partly surrounding a CAC, into which the gas would flow. Other elements of operation and design discussed in the report include variation of applied voltage and/or of gas flow to vary thrust, effects of CAC and shroud dimensions on thrust and weight, some representative electrode configurations, and several alternative designs, including one in which the basic CAC configuration would be modified into something shaped like a conventional rocket engine with converging/diverging nozzle and an anode with gas feed in the space that, in a conventional rocket engine, would be the combustion chamber.

Campbell, Jonathan W.↗
NASA NTRS2017

Association Between Vascular Density and Loss of Protective RAS During Early NPDR by Fractal Dimension

Purpose: Our hypothesis predicts that blood vessels within the retina increase in density during early-stage nonproliferative diabetic retinopathy (NPDR), based on previous results of a small retrospective study. For the current prospective study, the remodeling of arteries and veins during progression of early NPDR is assessed by a repertoire of parameters that includes the fractal dimension (D(sub f) ). In complex structures such as branching vascular trees, D(sub f) is a sensitive measure of space-filing capacity. The renin-angiotensin system (RAS) is implicated in DR pathogenesis and the function of circulating angiogenic cells (CACs), a critical bone marrow-derived population instrumental in vascular repair. Methods: Arterial and venous branching patterns were extracted from images of 6 normal controls and 3 early NPDR subjects (2 moderate, 1 mild) acquired by Heidelberg Spectralis (Registered Trademark) OCT following fluorescein angiography (FA). The vascular branching patterns were analyzed by NASAs VESsel GENeration Analysis (VESGEN) software, in which skeletonized representations were generated automatically to yield D(sub f) by the box-counting method. For binary 2D images, D(sub f) varies between limiting Euclidean dimensions of 1 and 2. Peripheral blood of diabetics and controls was collected for CD34+ CAC isolation. The gene expression of RAS in CACs was assessed by qPCR for Mas receptor to Ang-(1-7). The vasoreparative function of the CACs was measured by migration ability toward CXCL12 (SDF-1). Results: By D(sub f), venous and arterial densities were 1.370 +/- 0.006 and 1.329 +/- 0.016 for early NPDR, compared to 1.318 +/- 0.012 and 1.320 +/- 0.036 for control. The space filling capacity in early NPDR measured by D(sub f), a sensitive parameter, therefore demonstrated a pronounced increase for veins, but not for arteries. Mas receptor mRNA in CACs was increased in diabetics without DR but reduced with onset of NPDR, indicating possible loss of compensation of protective RAS during early DR. Migratory dysfunction of CD34+ cells was further associated with DR. Conclusions: As assessed by the fractal dimension in our preliminary study, the space-filling capacity of veins, but not arteries, was greater in early NPDR than in control. Larger patient populations will be examined as we complete our ongoing longitudinal study. Results further suggest the protective RAS axis within diabetic CACs is lost early in DR and is associated with increased vascular remodeling as evidenced by VESGEN analysis.

vascular↗
NASA NTRS2002

Complex Refractive Index of Ammonium Nitrate in the 2-20 micron Spectral Range

Using high resolution Fourier Transform Infrared Spectroscopy (FTIR) absorbance/transmittance spectral data for ammonium sulfate (AMS), calcium carbonate (CAC) and ammonium nitrate (AMN), comparisons were made with previously published complex refractive indices data for AMS and CAC to infer experimental parameters to determine the imaginary refractive index for AMN in the infrared wavelength range from 2 to 20 microns. Kramers-Kronig mathematical relations were applied to calculate the real refractive index for the three compositions. Excellent agreement for AMS and CAC with the published values was found, validating the complex refractive indices obtained for AMN. Backscatter calculations using a lognormal size distribution for AMS, AMN, and CAC aerosols were performed to show differences in their backscattered spectra.

Jarzembski, Maurice A.↗
NASA NTRS2004

Centrifugal Adsorption Cartridge System

The centrifugal adsorption cartridge system (CACS) is an apparatus that recovers one or more bioproduct(s) from a dilute aqueous solution or suspension flowing from a bioreactor. The CACS can be used both on Earth in unit gravity and in space in low gravity. The CACS can be connected downstream from the bioreactor; alternatively, it can be connected into a flow loop that includes the bioreactor so that the liquid can be recycled. A centrifugal adsorption cartridge in the CACS (see figure) includes two concentric cylinders with a spiral ramp between them. The volume between the inner and outer cylinders, and between the turns of the spiral ramp is packed with an adsorbent material. The inner cylinder is a sieve tube covered with a gas-permeable, hydrophobic membrane. During operation, the liquid effluent from the bioreactor is introduced at one end of the spiral ramp, which then constrains the liquid to flow along the spiral path through the adsorbent material. The spiral ramp also makes the flow more nearly uniform than it would otherwise be, and it minimizes any channeling other than that of the spiral flow itself. The adsorbent material is formulated to selectively capture the bioproduct(s) of interest. The bioproduct(s) can then be stored in bound form in the cartridge or else eluted from the cartridge. The centrifugal effect of the spiral flow is utilized to remove gas bubbles from the liquid. The centrifugal effect forces the bubbles radially inward, toward and through the membrane of the inner cylinder. The gas-permeable, hydrophobic membrane allows the bubbles to enter the inner cylinder while keeping the liquid out. The bubbles that thus enter the cylinder are vented to the atmosphere. The spacing between the ramps determines rate of flow along the spiral, and thereby affects the air-bubble-removal efficiency. The spacing between the ramps also determines the length of the fluid path through the cartridge adsorbent, and thus affects the bioproduct-capture efficiency of the cartridge. Depending on the application, several cartridges could be connected in a serial or parallel flow arrangement. A parallel arrangement can be used to increase product-capturing and flow capacities while maintaining a low pressure drop. A serial arrangement can be used to obtain high product-capturing capacity; alternatively, series-connected cartridges can be packed with different adsorbents to capture different bioproducts simultaneously.

Gonda, Steve R.↗
NASA NTRS2004

On the Constrained Attitude Control Problem

In this paper, we consider various classes of constrained attitude control (CAC) problem in single and multiple spacecraft settings. After categorizing attitude constraints into four distinct types, we provide an overview of the existing approaches to this problem. We then proceed to further expand on a recent algorithmic approach to the CAC problem. The paper concludes with an example demonstrating the viability of the proposed algorithm for a multiple spacecraft constrained attitude reconfiguration scenario.

semidefinite programming↗
NASA NTRS1984

Geologic mapping using thermal images

Thermal radiance data from the Heat Capacity Mapping Mission (HCMM) satellite has been used to measure surface reflectance data and to provide additional material composition information through remote sensing. The primary goal was to investigate the utility of HCMM data for geologic applications. Three techniques were used for displaying and combining thermal and visible near infrared (VNIR) data for two desert areas in southern California (Trona and Pisgah): color additive composites (CAC) for day and night IR and day VNIR, principal components, and calculation of thermal inertia images. The HCMM thermal data were more effective than Landsat data in producing separation of compositionally different areas including volcanic and intrusive rocks. The satellite CAC data produced an image for a 1 x 2 degree area, and the color picture was enlarged to a scale of 1:250,000. Playa composition, moisture content, presence of standing water, and vegetation cover were displayed in a variety of colors according to physical characteristics. Areas such as sand dunes were not distinguishable because of the coarse 500-mm HCMM resolution. HCMM thermal data have shown a new dimension to geologic remote sensing, and future satellite missions should allow the continued development of the thermal infrared data for geology.

Abrams, M. J.↗
NASA NTRS1993

Global temperature variations

Lower stratospheric temperature anomalies from MSU channel 4 were compared to ten years of radiosonde data to validate the satellite record, and the results were submitted for publication. Various assumed stratospheric weighting profiles were tested to determine whether the theoretical channel 4 weighting function had significant errors. It was found that the real weighting function is slightly sharper than the theoretical weighting function. We also found evidence for a step-function cooling in the radiosonde record during 1982, a period when two satellites were operating with no evidence of changes in the satellites. Lower tropospheric bulk temperature datasets continue to be sent to climate researchers and modelers, as well as to the Climate Analysis Center (CAC). The CAC is also implementing our MSU software to be able to do the MSU processing at their site. Drift in MSU channel 3 is being quantified and corrected to allow it to be used together with channel 2 for a better lowertropospheric gridpoint temperature product. A new global oceanic precipitation dataset has been produced from MSU channel 1 data, and compared to ten years of global raingage data.

Spencer, Roy W.↗
NASA NTRS2016

Association Between Increased Vascular Density and Loss of Protective RAS in Early-Stage NPDR

Our hypothesis predicts that retinal blood vessels increase in density during early-stage progression to moderate nonproliferative diabetic retinopathy (NPDR). The prevailing paradigm of NPDR progression is that vessels drop out prior to abnormal, vision-impairing regrowth at late-stage proliferative diabetic retinopathy (DR). However, surprising results for our previous preliminary study 1 with NASA's VESsel GENeration Analysis (VESGEN) software showed that vessels proliferated considerably during moderate NPDR compared to drop out at both mild and severe NPDR. Validation of our hypothesis will support development of successful early-stage regenerative therapies such as vascular repair by circulating angiogenic cells (CACs). The renin-angiotensin system (RAS)is implicated in the pathogenesis of DR and in the function of CACs, a critical bone marrow-derived population that is instrumental in vascular repair.

Fractal↗
NASA NTRS1984

Space simulation testing of the Earth Radiation Budget Satellite (ERBS)

The Earth radiation budget components and dynamics and the interactions of this energy cycle, which influences our climate were investigated. The satellite package was subjected to space simulation testing. The size of the spacecraft dictated that the testing be conducted in the new BRUTUS Thermal Vacuum Facility. Computer aided control (CAC), quartz crystal microbalance (QCM), and residual gas analysis (RGA) monitoring are combined with rigid contamination control procedures to protect the flight hardware from anomalous and potentially destructive out of scope test environments.

Magette, E.↗
NASA NTRS1988

Observations of stratospheric temperature changes coincident with the recent Antarctic ozone depletions

A high degree of correlation between the recent decline in Antarctic total ozone and cooling of the stratosphere during Austral spring has been noted in several recent studies (e.g., Sekiguchi, 1986; Angel, 1986). This study analyzes the observed temperature trends in detail, focusing on the spatial and temporal aspects of the observed cooling. Ozone losses and stratospheric cooling can be correlated for several reasons: (1) ozone losses (from an unspecified cause) will directly reduce temperatures due to decreased solar ultraviolet absorption (Shine, 1986), and/or (2) changes in both ozone and temperature structure due to modification of stratospheric circulation patterns (Mahlman and Fels, 1986). In order to scrutinize various ozone depletion scenarios, detailed information on the observed temperature changes is necessary; the goal is to provide such data. The data used are National Meteorological Center (NMC) Climate Analysis Center (CAC) derived temperatures, covering 1000 to 1 mb (0 to 48 km), for the period 1979 to 1987. Discussions on data origin and quality (assessed by extensive comparisons with radiosonde observations), along with other details of these observations, can be found in Newman and Randel (1988).

Randel, William J.↗
NASA NTRS1990

Automation in the Space Station module power management and distribution Breadboard

The Space Station Module Power Management and Distribution (SSM/PMAD) Breadboard, located at NASA's Marshall Space Flight Center (MSFC) in Huntsville, Alabama, models the power distribution within a Space Station Freedom Habitation or Laboratory module. Originally designed for 20 kHz ac power, the system is now being converted to high voltage dc power with power levels on a par with those expected for a space station module. In addition to the power distribution hardware, the system includes computer control through a hierarchy of processes. The lowest level process consists of fast, simple (from a computing standpoint) switchgear, capable of quickly safing the system. The next level consists of local load center processors called Lowest Level Processors (LLP's). These LLP's execute load scheduling, perform redundant switching, and shed loads which use more than scheduled power. The level above the LLP's contains a Communication and Algorithmic Controller (CAC) which coordinates communications with the highest level. Finally, at this highest level, three cooperating Artificial Intelligence (AI) systems manage load prioritization, load scheduling, load shedding, and fault recovery and management. The system provides an excellent venue for developing and examining advanced automation techniques. The current system and the plans for its future are examined.

Walls, Bryan↗
NASA NTRS1992

A global monthly sea surface temperature climatology

The paper presents a new global 2 deg x 2 deg monthly sea surface temperature (SST) climatology, referred here to as the Shea-Trenberth-Reynolds (STR) climatology, which was derived by modifying a 1950-1979-based SST climatology from the Climate Analysis Center (CAC), by using data from the Comprehensive Ocean-Atmosphere Data Set to improve the SST estimates in the regions of the Kuroshio and the Gulf Stream. A comparison of the STR climatology with the Alexander and Mobley SST climatology showed that the STR climatology is warmer in the Northern Hemisphere, and colder poleward of 45 deg S.

Shea, Dennis J.↗
NASA NTRS1994

Analyzing Flows In Rocket Nuclear Reactors

CAC is analytical prediction program to study heat-transfer and fluid-flow characteristics of circular coolant passage. Predicts, as function of time, axial and radial fluid conditions, temperatures of passage walls, rates of flow in each coolant passage, and approximate maximum material temperatures. Written in ANSI standard FORTRAN 77.

Clark, J. S.↗
NASA NTRS1993

Properties of the Central American cold surge

The Central American cold surge (CACS) is a frontal incursion from the United States into Central America and resembles the East Asian cold surge. They occur more frequently than analyzed by NMC or by published results, based on our observations between 1979 and 1990. Climatology and structure are quantified, based on surface and upper air stations throughout Central America and satellite products from GOES visible and infrared sensors and SSM/I precipitable water and rain rate sensors.

Mcguirk, James P.↗
NASA NTRS2001

A spontaneously arising mutation in connexin32 with repeated passage of FRTL-5 cells coincides with increased growth rate and reduced thyroxine release

In this study we examine changes in the cellular properties of FRTL-5 cells as a function of passage number, with particular emphasis on gap junction expression, karyotype, morphology, growth rate and thyroxine (T(4)) release. Early passage FRTL-5 follicular cells transfer dye through gap junctions from injected cell(s) to third-order neighboring cells and beyond within their respective follicles and have immuno-detectable connexin32 (Cx32) type gap junctional plaques in their lateral contacting plasma membranes. By contrast, FRTL-5 cells established as monolayers, or as follicles from cultures passed more than 15 times, did not transfer microinjected Lucifer Yellow dye to contiguous neighboring cells and did not express any immuno-detectable rat thyroid specific connexins (Cx43, Cx32 or Cx26). Western blots confirmed that total, membrane and cytosolic Cx32 protein was present only in early pass follicular cultures. To better understand the passage-dependent loss of Cx32 expression, RT-PCR primers were made to the most unique sequences of the rat Cx32 molecule, the cytoplasmic and carboxyl-terminal regions. These primers were used to screen FRTL-5 RNA from cultures of various passage numbers. The results revealed that later passage cultures had a single base deletion in the middle of the Cx32 cytoplasmic loop region at nucleotide position 378. This base deletion was in the middle position of the codon for amino acid 116, which is normally a CAC (histidine) but read with the frame shift was a CCC (proline). The four amino acids that followed this deletion were also altered with the fourth one becoming UAA, the ochre translation stop codon. This premature stopping of translation resulted in a truncation of 60% of the protein, which included the remaining cytoplasmic loop, third and fourth transmembrane regions and the carboxyl-terminus. The later passage cultures did not produce a carboxyl-terminal RT-PCR product, indicating that the mRNA was also truncated. These regions of the Cx32 molecule contain the sequences and epitopes to which probes and antibodies are directed, and as such alterations of these regions with repeated passage explains reports by others that FRTL-5 cells do not express Cx32, and implies that cultures used for these assessments were passed more than 15 times. To determine if genetic or epigenetic abnormalities existed in FRTL-5 cells we performed chromosome spreads from various passage cultures. FRTL-5 cells have been reported to be diploid and more recently non-diploid; however, we found them to be fully tetraploid. This tetraploidy appears to be unstable in that later passes are tetraploid plus two or three extra chromosomes. There were no obvious translocations, breaks or large-scale interstitial deletions of any chromosomes in the FRTL-5 cultures tested. As FRTL-5 cells were repeatedly passed their morphology changed. Monolayer areas spread from beneath the follicles, and the follicles became flattened in appearance. These physical changes were coincident with dramatically increased growth rates. Early cultures (passed 3-12 times) divided on average every 49+/-1 h, whereas later passes (passes 20-25) divided every 28+/-3 h. To correlate these changes with a measure of thyroid function we assayed T(4) output. Early passage follicular cultures incubated for 6 h with sodium iodide, released on average 5.27+/- 0.33 ng/ml of T(4)/100 follicles. Later passes, or early passes treated with heptanol to down-regulate Cx32, released an average of 3.84+/-0.50 ng/ml of T(4)/100 follicles. There was a 27% difference in T(4) release between early follicular cultures, that were coupled by Cx32, and late or down-regulated early follicular cultures, that were uncoupled (P<0.0001). Collectively, the physical changes documented in this study were coincident with the loss of functional Cx32. This implies a relationship between the loss of intercellular communication and changes in morphogenic appearance, growth rate and reduced thyroid function and supports the previously postulated, tumor-suppressor role for Cx32. FRTL-5 cultures from low passage numbers are an excellent model of primary thyroid cells. However, many reports in the literature ascribe features to FRTL-5 cells that are mutually inconsistent. These differences may be resolved in the future by addressing the passage number and the conditional differences of the cultures being studied.

NASA Discipline Radiation Health↗
NASA NTRS2008

Heart Rhythm Monitoring in the Constellation Lunar and Launch/Landing EVA Suit: Recommendations from an Expert Panel

Currently there are several physiological monitoring requirements for Extravehicular Activity (EVA) in the Human-Systems Interface Requirements (HSIR) document, including continuous heart rhythm monitoring. However, it is not known whether heart rhythm monitoring in the lunar surface space suit is a necessary capability for lunar surface operations or in launch/landing suit the event of a cabin depressurization enroute to or from the moon. Methods: Current US astronaut corps demographic information was provided to an expert panel of cardiovascular medicine experts, including specialists in electrophysiology, exercise physiology, interventional cardiology and arrhythmia. This information included averages for male/female age, body mass index (BMI), blood pressure, cholesterol, inflammatory markers, echocardiogram, ranges for coronary artery calcium (CAC) scores for long duration astronauts, and ranges for heart rate (HR) and metabolic (MET) rates obtained during microgravity and lunar EVA. Results: The panel determined that no uncontrolled hazard was likely to occur in the suit during lunar surface or contingency microgravity ops that would require ECG monitoring in the highly screened US astronaut population. However having the capability for rhythm monitoring inside the vehicle (IVA) was considered critical to manage an astronaut in distress. Discussion: Heart rate (HR) monitoring alone allows effective monitoring of astronaut health and function. Consequently, electrocardiographic (ECG) monitoring capability as a clinical tool is not essential in the lunar or launch/landing space suit. However, the panel considered that rhythm monitoring could be useful in certain clinical situations, it was not considered required for safe operations. Also, lunar vehicles should be required to have ECG monitoring capability with a minimum of 5-lead ECG (derived 12- lead) for IVA medical assessments.

Scheuring, Richard A.↗