Federal Government contracting - The legal debate regarding NASA service contracts.
Federal government contracting, discussing legality of NASA service contracts
Hollis, J. M.↗
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Combined Effect of Contraction Ratio and Chamber Pressure on the Performance of a Gaseous Hydrogen-Liquid-Oxygen Combustor for a Given Propellant Weight Flow and Oxidant-Fuel Ratio
The effect of contraction ratio and chamber pressure on the combustion performance of a gaseous-hydrogen-liquid-oxygen combustor was investigated analytically and experimentally. The experiment was conducted with a "two-dimensional" gaseous-hydrogen-liquid-oxygen engine of about 150-pound thrust. The contraction ratio was varied from 1.5 to 6 by changing the nozzle throat area. This variation resulted in a chamber pressure variation of about 25 to 120 pounds per square inch. The experimental results were corrected for heat transfer to the engine walls and momentum pressure losses. The experimental performance, as evaluated in terms of characteristic exhaust velocity, was 98 percent of theoretical at contraction ratios greater than 3 but decreased very rapidly at smaller contraction ratios. The heat-transfer rate increased with increasing contraction ratio and chamber pressure; it was about 1 Btu per square inch per second at a contraction ratio of 1.5 and increased to about 3 at a contraction ratio of 6. The combined effects of contraction-ratio and chamber-pressure changes on performance were investigated analytically with a mixing model and a vaporization model. The mixing model predicted very poor mixing at contraction ratios below 3 and almost perfect mixing at higher contraction ratios. The performance predicted by the vaporization model was very close to 100 percent for all contraction ratios. From these results, it was concluded that the performance was limited by poor mixing at low contraction ratios and chamber pressures.
Hersch, Martin↗
Collagen telopeptides (cross-linking sites) play a role in collagen gel lattice contraction
Solubilized interstitial collagens will form a fibrillar, gel-like lattice when brought to physiologic conditions. In the presence of human dermal fibroblasts the collagen lattice will contract. The rate of contraction can be determined by computer-assisted planemetry. The mechanisms involved in contraction are as yet unknown. Using this system it was found that the rate of contraction was markedly decreased when collagen lacking telopeptides was substituted for native collagen. Histidinohydroxylysinonorleucine (HHL) is a major stable trifunctional collagen cross-link in mature skin that involves a carboxyl terminal, telopeptide site 16c, the sixteenth amino acid residue from the carboxy terminal of the telopeptide region of alpha 1 (I) in type I collagen. Little, if any, HHL was present in native, purified, reconstituted, soluble collagen fibrils from 1% acetic acid-extracted 2-year-old bovine skin. In contrast, HHL cross-links were present (0.22 moles of cross-link per mole of collagen) in lattices of the same collagen contracted by fibroblasts. However, rat tail tendon does not contain HHL cross-links, and collagen lattices made of rat tail tendon collagen are capable of contraction. This suggests that telopeptide sites, and not mature HHL cross-links per se, are essential for fibroblasts to contract collagen lattices. Beta-aminopropionitrile fumarate (BAPN), a potent lathyrogen that perturbs collagen cross-linking by inhibition of lysyl oxidase, also inhibited the rate of lattice cell contraction in lattices composed of native collagen. However, the concentrations of BAPN that were necessary to inhibit the contraction of collagen lattices also inhibited fibroblast growth suggestive of cellular toxicity. In accordance with other studies, we found no inhibition of the rate of lattice contraction when fibronectin-depleted serum was used. Electron microscopy of contracted gels revealed typical collagen fibers with a characteristic axial periodicity. The data provide evidence that collagen telopeptide sites play a role in collagen gel lattice contraction.
Non-NASA Center↗
Comparative effects of contraction and angiotensin II on growth of adult feline cardiocytes in primary culture
The purposes of this study were 1) to determine whether angiotensin II causes growth of adult feline cardiocytes in long-term culture, 2) to compare the growth effects of angiotensin II with those resulting from electrically stimulated contraction, and 3) to determine whether the anabolic effects of contraction are exerted via the angiotensin type 1 receptor. Adult feline cardiocytes were cultured on laminin-coated trays in a serum-free medium. Cardiocytes were either electrically stimulated to contract (1 Hz, 5-ms pulse duration, alternating polarity) or were nonstimulated and quiescent. Quiescent cells were studied as controls and after treatment with angiotensin II (10(-8) M), losartan (10(-6) M; an angiotensin type 1-receptor antagonist), or angiotensin II plus losartan. Contracting cells were studied in the presence and absence of angiotensin II or losartan. In quiescent cardiocytes, angiotensin II treatment on day 7 significantly increased protein synthesis rates by 22% and protein content per cell by 17%. The effects of angiotensin II were completely blocked by losartan. Electrically stimulated contraction on days 4 and 7 in culture significantly increased protein synthesis rate by 18 and 38% and protein content per cell by 19 and 46%, respectively. Angiotensin II treatment did not further increase protein synthesis rate or protein content in contracting cardiocytes. Furthermore, losartan did not block the anabolic effects of contraction on protein synthesis rates or protein content. In conclusion, angiotensin II can exert a modest anabolic effect on adult feline cardiocytes in culture. In contracting feline cardiocytes, angiotensin II has no effect on growth. Growth caused by electrically stimulated contraction occurs more rapidly and is greater in magnitude than that caused by angiotensin II. Growth of contracting adult feline cardiocytes is not dependent on activation of the angiotensin receptor.
NASA Discipline Cardiopulmonary↗
Forearm muscle oxygenation decreases with low levels of voluntary contraction
The purpose of our investigation was to determine if the near infrared spectroscopy technique was sensitive to changes in tissue oxygenation at low levels of isometric contraction in the extensor carpi radialis brevis muscle. Nine subjects were seated with the right arm abducted to 45 degrees, elbow flexed to 85 degrees, forearm pronated 45 degrees, and wrist and forearm supported on an armrest throughout the protocol. Altered tissue oxygenation was measured noninvasively with near infrared spectroscopy. The near infrared spectroscopy probe was placed over the extensor carpi radialis brevis of the subject's right forearm and secured with an elastic wrap. After 1 minute of baseline measurements taken with the muscle relaxed, four different loads were applied just proximal to the metacarpophalangeal joint such that the subjects isometrically contracted the extensor carpi radialis brevis at 5, 10, 15, and 50% of the maximum voluntary contraction for 1 minute each. A 3-minute recovery period followed each level of contraction. At the end of the protocol, with the probe still in place, a value for ischemic tissue oxygenation was obtained for each subject. This value was considered the physiological zero and hence 0% tissue oxygenation. Mean tissue oxygenation (+/-SE) decreased from resting baseline (100% tissue oxygenation) to 89 +/- 4, 81 +/- 8, 78 +/- 8, and 47 +/- 8% at 5, 10, 15, and 50% of the maximum voluntary contraction, respectively. Tissue oxygenation levels at 10, 15, and 50% of the maximum voluntary contraction were significantly lower (p < 0.05) than the baseline value. Our results indicate that tissue oxygenation significantly decreases during brief, low levels of static muscle contraction and that near infrared spectroscopy is a sensitive technique for detecting deoxygenation noninvasively at low levels of forearm muscle contraction. Our findings have important implications in occupational medicine because oxygen depletion induced by low levels of muscle contraction may be directly linked to muscle fatigue.
NASA Center ARC↗
Uterine Contraction Modeling and Simulation
Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.
Liu, Miao↗
Effect of atrophy and contractions on myogenin mRNA concentration in chick and rat myoblast omega muscle cells
The skeletal rat myoblast omega (RMo) cell line forms myotubes that exhibit spontaneous contractions under appropriate conditions in culture. We examined if the RMo cells would provide a model for studying atrophy and muscle contraction. To better understand how to obtain contractile cultures, we examined levels of contraction under different growing conditions. The proliferation medium and density of plating affected the subsequent proportion of spontaneously contracting myotubes. Using a ribonuclease protection assay, we found that exponentially growing RMo myoblasts contained no detectable myogenin or herculin mRNA, while differentiating myoblasts contained high levels of myogenin mRNA but no herculin mRNA. There was no increase in myogenin mRNA concentration in either primary chick or RMo myotubes whose contractions were inhibited by depolarizing concentrations of potassium (K+). Thus, altered myogenin mRNA concentrations are not involved in atrophy of chick myotubes. Depolarizing concentrations of potassium inhibited spontaneous contractions in both RMo cultures and primary chick myotube cultures. However, we found that the myosin concentration of 6-d-old contracting RMo cells fed medium plus AraC was 11 +/- 3 micrograms myosin/microgram DNA, not significantly different from 12 +/- 4 micrograms myosin/microgram DNA (n = 3), the myosin concentration of noncontracting RMo cells (treated with 12 mM K+ for 6 d). Resolving how RMo cells maintained their myosin content when contraction is inhibited may be important for understanding atrophy.
Muscular Atrophy↗
The effect of finite turbulence spatial scale on the amplification of turbulence by a contracting stream
The turbulence downstream of a rapid contraction is calculated for the case when the turbulence scale can have the same magnitude as the mean-flow spatial scale. The approach used is based on the formulation of Goldstein (1978) for turbulence downstream of a contraction, with the added assumptions of a parallel mean flow at downstream infinity and turbulence calculated far enough downstream so that the nonuniformity of the mean flow field has decayed, and by treating the inverse contraction ratio as a small parameter. Consideration is given to the large-contraction-ratio and classical rapid-distortion theory limits, and to results at an arbitrary contraction ratio. It is shown that the amplification effect of the contraction is reduced when the spatial scale of the turbulence increases, with the upstream turbulence actually suppressed for a contraction ratio less than five and a turbulence spatial scale greater than three times the transverse dimensions of the downstream channel.
Goldstein, M. E.↗
Contraction design for small low-speed wind tunnels
An iterative design procedure was developed for 2- or 3-dimensional contractions installed on small, low speed wind tunnels. The procedure consists of first computing the potential flow field and hence the pressure distributions along the walls of a contraction of given size and shape using a 3-dimensional numerical panel method. The pressure or velocity distributions are then fed into 2-dimensional boundary layer codes to predict the behavior of the boundary layers along the walls. For small, low speed contractions, it is shown that the assumption of a laminar boundary layer originating from stagnation conditions at the contraction entry and remaining laminar throughout passage through the successful designs is justified. This hypothesis was confirmed by comparing the predicted boundary layer data at the contraction exit with measured data in existing wind tunnels. The measured boundary layer momentum thicknesses at the exit of four existing contractions, two of which were 3-D, were found to lie within 10 percent of the predicted values, with the predicted values generally lower. From the contraction wall shapes investigated, the one based on a 5th order polynomial was selected for newly designed mixing wind tunnel installation.
Bell, James H.↗
Contraction design for small low-speed wind tunnels
An iterative design procedure was developed for two- or three-dimensional contractions installed on small, low-speed wind tunnels. The procedure consists of first computing the potential flow field and hence the pressure distributions along the walls of a contraction of given size and shape using a three-dimensional numerical panel method. The pressure or velocity distributions are then fed into two-dimensional boundary layer codes to predict the behavior of the boundary layers along the walls. For small, low-speed contractions it is shown that the assumption of a laminar boundary layer originating from stagnation conditions at the contraction entry and remaining laminar throughout passage through the successful designs if justified. This hypothesis was confirmed by comparing the predicted boundary layer data at the contraction exit with measured data in existing wind tunnels. The measured boundary layer momentum thicknesses at the exit of four existing contractions, two of which were 3-D, were found to lie within 10 percent of the predicted values, with the predicted values generally lower. From the contraction wall shapes investigated, the one based on a fifth-order polynomial was selected for installation on a newly designed mixing layer wind tunnel.
Bell, James H.↗
Limb congestion enhances the synchronization of sympathetic outflow with muscle contraction
In this report, we examined if the synchronization of muscle sympathetic nerve activity (MSNA) with muscle contraction is enhanced by limb congestion. To explore this relationship, we applied signal-averaging techniques to the MSNA signal obtained during short bouts of forearm contraction (2-s contraction/3-s rest cycle) at 40% maximal voluntary contraction for 5 min. We performed this analysis before and after forearm venous congestion; an intervention that augments the autonomic response to sustained static muscle contractions via a local effect on muscle afferents. There was an increased percentage of the MSNA noted during second 2 of the 5-s contraction/rest cycles. The percentage of total MSNA seen during this particular second increased from minute 1 to 5 of contraction and was increased further by limb congestion (control minute 1 = 25.6 +/- 2.0%, minute 5 = 32.8 +/- 2.2%; limb congestion minute 1 = 29.3 +/- 2.1%, minute 5 = 37.8 +/- 3.9%; exercise main effect <0.005; limb congestion main effect P = 0.054). These changes in the distribution of signal-averaged MSNA were seen despite the fact that the mean number of sympathetic discharges did not increase over baseline. We conclude that synchronization of contraction and MSNA is seen during short repetitive bouts of handgrip. The sensitizing effect of contraction time and limb congestion are apparently due to feedback from muscle afferents within the exercising muscle.
Non-NASA Center↗
Physiological response to submaximal isometric contractions of the paravertebral muscles
STUDY DESIGN: Brief (30-second) isometric trunk extensions at 5%, 20%, 40%, 60%, and 80% of maximal voluntary contraction (MVC) and 3 minutes of prolonged trunk extension (20% MVC) in erect position were studied in nine healthy male subjects. OBJECTIVES: To investigate the intercorrelation between intramuscular pressure and tissue oxygenation of the paravertebral muscles during submaximal isometric contractions and further, to evaluate paravertebral electromyogram and intramuscular pressure as indicators of force development. SUMMARY OF BACKGROUND DATA: Local physiologic responses to muscle contraction are incompletely understood. METHODS: Relative oxygenation was monitored with noninvasive near-infrared spectroscopy, intramuscular pressure was measured with a transducer-tipped catheter, and surface electromyogram was monitored at three recording sites. RESULTS: The root mean square amplitudes of the paravertebral electromyogram (L4, left and right; T12, right) and intramuscular pressure measured in the lumbar multifidus muscle at L4 increased with greater force development in a curvilinear manner. A significant decrease in the oxygenation of the lumbar paravertebral muscle in response to muscle contraction was found at an initial contraction level of 20% MVC. This corresponded to a paravertebral intramuscular pressure of 30-40 mm Hg. However, during prolonged trunk extension, no further decrease in tissue oxygenation was found compared with the tissue oxygenation level at the end of the brief contractions, indicating that homeostatic adjustments (mean blood pressure and heart rate) over time were sufficient to maintain paravertebral muscle oxygen levels. CONCLUSION: At a threshold intramuscular pressure of 30-40 mm Hg during muscle contraction, oxygenation in the paravertebral muscles is significantly reduced. The effect of further increase in intramuscular pressure on tissue oxygenation over time may be compensated for by an increase in blood pressure and heart rate. Surface electromyogram amplitudes and intramuscular pressure can be used as indicators of paravertebral muscle force.
NASA Center ARC↗
Effects of axisymmetric contractions on turbulence of various scales
Digitally acquired and processed results from an experimental investigation of grid generated turbulence of various scales through and downstream of nine matched cubic contour contractions ranging in area ratio from 2 to 36, and in length to inlet diameter ratio from 0.25 to 1.50 are reported. An additional contraction with a fifth order contour was also utilized for studying the shape effect. Thirteen homogeneous and nearly isotropic test flow conditions with a range of turbulence intensities, length scales and Reynolds numbers were generated and used to examine the sensitivity of the contractions to upstream turbulence. The extent to which the turbulence is altered by the contraction depends on the incoming turbulence scales, the total strain experienced by the fluid, as well as the contraction ratio and the strain rate. Varying the turbulence integral scale influences the transverse turbulence components more than the streamwise component. In general, the larger the turbulence scale, the lesser the reduction in the turbulence intensity of the transverse components. Best agreement with rapid distortion theory was obtained for large scale turbulence, where viscous decay over the contraction length was negligible, or when a first order correction for viscous decay was applied to the results.
Tan-Atichat, J.↗
Application of Contraction Mappings to the Control of Nonlinear Systems
The theoretical and applied aspects of successive approximation techniques are considered for the determination of controls for nonlinear dynamical systems. Particular emphasis is placed upon the methods of contraction mappings and modified contraction mappings. It is shown that application of the Pontryagin principle to the optimal nonlinear regulator problem results in necessary conditions for optimality in the form of a two point boundary value problem (TPBVP). The TPBVP is represented by an operator equation and functional analytic results on the iterative solution of operator equations are applied. The general convergence theorems are translated and applied to those operators arising from the optimal regulation of nonlinear systems. It is shown that simply structured matrices and similarity transformations may be used to facilitate the calculation of the matrix Green functions and the evaluation of the convergence criteria. A controllability theory based on the integral representation of TPBVP's, the implicit function theorem, and contraction mappings is developed for nonlinear dynamical systems. Contraction mappings are theoretically and practically applied to a nonlinear control problem with bounded input control and the Lipschitz norm is used to prove convergence for the nondifferentiable operator. A dynamic model representing community drug usage is developed and the contraction mappings method is used to study the optimal regulation of the nonlinear system.
Killingsworth, W. R., Jr.↗
On the design of contractions and settling chambers for optimal turbulence manipulations in wind tunnels
The sensitivity of a moderate axisymmetric contraction of turbulence to upstream conditions is parametrically investigated in terms of turbulence intensities and integral length scales. Semi-empirical correlations are derived to characterize the development of turbulence intensities and integral length scales downstream of typical wind-tunnel turbulence manipulators. A new approach is described, permitting wind-tunnel designers to select the characteristic mesh of the turbulence manipulators, a well as the distance from them to the contraction, in order to obtain certain required turbulence characteristics in the test section at the exit of the contraction. The design charts strongly suggest that it may not be possible to achieve small scales and low intensities simultaneously, when using a contraction ratio of nine or larger. The results also confirm that the rapid distortion theory is only valid, with a proper viscous dissipation correction, up to the 'critical point' of a contraction. At that point, the scales of the various components of the velocity are equal and intercomponent transfer from the lateral to the streamwise velocities commences.
Nagib, H. M.↗
The Theory of Propellers III : the Slipstream Contraction with Numerical Values for Two-Blade and Four-Blade Propellers
As the conditions of the ultimate wake are concerned both theoretically and practically, the magnitude of the slipstream contraction has been calculated. It will be noted that the contraction in a representative case is of the order of only 1 percent of the propeller diameter. In consequence, all calculations need involve only first-order effects. Curves and tables are given for the contraction coefficient of two-blade and four-blade propellers for various values of the advance ratio; the contraction coefficient is defined as the contraction in the diameter of the wake helix in terms of the wake diameter at infinity. The contour lines of the wake helix are also shown at four values of the advance ratio in comparison with the contour lines for an infinite number of blades.
Theodorsen, Theodore↗
The advantages of cost plus award fee contracts
A Cost Plus Award Fee contract is the best procurement vehicle for the high-tech, one-of-a-kind, development projects that constitute most of NASA'S projects. The use of this type of contract requires more government and contractor effort than any other forms of contracts. An award fee contract is described as an arrangement whereby the government periodically awards a fee consistent with the cost, schedule and technical performance that is achieved by a contractor during a preset period with preset award fee pools. It's the only contracting method where both the government and contractor goals are closely linked. It also has a built-in mechanism to conveniently alter and emphasize program events in order to current external and internal situations. The award fee process also demands good communication between government and contractor participants.
Keathley, William C.↗
Advanced Transportation System Studies Technical Area 2 (TA-2) Heavy Lift Launch Vehicle Development Contract: Technical Results - Volume 2
The purpose of the Advanced Transportation System Studies (ATSS) Technical Area 2 (TA-2) Heavy Lift Launch Vehicle Development contract was to provide advanced launch vehicle concept definition and analysis to assist NASA in the identification of future launch vehicle requirements. Contracted analysis activities included vehicle sizing and performance analysis, subsystem concept definition, propulsion subsystem definition (foreign and domestic), ground operations and facilities analysis, and life cycle cost estimation. This document is Volume 2 of the final report for the contract. It provides documentation of selected technical results from various TA-2 analysis activities, including a detailed narrative description of the SSTO concept assessment results, a user's guide for the associated SSTO sizing tools, an SSTO turnaround assessment report, an executive summary of the ground operations assessments performed during the first year of the contract, a configuration-independent vehicle health management system requirements report, a copy of all major TA-2 contract presentations, a copy of the FLO launch vehicle final report, and references to Pratt & Whitney's TA-2 sponsored final reports regarding the identification of Russian main propulsion technologies.
Source record↗