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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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7 records
All sourcesNASA NTRSDOE OSTI
NASA NTRS2000

Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase

Fluid shear stress activates a member of the mitogen-activated protein (MAP) kinase family, extracellular signal-regulated kinase (ERK), by mechanisms dependent on cholesterol in the plasma membrane in bovine aortic endothelial cells (BAEC). Caveolae are microdomains of the plasma membrane that are enriched with cholesterol, caveolin, and signaling molecules. We hypothesized that caveolin-1 regulates shear activation of ERK. Because caveolin-1 is not exposed to the outside, cells were minimally permeabilized by Triton X-100 (0.01%) to deliver a neutralizing, polyclonal caveolin-1 antibody (pCav-1) inside the cells. pCav-1 then bound to caveolin-1 and inhibited shear activation of ERK but not c-Jun NH(2)-terminal kinase. Epitope mapping studies showed that pCav-1 binds to caveolin-1 at two regions (residues 1-21 and 61-101). When the recombinant proteins containing the epitopes fused to glutathione-S-transferase (GST-Cav(1-21) or GST-Cav(61-101)) were preincubated with pCav-1, only GST-Cav(61-101) reversed the inhibitory effect of the antibody on shear activation of ERK. Other antibodies, including m2234, which binds to caveolin-1 residues 1-21, had no effect on shear activation of ERK. Caveolin-1 residues 61-101 contain the scaffolding and oligomerization domains, suggesting that binding of pCav-1 to these regions likely disrupts the clustering of caveolin-1 or its interaction with signaling molecules involved in the shear-sensitive ERK pathway. We suggest that caveolae-like domains play a critical role in the mechanosensing and/or mechanosignal transduction of the ERK pathway.

Non-NASA Center↗
NASA NTRS1996

Analysis of Thick Sandwich Shells with Embedded Ceramic Tiles

The Composite Armored Vehicle (CAV) is an advanced technology demonstrator of an all-composite ground combat vehicle. The CAV upper hull is made of a tough light-weight S2-glass/epoxy laminate with embedded ceramic tiles that serve as armor. The tiles are bonded to a rubber mat with a carefully selected, highly viscoelastic adhesive. The integration of armor and structure offers an efficient combination of ballistic protection and structural performance. The analysis of this anisotropic construction, with its inherent discontinuous and periodic nature, however, poses several challenges. The present paper describes a shell-based 'element-layering' technique that properly accounts for these effects and for the concentrated transverse shear flexibility in the rubber mat. One of the most important advantages of the element-layering technique over advanced higher-order elements is that it is based on conventional elements. This advantage allows the models to be portable to other structural analysis codes, a prerequisite in a program that involves the computational facilities of several manufacturers and government laboratories. The element-layering technique was implemented into an auto-layering program that automatically transforms a conventional shell model into a multi-layered model. The effects of tile layer homogenization, tile placement patterns, and tile gap size on the analysis results are described.

Davila, Carlos G.↗
NASA NTRS1998

Report of the Cost Assessment and Validation Task Force on the International Space Station

The Cost Assessment and Validation (CAV) Task Force was established for independent review and assessment of cost, schedule and partnership performance on the International Space Station (ISS) Program. The CAV Task Force has made the following key findings: The International Space Station Program has made notable and reasonable progress over the past four years in defining and executing a very challenging and technically complex effort. The Program size, complexity, and ambitious schedule goals were beyond that which could be reasonably achieved within the $2.1 billion annual cap or $17.4 billion total cap. A number of critical risk elements are likely to have an adverse impact on the International Space Station cost and schedule. The schedule uncertainty associated with Russian implementation of joint Partnership agreements is the major threat to the ISS Program. The Fiscal Year (FY) 1999 budget submission to Congress is not adequate to execute the baseline ISS Program, cover normal program growth, and address the known critical risks. Additional annual funding of between $130 million and $250 million will be required. Completion of ISS assembly is likely to be delayed from one to three years beyond December 2003.

Source record↗
NASA NTRS1998

Cost Assessment and Validation Task Force on the International Space Station

The Cost Assessment and Validation (CAV) Task Force was established for independent review and assessment of cost, schedule and partnership performance on the International Space Station (ISS) Program. The CAV Task Force has made the following key findings: The International Space Station Program has made notable and reasonable progress over the past four years in defining and executing a very challenging and technically complex effort; The Program, size, complexity, and ambitious schedule goals were beyond that which could be reasonably achieved within the $2.1 billion annual cap or $17.4 billion total cap; A number of critical risk elements are likely to have an adverse impact on the International Space Station cost and schedule; The schedule uncertainty associated with Russian implementation of joint Partnership agreements is the major threat to the ISS Program; The Fiscal Year (FY) 1999 budget submission to Congress is not adequate to execute the baseline ISS Program, cover normal program, growth, and address the known critical risks. Additional annual funding of between $130 million and $250 million will be required; and Completion of ISS assembly is likely to be delayed from, one to three years beyond December 2003.

Source record↗
NASA NTRS1996

Steady-State Squeezing in the Micromaser Cavity Field

It is shown that the radiation field in the presently operated micromaser cavity may be squeezed when pumped with polarized atoms. The squeezing is in the steady state field corresponding to the action similar to that of the conventional micromaser, with the effect of cavity dissipation during entire t(sub c) = tau + t(sub cav).

Nayak, N.↗
NASA NTRS2004

Small Satellites and the DARPA/Air Force Falcon Program

The FALCON ((Force Application and Launch from CONUS) program is a technology demonstration effort with three major components: a Small Launch Vehicle (SLV), a Common Aero Vehicle (CAV), and a Hypersonic Cruise Vehicle (HCV). Sponsored by DARPA and executed jointly by the United States Air Force and DARPA with NASA participation, the objectives are to develop and demonstrate technologies that will enable both near-term and far-term capability to execute time-critical, global reach missions. The focus of this paper is on the SLV as it relates to small satellites and the implications of lower cost to orbit for small satellites. The target recurring cost for placing 1000 pounds payloads into a circular reference orbit of 28.5 degrees at 100 nautical miles is $5,000,000 per launch. This includes range costs but not the payload or payload integration costs. In addition to the nominal 1000 pounds to LEO, FALCON is seeking delivery of a range of orbital payloads from 220 pounds to 2200 pounds to the reference orbit. Once placed on alert status, the SLV must be capable of launch within 24 hours.

Weeks, David J.↗
NASA NTRSDate not supplied

NASA's Quesst Mission Status

Construction of NASA’s X-59 low-boom aircraft is nearing completion with its first flight scheduled within the next several months. The X-59 will be the low-boom noise source for a series of community noise surveys across the USA. The goal of NASA’s Quesst Mission is to collect and correlate noise and perceptual response data to low-loudness sonic booms so that the current prohibition on commercial supersonic aircraft flight overland can be reconsidered. This presentation describes the current state and future plans for the Quesst Mission and Commercial Supersonic Technology. Employment and internship opportunities for students and graduates are also outlined.

X-59↗