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Results for “BL2”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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13 records
All sourcesNASA NTRSDOE OSTI
DOE OSTI2023

Remote and automated high-throughput powder diffraction measurements enabled by a robotic sample changer at SSRL beamline 2-1

The general-purpose powder diffractometer beamline (BL2-1) at the Stanford Synchrotron Radiation Lightsource (SSRL) is described. The evolution of design and performance of BL2-1 are presented, in addition to current operating specifications, applications and measurement capabilities. Recent developments involve a robotic sample changer enabling high-throughput X-ray diffraction measurements, applicable to mail-in and remote operations. In situ and operando capabilities to measure samples with different form factors ( e.g. capillary, flat plate or thin film, and transmission) and under variable experimental conditions are discussed. Several example datasets and accompanying Rietveld refinements are presented.

43 PARTICLE ACCELERATORS↗
DOE OSTI2021

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

The papain-like protease (PL pro ) of SARS-CoV-2 is a validated antiviral drug target. Through a fluorescence resonance energy transfer-based high-throughput screening and subsequent lead optimization, we identified several PL pro inhibitors including Jun9-72-2 and Jun9-75-4 with improved enzymatic inhibition and antiviral activity compared to GRL0617, which was reported as a SARS-CoV PL pro inhibitor. Significantly, we developed a cell-based FlipGFP assay that can be applied to predict the cellular antiviral activity of PL pro inhibitors in the BSL-2 setting. X-ray crystal structure of PL pro in complex with GRL0617 showed that binding of GRL0617 to SARS-CoV-2 induced a conformational change in the BL2 loop to a more closed conformation. Molecular dynamics simulations showed that Jun9-72-2 and Jun9-75-4 engaged in more extensive interactions than GRL0617. Overall, the PL pro inhibitors identified in this study represent promising candidates for further development as SARS-CoV-2 antivirals, and the FlipGFP-PL pro assay is a suitable surrogate for screening PL pro inhibitors in the BSL-2 setting.

60 APPLIED LIFE SCIENCES↗
NASA NTRSDate not supplied

Multi-Wavelength Comparison of Jupiter’s Zonal Winds During the New Horizons and Cassini Flybys

We present Jovian zonal wind speeds measured during the Cassini and New Horizons Jupiter flybys in 2000 and 2007, respectively. We performed our cloud tracking wind measurements using an automated, two-dimensional correlation imaging velocimetry technique. We analyzed all LORRI panchromatic images from the New Horizons Jupiter flyby dataset. This LORRI measurement documents the state of Jupiter’s zonal mean wind speed in 2007 and extends the historical record of Jupiter’s winds that serve as useful points of comparison for Juno observations. Among the Cassini ISS images, we analyzed the CL1CL2, CB2, UV3, BL1, BL2, GRN, RED, IR1, IR2, IR3, IR4, MT2, and MT3 filters. Our Cassini measurements provide valuable context to understand the altitudes probed by LORRI. Comparing the panchromatic LORRI measurements against past wind measurements using images captured with various narrow and wide-band camera filters is not straightforward. Because the Cassini ISS CL1CL2 “clear” filter’s performance is similar to that of LORRI, comparing CL1CL2 winds against LORRI results will help determine if the New Horizons measurements represent Jupiter’s cloud-top zonal wind speeds or if they are sensitive to different altitudes. In addition to placing our New Horizons measurements in altitudinal context, the Cassini ISS's IR4, IR2, RED, GRN, and BL1 filters are similar to those on Europa Clipper EIS camera. Wind measurements performed using those ISS filters will enable comparison to future missions, including anticipated observations to be taken by Europa Clipper.

Jupiter↗
NASA NTRSDate not supplied

Preparing for Europa Clipper Jupiter Observations: Multi-Wavelength Zonal Winds During the New Horizons and Cassini Flybys

We present Jovian zonal wind speeds measured during the Cassini and New Horizons Jupiter flybys in 2000 and 2007, respectively. We performed our cloud tracking wind measurements using an automated, two-dimensional correlation imaging velocimetry technique. We analyzed all LORRI panchromatic images from the New Horizons Jupiter flyby dataset. This LORRI measurement documents the state of Jupiter’s zonal mean wind speed in 2007 and extends the historical record of Jupiter’s winds. Among the Cassini ISS images, we processed the CL1CL2, CB2, UV3, BL1, BL2, GRN, RED, IR1, IR2, IR3, IR4, MT2, and MT3 filters. Our Cassini measurements provide valuable context to understand the altitudes probed by LORRI. Comparing the panchromatic LORRI measurements against past wind measurements using images captured with various narrow and wide-band camera filters is not straightforward. Because the Cassini ISS CL1CL2 “clear” filter’s performance is similar to that of LORRI, comparing CL1CL2 winds against LORRI results will help determine if the New Horizons measurements represent Jupiter’s cloud-top zonal wind speeds or if they are sensitive to different altitudes. In addition to placing our New Horizons measurements in altitudinal context, the Cassini ISS's IR4, IR2, RED, GRN, and BL1 filters are similar to those on Europa Clipper EIS camera. Wind measurements performed using those ISS filters will enable comparison to future missions, including anticipated observations to be taken by Europa Clipper

Jupiter↗