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All sourcesNASA NTRSDOE OSTI
NASA NTRS2013

Toxicological Assessment of ISS Air Quality: September 2012 - October 2012 with Formaldehyde Supplement from May-October 2012

A summary of the analytical results from 6 grab sample containers (GSCs) and 12 pairs of formaldehyde badges collected on ISS and returned aboard 29S or 31 S is shown in an accompanying table. The average recoveries of the 3 surrogate standards from the GSCs were as follows: C-l3-acetone, 128%; fluorobenzene, 114%; and chlorobenzene, 78%. Recoveries of two lab-control formaldehyde badges averaged 95%.

James, John T.↗
NASA NTRS2012

Revised Toxicological Assessment of ISS Air Quality: May 2012 - August 2012

A summary of the analytical results from 12 grab sample containers (GSCs) collected on ISS and returned aboard 30S is shown in Table 1. The average recoveries of the 3 surrogate standards from the GSCs were as follows: 12C-acetone, 115 +/-- 11%; fluorobenzene, 108 +/- 8%; and chlorobenzene, 102 +/- 16%. Shaded rows indicate data that re limited due to low sample pressures. For completeness, previously reported data from the US Lab collected in May 2012 are included here as well. The revised report provides results from one returned sample that was unlabeled and originally assumed to be unused. The sample was prepared and analyzed for the purpose of measuring the surrogate compounds. It was later determined, based on serial number, that this was the HTB3 first ingress sample.

Meyers, Valerie↗
NASA NTRS2013

On the Role of SST Forcing in the 2011 and 2012 Extreme U.S. Heat and Drought: A Study in Contrasts

This study compares the extreme heat and drought that developed over the United States in 2011 and 2012 with a focus on the role of SST forcing. Experiments with the NASA GEOS-5 atmospheric general circulation model show that the winter/spring response over the U.S. to the Pacific SST is remarkably similar for the two years despite substantial differences in the tropical Pacific SST. As such, the pronounced winter and early spring temperature differences between the two years (warmth confined to the south in 2011 and covering much of the continent in 2012) primarily reflect differences in the contributions from the Atlantic and Indian Oceans, with both acting to cool the east and upper mid-west during 2011, while during 2012 the Indian Ocean reinforced the Pacific-driven continental-wide warming and the Atlantic played a less important role. During late spring and summer of 2011 the tropical Pacific SST force a continued warming and drying over the southern U.S., though considerably weaker than observed. Nevertheless, the observed anomalies fall within the models intra-ensemble spread. In contrast, the rapid development of intense heat and drying over the central U.S. during June and July of 2012 falls outside the models intra-ensemble spread. The response to the SST (a northward expansion of a modest summer warming linked to the Atlantic) gives little indication that 2012 would produce record-breaking precipitation deficits and heat in the central Great Plains. A diagnosis of the 2012 observed circulation anomalies shows that the most extreme heat and drought was tied to the development of a stationary Rossby wave and an associated anomalous upper tropospheric high maintained by weather transients.

SST Forcing↗
NASA NTRS2016

Aerosol Meteorology of the Maritime Continent for the 2012 7SEAS Southwest Monsoon Intensive Study - Part 1: Regional-scale Phenomena

The largest 7 Southeast Asian Studies (7SEAS) operation period within the Maritime Continent (MC) occurred in the August-September 2012 biomass burning season. Included was an enhanced deployment of Aerosol Robotic Network (AERONET) sun photometers, multiple lidars, and field measurements to observe transported smoke and pollution as it left the MC and entered the southwest monsoon trough. Here we describe the nature of the overall 2012 southwest monsoon (SWM) and biomass burning season to give context to the 2012 deployment. The MC in 2012 was in a slightly warm El Nino Southern Oscillation (ENSO) phase and with spatially typical burning activity. However, overall fire counts for 2012 were 10 lower than the Reid et al. (2012) baseline, with regions of significant departures from this norm, ranging from southern Sumatra (+30) to southern Kalimantan (42). Fire activity and monsoonal flows for the dominant burning regions were modulated by a series of intraseasonal oscillation events (e.g., Madden-Julian Oscillation, or MJO, and boreal summer intraseasonal oscillation, or BSISO). As is typical, fire activity systematically progressed eastward over time, starting with central Sumatran fire activity in June related to a moderately strong MJO event which brought drier air from the Indian Ocean aloft and enhanced monsoonal flow. Further burning in Sumatra and Kalimantan Borneo occurred in a series of significant events from early August to a peak in the first week of October, ending when the monsoon started to migrate back to its wintertime northeastern flow conditions in mid-October. Significant monsoonal enhancements and flow reversals collinear with tropical cyclone (TC) activity and easterly waves were also observed. Islands of the eastern MC, including Sulawesi, Java, and Timor, showed less sensitivity to monsoonal variation, with slowly increasing fire activity that also peaked in early October but lingered into November. Interestingly, even though fire counts were middling, resultant AERONET 500nm aerosol optical thickness (AOT) from fire activity was high, with maximums of 3.6 and 5.6 in the Sumatra and Kalimantan source regions at the end of the burning season and an average of approximately 1. AOTs could also be high at receptor sites, with a mean and maximum of 0.57 and 1.24 in Singapore and 0.61 and 0.8 in Kuching Sarawak. Ultimately, outside of the extreme 2015 El Nino event, average AERONET AOT values were higher than any other time since sites were established. Thus, while satellite fire data, models, and AERONET all qualitatively agree on the nature of smoke production and transport, the MC's complex environment resulted in clear differences in quantitative interpretation of these datasets.

Reid, Jeffrey S.↗
NASA NTRS2016

Aerosol Meteorology of Maritime Continent for the 2012 7SEAS Southwest Monsoon Intensive Study - Part 2: Philippine Receptor Observations of Fine-Scale Aerosol Behavior

The largest 7 Southeast Asian Studies (7SEAS) operations period within the Maritime Continent (MC) occurred in the August-September 2012 biomass burning season. Data included were observations aboard the MY Vasco, dispatched to the Palawan Archipelago and Sulu Sea of the Philippines for September 2012. At these locations, the Vasco observed MC smoke and pollution entering the southwest monsoon (SWM) monsoonal trough. Here we describe the research cruise findings and the finer-scale aerosol meteorology of this convectively active region. This 2012 cruise complemented a 2-week cruise in 2011 and was generally consistent with previous findings in terms of how smoke emission and transport related to monsoonal flows, tropical cyclones (TC), and the covariance between smoke transport events and the atmosphere's thermodynamic structure. Biomass burning plumes were usually mixed with significant amounts of anthropogenic pollution. Also key to aerosol behavior were squall lines and cold pools propagating across the South China Sea (SCS) and scavenging aerosol particles in their path. However, the 2012 cruise showed much higher modulation in aerosol frequency than its 2011 counterpart. Whereas in 2011 large synoptic-scale aerosol events transported high concentrations of smoke into the Philippines over days, in 2012 measured aerosol events exhibited a much shorter-term variation, sometimes only 312h. Strong monsoonal flow reversals were also experienced in 2012. Nucleation events in cleaner and polluted conditions, as well as in urban plumes, were observed. Perhaps most interestingly, several cases of squall lines preceding major aerosol events were observed, as opposed to 2011 observations where these lines largely scavenged aerosol particles from the marine boundary layer. Combined, these observations indicate pockets of high and low particle counts that are not uncommon in the region. These perturbations are difficult to observe by satellite and very difficult to model. Indeed, the Navy Aerosol Analysis and Prediction System (NAAPS) simulations captured longer period aerosol events quite well but largely failed to capture the timing of high-frequency phenomena. Ultimately, the research findings of these cruises demonstrate the real world challenges of satellite-based missions, significant aerosol life cycle questions such as those the future Aerosol/Clouds/Ecosystems (ACE) will investigate, and the importance of small-scale phenomena such as sea breezes, squall lines, and nucleation events embedded within SWM patterns in dominating aerosol life cycle and potential relationships to clouds.

Reid, Jeffrey S.↗
DOE OSTI2021

Spin Change of Asteroid 2012 TC4 Probably by Radiation Torques

Asteroid 2012 TC4 is a small (∼10 m) near-Earth object that was observed during its Earth close approaches in 2012 and 2017. Earlier analyses of light curves revealed its excited rotation state. We collected all available photometric data from the two apparitions to reconstruct its rotation state and convex shape model. We show that light curves from 2012 and 2017 cannot be fitted with a single set of model parameters; the rotation and precession periods are significantly different for these two data sets, and they must have changed between or during the two apparitions. Nevertheless, we could fit all light curves with a dynamically self-consistent model assuming that the spin states of 2012 TC4 in 2012 and 2017 were different. To interpret our results, we developed a numerical model of its spin evolution in which we included two potentially relevant perturbations: (i) gravitational torque due to the Sun and Earth and (ii) radiation torque, known as the Yarkovsky–O’Keefe–Radzievskii–Paddack (YORP) effect. Despite our model simplicity, we found that the role of gravitational torques is negligible. Instead, we argue that the observed change of its spin state may be plausibly explained as a result of the YORP torque. To strengthen this interpretation, we verify that (i) the internal energy dissipation due to material inelasticity and (ii) an impact with a sufficiently large interplanetary particle are both highly unlikely causes of its observed spin state change. If true, this is the first case where the YORP effect has been detected for a tumbling body.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
NASA NTRS2013

Causes and Predictability of the 2012 Great Plains Drought

Central Great Plains precipitation deficits during May-August 2012 were the most severe since at least 1895, eclipsing the Dust Bowl summers of 1934 and 1936. Drought developed suddenly in May, following near-normal precipitation during winter and early spring. Its proximate causes were a reduction in atmospheric moisture transport into the Great Plains from the Gulf of Mexico. Processes that generally provide air mass lift and condensation were mostly absent, including a lack of frontal cyclones in late spring followed by suppressed deep convection in summer owing to large-scale subsidence and atmospheric stabilization. Seasonal forecasts did not predict the summer 2012 central Great Plains drought development, which therefore arrived without early warning. Climate simulations and empirical analysis suggest that ocean surface temperatures together with changes in greenhouse gases did not induce a substantial reduction in summertime precipitation over the central Great Plains during 2012. Yet, diagnosis of the retrospective climate simulations also reveals a regime shift toward warmer and drier summertime Great Plains conditions during the recent decade, most probably due to natural decadal variability. As a consequence, the probability for severe summer Great Plains drought may have increased in the last decade compared to the 1980s and 1990s, and the so-called tail-risk for severe drought may have been heightened in summer 2012. Such an extreme drought event was nonetheless still found to be a rare occurrence within the spread of 2012 climate model simulations. Implications of this study's findings for U.S. seasonal drought forecasting are discussed.

Forecasts↗
NASA NTRS2014

Middle Atmospheric Changes Caused by the January and March 2012 Solar Proton Events

The recent 23-30 January and 7-11 March 2012 solar proton event (SPE) periods were substantial and caused significant impacts on the middle atmosphere. These were the two largest SPE periods of solar cycle 24 so far. The highly energetic solar protons produced considerable ionization of the neutral atmosphere as well as HOx (H, OH, HO2) and NOx (N, NO, NO2). We compute a NOx production of 1.9 and 2.1 Gigamoles due to these SPE periods in January and March 2012, respectively, which places these SPE periods among the 12 largest in the past 50 years. Aura Microwave Limb Sounder (MLS) observations of the peroxy radical, HO2, show significant enhancements of 0.9 ppbv in the northern polar mesosphere as a result of these SPE periods. Both MLS measurements and Goddard Space Flight Center (GSFC) two-dimensional (2D) model predictions indicated middle mesospheric ozone decreases of 20 percent for several days in the northern polar region with maximum depletions 60 percent as a result of the HOx produced in both the January and March 2012 SPE periods. The SCISAT-1 Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE) and the Envisat Michelson Interferometer for Passive Atmospheric Sounding (MIPAS) instruments measured NO and NO2 (NOx), which indicated enhancements of over 20 ppbv in most of the northern polar mesosphere for several days as a result of these SPE periods. The GSFC 2D model was used to predict the medium-term (months) influence and found that the polar Southern Hemisphere middle atmosphere ozone was most affected by these solar events due to the increased downward motion in the fall and early winter. The downward transport moved the SPE-produced NOy to lower altitudes and led to predicted modest destruction of ozone (5-9 percent) in the upper stratosphere days to weeks after the March 2012 event. Total ozone reductions were predicted to be a maximum of 1 percent in 2012 due to these SPEs.

ozone↗
DOE OSTI2025

Observation of the Ω⁡(2012) baryon at the LHC

A signal consistent with the Ω⁡(2012) baryon has been observed with a significance of 15⁢𝜎 in pp collisions at $\sqrt{𝑠}$ = 13 TeV at the LHC. In this paper, the analysis technique is described and measurements of the mass and width of the Ω⁡(2012) are reported, along with the first measurement of its transverse-momentum spectrum and yield. This paper corroborates the observation by the Belle Collaboration of this excited Ω state and the observation that the Ω⁡(2012) has a rather narrow width for a strongly decaying resonance. The yield measurement is combined with a statistical thermal model calculation of strange baryon yield ratios to obtain estimates of the Ω⁢(2012) − → $Ξ⁢\bar{\textrm{K}}$ branching ratios. These results will improve our understanding of the internal structure and mass spectrum of excited baryon states and serve as a baseline for searches regarding modifications of these properties in high-temperature media.

Acharya, S. [INFN] (ORCID:0000000292135329)↗
NASA NTRS2013

Simulations and Visualizations of Hurricane Sandy (2012) as Revealed by the NASA CAMVis

Storm Sandy first appeared as a tropical storm in the southern Caribbean Sea on Oct. 22, 2012, moved northeastward, turned northwestward, and made landfall near Brigantine, New Jersey in late October. Sandy devastated surrounding areas, caused an estimated damage of $50 billion, and became the second costliest tropical cyclone (TC) in U.S. History surpassed only by Hurricane Katrina (2005). To save lives and mitigate economic damage, a central question to be addressed is to what extent the lead time of severe storm prediction such as Sandy can be extended (e.g., Emanuel 2012; Kerr 2012). In this study, we present 10 numerical experiments initialized at 00 and 1200 UTC Oct. 22-26, 2012, with the NASA coupled advanced global modeling and visualization systems (CAMVis). All of the predictions realistically capture Sandy's movement with the northwestward turn prior to its landfall. However, three experiments (initialized at 0000 UTC Oct. 22 and 24 and 1200 UTC Oct. 22) produce larger errors. Among the 10 experiments, the control run initialized at 0000 UTC Oct. 23 produces a remarkable 7-day forecast. To illustrate the impact of environmental flows on the predictability of Sandy, we produce and discuss four-dimensional (4-D) visualizations with the control run. 4-D visualizations clearly demonstrate the following multiscale processes that led to the sinuous track of Sandy: the initial steering impact of an upper-level trough (appearing over the northwestern Caribbean Sea and Gulf of Mexico), the blocking impact of systems to the northeast of Sandy, and the binary interaction with a mid-latitude, upper-level trough that appeared at 130degrees west longitude on Oct. 23, moved to the East Coast and intensified during the period of Oct. 29-30 prior to Sandy's landfall.

visualizations↗
NASA NTRS2013

On the Use of NASA Earth Observations to Characterize the 2012 US Drought

As the harvest season approached in August 2012, much of the United States remained in the grip of a major drought. According to the United States Drought Monitor (USDM), 52 percent of the United States and Puerto Rico was in moderate drought conditions or worse by August 7, 2012 (see Figure 1a). Drought areas were concentrated in the agricultural states in the central U.S.A. The drought threatened global food prices and US biofuel feedstocks. Although areas east of the Mississippi River experienced some relief due to Hurricane Isaac, the drought persisted west of the Mississippi River Basin. The USDA Economic Research Service reports about 80 percent of the US agriculture experienced drought in 2012 making it the most extensive drought since the 1950's. The Financial Times reported 2012 losses at roughly $30 billion dollars. NASA maintains satellite and modelling capabilities that enable the assessment of drought severity and extent on a national and global basis.

water management↗
NASA NTRS2016

GOCI Yonsei Aerosol Retrieval (YAER) Algorithm and Validation During the DRAGON-NE Asia 2012 Campaign

The Geostationary Ocean Color Imager (GOCI) onboard the Communication, Ocean, and Meteorological Satellite (COMS) is the first multi-channel ocean color imager in geostationary orbit. Hourly GOCI top-of-atmosphere radiance has been available for the retrieval of aerosol optical properties over East Asia since March 2011. This study presents improvements made to the GOCI Yonsei Aerosol Retrieval (YAER) algorithm together with validation results during the Distributed Regional Aerosol Gridded Observation Networks - Northeast Asia 2012 campaign (DRAGONNE Asia 2012 campaign). The evaluation during the spring season over East Asia is important because of high aerosol concentrations and diverse types of Asian dust and haze. Optical properties of aerosol are retrieved from the GOCI YAER algorithm including aerosol optical depth (AOD) at 550 nm, fine-mode fraction (FMF) at 550 nm, single-scattering albedo (SSA) at 440 nm, Angstrom exponent (AE) between 440 and 860 nm, and aerosol type. The aerosol models are created based on a global analysis of the Aerosol Robotic Networks (AERONET) inversion data, and covers a broad range of size distribution and absorptivity, including nonspherical dust properties. The Cox-Munk ocean bidirectional reflectance distribution function (BRDF) model is used over ocean, and an improved minimum reflectance technique is used over land. Because turbid water is persistent over the Yellow Sea, the land algorithm is used for such cases. The aerosol products are evaluated against AERONET observations and MODIS Collection 6 aerosol products retrieved from Dark Target (DT) and Deep Blue (DB) algorithms during the DRAGON-NE Asia 2012 campaign conducted from March to May 2012. Comparison of AOD from GOCI and AERONET resulted in a Pearson correlation coefficient of 0.881 and a linear regression equation with GOCI AOD = 1.083 x AERONET AOD - 0.042. The correlation between GOCI and MODIS AODs is higher over ocean than land. GOCI AOD shows better agreement with MODIS DB than MODIS DT. The other GOCI YAER products (AE, FMF, and SSA) show lower correlation with AERONET than AOD, but still show some skills for qualitative use.

Choi, Myungje↗
NASA NTRS2017

Radiative Characteristics of Aerosol During Extreme Fire Event over Siberia in Summer 2012

Microphysical and optical properties of aerosol were studied during a mega-fire event in summer 2012 over Siberia using ground-based measurements of spectral solarradiation at the AERONET site in Tomsk and satellite observations. The data were analyzed using multi-year (2003-2013) measurements of aerosol characteristics under back-ground conditions and for less intense fires, differing in burning biomass type, stage of fire, remoteness from observation site, etc. (ordinary smoke). In June-August 2012, the average aerosol optical depth (AOD, 500 nm) had been 0.95+/-0.86, about a factor of 6 larger than background values (0.16+/-0.08), and a factor of 2.5 larger than in ordinary smoke. The AOD values were extremely high on 24-28 July and reached 3-5. A comparison with satellite observations showed that ground-based measurements in the region of Tomsk not only reflect the local AOD features, but are also characteristic for the territory of Western Siberia as a whole. Single scattering albedo (SSA, 440 nm) in this period ranged from 0.91 to 0.99 with an average of approx. 0.96 in the entire wavelength range of 440-1020 nm. The increase in absorptance of aerosol particles (SSA(440 nm)=0.92) and decrease in SSA with wavelength observed in ordinary smoke agree with the data from multi-year observations in analogous situations in the boreal zone of USA and Canada. Volume aerosol size distribution in extreme and ordinary smoke had a bimodal character with significant prevalence of fine-mode particles, but in summer 2012 the mean median radius and the width of the fine-mode distribution somewhat increased. In contrast to data from multi-year observations, in summer 2012 an increase in the volume concentration and median radius of the coarse mode was observed with growing AOD.

Zhuravleva, Tatiana B.↗
NASA NTRS2017

Spatial Variations in Titan's Atmospheric Temperature: ALMA and Cassini Comparisons from 2012 to 2015

Submillimeter emission lines of carbon monoxide (CO) in Titan's atmosphere provide excellent probes of atmospheric temperature due to the molecule's long chemical lifetime and stable, well constrained volume mixing ratio. Here we present the analysis of 4 datasets obtained with the Atacama Large Millimeter/Submillimeter Array (ALMA) in 2012, 2013, 2014, and 2015 that contain strong CO rotational transitions. Utilizing ALMA's high spatial resolution in the 2012, 2014, and 2015 observations, we extract spectra from 3 separate regions on Titan's disk using datasets with beam sizes ranging from 0.35 ×0.28'' to 0.39 ×0.34''. Temperature profiles retrieved by the NEMESIS radiative transfer code are compared to Cassini Composite Infrared Spectrometer (CIRS) and radio occultation science results from similar latitude regions. Disk-averaged temperature profiles stay relatively constant from year to year, while small seasonal variations in atmospheric temperature are present from 2012 to 2015 in the stratosphere and mesosphere ( approx. 100-500 km) of spatially resolved regions. We measure the stratopause (320 km) to in- crease in temperature by 5 K in northern latitudes from 2012 to 2015, while temperatures rise throughout the stratosphere at lower latitudes. We observe generally cooler temperatures in the lower stratosphere ( approx. 100 km) than those obtained through Cassini radio occultation measurements, with the notable exception of warming in the northern latitudes and the absence of previous instabilities; both of these results are indicators that Titan's lower atmosphere responds to seasonal effects, particularly at higher latitudes. While retrieved temperature profiles cover a range of latitudes in these observations, deviations from CIRS nadir maps and radio occultation measurements convolved with the ALMA beam-footprint are not found to be statistically significant, and discrepancies are often found to be less than 5 K throughout the atmosphere. ALMA's excellent sensitivity in the lower stratosphere (60-300 km) provides a highly complementary dataset to contemporary CIRS and radio science observations, including altitude regions where both of those measurement sets contain large uncertainties. The demonstrated utility of CO emission lines in the submillimeter as a tracer of Titan's atmospheric temperature lays the groundwork for future studies of other molecular species -particularly those that exhibit strong polar abundance enhancements or are pressure-broadened in the lower atmosphere, as temperature profiles are found to consistently vary with latitude in all three years by up to 15 K.

Thelen, Alexander E.↗
NASA NTRS2022

Ensemble Simulations of the 2012 July 12 Coronal Mass Ejection with the Constant-turn Flux Rope Model

Flux-rope-based magnetohydrodynamic modeling of coronal mass ejections (CMEs) is a promising tool for prediction of the CME arrival time and magnetic field at Earth. In this work, we introduce a constant-turn flux rope model and use it to simulate the 2012 July 12 16:48 CME in the inner heliosphere. We constrain the initial parameters of this CME using the graduated cylindrical shell (GCS) model and the reconnected flux in posteruption arcades. We correctly reproduce all the magnetic field components of the CME at Earth, with an arrival time error of approximately 1 hr. We further estimate the average subjective uncertainties in the GCS fittings by comparing the GCS parameters of 56 CMEs reported in multiple studies and catalogs. We determined that the GCS estimates of the CME latitude, longitude, tilt, and speed have average uncertainties of 5°.74, 11°.23, 24°.71, and 11.4%, respectively. Using these, we have created 77 ensemble members for the 2012 July 12 CME. We found that 55% of our ensemble members correctly reproduce the sign of the magnetic field components at Earth. We also determined that the uncertainties in GCS fitting can widen the CME arrival time prediction window to about 12 hr for the 2012 July 12 CME. On investigating the forecast accuracy introduced by the uncertainties in individual GCS parameters, we conclude that the half-angle and aspect ratio have little impact on the predicted magnetic field of the 2012 July 12 CME, whereas the uncertainties in longitude and tilt can introduce relatively large spread in the magnetic field predicted at Earth.

Talwinder Singh↗
DOE OSTI2025

HIV drug resistance during antiretroviral therapy scale-up in Uganda, 2012–19: a population-based, longitudinal study

Background With scale-up of antiretroviral therapy (ART) in sub-Saharan Africa, increasing pretreatment HIV drug resistance has been reported; however, the broader effect of ART expansion on population-level resistance patterns remains insufficiently quantified. We aimed to estimate the longitudinal prevalence of drug resistance and resistance-conferring mutations. Methods This study used data collected as part of the Rakai Community Cohort Study (RCCS), an open population-based census and cohort study conducted in southern Uganda. At each survey round, residents aged 15–49 years are invited to participate and receive a structured questionnaire that obtains sociodemographic, behavioural, and health information, including self-reported past and current ART use. Voluntary HIV testing is conducted using a rapid test algorithm and a venous blood sample. People with HIV provide samples for viral load quantification and deep sequencing. We analysed RCCS survey, HIV viral load, and deep sequencing (which was used to predict resistance) data from five survey rounds. The key outcomes were the population prevalence of viraemic people with HIV with non-nucleoside reverse transcriptase inhibitor (NNRTI), nucleoside reverse transcriptase inhibitor (NRTI), protease inhibitor, or multiclass resistance among all participants (regardless of HIV serostatus) in the 2015 and 2017 surveys. Prevalence of class-specific resistance and resistance-conferring substitutions were estimated using robust log-Poisson regression. Findings Between Aug 10, 2011, and Nov 4, 2020, there were 43 361 participants in the RCCS and 7923 (18·27%) people with HIV. Over five survey rounds, 93 622 participant visits occurred, among which 17 460 (18·65%) were from people with HIV. Over the analysis period, the median age of study participants remained similar (28 years [22–35] in 2012 and 29 years [21–38] in 2019). Sufficient data were available to reliably genotype 4072 (90·03%) of 4523 participant visits from 3407 people with HIV for at least one drug. Overall population prevalence of resistance contributed by viraemic pretreatment people with HIV decreased between 2012 and 2017 from 0·56% (95% CI 0·42–0·75) to 0·25% (0·18–0·33) for NNRTI and from 0·24% (0·15–0·37) to 0·05% (0·02–0·10) for NRTI (prevalence ratio 0·44 [0·29–0·68] for NNRTI and 0·21 [0·09–0·47] for NRTI). Between 2012 and 2017, NNRTI resistance among viraemic pretreatment people with HIV increased from 4·86% (3·69–6·42) to 9·61% (7·27–12·7; prevalence ratio 1·98 [1·34–2·91]). The prevalence of NNRTI and NRTI resistance was substantially higher among viraemic treatment-experienced people with HIV (51·49% [46·24–57·34] for NNRTI and 36·46% [30·06–44·22] for NRTI in 2017) than among pretreatment people with HIV. NNRTI and NRTI resistance was predominantly attributable to rtK103N and rtM184V. inT97A was observed at a similar prevalence among viraemic treatment-experienced (9·96% [6·41–15·48]) and viraemic pretreatment (10·56% [8·01–13·93]) people with HIV; no major dolutegravir resistance mutations were observed. Interpretation Despite rising NNRTI resistance among pretreatment people with HIV, overall population prevalence of pretreatment HIV drug-resistant viraemia decreased due to increasing ART uptake and viral suppression. This finding underscores the crucial role of achieving and maintaining high ART coverage in reducing transmission of drug-resistant HIV. The high prevalence of mutations conferring resistance to components of first-line ART regimens among viraemic people with HIV is potentially concerning. Funding National Institutes of Health, Johns Hopkins University Center for AIDS Research, Bill & Melinda Gates Foundation, and the US Centers for Disease Control and Prevention.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2020

Conscientious vaccination exemptions in kindergarten to eighth-grade children across Texas schools from 2012 to 2018: A regression analysis

Background: As conscientious vaccination exemption (CVE) percentages rise across the United States, so does the risk and occurrence of outbreaks of vaccine-preventable diseases such as measles. In the state of Texas, the median CVE percentage across school systems more than doubled between 2012 and 2018. During this period, the proportion of schools surpassing a CVE percentage of 3% rose from 2% to 6% for public schools, 20% to 26% for private schools, and 17% to 22% for charter schools. The aim of this study was to investigate this phenomenon at a fine scale. Methods and findings: Here, we use beta regression models to study the socioeconomic and geographic drivers of CVE trends in Texas. Using annual counts of CVEs at the school system level from the 2012–2013 to the 2017–2018 school year, we identified county-level predictors of median CVE percentage among public, private, and charter schools, the proportion of schools below a high-risk threshold for vaccination coverage, and five-year trends in CVEs. Since the 2012–2013 school year, CVE percentages have increased in 41 out of 46 counties in the top 10 metropolitan areas of Texas. We find that 77.6% of the variation in CVE percentages across metropolitan counties is explained by median income, the proportion of the population that holds a bachelor's degree, the proportion of the population that self-reports as ethnically white, the proportion of the population that is English speaking, and the proportion of the population that is under the age of five years old. Across the 10 top metropolitan areas in Texas, counties vary considerably in the proportion of school systems reporting CVE percentages above 3%. Sixty-six percent of that variation is explained by the proportion of the population that holds a bachelor’s degree and the proportion of the population affiliated with a religious congregation. Three of the largest metropolitan areas—Austin, Dallas–Fort Worth, and Houston—are potential vaccination exemption "hotspots," with over 13% of local school systems above this risk threshold. The major limitations of this study are inconsistent school-system-level CVE reporting during the study period and a lack of geographic and socioeconomic data for individual private schools. Conclusions: In this study, we have identified high-risk communities that are typically obscured in county-level risk assessments and found that public schools, like private schools, are exhibiting predictable increases in vaccination exemption percentages. As public health agencies confront the reemerging threat of measles and other vaccine-preventable diseases, findings such as ours can guide targeted interventions and surveillance within schools, cities, counties, and sociodemographic subgroups.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2025

2012 California Household Travel Survey Supplement

# 2012 California Household Travel Survey Supplement The 2012 California Household Travel Survey Supplement focused on gathering specific travel information from residents for the development of next-generation, activity-based models. Called the "Augment Survey," it supplemented the [2010–2012 California Household Travel Survey](https://www.nrel.gov/transportation/secure-transportation-data/tsdc-california-travel-survey). ## Data Collection Agency The Southern California Association of Governments (SCAG) hired Abt-SRBI, Inc. to conduct the survey. ## Methodology Travel data were collected from households via in-vehicle (625 vehicles) and wearable (244 participants) global positioning system (GPS) devices. ## Drive Cycle Processing and Filtering NREL has developed a GPS data filtration routine to filter erroneous data points in individual drive cycles sourced from GPS devices mounted in vehicles. Second-by-second drive cycle data collected from GPS-instrumented vehicles during this survey have passed through NREL's drive cycle processing and filtering routines. ## Survey Records Study records include 473 households. ## Transportation Data The SCAG data set contains data from 473 households that participated in one or more areas of study. Of these, 141 completed the wearable GPS portion of the study and 332 completed the vehicle GPS portion. There was no overlap between households participating in the two study areas (wearable and vehicle GPS). For details on available travel survey data and variable definitions, see the [data dictionary](https://www.nrel.gov/media/docs/libraries/tsdc/caltrans_scag_data_dictionary.pdf?sfvrsn=6ec36d7a_1). NREL-generated drive cycle data are also available for this survey. For details on available data and variable definitions, see the [drive cycle data dictionary](https://www.nrel.gov/media/docs/libraries/tsdc/drive_cycles_data_dictionary.pdf?sfvrsn=7de7e888_1). Transportation data are available as zipped files. [Download Winzip](http://www.winzip.com/downwz.htm).

32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗