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At least 1,783 records · Page 99
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

Chemical Imaging of Atmospheric Organic Particles in the Eastern North Atlantic Field Campaign Report

The ability to reliably predict future climate is hindered, in major part, by an insufficient understanding of atmospheric aerosol-radiation interactions and aerosol-cloud interactions. (IPCC 2013; Bony and Dufresne 2005) Factors affecting marine stratocumulus clouds are particularly important given that they are the dominant cloud type globally. Global climate models frequently misrepresent ubiquitous marine stratocumulus clouds for a variety of reasons, including a lack of understanding of how these cloud properties change with aerosol cloud condensation nuclei (CCN) concentration and composition.(Nam et al. 2012) Limited information is available regarding the sources of CCN in remote regions where marine stratocumulus clouds dominate. Measurements in these marine locations, which are periodically influenced by anthropogenic emissions, provide additional opportunity to study the impact of humans on cloud characteristics. The U.S. Department of Energy Atmospheric Radiation Measurement (ARM) user facility Eastern North Atlantic (ENA) observatory on Graciosa Island in the Azores is well suited to study these problems. The ENA site is exposed to a multitude of air masses as well as a variety of cloud regimes, as documented by passive and active satellite cloud retrieval. (Tselioudis et al. 2013) Thus, placing detailed aerosol and cloud measurements at the ARM ENA site may help gain a better understanding of the CCN budget and cloud interactions in remote environments. To provide detailed information on aerosol morphology, composition, and microphysical properties, size- segregated sampling was carried out at the ENA observatory on Graciosa Island during two intensive operating periods (IOPs). IOP1 occurred from June 17 to July 18, 2017, and IOP2 occurred from January 9 to February 21, 2018. Daytime and nighttime sampling were carried out separately to investigate any diurnal differences of aerosol composition due to differing meteorology. For both IOPs, a micro-orifice uniform deposit impactor (MOUDI) was used to collect particles for microscopic and microphysical analysis. A variety of microscopic substrates (formvar coated copper grids, silicon chips, silicon nitride windows, or molybdenum substrates) were used. Microscopic chemical characterization was carried out using computer-controlled scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy (CCSEM-EDX) and the synchrotron-based scanning transmission X-ray microscopy coupled with near-edge X-ray absorption spectroscopy (STXM-NEXAFS). (Laskin et al. 2006; Kilcoyne et al. 2003; Moffet et al. 2010) Two light sources were used for this analysis: 1) the Advanced Light Source at Lawrence Berkeley National Laboratory, and 2) The Canadian Light Source.

Eastern North Atlantic, ACE-ENA field campaign, Gr↗
NASA NTRS1997

Apparatus for providing vibrotactile sensory substitution of force feedback

A feedback apparatus for an operator to control an effector that is remote from the operator to interact with a remote environment has a local input device to be manipulated by the operator. Sensors in the effector's environment are capable of sensing the amplitude of forces arising between the effector and its environment, the direction of application of such forces, or both amplitude and direction. A feedback signal corresponding to such a component of the force, is generated and transmitted to the environment of the operator. The signal is transduced into a vibrotactile sensory substitution signal to which the operator is sensitive. Vibration producing apparatus present the vibrotactile signal to the operator. The full range of the force amplitude may be represented by a single, mechanical vibrator. Vibrotactile display elements can be located on the operator's limbs, such as on the hand, fingers, arms, legs, feet, etc. The location of the application of the force may also be specified by the location of a vibrotactile display on the operator's body. Alternatively, the location may be specified by the frequency of a vibrotactile signal.

Massimino, Michael J.↗
DOE OSTI2018

Cryogenic Frostpoint Hygrometer (CFH) Instrument Handbook

The U.S. Department of Energy (DOE) Atmospheric Radiation Measurement (ARM) Climate Research Facility’s Cryogenic Frostpoint Hygrometer (CFH) is a small, balloon-borne instrument that provides highly accurate measurements of water vapor in the atmosphere. The CFH, although highly modified, is based upon the National Oceanic and Atmospheric Administration (NOAA)/Climate Monitoring and Diagnostic Laboratory (CMDL) frostpoint hygrometer (FPH) that has been flown in Boulder, Colorado, since 1980. The CFH has a significantly greater sensitivity to water vapor than standard radiosondes, as it can measure the frostpoint or dewpoint temperatures at an accuracy better than 0.2 K corresponding to water volume mixing ratios accuracies of only a few parts per million. The main instrument part is a small mirror, which is cooled by a cryogen in order to be covered with a thin layer of water vapor condensate. A pair of photodiodes detects the condensation on the temperature-controlled mirror. The phase of the condensate is controlled by a force-freezing algorithm, allowing for clear interpretation of the dew point versus frostpoint. The replacement of analog electronics with a microprocessor, a feedback controller, and thermistor calibration have led to improved accuracy and performance of the CFH over its predecessors. Further characteristics like reduced power consumption and low instrument weight made the CFH a successful instrument to perform in situ balloon-borne measurements of water vapor in the upper troposphere and lower stratosphere. CFH measurements are now used worldwide to validate radiosonde, satellite, and ground-based profiler measurements.

47 OTHER INSTRUMENTATION↗
NASA NTRS1995

Effect of Hindlimb Unloading on Rat Soleus Fiber Force, Stiffness, and Calcium Sensitivity

The purpose of this study was to examine the time course of change in soleus muscle fiber peak force (N), tension (P(sub 0), kN/sq m), elastic modulus (E(sub 0)), and force-pCa and stiffness - pCa relationships. After 1, 2, or 3 wk of Hindlimb Unloading (HU), single fibers were isolated and placed between a motor arm and a transducer, and fiber diameter, peak absolute force, P(sub 0), E(sub 0), and force-pCa and stiffness-pca relationships were characterized. One week of HU resulted in a significant reduction in fiber diameter (68 +/- 2 vs. 57 +/- 1 micrometer), force (3.59 +/- 0.15 vs. 2.19 +/- 0.12 x 10(exp -4) N), P(sub 0) (102 +/- 4 vs. 85 +/- 2 kN/sq m), and E(sub 0) (1.96 +/- 0.12 vs. 1.37 +/- 0.13 X 10(exp 7) N/sq m) and 2 wk of HU caused a further decline in fiber diameter (45 +/- 1 micrometer), force (1.31 +/- 0.06 x 10(exp -4) N), and E(sub 0)(0.96 +/- 0.09 x 10(exp 7) N/sq m). Although the mean fiber diameter and absolute force continued to decline through 3 wk of HU, P(sub 0) recovered to values not significantly different from control. The P(sub 0)/E(sub 0) ratio was significantly increased after 1 (5.5 +/- 0.3 to 7.1 +/- 0.6), 2, and 3 wk of HU, and the 2-wk (9.5 +/- 0.4) and 3-wk (9.4 +/- 0.8) values were significantly greater than the 1-wk values. The force-pCa and stiffness-pCa curves were shifted right- ward after 1, 2, and 3 wk of HU. At 1 wk of HU, the Ca(2+) sensitivity of isometric force, assessed by Ca(2+) concentration required for half-maximal force, was increased from the control value of 1.83 +/- 0.12 to 2.30 +/- 0.10 micrometers. In conclusion, after HU, the decrease in soleus fiber P(sub 0) can be explained by a reduction in the number of myofibrillar cross bridges per cross-sectional area. Our working hypothesis is that the loss of contractile protein reduces the number of cross bridges per cross-sectional area and increases the filament lattice spacing. The increased spacing reduces cross-bridge force and stiffness, but P(sub 0)/E(sub 0) increases because of a quantitatively greater effect on stiffness.

McDonald Kerry S.↗
NASA NTRS2024

An Integrated Architecture Study for Autonomous Lunar Construction

Lunar construction is an expanding field within NASA’s Moon to Mars objectives that presents many challenges and requires innovative and reliable forms of autonomous operations on the surface of the Moon to further the technologies needed for human space exploration. Marshal Space Flight Center’s (MSFC) Advanced Concepts Office (ACO) addressed Lunar Infrastructure Objective LI-4 l by developing a Pre-Phase A, integrated architecture to inform a demonstration for lunar construction operations. The ACO study traded three architectures that would survey and prepare a construction area to build a landing pad out of lunar regolith using MMPACT (Moon-to-Mars Planetary Autonomous Construction Technology) platforms, rovers, and navigation outposts. The main trades examined navigation for the system/architecture, options for rover navigation, battery vs continuous tether power for the MMPACT robotic arm, and assigning site prep functionality to the rovers vs the platforms. Results of the study determined that the best options for the scenario provided would be local navigation (more accurate and continuous), a combination of Light Detection and Ranging (LiDAR) for initial site mapping with subsequent Smart Video Guidance Sensors (SVGS) to save power for construction, and using tethered power to decrease mission duration. The team also concluded that assigning site prep functionality to either the rovers or the platforms has benefits and challenges; future studies could explore having that functionality on both the rovers and platforms. Lastly, the team provided a Concept of Operations (ConOps) timeline that can be used in real-time ground demonstrations to explore the mission timeline, construction processes, autonomous operations, and communication systems that can be tested using MSFC’s lunar regolith field and Lunar Utilization Control Area (LUCA).

Sarah Triana↗
DOE OSTI2024

Security of Mobile Radiological Sources: Overview of Industry Applied Technologies

Small radiological sources used in industrial settings recurrently require transit between job sites. Securing these sources, while stationary, can be addressed with standard security approaches and equipment. Transport of these sources increases the risk and complexity of managing and maintaining control of these sources. Implementing methodologies to securely monitor and locate sources improves response and resolution of anomalous events during transit. The Mobile Source Transit Security (MSTS) system was developed to improve security and provide situational awareness of these mobile sources throughout their job cycle. The MSTS development effort focused on creating a set of systems that could be successfully implemented in industrial radiography and well-logging applications. The MSTS team worked to address source presence and location through use and storage. The MSTS system monitors radiological sources as they move from the base of operations to the job site and back. The system provides near-real-time monitoring of the mobile source location and status and early notification of source loss or theft by transmitting operational status and alerting anomalous conditions over telematic links worldwide. The MSTS system can trigger an armed response or initiation of search and recovery operations and will automatically alert management and responsible staff if a radioactive source is lost or stolen whether it is on-site, in transport, or in storage.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗
DOE OSTI2013

Shape controlled Sn doped ZnO nanostructures for tunable optical emission and transport properties

Pure and Sn doped ZnO nanostructures have been grown on SiO{sub 2}/Si substrates by vapor-solid technique without using any catalysts. It has been found that the morphology of the nanostructures depend strongly on the growth temperature and doping concentration. By proper tuning of the growth temperature, morphology of pure ZnO can be changed from tetrapods to multipods. On the other hand, by varying the doping concentration of Sn in ZnO, the morphology can be tuned from tetrapods to flower-like multipods to nanowires. X-ray diffraction pattern reveals that the nanostructures have a preferred (0002) growth orientation, and they are tensile strained with the increase of Sn doping in ZnO. Temperature-dependent photoluminescence characteristics of these nanostructures have been investigated in the range from 10 to 300 K. Pure ZnO tetrapods exhibited less defect state emissions than that of pure ZnO multipods. The defect emission is reduced with low concentration of Sn doping, but again increases at higher concentration of doping because of increased defects. Transport properties of pure and Sn doped ZnO tetrapods have been studied using complex-plane impedance spectroscopy. The contribution from the arms and junctions of a tetrapod could be distinguished. Sn doped ZnO samples showed lower conductivity but higher relaxation time than that of pure ZnO tetrapods.

36 MATERIALS SCIENCE↗
DOE OSTI2019

Architecture of the chromatin remodeler RSC and insights into its nucleosome engagement

Eukaryotic DNA is packaged into nucleosome arrays, which are repositioned by chromatin remodeling complexes to control DNA accessibility. The Saccharomyces cerevisiae RSC (Remodeling the Structure of Chromatin) complex, a member of the SWI/SNF chromatin remodeler family, plays critical roles in genome maintenance, transcription, and DNA repair. Here, we report cryo-electron microscopy (cryo-EM) and crosslinking mass spectrometry (CLMS) studies of yeast RSC complex and show that RSC is composed of a rigid tripartite core and two flexible lobes. The core structure is scaffolded by an asymmetric Rsc8 dimer and built with the evolutionarily conserved subunits Sfh1, Rsc6, Rsc9 and Sth1. The flexible ATPase lobe, composed of helicase subunit Sth1, Arp7, Arp9 and Rtt102, is anchored to this core by the N-terminus of Sth1. Our cryo-EM analysis of RSC bound to a nucleosome core particle shows that in addition to the expected nucleosome-Sth1 interactions, RSC engages histones and nucleosomal DNA through one arm of the core structure, composed of the Rsc8 SWIRM domains, Sfh1 and Npl6. Our findings provide structural insights into the conserved assembly process for all members of the SWI/SNF family of remodelers, and illustrate how RSC selects, engages, and remodels nucleosomes.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2013

Phase 1 Study of Erlotinib Plus Radiation Therapy in Patients With Advanced Cutaneous Squamous Cell Carcinoma

Purpose: To assess the toxicity profile of erlotinib therapy combined with postoperative adjuvant radiation therapy in patients with advanced cutaneous squamous cell carcinoma. Methods and Materials: This was a single-arm, prospective, phase 1 open-label study of erlotinib with radiation therapy to treat 15 patients with advanced cutaneous head-and-neck squamous cell carcinoma. Toxicity data were summarized, and survival was analyzed with the Kaplan-Meier method. Results: The majority of patients were male (87%) and presented with T4 disease (93%). The most common toxicity attributed to erlotinib was a grade 2-3 dermatologic reaction occurring in 100% of the patients, followed by mucositis (87%). Diarrhea occurred in 20% of the patients. The 2-year recurrence rate was 26.7%, and mean time to cancer recurrence was 10.5 months. Two-year overall survival was 65%, and disease-free survival was 60%. Conclusions: Erlotinib and radiation therapy had an acceptable toxicity profile in patients with advanced cutaneous squamous cell carcinoma. The disease-free survival in this cohort was comparable to that in historical controls.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2020

Investigating Secondary Aerosol Processes in the Amazon through Molecular-level Characterization of Semi-Volatile Organics

In areas where biogenic emissions are oxidized in the presence of anthropogenic pollutants, it has become increasingly apparent that secondary organic aerosol (SOA) formation from biogenic volatile organic compounds (BVOCs) is substantially enhanced. The Amazon forest is the dominant source of BVOCs globally, and the forest is rapidly being converted to urban and agricultural uses. We participated in a collaborative field study located in the Amazon region around Manaus, Brazil, in 2014 (Green Ocean Amazon; GoAmazon). This study was designed to comprehensively examine how BVOC emissions (specifically, the most highly emitted non-methane hydrocarbon, isoprene, and lesser studied sesquiterpenes) and their interaction with anthropogenic pollution (i.e., nitrogen oxides, sulfur dioxide, and black carbon) alter the atmosphere’s oxidative capacity, influence secondary aerosol formation, atmospheric composition and, ultimately, affect the earth’s radiation balance and climate. We provide the first hourly, in-situ measurement of 30 sesquiterpenes and 4 diterpenes, roughly estimating that sesquiterpene oxidation contributes to 10-14% of ozone reactive loss by terpenes and at least 0.4–5% (median 1 %) of total submicron OA mass. However, this is likely a low-end estimate, as evidence for additional unaccounted sesquiterpenes and their oxidation products clearly exists. We also provide new perspectives on sulfate, NO x , and particle acidity influencing isoprene-derived SOA, comparing the central Amazon environment with Southeastern U.S.A. summer, representing clean to polluted conditions, respectively. We find that summed concentrations of isoprene-derived SOA tracers correlated with particulate sulfate spanning three orders of magnitude, suggesting that 1 μg m -3 reduction in sulfate corresponds with at least ~0.5 μg m -3 reduction in isoprene-derived SOA. We also find that SOA mass derived from isoprene oxidation in the presence of NO x is primarily comprised of aerosol sulfate bound with isoprene oxidation products (i.e. organosulfates), ~97% in the Amazon and ~55% in the Southeastern U.S. We infer under natural conditions in high isoprene emission regions, preindustrial aerosol sulfate was almost exclusively isoprene-derived organosulfates, which are traditionally thought as representative of anthropogenic influence. We further report the first field observations showing that particle acidity impacts the distribution of isoprene oxidation tracers in the gas and particle phases, providing physicochemical insight into isoprene SOA formation chemistry. Coupled with other co-located measurements by the DOE Atmospheric Radiation Measurement (ARM) team and collaborating PIs at our measurement site (called T3), on the G1 aircraft, and at additional field sites (T0, T1, T2) this data set has been used to understand emission, oxidation, and particle formation pathways at the molecular level, to elucidate how these pathways change when influenced by anthropogenic sources, and to evaluate their importance for the atmospheric budget of aerosols and the earth’s radiation balance on regional scales. Recommendations: Further constraint of the role of sesquiterpenes on ozone (O 3 ) reactivity and SOA formation is limited by the availability of authentic standards and synthesized compounds of sesquiterpenes and their oxidation products. Future research efforts should focus on making such standards available via custom synthesis to allow for accurate quantification and focused oxidation experiments that will fully elucidate the chemistry of these compounds in the atmosphere. Further, reductions in aerosol sulfate (via SO 2 emissions control) continues to be one of the most effective methods to reduce SOA formation from isoprene, but the concerted role of ammonia (NH 3 ) gas emissions from (agricultural) industry and other sources requires more investigation to better understand the role of aerosol acidity in SOA formation and potential controls. As GoAmazon particles can be more acidic compared to areas with greater anthropogenic NH 3 emissions, this promotes relatively greater organosulfate (OS) formation from isoprene even in the presence of NO x . Because OS and inorganic sulfate differ in water uptake properties, this implies preindustrial aerosol sulfate (albeit less abundant) may have been less reflective than current earth system models assume. Further research should investigate the radiative impacts of organic vs inorganic sulfate in aerosols to improve model representation. Finally, future work (currently underway) should include constraint of the contributions of monoterpene (C 10 H 16 ) BVOCs and biomass burning VOCs as precursors to SOA formation in the region as well as their impacts on radiative forcing in the climate system.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2021

Interpreting the Diurnal Cycle of Clouds and Precipitation in the ARM GoAmazon Observations: Shallow to Deep Convection Transition

The Green Ocean Amazon (GoAmazon) 2014/5 field campaign data are used to study the diurnal cycle of clouds and precipitation. Through a careful classification of days with shallow cumulus, congestus and deep convection, we investigate the major differences among locally generated convection regimes and the most important environmental factors governing the shallow-to-deep convection transition. On shallow cumulus days, a greater sensible heat flux drives deeper boundary layer growth, which entrains drier free-tropospheric air and lowers the relative humidity, thus leading to a significantly higher cloud base than those on days with deeper convection. Congestus and deep convection regimes exhibit distinct cloud top height distributions with noticeable differences in the vertical wind shear in the mid-troposphere, suggesting an important role of wind shear in limiting the vertical extent of convection. On deep convection days, with preexisting nocturnal convection or cold-pools from external disturbances, the timing of peak surface precipitation (12:00–13:00 LST) tends to be in-phase with the diurnal variation in surface fluxes. However, it takes longer for local deep convection to develop without these disturbances. A plume model with thermodynamic and dynamical constraints is developed to explore the relative importance of various convection-controlling factors. Initial cloud-base vertical velocity and buoyancy are important in helping parcels ascend to the level of free convection (LFC). After parcels reach the LFC, entrainment of environmental air and lower free troposphere humidity become crucial in determining cloud top. Entrainment rate differentiates among convection regimes, which may be tied to the cloud size distribution at cloud base.

54 ENVIRONMENTAL SCIENCES↗
NASA NTRS2008

Characterizing ISS Charging Environments with On-Board Ionospheric Plasma Measurements

Charging of the International Space Station (ISS) is dominated by interactions of the biased United States (US) 160 volt solar arrays with the relatively high density, low temperature plasma environment in low Earth orbit. Conducting surfaces on the vehicle structure charge negative relative to the ambient plasma environment because ISS structure is grounded to the negative end of the US solar arrays. Transient charging peaks reaching potentials of some tens of volts negative controlled by photovoltaic array current collection typically occur at orbital sunrise and sunset as well as near orbital noon. In addition, surface potentials across the vehicle structure vary due to an induced v x B (dot) L voltage generated by the high speed motion of the conducting structure across the Earth's magnetic field. Induced voltages in low Earth orbit are typically only approx.0.4 volts/meter but the approx.100 meter scale dimensions of the ISS yield maximum induced potential variations ofapprox.40 volts across the vehicle. Induced voltages are variable due to the orientation of the vehicle structure and orbital velocity vector with respect to the orientation of the Earth's magnetic field along the ISS orbit. In order to address the need to better understand the ISS spacecraft potential and plasma environments, NASA funded development and construction of the Floating Potential Measurement Unit (FPMU) which was deployed on an ISS starboard truss arm in August 2006. The suite of FPMU instruments includes two Langmuir probes, a plasma impedance probe, and a potential probe for use in in-situ monitoring of electron temperatures and densities and the vehicle potential relative to the plasma environment. This presentation will describe the use of the FPMU to better characterize interactions of the ISS with the space environment, changes in ISS charging as the vehicle configuration is modified during ISS construction, and contributions of FPMU vehicle potential and plasma environment measurements to investigations of on-orbit anomalies in ISS systems.

Minow, Jospeh I.↗
NASA NTRS2014

Large Plant Growth Chambers: Flying Soon on a Space Station near You!

The International Space Station (ISS) now has platforms for conducting research on horticultural plant species, and those capabilities continue to grow. The Veggie vegetable production system will be deployed to the ISS in Spring of 2014 to act as an applied research platform with goals of studying food production in space, providing the crew with a source of fresh food, allowing behavioral health and plant microbiology experimentation, and being a source of recreation and enjoyment for the crew. Veggie was conceived, designed, and constructed by Orbital Technologies Corporation (ORBITEC, Madison, WI). Veggie is the largest plant growth chamber that NASA has flown to date, and is capable of growing a wide array of horticultural crops. It was designed for low energy usage, low launch mass and stowage volume, and minimal crew time requirements. The Veggie flight hardware consists of a light cap containing red (630 nanometers), blue, (455 nanometers) and green (530 nanometers) light emitting diodes. Interfacing with the light cap is an extendable bellows baseplate secured to the light cap via magnetic closures and stabilized with extensible flexible arms. The baseplate contains vents allowing air from the ISS cabin to be pulled through the plant growth area by a fan in the light cap. The baseplate holds a Veggie root mat reservoir that will supply water to plant pillows attached via elastic cords. Plant pillows are packages of growth media and seeds that will be sent to ISS dry and installed and hydrated on orbit. Pillows can be constructed in various sizes for different plant types. Watering will be via passive wicking from the root mat to the pillows. Science procedures will include photography or videography, plant thinning, pollination, harvesting, microbial sampling, water sampling, etcetera. Veggie is one of the ISS flight options currently available for research investigations on plants. The Plant Habitat (PH) is being designed and constructed through a NASA-ORBITEC collaboration, and is scheduled to fly on ISS around 2016. This large plant chamber will control light quality, level, and timing, temperature, CO2, relative humidity, and irrigation, while scrubbing ethylene. Additional monitoring capabilities include leaf temperature sensing and root zone moisture and oxygen sensing. The PH light cap will have red (630 nanometers), blue (450 nanometers), green (525 nanometers), far red (730 nanometers) and broad spectrum white light emitting diodes. There will be several internal cameras to monitor and record plant growth and operations.

Space Biology↗
NASA NTRS1997

Cardiovascular responses of snakes to hypergravity

Snakes have provided useful vertebrate models for understanding circulatory adaptation to gravity, attributable to their elongate body shape and evolutionary diversificaton in terms of ecology and behavior. Recently we have studied cardiovascular responses of snakes to hypergravic acceleration forces produced acutely in the head-to-tail direction (+Gz) on a short-arm centrifuge. Snakes were held in a nearly straight position within a horizontal plastic tube and subjected to a linear force gradient during acceleration. Carotid blood flow provided an integrated measure of cardiovascular performance. Thus, cardiovascular tolerance of snakes to stepwise increments of Gz was measured as the caudal Gz force at which carotid blood flow ceased. Tolerance to increasing Gz varies according to adaptive evolutionary history inferred from the ecology and behavior of species. With respect to data for six species we investigated, multiple regression analysis demonstrates that Gz tolerance correlates with gravitational habitat, independently of body length. Relative to aquatic and non-climbing species, carotid blood flow is better maintained in arboreal or scansorial species, which tolerate hypergravic forces of +2 to +3.5 Gz. Additionally, semi-arboreal rat snakes (Elaphe obsoleta) exhibit plasticity of responses to long-term, intermittent +1.5 Gz stress. Compared to non-acclimated controls, acclimated snakes show greater increases of heart rate during head-up tilt or acceleration, greater sensitivity of arterial pressure to circulating catecholamines, higher blood levels of prostaglandin ratios favorable to maintenance of arterial blood pressure, and medial hypertrophy in major arteries and veins. As in other vertebrates, Gz tolerance of snakes is enhanced by acclimation, high arterial pressure, comparatively large blood volume, and body movements. Vascular studies of snakes suggest the importance to acclimation of local responses involving vascular tissue, in addition to centrally mediated responses to fluid shifts.

Review, Tutorial↗
DOE OSTI2016

Simultaneous and coordinated rotational switching of all molecular rotors in a network

A range of artificial molecular systems have been created that can exhibit controlled linear and rotational motion. In the development of such systems, a key step is the addition of communication between molecules in a network. Here, we show that a two-dimensional array of dipolar molecular rotors can undergo simultaneous rotational switching by applying an electric field from the tip of a scanning tunnelling microscope. Several hundred rotors made from porphyrin-based double-decker complexes can be simultaneously rotated when in a hexagonal rotor network on a Cu(111) surface by applying biases above ±1 V at 80 K. The phenomenon is observed only in a hexagonal rotor network due to the degeneracy of the ground state dipole rotational energy barrier of the system. Defects are essential to increase electric torque on the rotor network and to stabilize the switched rotor domains. At low biases and low initial rotator angles, slight reorientations of individual rotors can occur resulting in the rotator arms pointing in different directions. In conclusion, analysis reveals that the rotator arm directions here are not random, but are coordinated to minimize energy via cross talk among the rotors through dipolar interactions.

77 NANOSCIENCE AND NANOTECHNOLOGY↗
NASA NTRS1991

A fast algorithm for control and estimation using a polynomial state-space structure

One of the major problems associated with the control of flexible structures is the estimation of system states. Since the parameters of the structures are not constant under varying loads and conditions, conventional fixed parameter state estimators can not be used to effectively estimate the states of the system. One alternative is to use a state estimator which adapts to the condition of the system. One such estimator is the Kalman filter. This filter is a time varying recursive digital filter which is based upon a model of the system being measured. This filter adapts the model according to the output of the system. Previously, the Kalman filter has only been used in an off-line capacity due to the computational time required for implementation. With recent advances in computer technology, it is becoming a viable tool for use in the on-line environment. A distributed Kalman filter implementation is described for fast estimation of the state of a flexible arm. A key issue, is the sensor structure and initial work on a distributed sensor that could be used with the Kalman filter is presented.

Shults, James R.↗
DOE OSTI2022

Feasibility and preliminary efficacy for morning bright light therapy to improve sleep and plasma biomarkers in US Veterans with TBI. A prospective, open-label, single-arm trial

Mild traumatic brain injury (TBI) is associated with persistent sleep-wake dysfunction, including insomnia and circadian rhythm disruption, which can exacerbate functional outcomes including mood, pain, and quality of life. Present therapies to treat sleep-wake disturbances in those with TBI (e.g., cognitive behavioral therapy for insomnia) are limited by marginal efficacy, poor patient acceptability, and/or high patient/provider burden. Thus, this study aimed to assess the feasibility and preliminary efficacy of morning bright light therapy, to improve sleep in Veterans with TBI (NCT03578003). Thirty-three Veterans with history of TBI were prospectively enrolled in a single-arm, open-label intervention using a lightbox (~10,000 lux at the eye) for 60-minutes every morning for 4-weeks. Pre- and post-intervention outcomes included questionnaires related to sleep, mood, TBI, post-traumatic stress disorder (PTSD), and pain; wrist actigraphy as a proxy for objective sleep; and blood-based biomarkers related to TBI/sleep. The protocol was rated favorably by ~75% of participants, with adherence to the lightbox and actigraphy being ~87% and 97%, respectively. Post-intervention improvements were observed in self-reported symptoms related to insomnia, mood, and pain; actigraphy-derived measures of sleep; and blood-based biomarkers related to peripheral inflammatory balance. The severity of comorbid PTSD was a significant positive predictor of response to treatment. Morning bright light therapy is a feasible and acceptable intervention that shows preliminary efficacy to treat disrupted sleep in Veterans with TBI. A full-scale randomized, placebo-controlled study with longitudinal follow-up is warranted to assess the efficacy of morning bright light therapy to improve sleep, biomarkers, and other TBI related symptoms.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2000

Spring and Summer Changes at the South Pole as Seen by the Mars Orbiter Camera

The Mars Orbiter Camera (MOC) on the Mars Global Surveyor (MGS) spacecraft has been able to follow individual features as the CO2 frost disappears and exposes the material underneath. Because the orbit of MGS is inclined at an angle of 93 degrees relative to the equator, the spacecraft gets especially good coverage of the ring at 87 degrees latitude. The following is a list of phenomena that have been seen during the spring and summer at the South Pole: (1) Circular depressions that are approximately ten meters deep and hundreds of meters in diameter. They are found only within the residual polar cap, the part that survives the summer. The high areas between the depressions are flat-topped mesas whose sides are concave circular arcs. In some places the depressions form patterns that exhibit north-south symmetry, suggesting some control by sunlight; (2) Dark layers that are exposed on the walls of the mesas. Each layer is at most a few meters thick. The dark layers might accumulate during climatic episodes of high atmospheric dust content, or they might accumulate during the annual cycling of dusty CO2; (3) Albedo differences that develop during the summer within the residual cap. These include subtle darkening of the floors of the depressions relative to the mesas and occasional major darkening of the floors, especially near the edge of the cap. The floors and mesas form a distinct stratum, suggesting they represent a distinct compositional boundary. For instance the floors may be water and the mesas may be CO2; (4) Small dark features that appear in spring on the seasonal frost outside the residual cap. Some of the features have parallel tails that are clearly shaped by the wind. Others are more symmetric, like dark snowflakes, with multiple branching arms. After the CO2 frost has disappeared the arms are seen as troughs and the centers as topographic lows; (5) Polygons whose sides are dark troughs. Those that are outside the residual cap seem to disappear when the frost disappears. The polygons and the dark snowflakelike structures may be related, and suggest that CO2 frost may form cohesive slabs; (6) Irregular depressions outside the residual cap. They look like degraded versions of the circular depressions inside the residual cap, and may be a remnant of the cap's changing location; and (7) Areas of burial and exhumation of circular depressions. Thomas et al. give an example with a sharp boundary: On one side the depressions are buried and on the other side they are exposed. In other cases there are rounded troughs up to one kilometer wide, which are dark in summer and appear to have eroded down below the floor of the circular depressions.

Ingersoll, A. P.↗