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At least 1,765 records · Page 98

Dynamic molecular architecture of the synaptonemal complex

During meiosis, pairing between homologous chromosomes is stabilized by the assembly of the synaptonemal complex (SC). The SC ensures the formation of crossovers between homologous chromosomes and regulates their distribution. However, how the SC regulates crossover formation remains elusive. We isolated an unusual mutation in Caenorhabditis elegans that disrupts crossover interference but not SC assembly. This mutation alters the unique C terminal domain of an essential SC protein, SYP-4, a likely ortholog of the vertebrate SC protein SIX6OS1. We use three-dimensional stochastic optical reconstruction microscopy (3D-STORM) to interrogate the molecular architecture of the SC from wild-type and mutant C. elegans animals. Using a probabilistic mapping approach to analyze super-resolution image data, we detect changes in the organization of the synaptonemal complex in wild-type animals that coincide with crossover designation. We also found that our syp-4 mutant perturbs SC architecture. Our findings add to growing evidence that the SC is an active material whose molecular organization contributes to chromosome-wide crossover regulation.

59 BASIC BIOLOGICAL SCIENCES↗

Data-driven global ocean modeling for seasonal to decadal prediction

Accurate modeling of ocean dynamics is crucial for enhancing our understanding of complex ocean circulation processes, predicting climate variability, and tackling challenges posed by climate change. Although great efforts have been made to improve traditional numerical models, predicting global ocean variability over multiyear scales remains challenging. Here, we propose ORCA-DL (Oceanic Reliable foreCAst via Deep Learning), a data-driven three-dimensional ocean model for seasonal to decadal prediction of global ocean dynamics. ORCA-DL accurately simulates the three-dimensional structure of global ocean dynamics with high physical consistency and outperforms state-of-the-art numerical models in capturing extreme events, including El Niño–Southern Oscillation and upper ocean heat waves. Moreover, ORCA-DL stably emulates ocean dynamics at decadal timescales, demonstrating its potential even for skillful decadal predictions and climate projections. Our results demonstrate the high potential of data-driven models for providing efficient and accurate global ocean modeling and prediction.

Science & Technology - Other Topics↗

Model 9975 Life Extension Test Package 3 - Interim Report - January 2017

Life extension package LE3 (9975-03203) has been instrumented and subjected to an elevated temperature environment for approximately 8 years. During this time, the cane fiberboard has been maintained at a maximum temperature of ~160 - 165 °F, which was established by a combination of internal (19 watts) and external heat sources. Several tests and parameters were used to characterize the package components. Results from these tests generally indicate agreement between this full-scale shipping package and small-scale laboratory tests on fiberboard samples, including the degradation models based on the laboratory tests. These areas of agreement include the rate of change of fiberboard weight, dimensions and density, and change in fiberboard thermal conductivity. Corrosion of the lead shield occurred at a high rate during the first several weeks of aging, but dropped significantly after most of the moisture in the fiberboard migrated away from the lead shield. Dimensional measurements of the lead shield indicate that no significant creep deformation has occurred. This is consistent with literature data that predict a very small creep deformation for the time at temperature experienced by this package. The SCV O-rings were verified to remain leak-tight after ~5 years aging at an average temperature of ~170 °F. This package provides an example of the extent to which moisture within a typical fiberboard assembly can redistribute in the presence of a temperature gradient such as might be created by a 19 watt internal heat load. The majority of water within the fiberboard migrated to the bottom layers of fiberboard, with approximately 2 kg of water (2 liters) eventually escaping from the package. Two conditions have developed that are not consistent with package certification requirements. The axial gap at the top of the package increased to a maximum value of 1.549 inches, exceeding the 1 inch criterion. In addition, staining and/or corrosion have formed in a few spots on the drum. However, the package remains capable of performing its function. Aging of this package continues.

42 ENGINEERING↗

Physics-based Induced Earthquake Forecasting: Process Understanding, and Hazards Mitigation

Disposal of saltwater co-produced with oil and gas is linked to elevated seismicity in the Central and Midwest US. There is a concern that these events may lead to widespread damage and an overall increase in seismicity. Thus an improved understanding of the spatially and temporally variable deformation and stress field associated with fluid injection operation is critically necessary for evaluating time-varying seismic hazards. Despite the improvements in seismic monitoring capacity and the resulting decrease in the magnitude detection threshold, estimates of induced earthquake probability remain elusive due to insufficient models incapable of accounting for the complex physics governing the process of induced seismicity. The proposed research effort will comprehensively analyze, integrate, and interpret geodetic, injection, and seismic data in the vicinity of the injection sites in Oklahoma to resolve the 4-dimensional distribution of pore pressure and stress in the shallow crust. This project, in particular, is focused on exploring the statistical relation between injection operation and increased earthquake hazard. The amplitude of and the extent to which pore pressure changes are determined by some factors, in particular, the hydrogeological properties of the rocks, such as diffusivity. Thus the available deformation data will be used to constrain hydrogeological properties of the medium, to accurately resolve the evolution of crustal stresses due to fluid injection. Having the time-varying models of stress changes, a statistical framework will be implemented to estimate the time-dependent probability of large earthquakes on the nearby fault systems. These data and models help to improve seismic hazard estimates and aid in constructing operational-induced earthquake forecast models. This information can also be integrated into the updated U.S. National Seismic Hazard Map, which local communities and authorities use in their earthquake risk estimates and mitigation efforts.

58 GEOSCIENCES↗

Assessing Hydrological Alteration Caused by Climate Change and Reservoir Operations in the San Joaquin River Basin, California

Freshwater aquatic ecosystems are highly sensitive to flow regime alteration caused by anthropogenic activities, including river regulation and atmospheric warming-induced climate change. Either climate change or reservoir operations are among the main drivers of changes in the flow regime of rivers globally. Using modeled unregulated and simulated regulated streamflow under historical and future climate scenarios, this study evaluated potential changes to the flow regime due to climate change and reservoir operations for the major tributaries of the San Joaquin River Basin, California United States. We selected a set of Indicators of Hydrologic Alteration (IHA) to evaluate historical and projected future trends of streamflow dynamics: rise and fall rates, durations and counts of low and high pulses, and the magnitude of extremes. Results show that most indicators have pronounced departures from baseline conditions under anticipated future climate conditions given existing reservoir operations. For example, the high pulse count decreases during regulated flow conditions compared to increased frequency under unregulated flow conditions. Finally, we observed a higher degree of flow regime alteration due to reservoir operations than climate change. The degree of alteration ranges from 1.0 to 9.0% across the basin among all future climate scenarios, while reservoir operations alter the flow regime with a degree of alteration from 8.0 to 25%. This study extends multi-dimensional hydrologic alteration analysis to inform climate adaptation strategies in managed river systems.

Maskey, Mahesh L.↗

Directional emission through dynamical tunneling in a deformed microcavity

We study directional emission through dynamical tunneling in a two-dimensional deformed microcavity. The tunneling emissions are characterized by free-space emergence with a finite distance {delta} from the cavity boundary. As the cavity deformation increases, it is shown numerically that one of two main outputs becomes dominant with a decreasing {delta} value. This asymmetrical enhancement of tunneling outputs can be understood by the influence of asymmetric short-time ray dynamics near the critical line on the dynamical tunneling process. In addition, the change of {delta} with deformation can be explained by the interference of tangential wave components brought by the dynamical tunneling.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Transient reflectance of photoexcited Cd{sub 3}As{sub 2}

We report ultrafast transient-grating measurements of crystals of the three-dimensional Dirac semimetal cadmium arsenide, Cd{sub 3}As{sub 2}, at both room temperature and 80 K. After photoexcitation with 1.5-eV photons, charge-carriers relax by two processes, one of duration 500 fs and the other of duration 3.1 ps. By measuring the complex phase of the change in reflectance, we determine that the faster signal corresponds to a decrease in absorption, and the slower signal to a decrease in the light's phase velocity, at the probe energy. We attribute these signals to electrons' filling of phase space, first near the photon energy and later at lower energy. We attribute their decay to cooling by rapid emission of optical phonons, then slower emission of acoustic phonons. We also present evidence that both the electrons and the lattice are strongly heated.

36 MATERIALS SCIENCE↗

Injection current in ferroelectric group-IV monochalcogenide monolayers

We study the injection current response tensor (also known as circular photogalvanic effect or ballistic current) in ferrolectric monolayer GeS, GeSe, SnS, and SnSe. We find that the injection current is perpendicular to the spontaneous in-plane polarization and could reach peak (bulk) values of the order of 10 10 AV –2 s –1 in the visible spectrum. The magnitude of the injection current is the largest reported in the literature to date for a two dimensional material. To rationalize the large injection current, we correlate the injection current spectrum with the joint density of states, electric polarization, strain, etc. We find that various factors such as anisotropy, in-plane polarization and wave function delocalization are important in determining the injection current tensor in these materials. Here, we also find that compression along the polar axis can increase the injection current (or change its sign), and hence strain can be an effective control knob for their nonlinear optical response. Conversely, the injection current can be a sensitive probe of the crystal structure.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Measurement of effective sheath width around the cutoff probe based on electromagnetic simulation

We inferred the effective sheath width using the cutoff probe and incorporating a full-wave three-dimensional electromagnetic (EM) simulation. The EM simulation reproduced the experimentally obtained plasma-sheath resonance (PSR) on the microwave transmission (S{sub 21}) spectrum well. The PSR frequency has a one-to-one correspondence with the width of the vacuum layer assumed to be the effective sheath in the EM simulation model. The sheath width was estimated by matching the S{sub 21} spectra of the experiment and the EM simulation for different widths of the sheath. We found that the inferred sheath widths quantitatively and qualitatively agree with the sheath width measured by incorporating an equivalent circuit model. These results demonstrate the excellent potential of the cutoff probe for inferring the effective sheath width from its experimental spectrum data.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Craniocaudal Safety Margin Calculation Based on Interfractional Changes in Tumor Motion in Lung SBRT Assessed With an EPID in Cine Mode

Purpose: To evaluate setup error and interfractional changes in tumor motion magnitude using an electric portal imaging device in cine mode (EPID cine) during the course of stereotactic body radiation therapy (SBRT) for non-small-cell lung cancer (NSCLC) and to calculate margins to compensate for these variations. Materials and Methods: Subjects were 28 patients with Stage I NSCLC who underwent SBRT. Respiratory-correlated four-dimensional computed tomography (4D-CT) at simulation was binned into 10 respiratory phases, which provided average intensity projection CT data sets (AIP). On 4D-CT, peak-to-peak motion of the tumor (M-4DCT) in the craniocaudal direction was assessed and the tumor center (mean tumor position [MTP]) of the AIP (MTP-4DCT) was determined. At treatment, the tumor on cone beam CT was registered to that on AIP for patient setup. During three sessions of irradiation, peak-to-peak motion of the tumor (M-cine) and the mean tumor position (MTP-cine) were obtained using EPID cine and in-house software. Based on changes in tumor motion magnitude ( Increment M) and patient setup error ( Increment MTP), defined as differences between M-4DCT and M-cine and between MTP-4DCT and MTP-cine, a margin to compensate for these variations was calculated with Stroom's formula. Results: The means ({+-}standard deviation: SD) of M-4DCT and M-cine were 3.1 ({+-}3.4) and 4.0 ({+-}3.6) mm, respectively. The means ({+-}SD) of Increment M and Increment MTP were 0.9 ({+-}1.3) and 0.2 ({+-}2.4) mm, respectively. Internal target volume-planning target volume (ITV-PTV) margins to compensate for Increment M, Increment MTP, and both combined were 3.7, 5.2, and 6.4 mm, respectively. Conclusion: EPID cine is a useful modality for assessing interfractional variations of tumor motion. The ITV-PTV margins to compensate for these variations can be calculated.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Momentum injection by supernovae in the interstellar medium

Supernova (SN) explosions deposit prodigious energy and momentum in their environments, with the former regulating multiphase thermal structure and the latter regulating turbulence and star formation rates in the interstellar medium (ISM). However, systematic studies quantifying the impact of SNe in realistic inhomogeneous ISM conditions have been lacking. Using three-dimensional hydrodynamic simulations, we investigate the dependence of radial momentum injection on both physical conditions (considering a range of mean density n{sub 0} = 0.1–100 cm{sup −3}) and numerical parameters. Our inhomogeneous simulations adopt two-phase background states that result from thermal instability in atomic gas. Although the supernova remnant (SNR) morphology becomes highly complex for inhomogeneous backgrounds, the radial momentum injection is remarkably insensitive to environmental details. For our two-phase simulations, the final momentum produced by a single SN is given by 2.8×10{sup 5} M{sub ⊙} km s{sup −1}n{sub 0}{sup −0.17}. This is only 5% less than the momentum injection for a homogeneous environment with the same mean density, and only 30% greater than the momentum at the time of shell formation. The maximum mass in hot gas is also quite insensitive to environmental inhomogeneity. Strong magnetic fields alter the hot gas mass at very late times, but the momentum injection remains the same. Initial experiments with multiple spatially correlated SNe show a momentum per event nearly as large as single-SN cases. We also present a full numerical parameter study to assess convergence requirements. For convergence in the momentum and other quantities, we find that the numerical resolution Δ and the initial size of the SNR r{sub init} must satisfy Δ,r{sub init}<r{sub sf}/3, where the shell formation radius is given by r{sub sf}=30 pc n{sub 0}{sup −0.46} for two-phase models (or 30% smaller for a homogeneous medium).

79 ASTRONOMY AND ASTROPHYSICS↗

Resonant scattering of phonons in the quasi-one-dimensional spin-chain compounds $A B_2O_6$ (A = Ni, Co; B = Sb, Ta)

In this paper, we report measurements of thermal conductivity ( κ ) on single crystals of the quasi-one-dimensional antiferromagnetic spin-chain compounds A B 2 O 6 ( A = Ni, Co; B = Sb, Ta) in the temperature range 5 ≤ T ≤ 300 K. We find that κ for all crystallographic directions is substantially suppressed in the Ta compounds in comparison to those of the Sb compounds despite their very similar magnetic and crystallographic structures. The data are well described by resonant scattering of phonons from two-level systems, with energy splittings of ~ 100 – 150 K and scattering strength an order of magnitude greater in the Ta compounds. We distinguish the effects of phonon-spin interactions from those related to changes in the low-energy phonon spectra caused by the different B -site ions.

36 MATERIALS SCIENCE↗

GRAVITATIONAL WAVE SIGNATURES OF MAGNETOHYDRODYNAMICALLY DRIVEN CORE-COLLAPSE SUPERNOVA EXPLOSIONS

By performing a series of two-dimensional, special relativistic magnetohydrodynamic (MHD) simulations, we study signatures of gravitational waves (GWs) in the MHD-driven core-collapse supernovae. In order to extract the gravitational waveforms, we present a stress formula including contributions both from magnetic fields and special relativistic corrections. By changing the precollapse magnetic fields and initial angular momentum distributions parametrically, we compute 12 models. As for the microphysics, a realistic equation of state is employed and the neutrino cooling is taken into account via a multiflavor neutrino leakage scheme. With these computations, we find that the total GW amplitudes show a monotonic increase after bounce for models with a strong precollapse magnetic field (10{sup 12} G) and with a rapid rotation imposed. We show that this trend stems both from the kinetic contribution of MHD outflows with large radial velocities and also from the magnetic contribution dominated by the toroidal magnetic fields that predominantly trigger MHD explosions. For models with weaker initial magnetic fields, the total GW amplitudes after bounce stay close to zero because the contribution from the magnetic fields cancels with the contribution from the hydrodynamic counterpart. These features can be clearly understood with a careful analysis of the explosion dynamics. We point out that the GW signals with the increasing trend, possibly visible to the next-generation detectors for a Galactic supernova, would be associated with MHD explosions with explosion energies exceeding 10{sup 51} erg.

79 ASTRONOMY AND ASTROPHYSICS↗

Nanopatterning of swinging substrates by ion-beam sputtering

Graphite substrates are azimuthally swung during ion-beam sputtering (IBS) at a polar angle θ = 78° from the surface normal. The swinging of the substrate not only causes quasi-two-dimensional mass transport but also makes various sputter effects from the different incident angles to work together. Through variation of the swing angle, both the transport and sputtering effects synergistically produce a series of salient patterns, such as asymmetric wall-like structures, which can grow to several tens of nanometers and exhibit a re-entrant orientational change with the increased swing angle. Thus, the present work demonstrates that dynamic variables such as the swing angle, which have been little utilized, offer an additional parameter space that can be exploited to diversify the sputtered patterns, thereby expanding the applicability of an IBS as well as the comprehension of the IBS nano patterning mechanism.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Lyapunov spectrum of the separated flow around the NACA 0012 airfoil and its dependence on numerical discretization

We investigate the impact of numerical discretization on the Lyapunov spectrum of separated flow simulations. The two-dimensional chaotic flow around the NACA 0012 airfoil at a low Reynolds number and large angle of attack is considered to that end. Time, space and accuracy-order refinement studies are performed to examine each of these effects separately. Numerical results show that the time discretization has a small impact on the dynamics of the system, whereas the spatial discretization can dramatically change them. Also, the finite-time Lyapunov exponents associated to unstable modes are shown to be positively skewed, and quasi-homoclinic tangencies are observed in the attractor of the system. The implications of these results on flow physics and sensitivity analysis of chaotic flows are discussed.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

LIMB-DARKENED RADIATION-DRIVEN WINDS FROM MASSIVE STARS

We calculated the influence of the limb-darkened finite-disk correction factor in the theory of radiation-driven winds from massive stars. We solved the one-dimensional m-CAK hydrodynamical equation of rotating radiation-driven winds for all three known solutions, i.e., fast, {Omega}-slow, and {delta}-slow. We found that for the fast solution, the mass-loss rate is increased by a factor of {approx}10%, while the terminal velocity is reduced about 10%, when compared with the solution using a finite-disk correction factor from a uniformly bright star. For the other two slow solutions, the changes are almost negligible. Although we found that the limb darkening has no effects on the wind-momentum-luminosity relationship, it would affect the calculation of synthetic line profiles and the derivation of accurate wind parameters.

79 ASTRONOMY AND ASTROPHYSICS↗

In vivo quantitative whole‐brain T 1 rho MRI of multiple sclerosis

Background To apply quantitative whole‐brain T 1 ‐rho (T 1ρ ) and T 2 imaging to the detection and quantification of brain changes resulting from multiple sclerosis (MS). Methods Twenty‐three MS patients with clinically isolated syndrome (10) and relapsing remitting MS (13) phenotypes, compared with 24 age‐matched healthy controls were imaged at 3 Tesla. An axial T 1ρ ‐weighted three‐dimensional turbo spin echo sequence with a variable flip angle and fluid suppression was used. Spin‐lock times of 0, 20, 40, 60, 80, and 100 ms were used. Corresponding T 2 maps were also acquired. Results Whole brain white matter (WM) T 1ρ maps were elevated compared with controls ( P = 0.002). WM lesion T 1ρ and T 2 values were highly correlated (r = 0.83), but T 1ρ demonstrated 25% better contrast to noise ratio ( P < 0.001). WM lesion T 1ρ correlated with disease duration. Gray matter T 1ρ was negatively correlated with the Expanded Disability Status Scale, r = −0.45, P = 0.03. Normal appearing gray matter and cortical gray matter lesions were negatively correlated on T 1ρ , but not on T 2 (r T1ρ = −0.63, p T1ρ = 0.03; r T2 = −0.17, p T2 = 0.6). Conclusion T 1ρ MRI demonstrates enhanced lesion contrast compared with T 2 , and in some cases may provide complementary information. T 1ρ may provide a useful measure of demyelinating processes in MS. J. MAGN. RESON. IMAGING 2015;42:1623–1630.

Gonyea, Jay V.↗