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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,765 records · Page 98
All sourcesNASA NTRSDOE OSTI
DOE OSTI2017

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor. The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear. PlexinD1, a transmembrane receptor that regulates neuronal and cardiovascular development, is a cargo of GIPCs. GIPC-mediated endocytic trafficking regulates PlexinD1 signaling. Here, we unravel the mechanisms of the interactions among PlexinD1, GIPCs and myosin VI by a series of crystal structures of these proteins in apo or bound states. GIPC1 forms a domain-swapped dimer in an autoinhibited conformation that hinders binding of both PlexinD1 and myosin VI. PlexinD1 binding to GIPC1 releases the autoinhibition, promoting its interaction with myosin VI. GIPCs and myosin VI interact through two distinct interfaces and form an open-ended alternating array. Our data support that this alternating array underlies the oligomerization of the GIPC/Myosin VI complexes in solution and cells.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2021

Bi-fated tendon-to-bone attachment cells are regulated by shared enhancers and KLF transcription factors

The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte transcriptomes, under regulation of shared regulatory elements and Krüppel-like factors (KLFs) transcription factors. High-throughput bulk and single-cell RNA sequencing of humeral attachment cells revealed expression of hundreds of chondrogenic and tenogenic genes, which was validated by in situ hybridization and single-molecule ISH. ATAC sequencing showed that attachment cells share accessible intergenic chromatin areas with either tenocytes or chondrocytes. Epigenomic analysis revealed enhancer signatures for most of these regions. Transgenic mouse enhancer reporter assays verified the shared activity of some of these enhancers. Finally, integrative chromatin and motif analyses and transcriptomic data implicated KLFs as regulators of attachment cells. Indeed, blocking expression of both Klf2 and Klf4 in developing limb mesenchyme impaired their differentiation.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2016

MxaY regulates the lanthanide-mediated methanol dehydrogenase switch in Methylomicrobium buryatense

Many methylotrophs, microorganisms that consume carbon compounds lacking carbon–carbon bonds, use two different systems to oxidize methanol for energy production and biomass accumulation. The MxaFI methanol dehydrogenase (MDH) contains calcium in its active site, while the XoxF enzyme contains a lanthanide in its active site. The genes encoding the MDH enzymes are differentially regulated by the presence of lanthanides. In this study, we found that the histidine kinase MxaY controls the lanthanide-mediated switch in Methylomicrobium buryatense 5GB1C. MxaY controls the transcription of genes encoding MxaFI and XoxF at least partially by controlling the transcript levels of the orphan response regulator MxaB. We identify a constitutively active version of MxaY, and identify the mutated residue that may be involved in lanthanide sensing. Finally, we find evidence to suggest that tight control of active MDH production is required for wild-type growth rates.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1964

High-pressure regulating system prevents pressure surges

Gas flow is controlled by means of a pressure regulating system which prevents pressure surges. A high-pressure fluid source, a spring-loaded fluid-damped regulator valve, an accumulator, a conventional normally closed command valve, and a control valve are the main components.

Keller, O. F.↗
NASA NTRS1966

Circuit protects regulated power supply against overload current

Sensing circuit in which a tunnel diode controls a series regulator transistor protects a low voltage transistorized dc regulator from damage by excessive load currents. When a fault occurs, the faulty circuit is limited to a preset percentage of the current when limiting first occurs.

Airth, H. B.↗
NASA NTRS1967

Voltage regulator/amplifier is self-regulated

Signal modulated, self-regulating voltage regulator/amplifier controls the output b-plus voltage in modulated regulator systems. It uses self-oscillation with feedback to a control circuit with a discontinuous amplitude action feedback loop.

Day, W. E.↗
NASA NTRS1969

Self-starting circuit for switching regulators

Schematic is provided on a self-starting circuit for a switching regulator which uses a logic circuit to sense a change in output voltage and provides a correction signal for dc power sources. With this device, the total power consumed by the logic circuitry is held to a minimum, and the circuit receives the optimum regulated supply power.

Schraut, E. H.↗
NASA NTRS1969

Improved dc voltage regulator

Simplified solid-state circuit provides a closely regulated dc voltage from an unregulated dc source. It eliminates the undesirable loading effect of the emitter-base current of a transistor used in an error-sensing circuit of a regulated dc power supply.

Barnes, H. F.↗
NASA NTRS1970

Voltage regulator with multiple parallel power source sections

Voltage regulator provides improved voltage-regulating system in which power dissipation and consequent heat generation are minimized. Each power source section is controlled sequentially so that only one operates in a linear range at a time.

Binckley, W. G.↗
NASA NTRS1972

Combination pressure regulator and safety valve: A Concept

Device for regulating high pressure liquefied gas to high pressure vapor generator using liquid oxygen is described. System includes pressure regulation and safety valve features. Construction of the equipment and method of operation are presented.

Acres, R. L.↗
NASA NTRS1972

Long-life, space-maintainable nuclear stage regulators and shutoff valves

The six most promising valve, regulator, and remote coupling concepts, representing the more radical designs from twenty concepts generated, were investigated. Of the three valves, one has no moving parts because shutoff sealing is accomplished by an electromagnetic field which ionized the flowing fluid. Another valve uses liquid metal to obtain sealing. In the third valve, high sealing forces are generated by heating and expanding trapped hydrogen. The pressure regulator is an electronically controlled, electromechanically operated, single state valve. Its complexity is in electronic circuitry, and the design results in less weight, increased reliability and performance flexibility, and multipurpose application. The two remote couplings feature the minimization of weight and mechanical complexity. One concept uses a low melting temperature metal alloy which is injected into the joint cavity; upon solidification, the alloy provides a seal and a structural joint. The second concept is based on the differential thermal expansion of the coupling mating parts. At thermal equilibrium there is a predetermined interference between the parts, and sealing is achieved by interference loading.

Source record↗
NASA NTRS1974

Versatile, analog-to-digital, power-regulator controller

Power controller uses digital techniques to vary duty ratio of switching-type power regulators. Duty ratio is adjusted by comparing error signal with ramp voltage signal. As compared to previously-used switching regulators, controller uses fewer components and no magnetics and is readily adaptable to thick-film technology.

Mclyman, W. T.↗
NASA NTRS1973

Underwater space suit pressure control regulator

A device is reported for regulating the pneumatic pressure in a ventilated space suit relative to the pressure imposed on the suit when being worn by a person underwater to simulate space environment for testing and experimentation. A box unit located on the chest area of the suit comprises connections for suit air supply and return lines and carries a regulator valve that stabilizes the air pressure differential between the inside and outside of the suit. The valve and suit pressure is controlled by the suit occupant and the valve includes a mechanism for quickly dumping the suit pressure in case of emergency. Pressure monitoring and relief devices are also included in the box unit.

Aldrich, B. R.↗
NASA NTRS1972

The Right to Regulate

An introduction to the historical and constitutional framework of industry regulation by local and Federal Governments is presented. Problems of the confiscation of private property without due process, government control and the rights and duties of the regulated industry are discussed.

Vittek, J. F.↗
NASA NTRS1973

Linearized stability analysis and design of a flyback dc-dc boost regulator.

Analytic expressions for the small-signal power-stage describing functions of a switched dc-dc boost regulator are derived from an approximate continuous circuit model which is developed by a time-averaging technique. Closed-loop stability is attained through the design of frequency compensation of the loop gain. Open- and closed-loop regulator output impedances are derived from the linearized models for the given configuration. The analysis and design are compared with and confirmed by breadboard measurements.

Wester, G. W.↗
NASA NTRS1974

Automatic controls and regulators: A compilation

Devices, methods, and techniques for control and regulation of the mechanical/physical functions involved in implementing the space program are discussed. Section one deals with automatic controls considered to be, essentially, start-stop operations or those holding the activity in a desired constraint. Devices that may be used to regulate activities within desired ranges or subject them to predetermined changes are dealt with in section two.

Source record↗
NASA NTRS1975

Development of a breadboard design of a high-performance, high-reliability switching regulator

A comparison of two potential conversion methods, the series inverter and the inductive energy transfer (IET) conversion technique, is presented. The investigations showed that a characteristic of the series inverter circuit (high equalizing current values in each half cycle) could not be accomplished with available components, and the investigations continued with the IET circuit only. An IET circuit system was built with the use of computer-aided design in a 2, 4, and 8 stage configuration, and these stages were staggered 180, 90, and 45 degrees, respectively. All stages were pulsewidth modulated to regulate over an input voltage range from 200 to 400 volts dc at a regulated output voltage of 56 volts. The output power capability was 100 to 500 watts for the 2 and 8 stage configuration and 50 to 250 watts for the 4 stage configuration. Equal control of up to eight 45 degree staggered stages was accomplished through the use of a digital-to-analog control circuit. Equal power sharing of all stages was achieved through a new technique using an inductively coupled balancing circuit. Conclusions are listed.

Lindena, S. J.↗