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NASA NTRS1997

Role of Thyroxine in Space-Developed Jellyfish

The Aurelia Metamorphosis Test System was previously used to determine the effects of the space environment on the development and behavior of tiny (1-2 mm) jellyfish ephyrae during the SLS-1 and IML-2 missions. Results from the SLS-1 experiment included the discovery that statolith numbers were significantly reduced in Earth-formed ephyrae flown for nine days in space as compared with ground-based controls. In addition, upon return to Earth, six times more ephyrae which had developed in space than those developed on Earth had pulsing abnormalities, indicating that either these animals did not form their neuromuscular structures normally while in space or they were unable to adapt to the Ig environment upon return to Earth. The metamorphosis process, which enables the formation of ephyrae from polyps is influenced by a hormone, Jf-T4 Oellyfish thyroxine) which is synthesized following iodine administration. Two groups of polyps in space, however, formed ephyrae without iodine administration indicating that Jf-T4 synthesis, utilization, or excretion was different in. the ephyrae. Increased synthesis or build-up in the media of the hormone may also be linked to the increased demineralization of statoliths found in space-exposed ephyrae. In previous experiments, we found that externally administered thyroxine causes increased demineralization of statoliths on Earth. Abnormal pulsina in ephyrae following return to Earth during the SLS-1 mission may also be traced to increased Jf-T4 levels. Thyroxine is known to be important to the normal development and function of the nervous system, heart, and skeletal muscles in higher animals. For this third Jellyfish-in-Space experiment, we proposed to quantitate the levels of Jf- T4 and of T4 receptors in space-developed ephyrae and media and to compare these levels with those of animals developing and at Ig in space and on Earth. We expected to be able to determine whether Jf-T4 synthesis and/or secretion is different in space-flownjellyfish than in controls and to determine which cells (nerve, muscle, lithocytes, etc.)may have enhanced Jf-T4 levels. However, NASA deselected this experiment in August, 1997.

Spangenberg, Dorothy B.↗
NASA NTRS2000

US Space VLBI Proposed Outreach Web Site

The study of how VLBI might be pursued in space began in the late 1970's, when it was realized that the size of the earth was a serious limitation to the study of compact radio sources. By going to space, achieving angular resolution at radio wavelengths that could not be obtained with VLBI systems that were limited by the size of the earth, important tests could not be made of quasar models. The technology appeared to be within reach, and an early space VLBI concept, QUASAT, emerged as a joint project, involving both US and European scientists. In 1984, a workshop was held in Gross Enzerdorf, Austria, under joint sponsorship of NASA and the European Space Agency (ESA). The principal conclusion of the workshop was that a VLBI station in space, telemetering its data to ground data stations, working in connection with ground-based radio telescopes, would give the opportunity to achieve angular resolution of a few tens of micro-arc-seconds, and could develop high-quality radio maps of many classes of radio sources. The ground telemetry stations would also function as the source of a stable local oscillator for the spacecraft, which needs a highly stable frequency reference. The Deep Space Network of NASA could play a vital role in both the frequency-locking system and data acquisition. One outcome of the Gross Enzerdorf workshop was the convening, by COSPAR, of an ad hoc Committee on Space VLBI, to review and recommend procedures by which international collaboration on VLBI in space might be coordinated and promoted. In October 1985, the committee met in Budapest and recommended that the Inter-Agency Consultative Group (IACG) would be an appropriate body to coordinate VLBI activities in space. At the same time ESA convened a committee to explore the technical aspects of coordinating ground and space VLBI activities. At this stage both NASA and ESA were supporting preliminary studies of the QUASAT mission, with effective coordination between the two groups. The Soviet Union had also begun planning a mission with the clear intent to fly it as soon as the could; the mission was designated RadioAstron. In December 1985, the Soviets formed an international study team for the RadioAstron mission, holding the first meeting in Moscow. Subsequent meetings of this international committee were held in Budapest in May 1986 and in Moscow in December 1986. Thus, in 1986 there were three VLBI mission concepts under study: the NASA QUASAT mission, an ESA counterpart, and the Soviet RadioAstron mission.

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NASA NTRS1999

Space Medicine: A Surgeon's Perspective

For the first four decades of human space flight NASA's priorities in life sciences and medical programs have been preventative medicine (astronaut selection and training); assessment of the physiologic effects of microgravity and other unique aspects of space flight, implementation of countermeasures to protect against adverse effects, and amelioration of these adverse effects. Because most of the U.S. space flight experience has been on short duration missions, the need for medical and diagnostic treatment capabilities have been limited.The first long-term crews will arrive on the International Space Station (ISS) in early 2000. This will usher in a new era, an era of sustained human presence in Low Earth Orbit. One of the principal purposes of the ISS program is to increase the knowledge of the effects of long duration space flight on humans, a pre-requisite to future exploration class missions beyond Low Earth Orbit (e.g., a return to the Moon or an exploration of Mars). Areas of particular interest include protection from radiation, muscle atrophy, bone loss, cardiovascular alterations, immune dysfunction, adverse psychological response to hazards and confinement, and neurovestibular alterations. In addition, long duration space flight requires the development of autonomous medical care capabilities, as the distances involved eliminate the possibility of real-time telemedicine or robotic intervention, and prevent a mission abort and a rapid return to Earth. The objectives of this presentation include: 1. A description of the International Space Station project, including its research facilities and on-orbit medical capabilities; 2. An overview of the physiological and medical problems associated with microgravity in space flight; 3. A review of NASA's biomedical research priorities and ongoing work to develop clinical care capabilities for space flight crews (including surgical interventions) and; 4. An overview of current and proposed research priorities for NASA Research Announcements, NASA Space Biomedical Research Institute, Small Business Innovation Research Grant, and other funding sources.

Dawson, David L.↗
NASA NTRS2000

National Space Biomedical Research Institute Annual Report

This report summarizes the activities of the National Space Biomedical Research Institute (NSBRI) during FY 2000. The NSBRI is responsible for the development of countermeasures against the deleterious effects of long-duration space flight and performs fundamental and applied space biomedical research directed towards this specific goal. Its mission is to lead a world-class, national effort in integrated, critical path space biomedical research that supports NASA's Human Exploration and Development of Space (HEDS) Strategic Plan by focusing on the enabling of long-term human presence in, development of, and exploration of space. This is accomplished by: designing, testing and validating effective countermeasures to address the biological and environmental impediments to long-term human space flight; defining the molecular, cellular, organ-level, integrated responses and mechanistic relationships that ultimately determine these impediments, where such activity fosters the development of novel countermeasures; establishing biomedical support technologies to maximize human performance in space, reduce biomedical hazards to an acceptable level, and deliver quality medical care; transferring and disseminating the biomedical advances in knowledge and technology acquired through living and working in space to the general benefit of mankind, including the treatment of patients suffering from gravity- and radiation-related conditions on Earth; and ensuring open involvement of the scientific community, industry and the public at large in the Institute's activities and fostering a robust collaboration with NASA, particularly through NASA's Lyndon B. Johnson Space Center. Attachment:Appendices (A,B,C,D,E,F,G,H,I,J,K,L,M,N,O, and P.).

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NASA NTRS2001

Commercial Space Research: Entering a New Stage

The Space Act which established NASA included direction that NASA is to foster to the maximum extent possible the commercial use of space. In order to achieve this, NASA began establishing in 1985, Commercial Space Centers (CSCs). These centers are a consortium of industry, academia, and government. Primarily university based, the CSCs are chartered to partner with industry to help companies learn how using space can improve their bottom line. Responsibility for the Commercial Space Centers rests with the Space Product Development Office at Marshall Space Flight Center. Since the program was established in 1985, SPD has sponsored nearly 180 commercial microgravity research payloads on 30 Shuttle missions. The vast majority of these missions were on the order of 6 days. Most companies have only had on average three flight opportunities to advance their product development efforts. From the product development standpoint of an individual company only three weeks of microgravity time have been obtained to date. Of key importance to a company is the fact that this time has not been continuous. Anywhere from one to three years elapses between flights. Despite these flight constraints, the companies in the SPD program have made considerable progress. For example, over the course of the program through 1999, industry has invested over half a billion dollars in cash and in-kind. Over a dozen new product lines are in development by the industrial partners of the Commercial Space Centers. Now the companies partnered with the SPD program have a new opportunity in the International Space Station. The long duration capability provided by the Station will provide double the amount of per company average microgravity time in just the first increment. Current planning through planning increment 5 shows that commercial investment in space research should now be positioned for greater returns.

Nall, Mark E.↗
NASA NTRS1990

Space Science Curricula

Johnson High School, Huntsville, Alabama started an international magnet program in 1987. One of the courses in the curriculum was in space science. They appealed to Marshall Space Flight Center (MSFC) when they couldn't find a suitable textbook, nor locate other classes in space science to provide a guideline. MSFC agreed to help and placed the school under an official 'Adopt-A-School' program. MSFC's chief scientist and others at the space center helped prepare a very comprehensive space science program. Examples of the subjects covered include problems of space travel, materials processing in space, technology utilization, robotics, space colonization, etc. MSFC followed up by working with Johnson High to determine if the curriculum is generally usable and workable. If it is, MSFC may make it available to other schools. MSFC not only developed the space science curriculum; they continue to support the program by sponsoring hands- on activities and tours of space research facilities.

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NASA NTRS2002

STS 107 Shuttle Press Kit: Providing 24/7 Space Science Research

Space shuttle mission STS-107, the 28th flight of the space shuttle Columbia and the 113th shuttle mission to date, will give more than 70 international scientists access to both the microgravity environment of space and a set of seven human researchers for 16 uninterrupted days. Columbia's 16-day mission is dedicated to a mixed complement of competitively selected and commercially sponsored research in the space, life and physical sciences. An international crew of seven, including the first Israeli astronaut, will work 24 hours a day in two alternating shifts to carry out experiments in the areas of astronaut health and safety; advanced technology development; and Earth and space sciences. When Columbia is launched from Kennedy Space Center's Launch Pad 39A it will carry a SPACEHAB Research Double Module (RDM) in its payload bay. The RDM is a pressurized environment that is accessible to the crew while in orbit via a tunnel from the shuttle's middeck. Together, the RDM and the middeck will accommodate the majority of the mission's payloads/experiments. STS-107 marks the first flight of the RDM, though SPACEHAB Modules and Cargo Carriers have flown on 17 previous space shuttle missions. Astronaut Rick Husband (Colonel, USAF) will command STS-107 and will be joined on Columbia's flight deck by pilot William 'Willie' McCool (Commander, USN). Columbia will be crewed by Mission Specialist 2 (Flight Engineer) Kalpana Chawla (Ph.D.), Mission Specialist 3 (Payload Commander) Michael Anderson (Lieutenant Colonel, USAF), Mission Specialist 1 David Brown (Captain, USN), Mission Specialist 4 Laurel Clark (Commander, USN) and Payload Specialist 1 Ilan Ramon (Colonel, Israeli Air Force), the first Israeli astronaut. STS-107 marks Husband's second flight into space - he served as pilot during STS-96, a 10-day mission that saw the first shuttle docking with the International Space Station. Husband served as Chief of Safety for the Astronaut Office until his selection to command the STS-107 crew. Anderson and Chawla will also be making their second spaceflights. Anderson first flew on STS-89 in January 1998 (the eighth Shuttle-Mir docking mission) while Chawla flew on STS-87 in November 1997 (the fourth U.S. Microgravity Payload flight). McCool, Brown, Clark and Ramon will be making their first flights into space.

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NASA NTRS2003

Asteroids as Propulsion Systems of Space Ships

Currently, rockets are used to change the trajectory of space ships and probes. This method is very expensive and requires a lot of fuel, which limits the feasibility of space stations, interplanetary space ships, and probes. Sometimes space probes use the gravity field of a planet However, there am only nine planets in the Solar System, all separated by great distances. There are tons of millions of asteroids in outer space. This paper offers a revolutionary method for changing the trajectory of space probes. The method uses the kinetic or rotary energy of asteroids, comet nuclei, meteorites or other space bodies (small planets, natural planetary satellites, space debris, etc.) to increase (to decrease) ship (probe) speed up to 1000 m/sec (or more) and to achieve any new direction in outer space. The flight possibilities of space ships and probes are increased by a factor of millions.

Bolonkin, Alexander↗
NASA NTRS2003

The Application of Advanced Cultivation Techniques in the Long Term Maintenance of Space Flight Plant Biological Systems

The development of the International Space Station (ISS) presents extensive opportunities for the implementation of long duration space life sciences studies. Continued attention has been placed in the development of plant growth chamber facilities capable of supporting the cultivation of plants in space flight microgravity conditions. The success of these facilities is largely dependent on their capacity to support the various growth requirements of test plant species. The cultivation requirements for higher plant species are generally complex, requiring specific levels of illumination, temperature, humidity, water, nutrients, and gas composition in order to achieve normal physiological growth and development. The supply of water, nutrients, and oxygen to the plant root system is a factor, which has proven to be particularly challenging in a microgravity space flight environment. The resolution of this issue is particularly important for the more intensive crop cultivation of plants envisaged in Nasa's advanced life support initiative. BioServe Space Technologies is a NASA, Research Partnership Center (RPC) at the University of Colorado, Boulder. BioServe has designed and operated various space flight plant habitat systems, and placed specific emphasis on the development and enhanced performance of subsystem components such as water and nutrient delivery, illumination, gas exchange and atmosphere control, temperature and humidity control. The further development and application of these subsystems to next generation habitats is of significant benefit and contribution towards the development of both the Space Plant biology and the Advanced Life Support Programs. The cooperative agreement between NASA Ames Research center and BioServe was established to support the further implementation of advanced cultivation techniques and protocols to plant habitat systems being coordinated at NASA Ames Research Center. Emphasis was placed on the implementation of passive-based water and nutrient support systems and techniques, which can be used to minimize demands on power, mass, and operational complexity in space flight studies. This effort has direct application to the development of next-generation space flight plant chambers such as the Plant Research Unit (PRU). Work was also directed at the development of in-flight plant preservation techniques and protocols consistent with the interest in applying recent developments in gene chip micro array technologies. Cultivation technologies and protocols were evaluated in a 55 day space flight plant growth study, conducted on the ISS, mission 9A (10/7/02 - 12/7/02).

Heyenga, A. G.↗
NASA NTRS2003

National Aeronautics and Space Administration Biological and Physical Research Enterprise Strategy

As the 21st century begins, NASA's new Vision and Mission focuses the Agency's Enterprises toward exploration and discovery.The Biological and Physical Research Enterprise has a unique and enabling role in support of the Agency's Vision and Mission. Our strategic research seeks innovations and solutions to enable the extension of life into deep space safely and productively. Our fundamental research, as well as our research partnerships with industry and other agencies, allow new knowledge and tech- nologies to bring improvements to life on Earth. Our interdisciplinary research in the unique laboratory of microgravity addresses opportunities and challenges on our home planet as well as in space environments. The Enterprise maintains a key role in encouraging and engaging the next generation of explorers from primary school through the grad- uate level via our direct student participation in space research.The Biological and Physical Research Enterprise encompasses three themes. The biological sciences research theme investigates ways to support a safe human presence in space. This theme addresses the definition and control of physiological and psychological risks from the space environment, including radiation,reduced gravity, and isolation. The biological sciences research theme is also responsible for the develop- ment of human support systems technology as well as fundamental biological research spanning topics from genomics to ecologies. The physical sciences research theme supports research that takes advantage of the space environment to expand our understanding of the fundamental laws of nature. This theme also supports applied physical sciences research to improve safety and performance of humans in space. The research partnerships and flight support theme establishes policies and allocates space resources to encourage and develop entrepreneurial partners access to space research.Working together across research disciplines, the Biological and Physical Research Enterprise is performing vital research and technology development to extend the reach of human space flight.

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NASA NTRS2004

Transformational System Concepts and Technologies for Our Future in Space

Continued constrained budgets and growing national and international interests in the commercialization and development of space requires NASA to be constantly vigilant, to be creative, and to seize every opportunity for assuring the maximum return on space infrastructure investments. Accordingly, efforts are underway to forge new and innovative approaches to transform our space systems in the future to ultimately achieve two or three or five times as much with the same resources. This bold undertaking can be achieved only through extensive cooperative efforts throughout the aerospace community and truly effective planning to pursue advanced space system design concepts and high-risk/high-leverage research and technology. Definitive implementation strategies and roadmaps containing new methodologies and revolutionary approaches must be developed to economically accommodate the continued exploration and development of space. Transformation can be realized through modular design and stepping stone development. This approach involves sustainable budget levels and multi-purpose systems development of supporting capabilities that lead to a diverse amy of sustainable future space activities. Transformational design and development requires revolutionary advances by using modular designs and a planned, stepping stone development process. A modular approach to space systems potentially offers many improvements over traditional one-of-a-kind space systems comprised of different subsystem element with little standardization in interfaces or functionality. Modular systems must be more flexible, scaleable, reconfigurable, and evolvable. Costs can be reduced through learning curve effects and economies of scale, and by enabling servicing and repair that would not otherwise be feasible. This paper briefly discusses achieving a promising approach to transforming space systems planning and evolution into a meaningful stepping stone design, development, and implementation process. The success of this well planned and orchestrated approach holds great promise for achieving innovation and revolutionary technology development for supporting future exploration and development of space.

Howell, Joe T.↗
NASA NTRS2005

Vision for Micro Technology Space Missions

It is exciting to contemplate the various space mission applications that Micro Electro Mechanical Systems (MEMS) technology could enable in the next 10-20 years. The primary objective of this chapter is to both stimulate ideas for MEMS technology infusion on future NASA space missions and to spur adoption of the MEMS technology in the minds of mission designers. This chapter is also intended to inform non-space oriented MEMS technologists, researchers and decision makers about the rich potential application set that future NASA Science and Exploration missions will provide. The motivation for this chapter is therefore to lead the reader down a path to identify and it is exciting to contemplate the various space mission applications that Micro Electro Mechanical Systems (MEMS) technology could enable in the next 10-20 years. The primary objective of this chapter is to both stimulate ideas for MEMS technology infusion on future NASA space missions and to spur adoption of the MEMS technology in the minds of mission designers. This chapter is also intended to inform non-space oriented MEMS technologists, researchers and decision makers about the rich potential application set that future NASA Science and Exploration missions will provide. The motivation for this chapter is therefore to lead the reader down a path to identify and consider potential long-term, perhaps disruptive or revolutionary, impacts that MEMS technology may have for future civilian space applications. A general discussion of the potential for MEMS in space applications is followed by a brief showcasing of a few selected examples of recent MEMS technology developments for future space missions. Using these recent developments as a point of departure, a vision is then presented of several areas where MEMS technology might eventually be exploited in future Science and Exploration mission applications. Lastly, as a stimulus for future research and development, this chapter summarizes a set of barriers to progress, design challenges and key issues that must be overcome in order for the community to move on, from the current nascent phase of developing and infusing MEMS technology into space missions, in order to achieve its full future potential.

Dennehy, Neil↗
NASA NTRS2004

Space Electronic Test Engineering

The Space Power and Propulsion Test Engineering Branch at NASA Glenn Research center has the important duty of controlling electronic test engineering services. These services include test planning and early assessment of Space projects, management and/or technical support required to safely and effectively prepare the article and facility for testing, operation of test facilities, and validation/delivery of data to customer. The Space Electronic Test Engineering Branch is assigned electronic test engineering responsibility for the GRC Space Simulation, Microgravity, Cryogenic, and Combustion Test Facilities. While working with the Space Power and Propulsion Test Engineering Branch I am working on several different assignments. My primary assignment deals with an electrical hardware unit known as Sunny Boy. Sunny Boy is a DC load Bank that is designed for solar arrays in which it is used to convert DC power form the solar arrays into AC power at 60 hertz to pump back into the electricity grid. However, there are some researchers who decided that they would like to use the Sunny Boy unit in a space simulation as a DC load bank for a space shuttle or even the International Space Station hardware. In order to do so I must create a communication link between a computer and the Sunny Boy unit so that I can preset a few of the limits (such power, set & constant voltage levels) that Sunny Boy will need to operate using the applied DC load. Apart from this assignment I am also working on a hi-tech circuit that I need to have built at a researcher s request. This is a high voltage analog to digital circuit that will be used to record data from space ion propulsion rocket booster tests. The problem that makes building this circuit so difficult is that it contains high voltage we must find a way to lower the voltage signal before the data is transferred into the computer to be read. The solution to this problem was to transport the signal using infrared light which will lower the voltage signal down low enough so that it is harmless to a computer. Along with my involvement in the Space Power and Propulsion Test Engineering Branch, I am obligated to assist all other members of the branch in their work. This will help me to strengthen and extend my knowledge of Electrical Engineering.

Chambers, Rodney D.↗
NASA NTRS2004

Space Test and Operations Port for Exploration Missions

The International Space Station (ISS) has from its inception included plans to support the testing of exploration vehicle/systems technology, the assembly of space transport vehicles, and a variety of operations support (communications, crew transfer, cargo handling, etc). Despite the fact that the ISS has gone through several re-designs and reductions in size and capabilities over the past 20 years, it still has the key capabilities, truss structure, docking nodes, etc required to support these exploration mission activities. ISS is much like a frontier outpost in the Old West, which may not have been in optimum location (orbit) for assisting travelers on their way to California (the Moon and Mars), but nevertheless because it had supplies and other support services (regular logistics from Earth, crewmembers, robotics, and technology test and assembly support capabilities) was regularly used as a stopover and next trip phase preparation site by all kinds of travelers. This paper will describe some of the ISS capabilities which are being used currently, and are being planned for use, by various payload sponsors, developers and Principal Investigators, sponsored by the NASA Office of Space Flight (Code M ISS Research Program Office - Department of Defense (DoD), NASA Hqs Office of Space Communications, Italian Space Agency, etc.). Initial ideas and concepts for payloads and technology testing which are being planned, or which are being investigated, for use in support of advanced space technology development and verification and exploration mission activities will be summarized. Some of the future ISS payloads and test activities already identified include materials and system component space environment testing, laser space communication system demonstrations (leading to the possible development of an ISS deep space communication node), and an advanced space propulsion testbed and ISS based, free-flying platform.

Holt, Alan C.↗
NASA NTRS2006

International Space Station Increment-6/8 Microgravity Environment Summary Report November 2002 to April 2004

This summary report presents the analysis results of some of the processed acceleration data measured aboard the International Space Station during the period of November 2002 to April 2004. Two accelerometer systems were used to measure the acceleration levels for the activities that took place during Increment-6/8. However, not all of the activities during that period were analyzed in order to keep the size of the report manageable. The National Aeronautics and Space Administration sponsors the Microgravity Acceleration Measurement System and the Space Acceleration Measurement System to support microgravity science experiments that require microgravity acceleration measurements. On April 19, 2001, both the Microgravity Acceleration Measurement System and the Space Acceleration Measurement System units were launched on STS-100 from the Kennedy Space Center for installation on the International Space Station. The Microgravity Acceleration Measurement System unit was flown to the station in support of science experiments requiring quasi-steady acceleration measurements, while the Space Acceleration Measurement System unit was flown to support experiments requiring vibratory acceleration measurement. Both acceleration systems are also used in support of the vehicle microgravity requirements verification as well as in support of the International Space Station support cadre. The International Space Station Increment-6/8 reduced gravity environment analysis presented in this report uses acceleration data collected by both sets of accelerometer systems: 1. The Microgravity Acceleration Measurement System, which consists of two sensors: the Orbital Acceleration Research Experiment Sensor Subsystem, a low frequency range sensor (up to 1 Hz), is used to characterize the quasi-steady environment for payloads and vehicle, and the High Resolution Accelerometer Package, which is used to characterize the vibratory environment up to 100 Hz. 2. The Space Acceleration Measurement System measures vibratory acceleration data in the range of 0.01 to 400 Hz. This summary report presents analysis of some selected quasi-steady and vibratory activities measured by these accelerometers during Increment-6/8 from November 2002 to April 2004.

Jules, Kenol↗
NASA NTRS2006

Current Characteristics and Trends of the Tracked Satellite Population in the Human Space Flight Regime

Since the end of the Apollo program in 1972, human space flight has been restricted to altitudes below 600 km above the Earth s surface with most missions restricted to a ceiling below 400 km. An investigation of the tracked satellite population transiting and influencing the human space flight regime during the past 11 years (equivalent to a full solar cycle) has recently been completed. The overall effects of satellite breakups and solar activity are typically less pronounced in the human space flight regime than other regions of low Earth orbit. As of January 2006 nearly 1500 tracked objects resided in or traversed the human space flight regime, although two-thirds of these objects were in orbits of moderate to high eccentricity, significantly reducing their effect on human space flight safety. During the period investigated, the spatial density of tracked objects in the 350-400 km altitude regime of the International Space Station demonstrated a steady decline, actually decreasing by 50% by the end of the period. On the other hand, the region immediately above 600 km experienced a significant increase in its population density. This regime is important for future risk assessments, since this region represents the reservoir of debris which will influence human space flight safety in the future. The paper seeks to put into sharper perspective the risks posed to human space flight by the tracked satellite population, as well as the influences of solar activity and the effects of compliance with orbital debris mitigation guidelines on human space flight missions. Finally, the methods and successes of characterizing the population of smaller debris at human space flight regimes are addressed.

Johnson, Nicholas L.↗
NASA NTRS2004

The Art of Space Flight Exercise Hardware: Design and Implementation

The design of space flight exercise hardware depends on experience with crew health maintenance in a microgravity environment, history in development of flight-quality exercise hardware, and a foundation for certifying proper project management and design methodology. Developed over the past 40 years, the expertise in designing exercise countermeasures hardware at the Johnson Space Center stems from these three aspects of design. The medical community has steadily pursued an understanding of physiological changes in humans in a weightless environment and methods of counteracting negative effects on the cardiovascular and musculoskeletal system. The effects of weightlessness extend to the pulmonary and neurovestibular system as well with conditions ranging from motion sickness to loss of bone density. Results have shown losses in water weight and muscle mass in antigravity muscle groups. With the support of university-based research groups and partner space agencies, NASA has identified exercise to be the primary countermeasure for long-duration space flight. The history of exercise hardware began during the Apollo Era and leads directly to the present hardware on the International Space Station. Under the classifications of aerobic and resistive exercise, there is a clear line of development from the early devices to the countermeasures hardware used today. In support of all engineering projects, the engineering directorate has created a structured framework for project management. Engineers have identified standards and "best practices" to promote efficient and elegant design of space exercise hardware. The quality of space exercise hardware depends on how well hardware requirements are justified by exercise performance guidelines and crew health indicators. When considering the microgravity environment of the device, designers must consider performance of hardware separately from the combined human-in-hardware system. Astronauts are the caretakers of the hardware while it is deployed and conduct all sanitization, calibration, and maintenance for the devices. Thus, hardware designs must account for these issues with a goal of minimizing crew time on orbit required to complete these tasks. In the future, humans will venture to Mars and exercise countermeasures will play a critical role in allowing us to continue in our spirit of exploration. NASA will benefit from further experimentation on Earth, through the International Space Station, and with advanced biomechanical models to quantify how each device counteracts specific symptoms of weightlessness. With the continued support of international space agencies and the academic research community, we will usher the next frontier in human space exploration.

Beyene, Nahom M.↗
NASA NTRS2006

Low-gravity Orbiting Research Laboratory Environment Potential Impact on Space Biology Research

One of the major objectives of any orbital space research platform is to provide a quiescent low gravity, preferably a zero gravity environment, to perform fundamental as well as applied research. However, small disturbances exist onboard any low earth orbital research platform. The impact of these disturbances must be taken into account by space research scientists during their research planning, design and data analysis in order to avoid confounding factors in their science results. The reduced gravity environment of an orbiting research platform in low earth orbit is a complex phenomenon. Many factors, among others, such as experiment operations, equipment operation, life support systems and crew activity (if it is a crewed platform), aerodynamic drag, gravity gradient, rotational effects as well as the vehicle structural resonance frequencies (structural modes) contribute to form the overall reduced gravity environment in which space research is performed. The contribution of these small disturbances or accelerations is precisely why the environment is NOT a zero gravity environment, but a reduced acceleration environment. This paper does not discuss other factors such as radiation, electromagnetic interference, thermal and pressure gradient changes, acoustic and CO2 build-up to name a few that affect the space research environment as well, but it focuses solely on the magnitude of the acceleration level found on orbiting research laboratory used by research scientists to conduct space research. For ease of analysis this paper divides the frequency spectrum relevant to most of the space research disciplines into three regimes: a) quasi-steady, b) vibratory and c) transient. The International Space Station is used as an example to illustrate the point. The paper discusses the impact of these three regimes on space biology research and results from space flown experiments are used to illustrate the potential negative impact of these disturbances (accelerations) on space biology research.

Jules, Kenol↗