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SU-F-J-156: The Feasibility of MR-Only IMRT Planning for Prostate Anatomy

Purpose: For prostate anatomy, previous investigations have shown that simulated CT (sCT) generated from MR images can be used for accurate dose computation. In this study, we demonstrate the feasibility of MR-only IMRT planning for prostate case. Methods: Regular CT (rCT) and MR images of the same patient were acquired for prostate anatomy. Regions-of-interest (ROIs) i.e. target and risk structures are delineated on the rCT. A simulated CT (sCT) is generated from the MR image using the method described by Schadewaldt N et al. Their work establishes the clinical acceptability of dose calculation results on the sCT when compared to rCT. rCT and sCT are rigidly registered to ensure proper alignment between the two images. rCT and sCT are overlaid on each other and slice-wise visual inspection confirms excellent agreement between the two images. ROIs on the rCT are copied over to sCT. Philips AutoPlanning solution is used for generating treatment plans. The same treatment technique protocol (plan parameters and clinical goals) is used to generate AutoPlan-rCT and AutoPlan-sCT respectively for rCT and and sCT. DVH comparison on ROIs and slice-wise evaluation of dose is performed between AutoPlan-rCT and AutoPlan-sCT. Delivery parameters i.e. beam and corresponding segments from the AutoPlan-sCT are copied over to rCT and dose is computed to get AutoPlan-sCT-on-rCT. Results: Plan evaluation is done based on Dose Volume Histogram (DVH) of ROIs and manual slice-wise inspection of dose distribution. Both AutoPlan-rCT and AutoPlan-sCT provide a clinically acceptable plan. Also, AutoPlan-sCT-on-rCT shows excellent agreement with AutoPlan-sCT. Conclusion: The study demonstrates that it is feasible to do IMRT planning on the simulated CT image obtained from MR image for prostate anatomy. The research is supported by Philips India Ltd.

60 APPLIED LIFE SCIENCES↗

Sensitive and Specific Peak Detection for SELDI-TOF Mass Spectrometry Using a Wavelet/Neural-Network Based Approach

SELDI-TOF mass spectrometer’s compact size and automated, high throughput design have been attractive to clinical researchers, and the platform has seen steady-use in biomarker studies. Despite new algorithms and preprocessing pipelines that have been developed to address reproducibility issues, visual inspection of the results of SELDI spectra preprocessing by the best algorithms still shows miscalled peaks and systematic sources of error. This suggests that there continues to be problems with SELDI preprocessing. In this work, we study the preprocessing of SELDI in detail and introduce improvements. While many algorithms, including the vendor supplied software, can identify peak clusters of specific mass (or m/z) in groups of spectra with high specificity and low false discover rate (FDR), the algorithms tend to underperform estimating the exact prevalence and intensity of peaks in those clusters. Thus group differences that at first appear very strong are shown, after careful and laborious hand inspection of the spectra, to be less than significant. Here we introduce a wavelet/neural network based algorithm which mimics what a team of expert, human users would call for peaks in each of several hundred spectra in a typical SELDI clinical study. The wavelet denoising part of the algorithm optimally smoothes the signal in each spectrum according to an improved suite of signal processing algorithms previously reported (the LibSELDI toolbox under development). The neural network part of the algorithm combines those results with the raw signal and a training dataset of expertly called peaks, to call peaks in a test set of spectra with approximately 95% accuracy. The new method was applied to data collected from a study of cervical mucus for the early detection of cervical cancer in HPV infected women. The method shows promise in addressing the ongoing SELDI reproducibility issues.

59 BASIC BIOLOGICAL SCIENCES↗

Heavy and Overweight Vehicle Defects (Interim Report)

The Federal Highway Administration (FHWA), along with the Federal Motor Carrier Safety Administration (FMCSA), has an interest in overweight commercial motor vehicles, how they affect infrastructure, and their impact on safety on the nation’s highways. To assist both FHWA and FMCSA in obtaining more information related to this interest, data was collected and analyzed from two separate sources. A large scale nationwide data collection effort was facilitated by the Commercial Vehicle Safety Alliance as part of a special study on overweight vehicles and an additional, smaller set, of data was collected from the state of Tennessee which included a much more detailed set of data. Over a six-month period, 1,873 Level I inspections were performed in 18 different states that volunteered to be a part of this study. Of the 1,873 inspections, a vehicle out-of-service (OOS) violation was found on 44.79% of the vehicles, a rate significantly higher than the national OOS rate of 27.23%. The main cause of a vehicle being placed OOS was brake-related defects, with approximately 30% of all vehicles having an OOS brake violation. Only about 4% of vehicles had an OOS tire violation, and even fewer had suspension and wheel violations. Vehicle weight violations were most common on an axle group as opposed to a gross vehicle weight violation. About two thirds of the vehicles cited with a weight violation were overweight on an axle group with an average amount of weight over the legal limit of about 2,000 lbs. Data collection is scheduled to continue through January 2014, with more potentially more states volunteering to collect data. More detailed data collections similar to the Tennessee data collection will also be performed in multiple states.

99 GENERAL AND MISCELLANEOUS↗

Examination of shipping packages 9975-01641, 9975-01692, 9975-03373, 9975-02101 AND 9975-02713

SRNL has assisted in the examination of five 9975 shipping packages following storage of nuclear material in K-Area Complex (KAC). Two packages (9975-01641 and -01692) with water intrusion resulting from a roof leak were selected for detailed examination after internal fiberboard degradation (mold) was observed. 9975-01692 contained regions of saturated fiberboard and significant mold, while the second package was less degraded. A third package (9975-03373) was removed from storage for routine surveillance activities, and set aside for further examination after a musty odor was noted inside. No additional degradation was noted in 9975-03373, but the lower assembly could not be removed from the drum for detailed examination. Two additional packages (9975-02101 and -02713) identified for further examination were among a larger group selected for surveillance as part of a specific focus on high-wattage packages. These two packages displayed several non-conforming conditions, including the following: (1) the axial gap criterion was exceeded, (2) a significant concentration of moisture was found in the bottom fiberboard layers, with active mold in this area, (3) condensation and/or water stains were observed on internal components (drum, lid, air shield), and (4) both drums contained localized corrosion along the bottom lip. It is recommended that a new screening check be implemented for packages that are removed from storage, as well as high wattage packages remaining in storage. An initial survey for corrosion along the drum bottom lip of high wattage packages could identify potential degraded packages for future surveillance focus. In addition, after packages have been removed from storage (and unloaded), the drum bottom lip and underside should be inspected for corrosion. The presence of corrosion could signal the need to remove the lower fiberboard assembly for further inspection of the fiberboard and drum prior to recertification of the package.

42 ENGINEERING↗

Destructive Examination of Shipping Package 9975-02019

Destructive and non-destructive examinations have been performed on the components of shipping package 9975-02019 as part of a comprehensive SRS surveillance program for plutonium material stored in the K-Area Complex (KAC). During the field surveillance inspection of this package in KAC, two non-conforming conditions were noted: the axial gap of 1.577 inch exceeded the 1 inch maximum criterion, and two areas of dried glue residue were noted on the upper fiberboard subassembly. This package was subsequently transferred to SRNL for more detailed inspection and destructive examination. In addition to the conditions noted in KAC, the following conditions were noted: - Numerous small spots of corrosion were observed along the bottom edge of the drum. - In addition to the smeared glue residue on the upper fiberboard subassembly, there was also a small dark stain. - Mold was present on the side and bottom of the lower fiberboard subassembly. Dark stains from elevated moisture content were also present in these areas. - A dark spot with possible light corrosion was observed on the primary containment vessel flange, and corresponding rub marks were observed on the secondary containment vessel ID. - The fiberboard thermal conductivity in the radial orientation was above the specified range. When the test was repeated with slightly lower moisture content, the result was acceptable. The moisture content for both tests was within a range typical of other packages in storage. The observed conditions must be fully evaluated by KAC to ensure the safety function of the package is being maintained. Several factors can contribute to the concentration of moisture in the fiberboard, including higher than average initial moisture content, higher internal temperature (due to internal heat load and placement within the array of packages), and the creation of additional moisture as the fiberboard begins to degrade.

42 ENGINEERING↗

Active Interrogation using Photofission Technique for Nuclear Materials Control and Accountability

Innovative systems with increased sensitivity and resolution are in great demand to detect diversion and to prevent misuse in support of nuclear materials management for the U.S. fuel cycle. Nuclear fission is the most important multiplicative process involved in non-destructive active interrogation. This process produces the most easily recognizable signature for nuclear materials. In addition to thermal or high-energy neutrons, high-energy gamma rays can also excite a nucleus and cause fission through a process known as photofission. Electron linear accelerators (linacs) are widely used as the interrogating photon sources for inspection methods involving photofission technique. After photofission reactions, prompt signals are much stronger than the delayed signals, but it is difficult to quantify them in practical measurements. Delayed signals are easily distinguishable from the interrogating radiation. Linac-based, advanced inspection techniques utilizing the delayed signals after photofission have been extensively studied for homeland security applications. Previous research also showed that a unique delayed gamma ray energy spectrum exists for each fissionable isotope. In this work, high-energy delayed γ-rays were demonstrated to be signatures for detection, identification, and quantification of special nuclear materials. Such γ-rays were measured in between linac pulses using independent data acquisition systems. A list-mode system was developed to measure low-energy delayed γ-rays after irradiation. Photofission product yields of 238 U and 239 Pu were determined based on the measured delayed γ-ray spectra. The differential yields of delayed γ-rays were also proven to be able to discriminate nuclear from non-nuclear materials. The measurement outcomes were compared with Monte Carlo simulation results. It was demonstrated that the current available codes have capabilities and limitations in the simulation of photofission process. A two-fold approach was used to address the high-rate challenge in used nuclear fuel assay based on photofission technique. First, a standard HPGe preamplifier was modified to improve its capabilities in high-rate pulsed photofission environment. Second, advanced pulse processing algorithms were shown to greatly improve throughput rate without large sacrifice in energy resolution at ultra-high input count rate. Two customized gamma spectroscopy systems were also developed in real-time on FPGAs. They were shown to have promising performance matching available commercial units.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Characterizing Complexity of Containerized Cargo X-ray Images

X-ray imaging can be used to inspect cargos imported into the United States. In order to better understand the performance of X-ray inspection systems, the X-ray characteristics (density, complexity) of cargo need to be quantified. In this project, an image complexity measure called integrated power spectral density (IPSD) was studied using both DNDO engineered cargos and stream-of-commerce (SOC) cargos. A joint distribution of cargo density and complexity was obtained. A support vector machine was used to classify the SOC cargos into four categories to estimate the relative fractions.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Safeguards by Design Challenge

The International Atomic Energy Agency (IAEA) defines Safeguards as a system of inspection and verification of the peaceful uses of nuclear materials as part of the Nuclear Nonproliferation Treaty. IAEA oversees safeguards worldwide. Safeguards by Design (SBD) involves incorporation of safeguards technologies, techniques, and instrumentation during the design phase of a facility, rather that after the fact. Design challenge goals are the following: Design a system of safeguards technologies, techniques, and instrumentation for inspection and verification of the peaceful uses of nuclear materials. Cost should be minimized to work with the IAEA’s limited budget. Dose to workers should always be as low are reasonably achievable (ALARA). Time is of the essence in operating facilities and flow of material should not be interrupted significantly. Proprietary process information in facilities may need to be protected, thus the amount of information obtained by inspectors should be the minimum required to achieve the measurement goal. Then three different design challenges are detailed: Plutonium Waste Item Measurement System, Marine-based Modular Reactor, and Floating Nuclear Power Plant (FNPP).

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗

OBSERVATION AND CONFIRMATION OF SIX STRONG-LENSING SYSTEMS IN THE DARK ENERGY SURVEY SCIENCE VERIFICATION DATA

We report the observation and confirmation of the first group- and cluster-scale strong gravitational lensing systems found in Dark Energy Survey data. Through visual inspection of data from the Science Verification season, we identified 53 candidate systems. We then obtained spectroscopic follow-up of 21 candidates using the Gemini Multi-object Spectrograph at the Gemini South telescope and the Inamori-Magellan Areal Camera and Spectrograph at the Magellan/Baade telescope. With this follow-up, we confirmed six candidates as gravitational lenses: three of the systems are newly discovered, and the remaining three were previously known. Of the 21 observed candidates, the remaining 15 either were not detected in spectroscopic observations, were observed and did not exhibit continuum emission (or spectral features), or were ruled out as lensing systems. The confirmed sample consists of one group-scale and five galaxy-cluster-scale lenses. The lensed sources range in redshift z ∼ 0.80–3.2 and in i -band surface brightness i {sub SB} ∼ 23–25 mag arcsec{sup −2} (2″ aperture). For each of the six systems, we estimate the Einstein radius θ {sub E} and the enclosed mass M {sub enc}, which have ranges θ {sub E} ∼ 5″–9″ and M {sub enc} ∼ 8 × 10{sup 12} to 6 × 10{sup 13} M {sub ⊙}, respectively.

79 ASTRONOMY AND ASTROPHYSICS↗

Structural Integrity Evaluation of the Lear Fan 2100 Aircraft

An in-situ nondestructive inspection was conducted to detect manufacturing and assembly induced defects in the upper two wing surfaces (skin s) and upper fuselage skin of the Lear Fan 2100 aircraft E009. The effects of the defects, detected during the inspection, on the integrity of the structure was analytically evaluated. A systematic evaluation was also conducted to determine the damage tolerance capability of the upper wing skin against impact threats and assembly induced damage. The upper wing skin was divided into small regions for damage tolerance evaluations. Structural reliability, margin of safety, allowable strains, and allowable damage size were computed. The results indicated that the impact damage threat imposed on composite military aircraft structures is too severe for the Lear Fan 2100 upper wing skin. However, the structural integrity is not significantly degraded by the assembly induced damage for properly assembled structures, such as the E009 aircraft.

Composites↗

A Markov Random Field Model for Texture-based Segmentation of Small Cracks in Thin InconelTubes

Markov random fields have been used for image segmentation since their introduction in the1980s. This work applies a method from Principal Component Thermography to enhance thecontrast in damage regions in 3D images derived from X-ray computed tomography (CT)inspections. The developed method is applied to sizing of small cracks in thin Inconel tubes designed as probability of detection (POD) samples for radiographic inspection.Misclassification errors arising from artifacts due to beam-hardening are reduced by fitting the boundary of the segmented damage region with the arc of an ellipse. Results are comparedagainst those obtained through manual inspection.

Image segmentation↗

Activities in Support of Continuing the Service of Nuclear Power Plant Safety-Related Concrete Structures

Nuclear power plant (NPP) concrete structures are described. In-service inspection and testing requirements in the U.S. are summarized. The license renewal process in the U.S. is outlined and its current status provided. Operating experience related to performance of the concrete structures is presented. Basic components of a program to manage aging of the concrete structures are identified and described: (1) Degradation mechanisms, damage models, and material performance; (2) Assessment and remediation: i.e., component selection, in- service inspection, non-destructive examinations, and remedial actions; and (3) Estimation of performance at present or some future point in time: i.e., application of structural reliability theory to the design and optimization of in-service inspection/maintenance strategies, and determination of the effects of degradation on plant risk. Finally, areas are noted where additional research would be of benefit to aging management of nuclear power plant concrete structures.

codes and standards↗

LWR Sustainability: Assessment of Aging of Nuclear Power Plant Safety Related Concrete Strutures

Current regulatory testing and inspection requirements are reviewed and a summary of degradation experience is presented. Techniques commonly used to inspect NPP concrete structures to assess and quantify age-related degradation are summarized. An approach for conduct of condition assessments of structures in NPPs is presented. Criteria, based primarily on visual indications, are provided for use in classification and assessment of concrete degradation. Materials and techniques for repair of degraded structures are generally discussed.

aging management↗

In-Field Performance Testing of the Fork Detector for Quantitative Spent Fuel Verification

Expanding spent fuel dry storage activities worldwide are increasing demands on safeguards authorities that perform inspections. The European Atomic Energy Community (EURATOM) and the International Atomic Energy Agency (IAEA) require measurements to verify declarations when spent fuel is transferred to difficult-to-access locations, such as dry storage casks and the repositories planned in Finland and Sweden. EURATOM makes routine use of the Fork detector to obtain gross gamma and total neutron measurements during spent fuel inspections. Data analysis is performed by modules in the integrated Review and Analysis Program (iRAP) software, developed jointly by EURATOM and the IAEA. Under the framework of the US Department of Energy–EURATOM cooperation agreement, a module for automated Fork detector data analysis has been developed by Oak Ridge National Laboratory (ORNL) using the ORIGEN code from the SCALE code system and implemented in iRAP. EURATOM and ORNL recently performed measurements on 30 spent fuel assemblies at the Swedish Central Interim Storage Facility for Spent Nuclear Fuel (Clab), operated by the Swedish Nuclear Fuel and Waste Management Company (SKB). The measured assemblies represent a broad range of fuel characteristics. Neutron count rates for 15 measured pressurized water reactor assemblies are predicted with an average relative standard deviation of 4.6%, and gamma signals are predicted on average within 2.6% of the measurement. The 15 measured boiling water reactor assemblies exhibit slightly larger deviations of 5.2% for the gamma signals and 5.7% for the neutron count rates, compared to measurements. These findings suggest that with improved analysis of the measurement data, existing instruments can provide increased verification of operator declarations of the spent fuel and thereby also provide greater ability to confirm integrity of an assembly. These results support the application of the Fork detector as a fully quantitative spent fuel verification technique.

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

A resting bottom sodium cooled fast reactor

This follows ICAPP 2011 paper 11059 'Fast Reactor with a Cold Bottom Vessel', on sodium cooled reactor vessels in thermal gradient, resting on soil. Sodium is frozen on vessel bottom plate, temperature increasing to the top. The vault cover rests on the safety vessel, the core diagrid welded to a toric collector forms a slab, supported by skirts resting on the bottom plate. Intermediate exchangers and pumps, fixed on the cover, plunge on the collector. At the vessel top, a skirt hanging from the cover plunges into sodium, leaving a thin circular slit partially filled by sodium covered by argon, providing leak-tightness and allowing vessel dilatation, as well as a radial relative holding due to sodium inertia. No 'air conditioning' at 400 deg. C is needed as for hanging vessels, and this allows a large economy. The sodium volume below the slab contains isolating refractory elements, stopping a hypothetical corium flow. The small gas volume around the vessel limits any LOCA. The liner cooling system of the concrete safety vessel may contribute to reactor cooling. The cold resting bottom vessel, proposed by the author for many years, could avoid the complete visual inspection required for hanging vessels. However, a double vessel, containing support skirts, would allow introduction of inspecting devices. Stress limiting thermal gradient is obtained by filling secondary sodium in the intermediate space. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Selection of materials for sodium fast reactor steam generators

Sodium Fast Reactor (SFR) is considered in France as the most mature technology of the different Generation IV systems. In the short-term the designing work is focused on the identification of the potential tracks to demonstrate licensing capability, availability, in-service inspection capability and economical performance. In that frame materials selection for the major components, as the steam generator, is a particularly key point managed within a French Research and Development program launched by AREVA, CEA and EDF. The choice of the material for the steam generator is indeed complex because various aspects shall be considered like mechanical and thermal properties at high temperature, interaction with sodium on one side and water and steam on the other side, resistance to wastage, procurement, fabrication, weldability and ability for inspection and in-situ intervention. The following relevant options are evaluated: the modified 9Cr1Mo ferritic-martensitic grade and the Alloy 800 austenitic grade. The objective of this paper is to assess for both candidates their abilities to reach the current SFR needs regarding material design data, from AFCEN RCC-MRx Code in particular, compatibility with environments and manufacturability. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗

Detection Of Special Nuclear Materials Tagged Neutrons

In order to detect Special Nuclear Materials (SNM) in unattended luggage or cargo containers in the field of homeland security, fissions are induced by 14 MeV neutrons produced by an associated particle DT neutron generator, and prompt fission particles correlated with tagged neutron are detected by plastic scintillators. SMN produce high multiplicity events due to induced fissions, whereas nonnuclear materials produce low multiplicity events due to cross-talk, (n,2n) or (n,n'γ) reactions. The data acquisition electronics is made of compact FPGA boards. The coincidence window is triggered by the alpha particle detection, allowing to tag the emission date and direction of the 14 MeV interrogating neutron. The first part of the paper presents experiment vs. calculation comparisons to validate MCNP-PoliMi simulations and the post-processing tools developed with the data analysis framework ROOT. Measurements have been performed using different targets (iron, lead, graphite), first with small plastic scintillators (10 x 10 x 10 cm{sup 3}) and then with large detectors (10 x 10 x 100 cm{sup 3}) to demonstrate that nuclear materials can be differentiated from nonnuclear dense materials (iron, lead) in iron and wood matrixes. A special attention is paid on SNM detection in abandoned luggage. In the second part of the paper, the performances of a cargo container inspection system are studied by numerical simulation, following previous work reported in. Detectors dimensions and shielding against the neutron generator background are optimized for container inspection. Events not correlated to an alpha particle (uncorrelated background), counting statistics, time and energy resolutions of the data acquisition system are all taken into account in a realistic numerical model. The impact of the container matrix (iron, ceramic, wood) has been investigated by studying the system capability to detect a few kilograms of SNM in different positions in the cargo container, within 10 min acquisitions. (authors)

36 MATERIALS SCIENCE↗

Robotics Technologies for Decommissioning of Fukushima Daiichi - 17077

The Fukushima Daiichi Nuclear Power Station (NPS) of Tokyo Electric Power Company (TEPCO) was the site of a severe nuclear accident after the 2011 Off the Pacific coast of Tohoku Earthquake and subsequent tsunami. Extensive structural damage occurred in the NPS facilities, including such environments as the reactor buildings and the primary containment vessels (PCVs). These are high radiation areas, having underwater areas, narrow spaces and so on. It is necessary to determine the extent of contamination and the location of debris to plan decommissioning operations. Survey targets in the past few years have been focused on inspections of the basement of the reactor buildings and the inside of the PCVs. Human operators cannot access these environments and work in them directly. Therefore, remotely operated robots and measurement technologies are needed to carry out various operations. For underwater surveys, we have developed a submersible crawling swimming robot that can avoid obstacles and inspect wide areas as it moves around. A shape-changing robot has been developed for passing through narrow spaces and crawling on rough floors. An ultrasonic imaging method combined with convex scanning and a divergent beam has been proposed to visualize environments in turbid water. In this paper, we describe details of the two survey robots and the underwater imaging method. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗