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At least 1,711 records · Page 95

Optimization of rotational arc station parameter optimized radiation therapy

Purpose: To develop a fast optimization method for station parameter optimized radiation therapy (SPORT) and show that SPORT is capable of matching VMAT in both plan quality and delivery efficiency by using three clinical cases of different disease sites. Methods: The angular space from 0° to 360° was divided into 180 station points (SPs). A candidate aperture was assigned to each of the SPs based on the calculation results using a column generation algorithm. The weights of the apertures were then obtained by optimizing the objective function using a state-of-the-art GPU based proximal operator graph solver. To avoid being trapped in a local minimum in beamlet-based aperture selection using the gradient descent algorithm, a stochastic gradient descent was employed here. Apertures with zero or low weight were thrown out. To find out whether there was room to further improve the plan by adding more apertures or SPs, the authors repeated the above procedure with consideration of the existing dose distribution from the last iteration. At the end of the second iteration, the weights of all the apertures were reoptimized, including those of the first iteration. The above procedure was repeated until the plan could not be improved any further. The optimization technique was assessed by using three clinical cases (prostate, head and neck, and brain) with the results compared to that obtained using conventional VMAT in terms of dosimetric properties, treatment time, and total MU. Results: Marked dosimetric quality improvement was demonstrated in the SPORT plans for all three studied cases. For the prostate case, the volume of the 50% prescription dose was decreased by 22% for the rectum and 6% for the bladder. For the head and neck case, SPORT improved the mean dose for the left and right parotids by 15% each. The maximum dose was lowered from 72.7 to 71.7 Gy for the mandible, and from 30.7 to 27.3 Gy for the spinal cord. The mean dose for the pharynx and larynx was reduced by 8% and 6%, respectively. For the brain case, the doses to the eyes, chiasm, and inner ears were all improved. SPORT shortened the treatment time by ∼1 min for the prostate case, ∼0.5 min for brain case, and ∼0.2 min for the head and neck case. Conclusions: The dosimetric quality and delivery efficiency presented here indicate that SPORT is an intriguing alternative treatment modality. With the widespread adoption of digital linac, SPORT should lead to improved patient care in the future.

60 APPLIED LIFE SCIENCES↗

A centimeter-long bacterium with DNA contained in metabolically active, membrane-bound organelles.

Cells of most bacterial species are around 2 micrometers in length, with some of the largest specimens reaching 750 micrometers. Using fluorescence, x-ray, and electron microscopy in conjunction with genome sequencing, we characterized Candidatus ( Ca. ) Thiomargarita magnifica, a bacterium that has an average cell length greater than 9000 micrometers and is visible to the naked eye. These cells grow orders of magnitude over theoretical limits for bacterial cell size, display unprecedented polyploidy of more than half a million copies of a very large genome, and undergo a dimorphic life cycle with asymmetric segregation of chromosomes into daughter cells. These features, along with compartmentalization of genomic material and ribosomes in translationally active organelles bound by bioenergetic membranes, indicate gain of complexity in the Thiomargarita lineage and challenge traditional concepts of bacterial cells.

Volland, Jean-Marie↗

Flux Growth, Thermal Properties, and Luminescence Spectra of (Er,Yb,Lu)Al{sub 3}(BO{sub 3}){sub 4} Solid Solutions

We have studied phase relations in the pseudoquaternary system LuAl{sub 3}(BO{sub 3}){sub 4}–(K{sub 2}Mo{sub 3}O{sub 10}–Al{sub 2}O{sub 3}–B{sub 2}O{sub 3}) in the temperature range 1130 to 900°C. The phase relations were represented in graphical form, as a projection of the formation of solid phases in this range onto the composition triangle at 900°C. Optimal results in terms of high-temperature solution growth have been obtained at 25 wt % LuAl{sub 3}(BO{sub 3}){sub 4} in the growth charge. Undoped and erbium–ytterbium codoped LuAl{sub 3}(BO{sub 3}){sub 4} (LuAB) single crystals have been grown from high-temperature solutions on “pointlike” seeds. The (Er,Yb):LuAB crystals are similar in thermal properties and luminescence spectra to (Er,Yb):YAl{sub 3}(BO{sub 3}){sub 4} and (Er,Yb):GdAl{sub 3}(BO{sub 3}){sub 4} crystals and can be used in diode-pumped lasers operating in the nominally eye-safe spectral region 1.5–1.6 μm.

36 MATERIALS SCIENCE↗

Rayleigh convective instability in a cloud medium

The problem of convective instability of an atmospheric layer containing a horizontally finite region filled with a cloud medium is considered. Solutions exponentially growing with time, i.e., solitary cloud rolls or spatially localized systems of cloud rolls, have been constructed. In the case of axial symmetry, their analogs are convective vortices with both ascending and descending motions on the axis and cloud clusters with ring-shaped convective structures. Depending on the anisotropy of turbulent exchange, the scale of vortices changes from the tornado scale to the scale of tropical cyclones. The solutions with descending motions on the axis can correspond to the formation of a tornado funnel or a hurricane eye in tropical cyclones.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Dissipative soliton vortices and tropical cyclones

We have obtained a new exact steady-state solution to the hydrodynamic equation for a viscous incompressible liquid, which is a generalization of the well-known Sullivan solution (1959), taking into account additionally the external (Eckman) friction and rotation of the system as a single whole. In contrast to the radial structure of a Sullivan vortex, different circulation directions of velocity field tangential component are possible in the new solution in the inner and outer cells. We have considered the correspondence of this solution to the radial vortex structure observed in tropical cyclones, where the precisely anticyclonic circulation always exists in the inner core (typhoon, hurricane eye), which is associated with descending vertical currents for the cyclonic direction of rotation (as well as ascending currents) outside this core.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Electroproduction of {rho}{sup 0} mesons on protons in quasielastic kinematics at intermediate energies and spin-flip mechanism of direct meson knockout

It is shown that the amplitude for the direct knockout of {rho}{sup 0} mesons plays an important role at energies W above the resonance region, W {>=} 2 GeV, and rather high values of Q{sup 2} {>=} 1.5-2 GeV{sup 2}/c{sup 2} and that it corresponds to the t pole in the channel of the virtual decay p {sup {yields}}p + {pi}{sup 0} accompanied by quark-spin flip upon momentum transfer to the meson, {pi}{sup 0} + {gamma}*{sub T} {sup {yields} {rho}0}. The contributions of several scalar mesons (p {sup {yields}}p + f{sub 0} channel), the contribution of the tensor meson f{sub 2}, and effects of the interference between different contributions were taken into account in addition to the contribution of the {pi}{sup 0} meson. The vectorand tensor-meson-dominance models were used to estimate the respective vertex constants. Within the proposed mechanism, the differential cross sections d{sigma}{sub L}/dt and d{sigma}{sub T}/dt were calculated for several W and Q{sup 2} values at which the respective total cross sections were measured by the CLAS Collaboration. Agreement with data on the transverse part of the total cross section, {sigma}{sub T}, was attained, whereby the assumption of a dominant role of magnetic spin transitions in the meson skin of the nucleon under conditions of quasielastic-knockout kinematics is confirmed. At the same time, the contribution of spin-flip transitions is suppressed in the longitudinal part of the cross section, {sigma}{sub L}, and this is confirmed by the results of our calculations. The behavior of the differential cross section d{sigma}{sub T}/dt is predicted with an eye to future experiments.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Particles of primary cosmic radiation generating extensive air showers of energy above 10{sup 20} eV in the atmosphere

In order to construct the energy spectrum on the basis of data from the Yakutsk array, a method similar to that employed at the AGASA array is applied in addition to the standard approach based on experimental procedures. Moreover, a new, original, method underlying the calculation of the spectrum in the region of energies above 10{sup 20} eV is used to estimate energies. In order to compare data obtained at different arrays, it is proposed to harness the universal spectrum based on HiRes data. Within the QGSJET2 model, it is shown that a shower of energy 2 x 10{sup 20} eV was observed at the Yakutsk array. In the same energy region (above 2 x 10{sup 20} eV), the AGASA array recorded four showers, while the Fly's Eye array and Pierre Auger Observatory (PAO) recorded one shower each. These data do not confirm the conclusion that the flux of primary-cosmic-ray particles decreases because of the Greisen-Zatsepin-Kuzmin effect.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Neutron Monitoring at the Area of IRC “Pamir-Chakaltaya” for Radiation Safety Control

The results of neutron monitoring at the high-altitude area of the International Research Center “Pamir-Chakaltay” at an altitude of 4370 meters above sea level are presented. Measurements with the help of radiometers PDA-Pack Eye, МКS-RМ1401К and RSU-01R revealed an excess of 5–7 times the neutron flux density at the 2-tier X-ray emulsion chamber in the hangar and in the storage areas of lead and rubber plates. At the same time, instrument readings experienced significant (up to 30%) fluctuations in time.

61 RADIATION PROTECTION AND DOSIMETRY↗

Antireflective nanostructured zinc oxide arrays produced by pulsed electrodeposition

Conditions for the pulsed electrochemical deposition of nanostructured zinc oxide arrays with a certain morphology, crystal structure, and optical properties from aqueous electrolytes onto substrates of transparent electrically conducting tin dioxide and on single-crystal silicon wafers with built-in homojunctions are studied in order to develop antireflection coatings for solar cells. It is shown that it is possible to obtain single-layer planar antireflection coatings or arrays of nanorods of this material, both having the form of hexagonal prisms and exhibiting the moth-eye effect.

36 MATERIALS SCIENCE↗

On the problem of internal optical loss and current leakage in laser heterostructures based on AlGaInAs/InP solid solutions

Semiconductor lasers based on MOCVD-grown AlGaInAs/InP separate-confinement heterostructures are studied. It is shown that raising only the energy-gap width of AlGaInAs-waveguides without the introduction of additional barriers results in more pronounced current leakage into the cladding layers. It is found that the introduction of additional barrier layers at the waveguide–cladding-layer interface blocks current leakage into the cladding layers, but results in an increase in the internal optical loss with increasing pump current. It is experimentally demonstrated that the introduction of blocking layers makes it possible to obtain maximum values of the internal quantum efficiency of stimulated emission (92%) and continuouswave output optical power (3.2 W) in semiconductor lasers in the eye-safe wavelength range (1400–1600 nm).

36 MATERIALS SCIENCE↗

Investigating the Link Between Radiologists Gaze, Diagnostic Decision, and Image Content

Objective: To investigate machine learning for linking image content, human perception, cognition, and error in the diagnostic interpretation of mammograms. Methods: Gaze data and diagnostic decisions were collected from six radiologists who reviewed 20 screening mammograms while wearing a head-mounted eye-tracker. Texture analysis was performed in mammographic regions that attracted radiologists attention and in all abnormal regions. Machine learning algorithms were investigated to develop predictive models that link: (i) image content with gaze, (ii) image content and gaze with cognition, and (iii) image content, gaze, and cognition with diagnostic error. Both group-based and individualized models were explored. Results: By pooling the data from all radiologists machine learning produced highly accurate predictive models linking image content, gaze, cognition, and error. Merging radiologists gaze metrics and cognitive opinions with computer-extracted image features identified 59% of the radiologists diagnostic errors while confirming 96.2% of their correct diagnoses. The radiologists individual errors could be adequately predicted by modeling the behavior of their peers. However, personalized tuning appears to be beneficial in many cases to capture more accurately individual behavior. Conclusions: Machine learning algorithms combining image features with radiologists gaze data and diagnostic decisions can be effectively developed to recognize cognitive and perceptual errors associated with the diagnostic interpretation of mammograms.

Tourassi, Georgia↗

Millions of targets under attack: a macroscopic characterization of the DoS ecosystem

Denial-of-Service attacks have rapidly increased in terms of frequency and intensity, steadily becoming one of the biggest threats to Internet stability and reliability. However, a rigorous comprehensive characterization of this phenomenon, and of countermeasures to mitigate the associated risks, faces many infrastructure and analytic challenges. We make progress toward this goal, by introducing and applying a new framework to enable a macroscopic characterization of attacks, attack targets, and DDoS Protection Services (DPSs). Our analysis leverages data from four independent global Internet measurement infrastructures over the last two years: backscatter traffic to a large network telescope; logs from amplification honeypots; a DNS measurement platform covering 60% of the current namespace; and a DNS-based data set focusing on DPS adoption. Our results reveal the massive scale of the DoS problem, including an eye-opening statistic that one-third of all / 24 networks recently estimated to be active on the Internet have suffered at least one DoS attack over the last two years. We also discovered that often targets are simultaneously hit by different types of attacks. In our data, Web servers were the most prominent attack target; an average of 3% of the Web sites in .com, .net, and .org were involved with attacks, daily. Finally, we shed light on factors influencing migration to a DPS.

Jonker, Mattijs↗

FiberFlex: Real-time FPGA-based Intelligent and Distributed Fiber Sensor System for Pedestrian Recognition

In recent years, security monitoring of public places and critical infrastructure has heavily relied on the widespread use of cameras, raising concerns about personal privacy violations. To balance the need for effective security monitoring with the protection of personal privacy, we explore the potential of optical fiber sensors for this application. This article proposes FiberFlex, an intelligent and distributed fiber sensor system. Ultizing Field Programmable Gate Arrays (FPGA) high-level synthesis (HLS) acceleration, FiberFlex offers real-time pedestrian detection by co-designing the entire pipeline of optical signal acquisition, processing, and recognition networks based on the principles of optical fiber sensing. As a promising alternative to traditional camera-based monitoring systems, FiberFlex achieves pedestrian detection by analyzing the vibration patterns caused by pedestrian footsteps, enabling security monitoring while preserving individual privacy. FiberFlex comprises three modules: First , fiber-optic sensing system: A fiber-optic distributed acoustic sensing (DAS) system is built and used to measure the ground vibration waves generated by people walking. Second , algorithms: We first collect the training data by measuring the ground vibration waves, label the data, and use the data to train the neural network models to perform pedestrian recognition. Third , hardware accelerators: We use HLS tools to design hardware modules on FPGA for data collection and pre-processing and integrate them with the downstream neural network accelerators to perform in-line real-time pedestrian detection. The final detection results are sent back from FPGA to the host CPU. We implement our system FiberFlex with the in-house built DAS system and AMD/Xilinx Kintex7 FPGA KC705 board and verify the whole system using the real-world collected data. We conduct recognition tests on five test subjects of varying ages, heights, and weights in a fixed sensing area. Each subject experienced 20 real-time recognition tests using their daily walking habits, and the subjects were given adequate rest between tests. After 100 tests on five test subjects, the overall real-time recognition accuracy exceeded \(88.0\%\) . The whole system uses 55 W of power, 33 W in the optical DAS system and 22 W in the FPGA. Relying on its end-to-end interdisciplinary design, FiberFlex seamlessly combines fiber-optic sensors with FPGA accelerators to enable low-power real-time security monitoring without compromising privacy, making it a valuable addition to the existing security monitoring network. According to FiberFlex, more valuable research can be conducted in the future, such as fall monitoring for the elderly, migration of identification networks between different application scenarios, and improvement of anti-interference performance in more complex environments. In future perception networks, where the “eyes” are not feasible, let’s use fiber optic touch instead.

Distributed↗

Review—Multifunctional Materials for Enhanced Li-Ion Batteries Durability: A Brief Review of Practical Options

Transition metal (TM) ions dissolution from positive electrodes, migration to and deposition on negative electrodes, followed by Mn-catalyzed reactions of solvents and anions, with loss of Li+ ions, is a major degradation (DMDCR) mechanism in Li-ion batteries (LIBs) with spinel positive electrode materials. While the details of the DMDCR mechanism are still under debate, it is clear that HF and other acid species’ attack is the main cause in solutions with LiPF6 electrolyte. We first review the work on various mitigation measures for the DMDCR mechanism, now spanning more than two decades. We then discuss recent progress on our understanding of Mn species in electrolyte solutions and the extension of a mitigation measure first proposed by Tarascon and coworkers in 1999, namely chelation of TM cations, to Mn cation trapping, HF scavenging, and alkali metal ions dispensing multi-functional materials. We focus on practicable, drop-in technical solutions, based on placing such materials in the inter-electrode space, with significant benefits for LIBs performance: increased capacity retention during operation at room and above-ambient temperatures as well as robust (both maximally ionically conducting and electronically insulating) solid-electrolyte interfaces, having reduced charge transfer and film resistances at both negative and positive electrodes. We illustrate the multifunctional materials approach with both new and previously published data. We also discuss and offer our evaluation regarding the merits and drawbacks of the various mitigation measures, with an eye for practically relevant technical solutions capable to meet both the performance requirements and cost constraints for commercial LIBs, and end with recommendations for future work.

25 ENERGY STORAGE↗

Cryptotomography: reconstructing 3D Fourier intensities from randomly oriented single-shot diffraction patterns (CXIDB ID 9)

These 2000 single-shot diffraction patterns include were either background-scattering only or hits (background-scattering plus diffraction signal from sub-micron ellipsoidal particles at random, undetermined orientations). Candidate hits were identified by eye, and the remainder were presumed as background. 54 usable, background-subtracted hits in this set (procedure in referenced article) were used to reconstruct the 3D diffraction intensities of the average ellipsoidal particle.

BL2↗

Geographic Visualization of Power-Grid Dynamics

The visualization enables the simulation analyst to see changes in the frequency through time and space. With this technology, the analyst has a bird's eye view of the frequency at loads and generators as the simulated power system responds to the loss of a generator, spikes in load, and other contingencies. The significance of a contingency to the operation of an electrical power system depends critically on how the resulting tansients evolve in time and space. Consequently, these dynamic events can only be understood when seen in their proper geographic context. this understanding is indispensable to engineers working on the next generation of distributed sensing and control systems for the smart grid. By making possible a natural and intuitive presentation of dynamic behavior, our new visualization technology is a situational-awareness tool for power-system engineers.

Sukumar, SreenivasR.↗

colormap_util

Our Python module, colormap_module, presented here can be used to analyze and manipulate colormaps and has two main aims: (i) compare existing and new custom colormaps quantitatively by comparing their values in a color space, called CAM02-UCS, that directly shows how a human perceives their hue, saturation, and lightness values and (ii) create isoluminant colormaps from existing or custom colormaps and (iii) mix isoluminant colormap data with a 4th dimension of data by manipulating lightness values across the image and present the new image. Our module was designed to be a tool for the community to use as a whole, allowing scientists to present, analyze, and manipulate colormaps they have created and/or decided to use for a particular type of data. By being able to do this, the scientific community as a whole will think more about the colormaps they choose, see why particular colormaps are bad to use for certain types of data, and move toward using colormaps our eyes can interpret much more efficiently.

Source record↗

EyeON

EyeON: Eye on Operational technology Software Supply Chain attacks have risen drastically over the past few years, none more well-known and impactful than the SolarWinds compromise. Criminal organizations inserted an attack vector into a specific version of the source code, giving themselves an air of credibility. Once news broke on SolarWinds, identifying compromised sites was very difficult, even knowing the culprit update. Software Bills of Materials (SBOM) have been touted as the solution to reclaiming control of your software supply chain. Deployment of SBOMs has been slow, however, due to conflicting standards, opaque storage requirements, and vendor adoption. Additionally, the path from obtaining an SBOM and securing your supply chain is unclear; how can an SBOM library be leveraged to provide insight to your attack surface? The EyeON tool, sponsored by Department of Energy Cybersecurity, Energy Security, and Emergency Response (DoE CESER), aims to address these gaps by providing an encapsulated solution to tracking which updates have been installed in an enterprise, and alerting system administrators to vulnerabilities as they become known. Similar to a virus scanner, EyeON is a command line tool to parse either a single file, nested directory structure, or filesystem. It collects data such as signature (hashes), version information, VirusTotal tags, compiler, compilation date, and code signing information. Users will anonymously submit scan data periodically to DoE CESER, who will then compile a database of known software products employed by Critical Infrastructure and broadcast alerts based on discovered flaws as they arise.

Tenzing, Wangmo↗