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Farfield Plume Measurement and Analysis on the NASA-300M

NASA is developing a 15-kW Hall thruster to support future NASA missions. This activity is funded under the Space Technology Mission Directorate Solar Electric Propulsion Technology Demonstration project. As a part of the development process, the far-field plume characteristics of the NASA-300M, a 20-kW Hall thruster, were studied. The results will be used to study how various aspects of the operation of this thruster affect the overall performance. This data will be used to guide future design work and serve as a baseline for comparison to a magnetically shielded version of the NASA-300M that will be tested in the future. For this study, a far-field Faraday probe was swept in a polar fashion to map the ion current density. An ExB probe (Wien filter), two retarding potential analyzers, and a Langmuir probe were mounted at a fixed location on the thruster axis in the far-field plume. The data reduction method followed recommendations in recent studies by Brown, Reid, and Shastry with modifications that are tailored to the plasma plume environment of high-power Hall thrusters. Results from this and prior testing show that the plume is richer in doubly-charged ions, larger in spatial extent, and capable of greater probe heating than lower power thrusters. These characteristics require special treatment in experimental setup and data analysis, which will be the main focus of this paper. In particular, covered topics will include a new, more accurate, method of integration for analysis of the ExB probe data and effect of secondary electron emission on the Faraday probe data.

Huang, Wensheng↗

The NASA Ames Closed Environmental Research Chamber: Present Status

The Closed Environmental Research Chamber (CERC) at the NASA Ames Research Center was created to investigate both components and complete systems for life support of advanced space exploration missions. This facility includes a Main Chamber, an Airlock, a Sample Transfer Lock, a Vacuum System, an Air Recompression System, a dedicated control room and a pit area for housing supporting and environmental control systems. The Main Chamber provides 310 sq ft of internal working/living space on two levels. It is planned that the CERC will be a human-rated facility for habitation simulation under mass balance closure conditions. The internal pressure will be variable over the range of 14.7 psia to 5 psia with accompanying capability for variation in atmosphere composition to maintain the oxygen partial pressure at 160 mm Hg. The CERC will be provided with a core set of primary life support subsystems for temperature and humidity control, C02 removal and trace contaminant control. Interfacing with external life support technology test b~ds with be provided, along with connection to centralized, microprocessor-based data acquisition and control systems. This paper will discuss the current status of the CERC facility and show how it is being used to address the advanced technology requirements necessary to implement an integrated working and living environment for a planetary habitat. In particular, it will be shown how the CERC, along with a human-powered centrifuge, a planetary terrain simulator and advanced displays and a virtual reality capability will work together to develop and demonstration applicable technologies for future planetary habitats. Artificial intelligence and expert system programming techniques will be used extensively to provide an automated environment for a 4-person crew. There will be several robotic mechanisms performing exploration tasks external to the habitat that will be controlled through the virtual environment to provide representative workloads for the crew. Finally, there will be a discussion of how effective are innovative new multidisciplinary test facilities to the investigation of the wide range of human and machine problems inherent in exploration missions.

Gross, Anthony R.↗

BioSentinel: An Adaptable Platform for Studying the Biological Effects of Deep Space Radiation

NASA's BioSentinel mission is a 6U nanosatellite with autonomous life support that will utilize the budding yeast Saccharomyces cerevisiae to study the DNA damage response to the deep space radiation environment. BioSentinel is planned to launch in 2019 as a secondary payload on the Space Launch System's first Exploration Mission (EM-1), and will undergo a lunar fly-by and enter heliocentric orbit after deployment. As the first biological mission beyond Low Earth Orbit (LEO) in nearly half a century, this mission will help fill critical gaps in knowledge about the effects of uniquely composed, chronic, low-flux deep space radiation on biological systems. Yeast is well-suited for this mission due to its desiccation tolerance and space-flight heritage. As a eukaryotic model organism, it also serves as a robust analog for human cells. Data gathered on this mission will thus inform us of the hazards involved in long-duration human exploration in deep space, and the protections necessary to mitigate them. Due to its low-cost, flexible and advanced technology, the 4U BioSensor payload contained within the nanosatellite is adaptable to other model microorganisms, exploration platforms and environments relevant to human exploration, such as the ISS, the Lunar Orbital Platform - Gateway and future lunar landers. In order to query the DNA damage response to deep space radiation, BioSentinel contains a wild type yeast strain as a positive control, and a radiation sensitive rad51 mutant strain that is defective for DNA repair. Yeast cells are desiccated in microfluidic cards, and rehydrated with growth medium and metabolic indicator dye at the desired time points during the mission. A thermal control system supports these stasis and growth states, and an optical system continuously measures cell growth and metabolism. An onboard radiation spectrometer and dosimeter allows us to correlate the dose, energy and particle-type of deep space radiation to the biological response. Data received from the deep space biosensor will be compared to control payloads on Earth and the ISS. Ongoing science testing for the BioSentinel project includes optimization for cell viability, desiccation tolerance, and long-term biocompatibility, as well as radiation experiments to understand the sensitivity and responsiveness of cells to varying radiation doses and particle types.

BioSentinel↗

A Comparative Analysis of Occupant Response Between Component and Full Vehicle Tests of Fokker F28 Aircraft Hardware

In 2019, the National Aeronautics and Space Administration (NASA) Langley Research Center (LaRC) conducted a full-scale crash test of a Fokker F28 MK1000 aircraft. This test concluded a multi-year research effort in which two component fuselage sections of a matching Fokker F28 aircraft were previously tested under similar vertical impact conditions. Due to facility and cost constraints of full-scale testing, aircraft are typically evaluated through component level tests (i.e. vertical drops of fuselage subsections or isolated seat tests). Although more practical, these tests are limited in their ability fully replicate the complex multi-axis loading environment induced on the occupants during a full-aircraft crash event. Because of this, there is risk that component level testing does not provide a complete assessment of vehicle crashworthiness. Comparative analysis between full-scale and component level testing of the Fokker F28 aircraft provides an excellent opportunity to evaluate differences in crashworthiness prediction made between these levels of test fidelity. In this study, Anthropomorphic Test Device (ATD, a.k.a crash test dummies) responses measured during the Fokker full scale impact test were compared to those measured in the component fuselage section drops. A variety of ATD configurations (5th, 50th, 95th) and positions (upright, braced) were tested in both the full-scale and component tests. ATD injury metric response comparisons were made across these ATD variations in addition to comparisons made with respect to ATD location within the vehicle. Results found the addition of horizontal impact velocity, achieved in the full-scale testing, along with aircraft structural effects altered ATD based crashworthiness assessment of the vehicle.

Crashworthiness↗

Mapping the Ancient Maya Landscape from Space

This project uses new satellite and airborne imagery in combination with remote sensing, GIS, and GPS technology to understand the dynamics of how the Maya successfully interacted with their karst topographic landscape for several centuries in the northern Peten region of Guatemala. The ancient Maya attained one of the greatest population densities in human history in the tropical forest of the Peten, Guatemala, and it was in this region that the Maya civilization began, flourished, and abruptly disappeared for unknown reasons around AD 800. How the Maya were able to successfully manage water and feed this dense population is not known at this time. However, a recent NASA-funded project was the first to investigate large seasonal swamps (bajos) that make up 40 percent of the landscape. Through the use of remote sensing, ancient Maya features such as cities, roadways, canals and water reservoirs have been detected and verified through ground reconnaissance. The results of this research cast new light on the adaptation of the ancient Maya to their environment. Micro-environmental variation within the wetlands was elucidated and the different vegetational associations identified in the satellite imagery. More than 70 new archeological sites within and at the edges of the bajo were mapped and tested. Modification of the landscape by the Maya in the form of dams and reservoirs in the Holmul River and its tributaries and possible drainage canals in bajos was demonstrated. The recent acquisition of one-meter IKONOS imagery and high resolution STAR-3i radar imagery (2.5m backscatter/ 10m DEM), opens new possibilities for understanding how a civilization was able to survive for centuries upon a karst topographic landscape and their human-induced effects upon the local climate. This understanding is critical for the current population that is presently experiencing rapid population growth and destroying the landscape through non-traditional farming and grazing techniques, resulting in socioeconomic problems.

Sever, Tom↗

Use of Heated Helium to Simulate Surface Pressure Fluctuations on the Launch Abort Vehicle During Abort Motor Firing

The solid-rocket plumes from the Abort motor of the Multi-Purpose Crew Vehicle (MPCV, also know as Orion) were simulated using hot, high pressure, Helium gas to determine the surface pressure fluctuations on the vehicle in the event of an abort. About 80 different abort situations over a wide Mach number range, (0.3< or =M< or =1.2) and vehicle attitudes (+/-15deg) were simulated inside the NASA Ames Unitary Plan, 11-Foot Transonic Wind Tunnel. For each abort case, typically two different Helium plume and wind tunnel conditions were used to bracket different flow matching critera. This unique, yet cost-effective test used a custom-built hot Helium delivery system, and a 6% scale model of a part of the MPCV, known as the Launch Abort Vehicle. The test confirmed the very high level of pressure fluctuations on the surface of the vehicle expected during an abort. In general, the fluctuations were found to be dominated by the very near-field hydrodynamic fluctuations present in the plume shear-layer. The plumes were found to grow in size for aborts occurring at higher flight Mach number and altitude conditions. This led to an increase in the extent of impingement on the vehicle surfaces; however, unlike some initial expectations, the general trend was a decrease in the level of pressure fluctuations with increasing impingement. In general, the highest levels of fluctuations were found when the outer edges of the plume shear layers grazed the vehicle surface. At non-zero vehicle attitudes the surface pressure distributions were found to become very asymmetric. The data from these wind-tunnel simulations were compared against data collected from the recent Pad Abort 1 flight test. In spite of various differences between the transient flight situation and the steady-state wind tunnel simulations, the hot-Helium data were found to replicate the PA1 data fairly reasonably. The data gathered from this one-of-a-kind wind-tunnel test fills a gap in the manned-space programs, and will be used to establish the acoustic environment for vibro-acoustic qualification testing of the MPCV.

Panda, Jayanta↗

Hypogravity's Effect on the Life Cycle of Japanese Quail

A series of studies were conducted to determine the effect of activities preceding space-flight and during space-flight on quail embryonic development. While the overall development of the quail embryos was evaluated, the report presented herein, focused on calcium utilization or uptake from eggshells by developing embryos during incubation in space and on earth. In the pre-space trials, fertilized quail eggs were subjected to pre-night dynamics including forces of centrifugation, vibration, or a combination of vibration and centrifugation prior to incubation for 6 or 16 days. In another trial, fertile quail eggs were tested for survivability in a refrigerator stowage kit for eggs (RSKE) which was subsequently used to transport the eggs to space. Eggs in the RSKE were subjected to shuttle launch dynamics including G force and random vibration profiles. In the space- flight trials, 48 fertile quail eggs were launched on space shuttle Flight STS-76 and were subsequently incubated in a Slovakian incubator onboard space station, MIR. Two sets of ground controls each with 48 fertile eggs with and without exposure to launch dynamics were initiated 5 days post-launch. There was a laboratory control (incubated in Lyon RX2 incubator at 37.5 C) and a synchronous control (incubated in Lyon RX2 incubator at 39 - 400 C), which simulated the temperature of the space-flight incubator. Following space-flight trials, post-flight trials were conducted where quail eggs were incubated in Lyon RX2 or Slovakian incubators under various temperatures with or without launch dynamics. Eggshells from all study trials were retrieved and analyzed for calcium content to determine if its utilization by developing quail embryos was affected by activities preceding space-flight or during incubation in space under microgravity. Results from the pre-flight and post-flight showed that pre-flight activities and shuttle launch dynamics had no effect on calcium uptake from the eggshell by developing embryos. However, calcium uptake from the eggshell by developing embryos incubated in micro,aravity was impaired by 12.6% when compared to embryos incubated on earth under laboratory control environment. This impairment was unlikely due to factors other than microgravity. In general, calcium utilization by developing embryos increased with age of incubation with the most increase occurring at day 16 of incubation.

Hester, Patricia Y.↗

Pyroshock Environments Characterized for Spacecraft Missions

Pyrotechnic shock, or pyroshock, is the transient response of a structure to loading induced by the ignition of pyrotechnic (explosive or propellant activated) devices. These devices are typically used to separate structural systems (e.g., separate a spacecraft from a launch vehicle) and deploy appendages (e.g., solar panels). Pyroshocks are characterized by high peak acceleration, high-frequency content, and short duration. Because of their high acceleration and high-frequency, pyroshocks can cause spaceflight hardware to fail. Verifying by test that spaceflight hardware can withstand the anticipated shock environment is considered essential to mission success. The Earth Observing System (EOS) AM-1 spacecraft for NASA's Mission to Planet Earth is scheduled to be launched on an Atlas IIAS vehicle in 1999, and the NASA Lewis Research Center is the launch vehicle integrator for this NASA Goddard Space Flight Center spacecraft. The EOS spacecraft was subjected to numerous ground shock tests to verify that its scientific instruments and avionics components will withstand the shock-induced vibration produced when the spacecraft separates from the launch vehicle. Shock test data from these tests represent the third largest available pyroshock database in the United States. Future spacecraft missions will directly benefit from the knowledge gained from these tests. The payload separation system used for EOS is a new system that operates by firing six separation nuts. This system was tested to verify its functional operation and to characterize the resulting shock levels. The launch vehicle contractor (Lockheed Martin Astronautics) and spacecraft contractor (Lockheed Martin Missiles & Space) completed 16 separation test firings. This resulted in an unusually large amount of pyroshock data. Typically, only one or two pyroshock test firings are performed for a spacecraft mission. Because of the size of this separation system shock database, engineers were able to perform unique statistical analyses to characterize the distribution of the test data. For example, it was proven that the shock data follow a lognormal distribution, a concept often assumed but rarely proven. The test-to-test repeatability of the shock source level was analyzed, and the effects of various test configurations and separation nut production lots were examined and quantified. Engineers investigated the change in shock level as the shock traveled from the spacecraft separation interface to the avionics components of the upper stage and analyzed the effects of the structural fidelity (simulator versus real) of the components and their weight on vibrational response. In addition, the shock attenuation with distance and across joints was quantified and compared with concepts originally generated in 1970, and the effects of separation nut preload and firing sequences effects were examined. Because of this EOS shock testing and the analyses performed at NASA Lewis, a significant amount of new information on pyroshock and its characteristics is now available to the aerospace industry. We hope that this information will help future spacecraft test planners to perform better and cheaper spacecraft separation shock tests and to better understand their test data.

Hughes, William O.↗

Polarimetric Remote Sensing of Atmospheric Aerosols: Instruments, Methodologies, Results, and Perspectives

Polarimetry is one of the most promising types of remote sensing for improved characterization of atmospheric aerosol. Indeed, aerosol particles constitute a highly variable atmospheric component characterized by a large number of parameters describing particle sizes, morphologies (including shape and internal structure), absorption and scattering properties, amounts, horizontal and vertical distribution, etc. Reliable monitoring of all these parameters is very challenging, and therefore the aerosol effects on climate and environment are considered to be among the most uncertain factors in climate and environmental research. In this regard, observations that provide both the angular distribution of the scattered atmospheric radiation as well as its polarization state at multiple wavelengths covering the UV–SWIR spectral range carry substantial implicit information on the atmospheric composition. Therefore, high expectations in improving aerosol characterization are associated with detailed passive photopolarimetric observations. The critical need to use space-borne polarimetry for global accurate monitoring of detailed aerosol properties was first articulated in the late 1980s and early 1990s. By now, several orbital instruments have already provided polarization observations from space, and a number of advanced missions are scheduled for launch in the coming years by international and national space agencies. The first and most extensive record of polarimetric imagery was provided by POLDER-I, POLDER-II, and POLDER/PARASOL multi-angle multi-spectral polarization sensors. Polarimetric observations with the POLDER-like design intended for collecting extensive multi-angular multi-spectral measurements will be provided by several instruments, such as the MAI/TG-2, CAPI/TanSat, and DPC/GF-5 sensors recently launched by the Chinese Space Agency. Instruments such as the 3MI/MetOp-SG, MAIA, SpexOne and HARP2 on PACE, POSP, SMAC, PCF, DPC–Lidar, ScanPol and MSIP/Aerosol-UA, MAP/Copernicus CO2 Monitoring, etc. are planned to be launched by different space agencies in the coming decade. The concepts of these future instruments, their technical designs, and the accompanying algorithm development have been tested intensively and analyzed using diverse airborne prototypes. Certain polarimetric capabilities have also been implemented in such satellite sensors as GOME-2/MetOp and SGLI/GCOM-C.

Aerosols↗

Development of Control System Functional Capabilities within the IES Plug-and-Play Simulation Environment

The concept of an Integrated Energy System (IES) is meant to combine different energy technologies in synergistic ways to achieve a more secure and economical energy supply. The RAVEN-based HYBRID framework is used to find the optimal installed capacity and the optimal economical dispatch of each component of the IES. A new RAVEN (Risk Analysis Virtual ENvironment) plugin for grid and capacity optimization (HERON) has been developed for optimizing the production variables of the IES given the demand profile. Currently, only the limits that affect the production variables and their corresponding time rates of change are considered (explicit constraints). However, other variables are additionally subject to constraints, but the associated limits are not accounted for (implicit constraints). In particular, for the power dispatch problem, the optimization algorithm takes into account the limits on the electrical power output and the corresponding hourly power variations but does not consider other constraints on process variables whose response effects the service life of the IES. This report describes a scheme that allows accounting for implicit constraints without increasing the size of the optimization problem. The Reference Governor (RG) algorithm is traditionally used for enforcing state and control constraints by modifying the set-point trajectories supplied to the feedback regulators. In our application, the RG is coupled within an iterative loop with the HERON-power dispatcher to generate optimal trajectories that ensure the operational constraints are met. A data-driven procedure to derive a representation of the dynamics of the controlled system was developed. First, the variables that represented the state of the system are selected (PCA-based approach), and then state-space representation matrices are derived from the collected measurements (DMDc algorithm). A preliminary version of the developed workflow based on Linear Time Invariant matrices was assessed by adopting a two-unit test case. More sophisticated versions of this workflow foreseeing the on-line derivation of system matrices will be deployed in FY 2021. Finally, a “plug-and-play” library of controllers and state observers was developed in Dymola. Some aspects of the current configuration of the IES unit components, e.g., the encapsulation of the control schemes into dedicated blocks, are consistent with the “plug-and-play” philosophy. Other features, e.g., the system buses collecting the input and the output variables, are not. For this reason, once listed and described the limits of the current configuration, necessary modifications to the plant model interface are presented. As a test-case, the interfaces of the SES model in the RAVEN-based HYBRID framework were reworked accordingly, and two different control schemes were applied to the same plant model.

24 POWER TRANSMISSION AND DISTRIBUTION↗

Changes in the immune system during and after spaceflight

The results of immunological analyses before, during and after spaceflight, have established the fact that spaceflight can result in a blunting of the immune mechanisms of human crew members and animal test species. There is some evidence that the immune function changes in short-term flights resemble those occurring after acute stress, while the changes during long-term flights resemble those caused by chronic stress. In addition, this blunting of the immune function occurs concomitant with a relative increase in potentially infectious microorganisms in the space cabin environment. This combination of events results in an increased probability of inflight infectious events. The realization of this probability has been shown to be partially negated by the judicious use of a preflight health stabilization program and other operational countermeasures. The continuation of these countermeasures, as well as microbial and immunological monitoring, are recommended for continued spaceflight safety.

manned↗

TPSAS-NF1676L-21180-DND

Ablative materials are used as the Thermal Protection System (TPS) for space vehicles that enter a planetary atmosphere. During the entry phase, the vehicle experiences high rates of aerodynamic heating. These ablative materials, acting as a heat shield, protect the vehicle from the harsh environment and ensure a safe entry. Ablative materials reduce the incoming heat flux through various phenomena such as near-surface oxidation, pyrolysis chemical reaction, vaporization, and other erosive processes, collectively known as ablation. Spallation is one such ablative process, in which solid particles are ejected from the material into the flow field. The many conditions leading to spallation, however, are not well understood and cannot be described accurately by simple phenomenological models. However, the spallation phenomenon might impact the aerodynamic heating rates of re-entry vehicles using ablative heat shields. For example, the solid particles ejected from the surface can modify the near surface chemical processes and flow field. To investigate spallation effects, a code was developed to compute the dynamics of spalled particles. The code uses a finite-rate chemistry model to study the chemical interactions of the particles with the flow field. The spallation code is dynamically coupled to a CFD solver that models the time accurate hypersonic flow field around an ablative sample. An experimental investigation was also performed at the NASA Langley HYMETS facility. HYMETS is a 400 kW arcjet that can simulate hypersonic flight and Earth or Martian entry conditions. Using high speed cameras, an IR camera, NIR and UV-VIS spectrometers, and other diagnostic instruments, test data on various graphite, LI-900, FiberForm, and PICA test samples were obtained, using target heat flux conditions of 100, 200, and 400 W/cm 2 . From the test campaign, measurements of particle velocity, acceleration and trajectory are obtained.

A Martin↗

Gene expression changes in peripheral blood mononuclear cells of ISS crewmembers suggest impacts of spaceflight on cell death

In space, living organisms are exposed to numerous stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. This study is part of the Functional Immune Project, intended to determine alterations in crewmembers` immunobiology before, during, and after spaceflight. For this project, blood samples were collected from International Space Station (ISS) crewmembers at the following time points: i) at two pre-flight time points of 180 days (L180) and 45 days (L45) before launch. ii) During flight, blood was drawn at approximately the midpoint (mid-flight, MF) of the mission, and shortly before egress from the ISS (late-flight, LF). iii) Post-flight blood samples were collected within 24 hrs (R0), 30 days (R30) and 90 days (R90) after landing. For each crewmember, blood was also drawn from a matching test subject on the ground at the corresponding time point. For both the ISS crewmembers and the ground control subjects, total RNA was isolated from peripheral blood mononuclear cells (PBMC) and mRNA was analysed using next generation RNA-sequencing (NGS). Differentially expressed genes were determined by performing contrast analysis. Using the data from all of the time points from the ground control subjects as a control, a number of dysregulated genes were identified in astronauts at MF, LF and R0, including downregulations of several cell cycle related genes including CDKN1A and VEGFA at MF and LF. Pathway analysis of these differentially expressed genes indicated that, in space, pathways associated with autophagy and senescence were affected. Our analysis also indicated that the genes related to metabolisms were downregulated in the microgravity environment. Taken together, our data suggests that PBMC in the ISS crewmembers may be starved, resulting in autophagy and delayed senescence in space. Such findings are in agreement with delayed cell death in PBMC under simulated microgravity conditions on the ground and offer an explanation for telomere lengthening that has been reported among the ISS astronauts in flight.

Maria Moreno-Villanueva↗

Gene Expression Changes in Peripheral Blood Mononuclear Cells of ISS Crewmembers Suggest Impacts of Spaceflight on Cell Death

In space, living organisms are exposed to numerous stress factors including microgravity and space radiation. For humans, these harmful environmental factors have been known to cause negative health impacts such as immune dysfunction. Understanding the mechanisms by which spaceflight impacts human health at the molecular level is critical not only for accurately assessing the risks associated with spaceflight, but also for developing effective countermeasures. This study is part of the Functional Immune Project, intended to determine alterations in crewmembers` immunobiology before, during, and after spaceflight. For this project, blood samples were collected from International Space Station (ISS) crewmembers at the following time points: i) at two pre-flight time points of 180 days (L180) and 45 days (L45) before launch. ii) During flight, blood was drawn at approximately the midpoint (mid-flight, MF) of the mission, and shortly before egress from the ISS (late-flight, LF). iii) Post-flight blood samples were collected within 24 hrs (R0), 30 days (R30) and 90 days (R90) after landing. For each crewmember, blood was also drawn from a matching test subject on the ground at the corresponding time point. For both the ISS crewmembers and the ground control subjects, total RNA was isolated from peripheral blood mononuclear cells (PBMC) and mRNA was analysed using next generation RNA-sequencing (NGS). Differentially expressed genes were determined by performing contrast analysis. Using the data from all of the time points from the ground control subjects as a control, a number of dysregulated genes were identified in astronauts at MF, LF and R0, including downregulations of several cell cycle related genes including CDKN1A and VEGFA at MF and LF. Pathway analysis of these differentially expressed genes indicated that, in space, pathways associated with autophagy and senescence were affected. Our analysis also indicated that the genes related to metabolisms were downregulated in the microgravity environment. Taken together, we hypothesize that PBMC in the ISS crewmembers may be starved, resulting in autophagy and delayed senescence in space. Such findings are in agreement with delayed cell death in PBMC under simulated microgravity conditions on the ground and offer an explanation for telomere lengthening that has been reported among the ISS astronauts in flight

Maria Moreno-Villanueva↗

Evidence Report: Risk of Injury and Compromised Performance due to EVA Operations

During future missions to the Moon and Mars, each crewmember will most likely perform up to 24 hours a week of extravehicular activity (EVA) in support of exploration, science, construction, and maintenance tasks. Achieving mission objectives will require EVA systems and operations concepts that maximize human performance and efficiency while minimizing health and safety risks for crewmembers. Currently, over 450 EVAs have been performed in microgravity using the Extravehicular Mobility Unit (EMU). The EMU space suit has enabled the successful assembly and maintenance of the International Space Station (ISS) for over 20 years, as well as deployment of payload experiments, solar arrays, satellite launches and repairs. This EVA work was accomplished at a slower cadence than is expected for Moon and Mars, with ISS crewmembers performing no more than 7 EVAs during a single mission and without any back-to-back EVAs. Despite their success, ISS EVAs have resulted in more injury to EVA crewmembers than may be acceptable for long-duration exploration missions. The Apollo astronauts completed EVA tasks in suits that were designed for their short-duration lunar missions, although suit mobility problems were evident. The more frequent EVAs and more varied EVA tasks that are anticipated during the future longer-duration exploration missions will require EVA suits and systems that are better oriented to human health and performance than those used during the Apollo Program. Many of the problems that were encountered with the Apollo EVA suits (e.g., limited mobility and dexterity, high and aft center of gravity, and other features requiring significant crew compensation) will need to be corrected or mitigated to optimize EVA objectives of exploration missions. It is critical that we understand how EVA system design variables such as suit pressure, weight/mass, center-of-gravity location, joint ranges of motion, and biomedical monitoring, affects the ability of astronauts to perform safe, efficient, and effective EVAs. To achieve this understanding, EVA researchers will need to develop and execute an integrated human testing program across multiple environments. The research will provide objective data that will enable informed design decisions and crewmember standards, thereby ensuring EVA systems that optimize crewmember health, safety, efficiency, and performance. This report describes the risks to crew health, safety, performance, and efficiency caused by EVA operations, and it provides the evidence base to substantiate the importance of the risk.

EVA↗

Behavioral, Brain Imaging and Genomic Measures to Predict Functional Outcomes Post - Bed Rest and Spaceflight

Astronauts experience sensorimotor disturbances during their initial exposure to microgravity and during the re-adaptation phase following a return to an Earth-gravitational environment. These alterations may disrupt crewmembers' ability to perform mission critical functional tasks requiring ambulation, manual control and gaze stability. Interestingly, astronauts who return from spaceflight show substantial differences in their abilities to readapt to a gravitational environment. The ability to predict the manner and degree to which individual astronauts would be affected would improve the effectiveness of countermeasure training programs designed to enhance sensorimotor adaptability. For such an approach to succeed, we must develop predictive measures of sensorimotor adaptability that will allow us to foresee, before actual spaceflight, which crewmembers are likely to experience the greatest challenges to their adaptive capacities. The goals of this project are to identify and characterize this set of predictive measures. Our approach includes: 1) behavioral tests to assess sensory bias and adaptability quantified using both strategic and plastic-adaptive responses; 2) imaging to determine individual brain morphological and functional features, using structural magnetic resonance imaging (MRI), diffusion tensor imaging, resting state functional connectivity MRI, and sensorimotor adaptation task-related functional brain activation; and 3) assessment of genotypic markers of genetic polymorphisms in the catechol-O-methyl transferase, dopamine receptor D2, and brain-derived neurotrophic factor genes and genetic polymorphisms of alpha2-adrenergic receptors that play a role in the neural pathways underlying sensorimotor adaptation. We anticipate that these predictive measures will be significantly correlated with individual differences in sensorimotor adaptability after long-duration spaceflight and exposure to an analog bed rest environment. We will be conducting a retrospective study, leveraging data already collected from relevant ongoing or completed bed rest and spaceflight studies. These data will be combined with predictor metrics that will be collected prospectively (as described for behavioral, brain imaging and genomic measures) from these returning subjects to build models for predicting post-mission (bed rest - non-astronauts or space flight - astronauts) adaptive capability as manifested in their outcome measures. To date we have completed a study on 15 normal subjects with all of the above measures. In this presentation we will discuss the optimized set of tests for predictive metrics to be used for evaluating post mission adaptive capability as manifested in their outcome measures. Comparisons of model performance will allow us to better design and implement sensorimotor adaptability training countermeasures against decrements in post-mission adaptive capability that are customized for each crewmember's sensory biases, adaptive capacity, brain structure and functional capacities, and genetic predispositions. The ability to customize adaptability training will allow more efficient use of crew time during training and will optimize training prescriptions for astronauts to ensure expected outcomes.

Mulavara, A. P.↗

Effectiveness of Needles Vial Adaptors and Blunt Cannulas for Drug Administration in a Microgravity Environment

The need for a new system of injectable medications aboard the International Space Station (ISS) was identified. It is desired that this system fly medications in their original manufacturer's packaging, allowing the system to comply with United States Pharmacopeia (USP) guidelines while minimizing the resupply frequency due to medication expiration. Pre-filled syringes are desired, however, the evolving nature of the healthcare marketplace requires flexibility in the redesign. If medications must be supplied in a vial, a system is required that allows for the safe withdrawal of medication from the vial into a syringe for administration in microgravity. During two reduced gravity flights, the effectiveness of two versions of a blunt cannula and needleless vial adaptors was evaluated to facilitate the withdrawal of liquid medication from a vial into a syringe for injection. Other parameters assessed included the ability to withdraw the required amount of medication and whether this is dependent on vial size, liquid, or the total volume of fluid within the vial. Injectable medications proposed for flight on ISS were used for this evaluation. Due to differing sizes of vials and the fluid properties of the medications, the needleless vial adaptors proved to be too cumbersome to recommend for use on the ISS. The blunt cannula, specifically the plastic version, proved to be more effective at removing medication from the various sizes of vials and are the recommended hardware for ISS. Fluid isolation within the vials and syringes is an important step in preparing medication for injection regardless of the hardware used. Although isolation is a challenge in the relatively short parabolas during flight, it is not an obstacle for sustained microgravity. This presentation will provide an overview of the products tested as well as the challenges identified during the microgravity flights.

Hailey, Melinda↗

A Vehicle Management End-to-End Testing and Analysis Platform for Validation of Mission and Fault Management Algorithms to Reduce Risk for NASAs Space Launch System

The engineering development of the National Aeronautics and Space Administration's (NASA) new Space Launch System (SLS) requires cross discipline teams with extensive knowledge of launch vehicle subsystems, information theory, and autonomous algorithms dealing with all operations from pre-launch through on orbit operations. The nominal and off-nominal characteristics of SLS's elements and subsystems must be understood and matched with the autonomous algorithm monitoring and mitigation capabilities for accurate control and response to abnormal conditions throughout all vehicle mission flight phases, including precipitating safing actions and crew aborts. This presents a large and complex systems engineering challenge, which is being addressed in part by focusing on the specific subsystems involved in the handling of off-nominal mission and fault tolerance with response management. Using traditional model-based system and software engineering design principles from the Unified Modeling Language (UML) and Systems Modeling Language (SysML), the Mission and Fault Management (M&FM) algorithms for the vehicle are crafted and vetted in Integrated Development Teams (IDTs) composed of multiple development disciplines such as Systems Engineering (SE), Flight Software (FSW), Safety and Mission Assurance (S&MA) and the major subsystems and vehicle elements such as Main Propulsion Systems (MPS), boosters, avionics, Guidance, Navigation, and Control (GNC), Thrust Vector Control (TVC), and liquid engines. These model-based algorithms and their development lifecycle from inception through FSW certification are an important focus of SLS's development effort to further ensure reliable detection and response to off-nominal vehicle states during all phases of vehicle operation from pre-launch through end of flight. To test and validate these M&FM algorithms a dedicated test-bed was developed for full Vehicle Management End-to-End Testing (VMET). For addressing fault management (FM) early in the development lifecycle for the SLS program, NASA formed the M&FM team as part of the Integrated Systems Health Management and Automation Branch under the Spacecraft Vehicle Systems Department at the Marshall Space Flight Center (MSFC). To support the development of the FM algorithms, the VMET developed by the M&FM team provides the ability to integrate the algorithms, perform test cases, and integrate vendor-supplied physics-based launch vehicle (LV) subsystem models. Additionally, the team has developed processes for implementing and validating the M&FM algorithms for concept validation and risk reduction. The flexibility of the VMET capabilities enables thorough testing of the M&FM algorithms by providing configurable suites of both nominal and off-nominal test cases to validate the developed algorithms utilizing actual subsystem models such as MPS, GNC, and others. One of the principal functions of VMET is to validate the M&FM algorithms and substantiate them with performance baselines for each of the target vehicle subsystems in an independent platform exterior to the flight software test and validation processes. In any software development process there is inherent risk in the interpretation and implementation of concepts from requirements and test cases into flight software compounded with potential human errors throughout the development and regression testing lifecycle. Risk reduction is addressed by the M&FM group but in particular by the Analysis Team working with other organizations such as S&MA, Structures and Environments, GNC, Orion, Crew Office, Flight Operations, and Ground Operations by assessing performance of the M&FM algorithms in terms of their ability to reduce Loss of Mission (LOM) and Loss of Crew (LOC) probabilities. In addition, through state machine and diagnostic modeling, analysis efforts investigate a broader suite of failure effects and associated detection and responses to be tested in VMET to ensure reliable failure detection, and confirm responses do not create additional risks or cause undesired states through interactive dynamic effects with other algorithms and systems. VMET further contributes to risk reduction by prototyping and exercising the M&FM algorithms early in their implementation and without any inherent hindrances such as meeting FSW processor scheduling constraints due to their target platform - the ARINC 6535-partitioned Operating System, resource limitations, and other factors related to integration with other subsystems not directly involved with M&FM such as telemetry packing and processing. The baseline plan for use of VMET encompasses testing the original M&FM algorithms coded in the same C++ language and state machine architectural concepts as that used by FSW. This enables the development of performance standards and test cases to characterize the M&FM algorithms and sets a benchmark from which to measure their effectiveness and performance in the exterior FSW development and test processes. This paper is outlined in a systematic fashion analogous to a lifecycle process flow for engineering development of algorithms into software and testing. Section I describes the NASA SLS M&FM context, presenting the current infrastructure, leading principles, methods, and participants. Section II defines the testing philosophy of the M&FM algorithms as related to VMET followed by section III, which presents the modeling methods of the algorithms to be tested and validated in VMET. Its details are then further presented in section IV followed by Section V presenting integration, test status, and state analysis. Finally, section VI addresses the summary and forward directions followed by the appendices presenting relevant information on terminology and documentation.

Trevino, Luis↗