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At least 1,675 records · Page 93

Human microbiome science: vision for the future, Bethesda, MD, July 24 to 26, 2013

A conference entitled ‘Human microbiome science: Vision for the future’ was organized in Bethesda, MD from July 24 to 26, 2013. The event brought together experts in the field of human microbiome research and aimed at providing a comprehensive overview of the state of microbiome research, but more importantly to identify and discuss gaps, challenges and opportunities in this nascent field. This report summarizes the presentations but also describes what is needed for human microbiome research to move forward and deliver medical translational applications.

59 BASIC BIOLOGICAL SCIENCES↗

Integration of Human Reliability Analysis Models into the Simulation-Based Framework for the Risk-Informed Safety Margin Characterization Toolkit

This report presents an application of a computation-based human reliability analysis (HRA) framework called the Human Unimodel for Nuclear Technology to Enhance Reliability (HUNTER). HUNTER has been developed not as a standalone HRA method but rather as framework that ties together different HRA methods to model dynamic risk of human activities as part of an overall probabilistic risk assessment (PRA). While we have adopted particular methods to build an initial model, the HUNTER framework is meant to be intrinsically flexible to new pieces that achieve particular modeling goals. In the present report, the HUNTER implementation has the following goals: • Integration with a high fidelity thermal-hydraulic model capable of modeling nuclear power plant behaviors and transients • Consideration of a PRA context • Incorporation of a solid psychological basis for operator performance • Demonstration of a functional dynamic model of a plant upset condition and appropriate operator response This report outlines these efforts and presents the case study of a station blackout scenario to demonstrate the various modules developed to date under the HUNTER research umbrella.

98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL P↗

Planning and Analyses Performed to Install Halden’s Advanced Control Room Concept in the Human Systems Simulation Laboratory

The United States (U.S.) Department of Energy (DOE) sponsors the Light Water Reactor Sustainability (LWRS) Program, which has the goal of sustaining U.S. nuclear assets through conducting high-quality, value-added research and development (R&D) that provides the technical bases to extend the operating life of commercial NPPs. One area in the LWRS program is the Plant Modernization pathway, which includes human factors R&D, human factors engineering (HFE), and ergonomics, conducts targeted R&D to address aging and reliability concerns with the legacy instrumentation and control (I&C) and related information systems in NPPs. LWRS program researchers have been conducting R&D that enables the modernization of the I&C technologies in NPP main control rooms and have authored numerous reports on those research activities. Interestingly, however, virtually all of the control room modernization activities that have been researched in collaboration with various U.S. utility partners has been on upgrades that are the first steps to position these legacy control rooms for further full nuclear plant modernization. So, while many nuclear utility owners and operators have taken the first steps toward the digitalization of the control room I&C, LWRS program researchers are not aware of what any utility’s end-state vision is for full control room modernization. Thus, the purpose of this LWRS R&D activity is to start developing an advanced control room interface concept for legacy NPPs and to demonstrate it in the Human Systems Simulation Laboratory (HSSL) at Idaho National Laboratory (INL) so that utility partners can see what a potential end state is for their control room upgrade activities. The end state shows what a fully modernized control room looks like and how it works, and is the result of HFE and I&C work to transition the existing control room and its concept of operations to a new advanced control room configuration. This report documents the planning and analyses performed to install an advanced control room concept in the HSSL. Future LWRS reports will document the process to set up the HSSL and the gPWR with the HSI developed in Halden, and then document how LWRS program researchers at INL and Halden are supporting the capability to conduct future studies by creating additional HSIs that support control room modernization.

99 GENERAL AND MISCELLANEOUS↗

Demonstration and Evaluation of the Human-Technology Integration Guidance for Plant Modernization

The significance of nuclear power in its role producing carbon-free electricity to the U.S. cannot be overstated. However, with changes in the energy market coupled with changes in incentives given to certain resources like solar and wind, the operating and maintenance costs for these sources have seen a significant reduction, which has consequently negatively impacted the economic viability of the existing U.S. nuclear power plant fleet. Digital instrumentation and control (I&C) and control room modernization is a major critical work domain to reduce operating and maintenance costs. Existing nuclear power plants are commonly configured with mostly legacy analog I&C as well as isolated pockets of digital I&C (a plant process computer, digital recorders, etc.). One challenge with this analog I&C is that replacement parts are becoming prohibitively more expensive and difficult to obtain. Moreover, a significant challenge with the existing analog I&C is that the way in which plants are currently operated and maintained is no longer competitive with other electricity generating sources, like natural gas, where advanced digital I&C technologies are commonplace. This gap between the waynuclear power plants are operated compared to other electricity generating sources significantly challenges the economic viability of the nuclear industry. Indeed, digital I&C systems can fundamentally change the way the plant is operated (i.e., the concept of operation). The introduction of digital I&C technologies offers a wealth of benefits to the nuclear industry. However, it is important to emphasize that, to realize these benefits, a careful understanding of how to integrate technology in a collaborative way that leverages the capabilities of people and technologies is necessary. Human-technology integration applies human factors engineering methods and tools to ensure the safe and reliable use of these technologies while ensuring that the inherent features of the technologies that provide economic value are not missed. The scope of this work documents the demonstration of the recently developed human and technology integration methodology, as applied to developing a new vision and concept of operations for a major U.S. nuclear power plant fleet. This report focuses on the methodological aspects of developing a vision and concept of operations. This report shares the tools, activities, and lessons learned during a modernization currently underway for industry as a whole to consider when planning any significant digital modification and developing a new vision and concept of operations.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗

An Approach to Dependence Assessment in Human Reliability Analysis: Application of Lag and Linger Effects

Dependence assessment refers to an approach used in human reliability analysis (HRA) to adjust a human error probability (HEP) for the following action by considering the impact of the preceding action. It has been known to significantly affect the overall results of probabilistic safety assessment (PSA). If the dependence assessment is not adequate, the result could be unconvincing for explaining the operator failures in the context of PSA. To date, several methods and some recent research have identified suggestions for treating dependence issues in HRA; however, these are still exclusively based on the intrinsic approach of the Technique for Human Error Rate Prediction (THERP), an HRA method. THERP inevitably has a challenge with the subjectivity of expert evaluation as well as the requirement for PSA and HRA expertise with resource-intensive and time-consuming processes. This paper suggests an approach to dependence assessment that could not only minimize the influence of expert judgment, but also saves time to perform the analysis with reasonable manpower. It modifies existing HRA methods with considering lag and linger effects to apply dependence effects for them. Based on a representative HRA method, i.e., Standardized Plant Analysis Risk - HRA (SPAR-H), guidance for how to apply lag and linger effects for the HRA method is suggested. Then, an investigation is carried out to compare quantification results of the revised HRA method with that of the original approach based on experimental data.

99 GENERAL AND MISCELLANEOUS↗

Characterization of Recovery Human Action Mechanisms in Nuclear Power Plants

Recovery human action is defined as the action that prevents deviant conditions from producing unwanted effects. Analyzing recovery actions has been a critical part in human reliability analysis (HRA). However, there are a couple of limitations to treat recovery actions only depending on the current HRA methods. Representatively, the existing recovery analysis does not specifically consider recovery actions as are occurred in actual nuclear power plants (NPPs). The overall goal of this study aims to develop a novel recovery analysis method to account for human action recoveries in context of scenarios as well as complement the limitations of existing recovery analysis. In this paper, the recovery analysis in current HRA methods and their challenges are introduced. A strategy to achieve the goal is introduced with a modified recovery definition. Then, how we have researched the approach will be introduced in the paper.

99 GENERAL AND MISCELLANEOUS↗

Ocular input for human melatonin regulation: relevance to breast cancer

The impact of breast cancer on women across the world has been extensive and severe. As prevalence of breast cancer is greatest in industrialized regions, exposure to light at night has been proposed as a potential risk factor. This theory is supported by the epidemiological observations of decreased breast cancer in blind women and increased breast cancer in women who do shift-work. In addition, human, animal and in vitro studies which have investigated the melatonin-cancer dynamic indicate an apparent relationship between light, melatonin and cancer, albeit complex. Recent developments in understanding melatonin regulation by light in humans are examined, with particular attention to factors that contribute to the sensitivity of the light-induced melatonin suppression response. Specifically, the role of spectral characteristics of light is addressed, and recent relevant action spectrum studies in humans and other mammalian species are discussed. Across five action spectra for circadian and other non-visual responses, a peak sensitivity between 446-484 nm was identified. Under highly controlled exposure circumstances, less than 1 lux of monochromatic light elicited a significant suppression of nocturnal melatonin. In view of the possible link between light exposure, melatonin suppression and cancer risk, it is important to continue to identify the basic related ocular physiology. Visual performance, rather than circadian function, has been the primary focus of architectural lighting systems. It is now necessary to reevaluate lighting strategies, with consideration of circadian influences, in an effort to maximize physiological homeostasis and health.

Review↗

Antigen S1, encoded by the MIC1 gene, is characterized as an epitope of human CD59, enabling measurement of mutagen-induced intragenic deletions in the AL cell system

S1 cell membrane antigen is encoded by the MIC1 gene on human chromosome 11. This antigen has been widely used as a marker for studies in gene mapping or in analysis of mutagen-induced gene deletions/mutations, which utilized the human-hamster hybrid cell-line, AL-J1, carrying human chromosome 11. Evidence is presented here which identifies S1 as an epitope of CD59, a cell membrane complement inhibiting protein. E7.1 monoclonal antibody, specific for the S1 determinant, was found to react strongly with membrane CD59 in Western blotting, and to bind to purified, urinary form of CD59 in ELISAs. Cell membrane expression of S1 on various cell lines always correlated with that of CD59 when examined by immunofluorescent staining. In addition, E7.1 antibody inhibited the complement regulatory function of CD59. Identification of S1 protein as CD59 has increased the scope of the AL cell system by enabling analysis of intragenic mutations, and multiplex PCR analysis of mutated cells is described, showing variable loss of CD59 exons.

Non-NASA Center↗

Human versus automation in responding to failures: an expected-value analysis

A simple analytical criterion is provided for deciding whether a human or automation is best for a failure detection task. The method is based on expected-value decision theory in much the same way as is signal detection. It requires specification of the probabilities of misses (false negatives) and false alarms (false positives) for both human and automation being considered, as well as factors independent of the choice--namely, costs and benefits of incorrect and correct decisions as well as the prior probability of failure. The method can also serve as a basis for comparing different modes of automation. Some limiting cases of application are discussed, as are some decision criteria other than expected value. Actual or potential applications include the design and evaluation of any system in which either humans or automation are being considered.

NASA Discipline Space Human Factors↗

Uncertain responses by humans and rhesus monkeys (Macaca mulatta) in a psychophysical same-different task

The authors asked whether animals, like humans, use an uncertain response adaptively to escape indeterminate stimulus relations. Humans and monkeys were placed in a same-different task, known to be challenging for animals. Its difficulty was increased further by reducing the size of the stimulus differences, thereby making many same and different trials difficult to tell apart. Monkeys do escape selectively from these threshold trials, even while coping with 7 absolute stimulus levels concurrently. Monkeys even adjust their response strategies on short time scales according to the local task conditions. Signal-detection and optimality analyses confirm the similarity of humans' and animals' performances. Whereas associative interpretations account poorly for these results, an intuitive uncertainty construct does so easily. The authors discuss the cognitive processes that allow uncertainty's adaptive use and recommend further comparative studies of metacognition.

NASA Discipline Space Human Factors↗

Rejoining and misrejoining of radiation-induced chromatin breaks. I. experiments with human lymphocytes

Fluorescence in situ hybridization with a composite probe for human chromosome 4 and a probe that stained all centromeres was used to study gamma-ray induced breakage, rejoining and misrejoining in prematurely condensed chromosomes in human lymphocytes. Dose-response curves for the induction of all types of aberrations in prematurely condensed human chromosomes 4 were determined immediately after irradiation and after 8 h postirradiation incubation. In addition, aberrations were measured after various incubation times from 0 to 18 h after a dose of 7 Gy. Unrejoined chromosome breaks were the most frequent type of aberration observed immediately after irradiation. Approximately 15% of total aberrations observed were chromosome exchanges. After 8 h postirradiation incubation, the frequency of breaks in prematurely condensed chromosomes declined to about 20% of the initial value, and chromosomal exchanges became the most frequent aberration. Results of metaphase analysis were similar to those for prematurely condensed chromosomes after 8 h incubation with the exception that a significantly lower frequency of fragments was observed. Symmetrical and asymmetrical interchanges were found at similar frequencies at all doses. No complex exchanges were observed in lymphocyte chromosomes immediately after exposure. They accounted for about 1% of total exchanges in metaphase chromosomes at doses <3 Gy and about 14% at 7 Gy. Incomplete exchanges amounted to approximately 15% of total exchanges at all doses. The kinetics of break rejoining was exponential, and the frequency of exchanges increased with kinetics similar to that observed for the rejoining of the breaks. This increase in the total exchanges as a function of the time between irradiation and fusion was due to a rapid increase in reciprocal interchanges, and a slower increase in complex exchanges; the frequency of incomplete exchanges increased initially, then decreased with prolonged incubation to the level observed in metaphase. It is concluded that the formation of each kind of chromosome aberrations follows different kinetics.

NASA Discipline Radiation Health↗

An Overview of the Human Systems Integration Division

This presentation will provide an overview of the Human Systems Integration Division, and will highlight some of the human performance modeling efforts undertaken in previously presented MIDAS human performance modeling efforts.

human systems integration↗

Artemis: An Overview of NASA’s Activities to Return Humans to the Moon

NASA is well underway in its plans to return humans to the Moon and build long-term infrastructure both in orbit and on the surface. Following the Artemis I and Artemis II flight tests, NASA will begin crewed landings and regular missions to the Moon. Artemis will return value to the American public and the global community, enable groundbreaking scientific discovery, and prepare NASA and its partners for exploration of the solar system. Work on the initial Human Landing System (HLS), procurement activities for future HLS, and work on the initial modules of the lunar-orbiting Gateway are underway. International partnerships are playing a critical role in the planning, development, and execution of these missions. As of December 2021, three international partners have entered agreements to contribute to the Gateway and 14 nations have signed the Artemis accords. A new spacesuit acquisition strategy will stimulate economic growth and meet the growing needs of NASA and emerging customers. Requirements development is underway for an unpressurized lunar surface rover and plans for a pressurized rover, foundation surface habitat, and the Artemis Base Camp are in work. This paper will provide an update on the HLS demonstration missions and the procurement status for HLS services; a comprehensive look at the Gateway’s components and related statuses; a summary of planned surface systems; and an outline of the strategies NASA will use to successfully implement these plans, preparing for humanity's next giant leap: Mars.

Artemis↗

Safe Human Expeditions Beyond Low Earth Orbit (LEO)

The NASA Engineering and Safety Center (NESC) conducted an interdisciplinary study and workshop focusing on capabilities needed for crew health and safety on long-duration deep space expeditions in support of the Artemis Program and missions to Mars. The study focused on integration among four disciplines: 1) space weather monitoring and forecasting, 2) shielding technologies, 3) human health research, and 4) human factors engineering tools. An integrated risk assessment was performed to inform characteristics of mission architecture and capabilities needed for safe, long-duration human expeditions beyond low Earth orbit. This report contains the outcome of the NESC assessment.

Low Earth Orbit↗

A Remote Vehicle Operations Center’s Role in Collecting Human Factors Data

The National Aeronautics and Space Administration is supporting research to develop a prototype remote vehicle operations center at Langley Research Center to explore current and future advanced air mobility operations using small unmanned aerial systems vehicles as surrogates for future, larger-scale passenger carrying vehicles. Data collected within the Remote Operations for Autonomous Missions (ROAM) Unmanned Aerial Systems (UAS) Operations Center will be used to explore different roles and responsibilities of remote operators managing multiple autonomous vehicles, with the goal of exploring human-autonomy teaming concepts that enable m:N operations (i.e., m operators managing N vehicles). ROAM has developed into a world-class research, development, and technology (RD&T) environment that can support both the collection of human factors data and the command and control of remote vehicles in beyond visual line of sight conditions. Presented in this paper is an overview of ROAM, with a focus on the design components that support human factors data collection and a review of initial usability results of the facility.

Human factors↗

Foundational Human-Autonomy Teaming Research and Development in Scalable Remotely Operated Advanced Air Mobility Operations: Research Model and Initial Work

To achieve the scalability envisioned for many Advanced Air Mobility (AAM) applications, uncrewed aerial system (UAS) concepts are being pursued with the goal of enabling fewer human operators to manage more increasingly autonomous vehicles. NASA’s Transformational Tools and Technologies – Revolutionary Aviation Mobility (T3-RAM) subproject has identified human-autonomy teaming (HAT) as a critical area of research required to support these operations. Under T3-RAM, the HAT Foundational Research Activity has been tasked with providing basic research to identify HAT and human-automation interaction (HAI) principles that can be used to achieve scalable multi-vehicle UAS operations. This paper first outlines a research model to produce ecologically relevant basic research, then contextualizes completed and planned research and development activities within this model. Proposed research threads are presented, along with their practical and theoretical implications.

Human-Autonomy Teaming↗

A Remote Vehicle Operations Center’s Role in Collecting Human Factors Data

The National Aeronautics and Space Administration is supporting research to develop a prototype remote vehicle operations center at Langley Research Center to explore current and future advanced air mobility operations using small unmanned aerial systems vehicles as surrogates for future, larger-scale passenger carrying vehicles. Data collected within the Remote Operations for Autonomous Missions (ROAM) Unmanned Aerial Systems (UAS) Operations Center will be used to explore different roles and responsibilities of remote operators managing multiple autonomous vehicles, with the goal of exploring human-autonomy teaming concepts that enable m:N operations (i.e., m operators managing N vehicles). ROAM has developed into a world-class research, development, and technology (RD&T) environment that can support both the collection of human factors data and the command and control of remote vehicles in beyond visual line of sight conditions. Presented in this paper is an overview of ROAM, with a focus on the design components that support human factors data collection and a review of initial usability results of the facility.

Human factors↗

IDHEAS – A NEW APPROACH FOR HUMAN RELIABILITY ANALYSIS

This paper describes a method, IDHEAS (Integrated Decision-Tree Human Event Analysis System) that has been developed jointly by the US NRC and EPRI as an improved approach to Human Reliability Analysis (HRA) that is based on an understanding of the cognitive mechanisms and performance influencing factors (PIFs) that affect operator responses. The paper describes the various elements of the method, namely the performance of a detailed cognitive task analysis that is documented in a crew response tree (CRT), and the development of the associated time-line to identify the critical tasks, i.e. those whose failure results in a human failure event (HFE), and an approach to quantification that is based on explanations of why the HFE might occur.

99 GENERAL AND MISCELLANEOUS↗